BindingDB logo
myBDB logout

PubMed code 10229636

Compile data set for download or QSAR
Found 30 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
 0.0620n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to inhibit GTP-gamma-S binding to Opioid receptor delta 1 of guinea pig caudate.

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
 0.220n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076495
PNG
(16-methoxy-22-methyl-(13R)-14-oxa-11,22-diazahepta...)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]45[C@@H](Oc1c24)c1[nH]c2ccccc2c1C[C@@]35O
Show InChI InChI=1S/C24H24N2O3/c1-26-10-9-23-19-13-7-8-17(28-2)21(19)29-22(23)20-15(12-24(23,27)18(26)11-13)14-5-3-4-6-16(14)25-20/h3-8,18,22,25,27H,9-12H2,1-2H3/t18-,22+,23+,24-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 0.800n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
 3.20n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to inhibit GTP-gamma-S binding to Opioid receptor mu 1 of guinea pig caudate.

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076496
PNG
(17-cyclopropylmethyl-6,7-didehydro-4-hydroxy-3-met...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3CC3CC3)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C27H30N2O2/c1-31-24-9-8-17-12-23-20-13-19-18-4-2-3-5-21(18)28-22(19)14-27(20,25(17)26(24)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,20,23,28,30H,6-7,10-15H2,1H3/t20-,23+,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 7n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
 8.90n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to inhibit GTP-gamma-S binding to Opioid receptor kappa 1 of guinea pig caudate.

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076499
PNG
(24-cyclopropylmethyl-19-methoxy-4,24-diazahexacycl...)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(Cc5[nH]c6ccccc6c5C[C@@]34O)c2c1O
Show InChI InChI=1S/C27H30N2O3/c1-32-22-9-8-17-12-23-27(31)13-19-18-4-2-3-5-20(18)28-21(19)14-26(27,24(17)25(22)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,23,28,30-31H,6-7,10-15H2,1H3/t23-,26-,27-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 22n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50076496
PNG
(17-cyclopropylmethyl-6,7-didehydro-4-hydroxy-3-met...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3CC3CC3)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C27H30N2O2/c1-31-24-9-8-17-12-23-20-13-19-18-4-2-3-5-21(18)28-22(19)14-27(20,25(17)26(24)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,20,23,28,30H,6-7,10-15H2,1H3/t20-,23+,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 22n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to inhibit GTP-gamma-S binding to Opioid receptor delta 1 of guinea pig caudate

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
 27n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 by the displacement of [3H]DAMGO radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50076495
PNG
(16-methoxy-22-methyl-(13R)-14-oxa-11,22-diazahepta...)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]45[C@@H](Oc1c24)c1[nH]c2ccccc2c1C[C@@]35O
Show InChI InChI=1S/C24H24N2O3/c1-26-10-9-23-19-13-7-8-17(28-2)21(19)29-22(23)20-15(12-24(23,27)18(26)11-13)14-5-3-4-6-16(14)25-20/h3-8,18,22,25,27H,9-12H2,1-2H3/t18-,22+,23+,24-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 30n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]U-69593 radioligand from Opioid receptor kappa 1

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM21864
PNG
((21R)-22-(cyclopropylmethyl)-14-oxa-11,22-diazahep...)
Show SMILES [H][C@@]12Cc3ccc(O)c4OC5c6[nH]c7ccccc7c6CC1(O)C5(CCN2CC1CC1)c34 |THB:27:26:21:31.2.3|
Show InChI InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2/t20-,24?,25?,26?/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
Purchase

PC cid
PC sid
UniChem

Similars
Article
PubMed
 30n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]U-69593 radioligand from Opioid receptor kappa 1

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076495
PNG
(16-methoxy-22-methyl-(13R)-14-oxa-11,22-diazahepta...)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]45[C@@H](Oc1c24)c1[nH]c2ccccc2c1C[C@@]35O
Show InChI InChI=1S/C24H24N2O3/c1-26-10-9-23-19-13-7-8-17(28-2)21(19)29-22(23)20-15(12-24(23,27)18(26)11-13)14-5-3-4-6-16(14)25-20/h3-8,18,22,25,27H,9-12H2,1-2H3/t18-,22+,23+,24-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 66n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 by the displacement of [3H]DAMGO radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076498
PNG
(6,7-Didehydro-4-hydroxy-3-methoxy-17-methyl-6,7:2'...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3C)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C24H26N2O2/c1-26-10-9-24-13-19-16(15-5-3-4-6-18(15)25-19)12-17(24)20(26)11-14-7-8-21(28-2)23(27)22(14)24/h3-8,17,20,25,27H,9-13H2,1-2H3/t17-,20+,24-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 94n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076501
PNG
(19-methoxy-24-methyl-4,24-diazahexacyclo[12.7.3.01...)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(Cc5[nH]c6ccccc6c5C[C@@]34O)c2c1O
Show InChI InChI=1S/C24H26N2O3/c1-26-10-9-23-13-18-16(15-5-3-4-6-17(15)25-18)12-24(23,28)20(26)11-14-7-8-19(29-2)22(27)21(14)23/h3-8,20,25,27-28H,9-13H2,1-2H3/t20-,23-,24-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 218n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076497
PNG
(6,7-Dedihydro-17-ethyl-4-hydroxy-3-methoxymethyl-6...)
Show SMILES CCN1CC[C@]23Cc4[nH]c5ccccc5c4C[C@H]2[C@H]1Cc1ccc(OC)c(O)c31
Show InChI InChI=1S/C25H28N2O2/c1-3-27-11-10-25-14-20-17(16-6-4-5-7-19(16)26-20)13-18(25)21(27)12-15-8-9-22(29-2)24(28)23(15)25/h4-9,18,21,26,28H,3,10-14H2,1-2H3/t18-,21+,25-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 515n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076500
PNG
(24-ethyl-19-methoxy-4,24-diazahexacyclo[12.7.3.01,...)
Show SMILES CCN1CC[C@]23Cc4[nH]c5ccccc5c4C[C@@]2(O)[C@H]1Cc1ccc(OC)c(O)c31
Show InChI InChI=1S/C25H28N2O3/c1-3-27-11-10-24-14-19-17(16-6-4-5-7-18(16)26-19)13-25(24,29)21(27)12-15-8-9-20(30-2)23(28)22(15)24/h4-9,21,26,28-29H,3,10-14H2,1-2H3/t21-,24-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 684n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor delta 1 by the displacement of [3H]DADLE radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076500
PNG
(24-ethyl-19-methoxy-4,24-diazahexacyclo[12.7.3.01,...)
Show SMILES CCN1CC[C@]23Cc4[nH]c5ccccc5c4C[C@@]2(O)[C@H]1Cc1ccc(OC)c(O)c31
Show InChI InChI=1S/C25H28N2O3/c1-3-27-11-10-24-14-19-17(16-6-4-5-7-18(16)26-19)13-25(24,29)21(27)12-15-8-9-20(30-2)23(28)22(15)24/h4-9,21,26,28-29H,3,10-14H2,1-2H3/t21-,24-,25-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 797n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 by the displacement of [3H]DAMGO radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50076496
PNG
(17-cyclopropylmethyl-6,7-didehydro-4-hydroxy-3-met...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3CC3CC3)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C27H30N2O2/c1-31-24-9-8-17-12-23-20-13-19-18-4-2-3-5-21(18)28-22(19)14-27(20,25(17)26(24)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,20,23,28,30H,6-7,10-15H2,1H3/t20-,23+,27-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.25E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to inhibit GTP-gamma-S binding to Opioid receptor mu 1 of guinea pig caudate.

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50076496
PNG
(17-cyclopropylmethyl-6,7-didehydro-4-hydroxy-3-met...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3CC3CC3)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C27H30N2O2/c1-31-24-9-8-17-12-23-20-13-19-18-4-2-3-5-21(18)28-22(19)14-27(20,25(17)26(24)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,20,23,28,30H,6-7,10-15H2,1H3/t20-,23+,27-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>1.25E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to inhibit GTP-gamma-S binding to Opioid receptor kappa 1 of guinea pig caudate

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076497
PNG
(6,7-Dedihydro-17-ethyl-4-hydroxy-3-methoxymethyl-6...)
Show SMILES CCN1CC[C@]23Cc4[nH]c5ccccc5c4C[C@H]2[C@H]1Cc1ccc(OC)c(O)c31
Show InChI InChI=1S/C25H28N2O2/c1-3-27-11-10-25-14-20-17(16-6-4-5-7-19(16)26-20)13-18(25)21(27)12-15-8-9-22(29-2)24(28)23(15)25/h4-9,18,21,26,28H,3,10-14H2,1-2H3/t18-,21+,25-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.35E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 by the displacement of [3H]DAMGO radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076499
PNG
(24-cyclopropylmethyl-19-methoxy-4,24-diazahexacycl...)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(Cc5[nH]c6ccccc6c5C[C@@]34O)c2c1O
Show InChI InChI=1S/C27H30N2O3/c1-32-22-9-8-17-12-23-27(31)13-19-18-4-2-3-5-20(18)28-21(19)14-26(27,24(17)25(22)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,23,28,30-31H,6-7,10-15H2,1H3/t23-,26-,27-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.85E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 by the displacement of [3H]DAMGO radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076498
PNG
(6,7-Didehydro-4-hydroxy-3-methoxy-17-methyl-6,7:2'...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3C)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C24H26N2O2/c1-26-10-9-24-13-19-16(15-5-3-4-6-18(15)25-19)12-17(24)20(26)11-14-7-8-21(28-2)23(27)22(14)24/h3-8,17,20,25,27H,9-13H2,1-2H3/t17-,20+,24-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.82E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 by the displacement of [3H]DAMGO radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076501
PNG
(19-methoxy-24-methyl-4,24-diazahexacyclo[12.7.3.01...)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(Cc5[nH]c6ccccc6c5C[C@@]34O)c2c1O
Show InChI InChI=1S/C24H26N2O3/c1-26-10-9-23-13-18-16(15-5-3-4-6-17(15)25-18)12-24(23,28)20(26)11-14-7-8-19(29-2)22(27)21(14)23/h3-8,20,25,27-28H,9-13H2,1-2H3/t20-,23-,24-/m1/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 2.85E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 by the displacement of [3H]DAMGO radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50076499
PNG
(24-cyclopropylmethyl-19-methoxy-4,24-diazahexacycl...)
Show SMILES COc1ccc2C[C@H]3N(CC4CC4)CC[C@@]4(Cc5[nH]c6ccccc6c5C[C@@]34O)c2c1O
Show InChI InChI=1S/C27H30N2O3/c1-32-22-9-8-17-12-23-27(31)13-19-18-4-2-3-5-20(18)28-21(19)14-26(27,24(17)25(22)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,23,28,30-31H,6-7,10-15H2,1H3/t23-,26-,27-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 3.16E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]U-69593 radioligand from Opioid receptor kappa 1

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50076497
PNG
(6,7-Dedihydro-17-ethyl-4-hydroxy-3-methoxymethyl-6...)
Show SMILES CCN1CC[C@]23Cc4[nH]c5ccccc5c4C[C@H]2[C@H]1Cc1ccc(OC)c(O)c31
Show InChI InChI=1S/C25H28N2O2/c1-3-27-11-10-25-14-20-17(16-6-4-5-7-19(16)26-20)13-18(25)21(27)12-15-8-9-22(29-2)24(28)23(15)25/h4-9,18,21,26,28H,3,10-14H2,1-2H3/t18-,21+,25-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 3.64E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]U-69593 radioligand from Opioid receptor kappa 1

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50076500
PNG
(24-ethyl-19-methoxy-4,24-diazahexacyclo[12.7.3.01,...)
Show SMILES CCN1CC[C@]23Cc4[nH]c5ccccc5c4C[C@@]2(O)[C@H]1Cc1ccc(OC)c(O)c31
Show InChI InChI=1S/C25H28N2O3/c1-3-27-11-10-24-14-19-17(16-6-4-5-7-18(16)26-19)13-25(24,29)21(27)12-15-8-9-20(30-2)23(28)22(15)24/h4-9,21,26,28-29H,3,10-14H2,1-2H3/t21-,24-,25-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>5.30E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]U-69593 radioligand from Opioid receptor kappa 1

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50076501
PNG
(19-methoxy-24-methyl-4,24-diazahexacyclo[12.7.3.01...)
Show SMILES COc1ccc2C[C@H]3N(C)CC[C@@]4(Cc5[nH]c6ccccc6c5C[C@@]34O)c2c1O
Show InChI InChI=1S/C24H26N2O3/c1-26-10-9-23-13-18-16(15-5-3-4-6-17(15)25-18)12-24(23,28)20(26)11-14-7-8-19(29-2)22(27)21(14)23/h3-8,20,25,27-28H,9-13H2,1-2H3/t20-,23-,24-/m1/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>6.70E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]U-69593 radioligand from Opioid receptor kappa 1

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50076498
PNG
(6,7-Didehydro-4-hydroxy-3-methoxy-17-methyl-6,7:2'...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3C)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C24H26N2O2/c1-26-10-9-24-13-19-16(15-5-3-4-6-18(15)25-19)12-17(24)20(26)11-14-7-8-21(28-2)23(27)22(14)24/h3-8,17,20,25,27H,9-13H2,1-2H3/t17-,20+,24-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
>6.80E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Ability to displace [3H]U-69593 radioligand from Opioid receptor kappa 1

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50076496
PNG
(17-cyclopropylmethyl-6,7-didehydro-4-hydroxy-3-met...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3CC3CC3)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C27H30N2O2/c1-31-24-9-8-17-12-23-20-13-19-18-4-2-3-5-21(18)28-22(19)14-27(20,25(17)26(24)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,20,23,28,30H,6-7,10-15H2,1H3/t20-,23+,27-/m0/s1
PDB

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 7.92E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 by the displacement of [3H]U-69593 radioligand in guinea pig brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50076496
PNG
(17-cyclopropylmethyl-6,7-didehydro-4-hydroxy-3-met...)
Show SMILES COc1ccc2C[C@@H]3[C@@H]4Cc5c(C[C@]4(CCN3CC3CC3)c2c1O)[nH]c1ccccc51
Show InChI InChI=1S/C27H30N2O2/c1-31-24-9-8-17-12-23-20-13-19-18-4-2-3-5-21(18)28-22(19)14-27(20,25(17)26(24)30)10-11-29(23)15-16-6-7-16/h2-5,8-9,16,20,23,28,30H,6-7,10-15H2,1H3/t20-,23+,27-/m0/s1
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
Article
PubMed
 1.33E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor mu 1 by the displacement of [3H]DAMGO radioligand in rat brain membranes

J Med Chem 42: 1673-9 (1999)


Article DOI: 10.1021/jm9807003
BindingDB Entry DOI: 10.7270/Q24M957P
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%