Affinity Data by PubMed id=10386942

PubMed code 10386942

Found 14 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50206060 (1-(2,5-dimethoxyphenethyl)-3-(5-bromopyridin-2-yl)...) Show SMILES COc1ccc(OC)c(CCNC(=S)Nc2ccc(Br)cn2)c1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50078263 (1-(5-Bromo-pyridin-2-yl)-3-[2-(2-fluoro-phenyl)-et...) Show SMILES Fc1ccccc1CCNC(=S)Nc1ccc(Br)cn1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50078261 (1-(5-Bromo-pyridin-2-yl)-3-[2-(2-chloro-phenyl)-et...) Show SMILES Clc1ccccc1CCNC(=S)Nc1ccc(Br)cn1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50078255 (1-(5-Bromo-pyridin-2-yl)-3-[2-(3-fluoro-phenyl)-et...) Show SMILES Fc1cccc(CCNC(=S)Nc2ccc(Br)cn2)c1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM1866 (3-(5-bromopyridin-2-yl)-1-[2-(pyridin-2-yl)ethyl]t...) Show SMILES Brc1ccc(NC(=S)NCCc2ccccn2)nc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM2337 (6-benzyl-1-(ethoxymethyl)-5-(propan-2-yl)-1,2,3,4-...) Show SMILES CCOCn1c(Cc2ccccc2)c(C(C)C)c(=O)[nH]c1=O Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM1944 (BHAP deriv. \| CHEMBL593 \| DELAVIRDINE MESYLATE \| D...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB PubMed	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50081459 (1-(5-Chloro-pyridin-2-yl)-3-(2-cyclohex-1-enyl-eth...) Show SMILES Clc1ccc(NC(=S)NCCC2=CCCCC2)nc1 \|t:11\| Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50078253 (4-Benzyl-3-isopropyl-6-methylsulfanylmethylsulfany...) Show SMILES CSCSc1cc(Cc2ccccc2)c(C(C)C)c(=O)[nH]1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50078260 (1-(5-Bromo-pyridin-2-yl)-3-piperidin-1-ylmethyl-th...) Show SMILES Brc1ccc(NC(=S)NCN2CCCCC2)nc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50078254 (1-(5-Bromo-pyridin-2-yl)-3-[2-(4-fluoro-phenyl)-et...) Show SMILES Fc1ccc(CCNC(=S)Nc2ccc(Br)cn2)cc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50078262 (4-(3,5-Dimethyl-benzyl)-3-isopropyl-6-methylsulfan...) Show SMILES Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	7.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50078258 (1-(5-Bromo-pyridin-2-yl)-3-morpholin-4-ylmethyl-th...) Show SMILES Brc1ccc(NC(=S)NCN2CCOCC2)nc1 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM1434 (11-cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido[3...) Show SMILES Cc1ccnc2N(C3CC3)c3ncccc3C(=O)Nc12 Show InChI	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank MMDB PDB PubMed	n/a	n/a	2.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
Institute Curated by ChEMBL					Assay Description Inhibition of purified recombinant HIV-1 reverse transcriptase				Bioorg Med Chem Lett 9: 1593-8 (1999) BindingDB Entry DOI: 10.7270/Q27H1K3Q
Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

* indicates data uncertainty>20%