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PubMed code 10340623

Compile data set for download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077089
PNG
(4-[(S)-((2S,5R)-4-Benzo[1,3]dioxol-5-ylmethyl-2,5-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(Cc2ccc3OCOc3c2)C[C@@H]1C)c1ccccc1
Show InChI InChI=1S/C32H39N3O3/c1-5-33(6-2)32(36)28-15-13-27(14-16-28)31(26-10-8-7-9-11-26)35-20-23(3)34(19-24(35)4)21-25-12-17-29-30(18-25)38-22-37-29/h7-18,23-24,31H,5-6,19-22H2,1-4H3/t23-,24+,31+/m1/s1
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n/an/a 0.540n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077083
PNG
(4-[(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(Cc2ccc3OCOc3c2)CC1)c1ccccc1
Show InChI InChI=1S/C30H35N3O3/c1-3-32(4-2)30(34)26-13-11-25(12-14-26)29(24-8-6-5-7-9-24)33-18-16-31(17-19-33)21-23-10-15-27-28(20-23)36-22-35-27/h5-15,20,29H,3-4,16-19,21-22H2,1-2H3
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n/an/a 1.40n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077085
PNG
(CHEMBL27432 | N,N-Diethyl-4-{phenyl-[4-(1,2,3,4-te...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC2CCc3ccccc3C2)CC1)c1ccccc1
Show InChI InChI=1S/C33H41N3O/c1-3-35(4-2)33(37)30-18-16-29(17-19-30)32(28-11-6-5-7-12-28)36-22-20-34(21-23-36)25-26-14-15-27-10-8-9-13-31(27)24-26/h5-13,16-19,26,32H,3-4,14-15,20-25H2,1-2H3
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n/an/a 1.80n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50039029
PNG
((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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n/an/a 2n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077081
PNG
(CHEMBL27779 | N,N-Diethyl-4-{[4-(2-hydroxy-ethyl)-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CCO)CC1)c1ccccc1
Show InChI InChI=1S/C24H33N3O2/c1-3-26(4-2)24(29)22-12-10-21(11-13-22)23(20-8-6-5-7-9-20)27-16-14-25(15-17-27)18-19-28/h5-13,23,28H,3-4,14-19H2,1-2H3
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n/an/a 5.5n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077086
PNG
(4-[(4-Cyclopentyl-piperazin-1-yl)-phenyl-methyl]-N...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC1)C1CCCC1)c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-3-28(4-2)27(31)24-16-14-23(15-17-24)26(22-10-6-5-7-11-22)30-20-18-29(19-21-30)25-12-8-9-13-25/h5-7,10-11,14-17,25-26H,3-4,8-9,12-13,18-21H2,1-2H3
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n/an/a 5.80n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077066
PNG
(4-[(4-Allyl-piperazin-1-yl)-phenyl-methyl]-N,N-die...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h4,7-15,24H,1,5-6,16-20H2,2-3H3
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n/an/a 8n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077066
PNG
(4-[(4-Allyl-piperazin-1-yl)-phenyl-methyl]-N,N-die...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h4,7-15,24H,1,5-6,16-20H2,2-3H3
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n/an/a 8n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077066
PNG
(4-[(4-Allyl-piperazin-1-yl)-phenyl-methyl]-N,N-die...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h4,7-15,24H,1,5-6,16-20H2,2-3H3
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n/an/a 8n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077091
PNG
(CHEMBL416930 | N,N-Diethyl-4-{[4-(4-hydroxy-phenyl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC1)c1ccc(O)cc1)c1ccccc1
Show InChI InChI=1S/C28H33N3O2/c1-3-29(4-2)28(33)24-12-10-23(11-13-24)27(22-8-6-5-7-9-22)31-20-18-30(19-21-31)25-14-16-26(32)17-15-25/h5-17,27,32H,3-4,18-21H2,1-2H3
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n/an/a 10n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077082
PNG
(CHEMBL150430 | CHEMBL27944 | N,N-Diethyl-4-[phenyl...)
Show SMILES CCCN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C25H35N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h7-15,24H,4-6,16-20H2,1-3H3
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n/an/a 11n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077093
PNG
(4-[(4-Allyl-[1,4]diazepan-1-yl)-phenyl-methyl]-N,N...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C26H35N3O/c1-4-17-27-18-10-19-29(21-20-27)25(22-11-8-7-9-12-22)23-13-15-24(16-14-23)26(30)28(5-2)6-3/h4,7-9,11-16,25H,1,5-6,10,17-21H2,2-3H3
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n/an/a 13n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Compound was tested for inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing human delta opioid receptor

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077088
PNG
(CHEMBL27579 | N,N-Diethyl-4-[(octahydro-quinoxalin...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCNC2CCCCC12)c1ccccc1
Show InChI InChI=1S/C26H35N3O/c1-3-28(4-2)26(30)22-16-14-21(15-17-22)25(20-10-6-5-7-11-20)29-19-18-27-23-12-8-9-13-24(23)29/h5-7,10-11,14-17,23-25,27H,3-4,8-9,12-13,18-19H2,1-2H3
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n/an/a 29n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077090
PNG
(4-[(3,5-Dimethyl-piperazin-1-yl)-phenyl-methyl]-N,...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CC(C)NC(C)C1)c1ccccc1
Show InChI InChI=1S/C24H33N3O/c1-5-26(6-2)24(28)22-14-12-21(13-15-22)23(20-10-8-7-9-11-20)27-16-18(3)25-19(4)17-27/h7-15,18-19,23,25H,5-6,16-17H2,1-4H3
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n/an/a 42n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077084
PNG
(4-{[Benzyl-(2-dimethylamino-ethyl)-amino]-phenyl-m...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N(CCN(C)C)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H37N3O/c1-5-31(6-2)29(33)27-19-17-26(18-20-27)28(25-15-11-8-12-16-25)32(22-21-30(3)4)23-24-13-9-7-10-14-24/h7-20,28H,5-6,21-23H2,1-4H3
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n/an/a 70n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077087
PNG
(4-[(2-Amino-2-methyl-propylamino)-phenyl-methyl]-N...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(NCC(C)(C)N)c1ccccc1
Show InChI InChI=1S/C22H31N3O/c1-5-25(6-2)21(26)19-14-12-18(13-15-19)20(24-16-22(3,4)23)17-10-8-7-9-11-17/h7-15,20,24H,5-6,16,23H2,1-4H3
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n/an/a 120n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50077084
PNG
(4-{[Benzyl-(2-dimethylamino-ethyl)-amino]-phenyl-m...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N(CCN(C)C)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H37N3O/c1-5-31(6-2)29(33)27-19-17-26(18-20-27)28(25-15-11-8-12-16-25)32(22-21-30(3)4)23-24-13-9-7-10-14-24/h7-20,28H,5-6,21-23H2,1-4H3
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n/an/a 483n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077089
PNG
(4-[(S)-((2S,5R)-4-Benzo[1,3]dioxol-5-ylmethyl-2,5-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(Cc2ccc3OCOc3c2)C[C@@H]1C)c1ccccc1
Show InChI InChI=1S/C32H39N3O3/c1-5-33(6-2)32(36)28-15-13-27(14-16-28)31(26-10-8-7-9-11-26)35-20-23(3)34(19-24(35)4)21-25-12-17-29-30(18-25)38-22-37-29/h7-18,23-24,31H,5-6,19-22H2,1-4H3/t23-,24+,31+/m1/s1
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n/an/a 702n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50077092
PNG
(4-{[(2-Dimethylamino-ethyl)-ethyl-amino]-phenyl-me...)
Show SMILES CCN(CCN(C)C)C(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C24H35N3O/c1-6-26(7-2)24(28)22-16-14-21(15-17-22)23(20-12-10-9-11-13-20)27(8-3)19-18-25(4)5/h9-17,23H,6-8,18-19H2,1-5H3
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n/an/a 845n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Inhibition of binding of [3H]- -naltrindole (0.15 nM) to membranes from CHO cells expressing Opioid receptor delta 1

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50077066
PNG
(4-[(4-Allyl-piperazin-1-yl)-phenyl-methyl]-N,N-die...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h4,7-15,24H,1,5-6,16-20H2,2-3H3
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n/an/a 1.99E+3n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50077083
PNG
(4-[(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(Cc2ccc3OCOc3c2)CC1)c1ccccc1
Show InChI InChI=1S/C30H35N3O3/c1-3-32(4-2)30(34)26-13-11-25(12-14-26)29(24-8-6-5-7-9-24)33-18-16-31(17-19-33)21-23-10-15-27-28(20-23)36-22-35-27/h5-15,20,29H,3-4,16-19,21-22H2,1-2H3
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n/an/a 3.90E+3n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50039029
PNG
((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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n/an/a 4.10E+3n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards Opioid receptor kappa 1 using [3H]- U-69,593 (1.5 nM) as radioligand in guinea pig brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50039029
PNG
((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077085
PNG
(CHEMBL27432 | N,N-Diethyl-4-{phenyl-[4-(1,2,3,4-te...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC2CCc3ccccc3C2)CC1)c1ccccc1
Show InChI InChI=1S/C33H41N3O/c1-3-35(4-2)33(37)30-18-16-29(17-19-30)32(28-11-6-5-7-12-28)36-22-20-34(21-23-36)25-26-14-15-27-10-8-9-13-31(27)24-26/h5-13,16-19,26,32H,3-4,14-15,20-25H2,1-2H3
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n/an/a 6.24E+3n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077082
PNG
(CHEMBL150430 | CHEMBL27944 | N,N-Diethyl-4-[phenyl...)
Show SMILES CCCN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C25H35N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h7-15,24H,4-6,16-20H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077083
PNG
(4-[(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(Cc2ccc3OCOc3c2)CC1)c1ccccc1
Show InChI InChI=1S/C30H35N3O3/c1-3-32(4-2)30(34)26-13-11-25(12-14-26)29(24-8-6-5-7-9-24)33-18-16-31(17-19-33)21-23-10-15-27-28(20-23)36-22-35-27/h5-15,20,29H,3-4,16-19,21-22H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077084
PNG
(4-{[Benzyl-(2-dimethylamino-ethyl)-amino]-phenyl-m...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N(CCN(C)C)Cc1ccccc1)c1ccccc1
Show InChI InChI=1S/C29H37N3O/c1-5-31(6-2)29(33)27-19-17-26(18-20-27)28(25-15-11-8-12-16-25)32(22-21-30(3)4)23-24-13-9-7-10-14-24/h7-20,28H,5-6,21-23H2,1-4H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077091
PNG
(CHEMBL416930 | N,N-Diethyl-4-{[4-(4-hydroxy-phenyl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC1)c1ccc(O)cc1)c1ccccc1
Show InChI InChI=1S/C28H33N3O2/c1-3-29(4-2)28(33)24-12-10-23(11-13-24)27(22-8-6-5-7-9-22)31-20-18-30(19-21-31)25-14-16-26(32)17-15-25/h5-17,27,32H,3-4,18-21H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077081
PNG
(CHEMBL27779 | N,N-Diethyl-4-{[4-(2-hydroxy-ethyl)-...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CCO)CC1)c1ccccc1
Show InChI InChI=1S/C24H33N3O2/c1-3-26(4-2)24(29)22-12-10-21(11-13-22)23(20-8-6-5-7-9-20)27-16-14-25(15-17-27)18-19-28/h5-13,23,28H,3-4,14-19H2,1-2H3
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Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077066
PNG
(4-[(4-Allyl-piperazin-1-yl)-phenyl-methyl]-N,N-die...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h4,7-15,24H,1,5-6,16-20H2,2-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))		BDBM50077066
PNG
(4-[(4-Allyl-piperazin-1-yl)-phenyl-methyl]-N,N-die...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h4,7-15,24H,1,5-6,16-20H2,2-3H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



Organon Laboratories Ltd.

Curated by ChEMBL


Assay Description
Binding affinity towards mu opioid receptor using [3H]- -DAMGO (1.5 nM) as radioligand in rat brain membranes

Bioorg Med Chem Lett 9: 1329-34 (1999)


BindingDB Entry DOI: 10.7270/Q2V40TCM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%