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PubMed code 10395478

Compile data set for download or QSAR
Found 126 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3928
PNG
(5-Substituted 1-Phenylbenzimidazole 17 | 5-[3-(N,N...)
Show SMILES CN(C)CCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C18H21N3O/c1-20(2)11-6-12-22-16-9-10-18-17(13-16)19-14-21(18)15-7-4-3-5-8-15/h3-5,7-10,13-14H,6,11-12H2,1-2H3
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PubMed
n/an/a 150n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3929
PNG
(5-Substituted 1-Phenylbenzimidazole 18 | 5-[4-(N,N...)
Show SMILES CN(C)CCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-21(2)12-6-7-13-23-17-10-11-19-18(14-17)20-15-22(19)16-8-4-3-5-9-16/h3-5,8-11,14-15H,6-7,12-13H2,1-2H3
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PubMed
n/an/a 160n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3931
PNG
(4-{3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]propyl...)
Show SMILES C(COc1ccc2n(cnc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C20H23N3O2/c1-2-5-17(6-3-1)23-16-21-19-15-18(7-8-20(19)23)25-12-4-9-22-10-13-24-14-11-22/h1-3,5-8,15-16H,4,9-14H2
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n/an/a 170n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3918
PNG
(5-Ethoxy-1-phenylbenzimidazole Hydrochloride | 5-S...)
Show SMILES CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H14N2O/c1-2-18-13-8-9-15-14(10-13)16-11-17(15)12-6-4-3-5-7-12/h3-11H,2H2,1H3
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n/an/a 240n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3919
PNG
(1-Phenyl-5-propoxybenzimidazole Hydrochloride | 1-...)
Show SMILES CCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O/c1-2-10-19-14-8-9-16-15(11-14)17-12-18(16)13-6-4-3-5-7-13/h3-9,11-12H,2,10H2,1H3
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n/an/a 250n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3932
PNG
(4-{4-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]butyl}...)
Show SMILES C(CCN1CCOCC1)COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C21H25N3O2/c1-2-6-18(7-3-1)24-17-22-20-16-19(8-9-21(20)24)26-13-5-4-10-23-11-14-25-15-12-23/h1-3,6-9,16-17H,4-5,10-15H2
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n/an/a 270n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3933
PNG
(1-(4-Aminophenyl)-5-methoxybenzimidazole Dihydroch...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccc(N)cc1
Show InChI InChI=1S/C14H13N3O/c1-18-12-6-7-14-13(8-12)16-9-17(14)11-4-2-10(15)3-5-11/h2-9H,15H2,1H3
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n/an/a 280n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3925
PNG
(3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]propane-1...)
Show SMILES OCC(O)COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O3/c19-9-13(20)10-21-14-6-7-16-15(8-14)17-11-18(16)12-4-2-1-3-5-12/h1-8,11,13,19-20H,9-10H2
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n/an/a 310n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3924
PNG
(5-(2,3-Epoxypropoxy)-1-phenylbenzimidazole | 5-(ox...)
Show SMILES C(Oc1ccc2n(cnc2c1)-c1ccccc1)C1CO1
Show InChI InChI=1S/C16H14N2O2/c1-2-4-12(5-3-1)18-11-17-15-8-13(6-7-16(15)18)19-9-14-10-20-14/h1-8,11,14H,9-10H2
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n/an/a 320n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3954
PNG
((5-methoxy-1-phenyl-1H-1,3-benzodiazol-6-yl)methan...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1CO
Show InChI InChI=1S/C15H14N2O2/c1-19-15-8-13-14(7-11(15)9-18)17(10-16-13)12-5-3-2-4-6-12/h2-8,10,18H,9H2,1H3
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n/an/a 370n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3847
PNG
(1-Phenylbenzimidazole deriv. 64 | 5-Substituted 1-...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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PubMed
n/an/a 430n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3848
PNG
(1-Phenylbenzimidazole deriv. 65 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a 440n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3923
PNG
(4-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]butan-1-o...)
Show SMILES OCCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H18N2O2/c20-10-4-5-11-21-15-8-9-17-16(12-15)18-13-19(17)14-6-2-1-3-7-14/h1-3,6-9,12-13,20H,4-5,10-11H2
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n/an/a 450n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3938
PNG
(1-phenyl-1H-1,3-benzodiazole-4,5-diol | 4,5-Dihydr...)
Show SMILES Oc1ccc2n(cnc2c1O)-c1ccccc1
Show InChI InChI=1S/C13H10N2O2/c16-11-7-6-10-12(13(11)17)14-8-15(10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 460n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3922
PNG
(1-phenyl-5-(prop-2-en-1-yloxy)-1H-1,3-benzodiazole...)
Show SMILES C=CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-2-10-19-14-8-9-16-15(11-14)17-12-18(16)13-6-4-3-5-7-13/h2-9,11-12H,1,10H2
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n/an/a 610n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3926
PNG
(5-(2-Aminoethoxy)-1-phenylbenzimidazole Dihydrochl...)
Show SMILES NCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H15N3O/c16-8-9-19-13-6-7-15-14(10-13)17-11-18(15)12-4-2-1-3-5-12/h1-7,10-11H,8-9,16H2
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PubMed
n/an/a 650n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3930
PNG
(4-{2-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]ethyl}...)
Show SMILES C(CN1CCOCC1)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H21N3O2/c1-2-4-16(5-3-1)22-15-20-18-14-17(6-7-19(18)22)24-13-10-21-8-11-23-12-9-21/h1-7,14-15H,8-13H2
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n/an/a 730n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3935
PNG
(5-(Methylthio)-1-phenylbenzimidazole Hydrochloride...)
Show SMILES CSc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2S/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a 740n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3953
PNG
(5-Substituted 1-Phenylbenzimidazole 42 | Methyl 5-...)
Show SMILES COC(=O)c1cc2n(cnc2cc1OC)-c1ccccc1
Show InChI InChI=1S/C16H14N2O3/c1-20-15-9-13-14(8-12(15)16(19)21-2)18(10-17-13)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a 870n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3949
PNG
(5-Methoxy-6-methyl-1-phenylbenzimidazole Hydrochlo...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C
Show InChI InChI=1S/C15H14N2O/c1-11-8-14-13(9-15(11)18-2)16-10-17(14)12-6-4-3-5-7-12/h3-10H,1-2H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3955
PNG
(5-Methoxy-1-phenylbenzimidazole-6-carboxaldehyde H...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C=O
Show InChI InChI=1S/C15H12N2O2/c1-19-15-8-13-14(7-11(15)9-18)17(10-16-13)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a 1.00E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3946
PNG
(5,6-Dimethoxy-1-phenylbenzimidazole Hydrochloride ...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1OC
Show InChI InChI=1S/C15H14N2O2/c1-18-14-8-12-13(9-15(14)19-2)17(10-16-12)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a 1.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3921
PNG
(5-Butoxy-1-phenylbenzimidazole Hydrochloride | 5-S...)
Show SMILES CCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H18N2O/c1-2-3-11-20-15-9-10-17-16(12-15)18-13-19(17)14-7-5-4-6-8-14/h4-10,12-13H,2-3,11H2,1H3
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n/an/a 1.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3927
PNG
(5-Substituted 1-Phenylbenzimidazole 16 | 5-[2-(N,N...)
Show SMILES CN(C)CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H19N3O/c1-19(2)10-11-21-15-8-9-17-16(12-15)18-13-20(17)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3
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n/an/a 1.50E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3938
PNG
(1-phenyl-1H-1,3-benzodiazole-4,5-diol | 4,5-Dihydr...)
Show SMILES Oc1ccc2n(cnc2c1O)-c1ccccc1
Show InChI InChI=1S/C13H10N2O2/c16-11-7-6-10-12(13(11)17)14-8-15(10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 1.90E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3948
PNG
(12-phenyl-4,6-dioxa-10,12-diazatricyclo[7.3.0.0^{3...)
Show SMILES C1Oc2cc3ncn(-c4ccccc4)c3cc2O1
Show InChI InChI=1S/C14H10N2O2/c1-2-4-10(5-3-1)16-8-15-11-6-13-14(7-12(11)16)18-9-17-13/h1-8H,9H2
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n/an/a 2.20E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3947
PNG
(1-phenyl-1H-1,3-benzodiazole-5,6-diol | 5,6-Dihydr...)
Show SMILES Oc1cc2ncn(-c3ccccc3)c2cc1O
Show InChI InChI=1S/C13H10N2O2/c16-12-6-10-11(7-13(12)17)15(8-14-10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 2.30E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3950
PNG
(5-Hydroxy-6-methyl-1-phenylbenzimidazole Hydrochlo...)
Show SMILES Cc1cc2n(cnc2cc1O)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-10-7-13-12(8-14(10)17)15-9-16(13)11-5-3-2-4-6-11/h2-9,17H,1H3
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n/an/a 2.50E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3920
PNG
(1-phenyl-5-(propan-2-yloxy)-1H-1,3-benzodiazole | ...)
Show SMILES CC(C)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O/c1-12(2)19-14-8-9-16-15(10-14)17-11-18(16)13-6-4-3-5-7-13/h3-12H,1-2H3
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n/an/a 3.10E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3934
PNG
(1-phenyl-1H-1,3-benzodiazole-5-thiol | 5-Mercapto-...)
Show SMILES Sc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2S/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a 3.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3928
PNG
(5-Substituted 1-Phenylbenzimidazole 17 | 5-[3-(N,N...)
Show SMILES CN(C)CCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C18H21N3O/c1-20(2)11-6-12-22-16-9-10-18-17(13-16)19-14-21(18)15-7-4-3-5-8-15/h3-5,7-10,13-14H,6,11-12H2,1-2H3
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n/an/a 4.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3952
PNG
(5-Hydroxy-1-phenylbenzimidazole-6-carboxylic Acid ...)
Show SMILES OC(=O)c1cc2n(cnc2cc1O)-c1ccccc1
Show InChI InChI=1S/C14H10N2O3/c17-13-7-11-12(6-10(13)14(18)19)16(8-15-11)9-4-2-1-3-5-9/h1-8,17H,(H,18,19)
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n/an/a 4.30E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3937
PNG
(5-Substituted 1-Phenylbenzimidazole 26 | N,N-dimet...)
Show SMILES CN(C)C(=S)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H15N3OS/c1-18(2)16(21)20-13-8-9-15-14(10-13)17-11-19(15)12-6-4-3-5-7-12/h3-11H,1-2H3
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n/an/a 4.60E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3848
PNG
(1-Phenylbenzimidazole deriv. 65 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a 6.40E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3929
PNG
(5-Substituted 1-Phenylbenzimidazole 18 | 5-[4-(N,N...)
Show SMILES CN(C)CCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-21(2)12-6-7-13-23-17-10-11-19-18(14-17)20-15-22(19)16-8-4-3-5-9-16/h3-5,8-11,14-15H,6-7,12-13H2,1-2H3
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n/an/a 6.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3939
PNG
(4-Hydroxy-5-methoxy-1-phenylbenzimidazole | 5-Subs...)
Show SMILES COc1ccc2n(cnc2c1O)-c1ccccc1
Show InChI InChI=1S/C14H12N2O2/c1-18-12-8-7-11-13(14(12)17)15-9-16(11)10-5-3-2-4-6-10/h2-9,17H,1H3
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n/an/a 7.10E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3794
PNG
(1-Phenylbenzimidazole 3 | 1-Phenylbenzimidazole de...)
Show SMILES c1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2/c1-2-6-11(7-3-1)15-10-14-12-8-4-5-9-13(12)15/h1-10H
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n/an/a 9.30E+3n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3931
PNG
(4-{3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]propyl...)
Show SMILES C(COc1ccc2n(cnc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C20H23N3O2/c1-2-5-17(6-3-1)23-16-21-19-15-18(7-8-20(19)23)25-12-4-9-22-10-13-24-14-11-22/h1-3,5-8,15-16H,4,9-14H2
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n/an/a 9.80E+3n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3954
PNG
((5-methoxy-1-phenyl-1H-1,3-benzodiazol-6-yl)methan...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1CO
Show InChI InChI=1S/C15H14N2O2/c1-19-15-8-13-14(7-11(15)9-18)17(10-16-13)12-5-3-2-4-6-12/h2-8,10,18H,9H2,1H3
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3947
PNG
(1-phenyl-1H-1,3-benzodiazole-5,6-diol | 5,6-Dihydr...)
Show SMILES Oc1cc2ncn(-c3ccccc3)c2cc1O
Show InChI InChI=1S/C13H10N2O2/c16-12-6-10-11(7-13(12)17)15(8-14-10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 1.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3932
PNG
(4-{4-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]butyl}...)
Show SMILES C(CCN1CCOCC1)COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C21H25N3O2/c1-2-6-18(7-3-1)24-17-22-20-16-19(8-9-21(20)24)26-13-5-4-10-23-11-14-25-15-12-23/h1-3,6-9,16-17H,4-5,10-15H2
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n/an/a 1.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3928
PNG
(5-Substituted 1-Phenylbenzimidazole 17 | 5-[3-(N,N...)
Show SMILES CN(C)CCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C18H21N3O/c1-20(2)11-6-12-22-16-9-10-18-17(13-16)19-14-21(18)15-7-4-3-5-8-15/h3-5,7-10,13-14H,6,11-12H2,1-2H3
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n/an/a 1.40E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3839
PNG
(1-Phenylbenzimidazole 4 | 1-Phenylbenzimidazole de...)
Show SMILES Oc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-12-8-4-7-11-13(12)14-9-15(11)10-5-2-1-3-6-10/h1-9,16H
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n/an/a 1.40E+4n/an/an/an/a7.425



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3925
PNG
(3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]propane-1...)
Show SMILES OCC(O)COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O3/c19-9-13(20)10-21-14-6-7-16-15(8-14)17-11-18(16)12-4-2-1-3-5-12/h1-8,11,13,19-20H,9-10H2
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n/an/a 1.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3924
PNG
(5-(2,3-Epoxypropoxy)-1-phenylbenzimidazole | 5-(ox...)
Show SMILES C(Oc1ccc2n(cnc2c1)-c1ccccc1)C1CO1
Show InChI InChI=1S/C16H14N2O2/c1-2-4-12(5-3-1)18-11-17-15-8-13(6-7-16(15)18)19-9-14-10-20-14/h1-8,11,14H,9-10H2
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3933
PNG
(1-(4-Aminophenyl)-5-methoxybenzimidazole Dihydroch...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccc(N)cc1
Show InChI InChI=1S/C14H13N3O/c1-18-12-6-7-14-13(8-12)16-9-17(14)11-4-2-10(15)3-5-11/h2-9H,15H2,1H3
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n/an/a 1.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3951
PNG
(5-Methoxy-1-phenylbenzimidazole-6-carboxylic Acid ...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C15H12N2O3/c1-20-14-8-12-13(7-11(14)15(18)19)17(9-16-12)10-5-3-2-4-6-10/h2-9H,1H3,(H,18,19)
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n/an/a 2.10E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3847
PNG
(1-Phenylbenzimidazole deriv. 64 | 5-Substituted 1-...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3952
PNG
(5-Hydroxy-1-phenylbenzimidazole-6-carboxylic Acid ...)
Show SMILES OC(=O)c1cc2n(cnc2cc1O)-c1ccccc1
Show InChI InChI=1S/C14H10N2O3/c17-13-7-11-12(6-10(13)14(18)19)16(8-15-11)9-4-2-1-3-5-9/h1-8,17H,(H,18,19)
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n/an/a 2.20E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3936
PNG
(4-{3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)sulfanyl]p...)
Show SMILES C(CSc1ccc2n(cnc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C20H23N3OS/c1-2-5-17(6-3-1)23-16-21-19-15-18(7-8-20(19)23)25-14-4-9-22-10-12-24-13-11-22/h1-3,5-8,15-16H,4,9-14H2
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n/an/a 2.40E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3955
PNG
(5-Methoxy-1-phenylbenzimidazole-6-carboxaldehyde H...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C=O
Show InChI InChI=1S/C15H12N2O2/c1-19-15-8-13-14(7-11(15)9-18)17(10-16-13)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3932
PNG
(4-{4-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]butyl}...)
Show SMILES C(CCN1CCOCC1)COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C21H25N3O2/c1-2-6-18(7-3-1)24-17-22-20-16-19(8-9-21(20)24)26-13-5-4-10-23-11-14-25-15-12-23/h1-3,6-9,16-17H,4-5,10-15H2
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3938
PNG
(1-phenyl-1H-1,3-benzodiazole-4,5-diol | 4,5-Dihydr...)
Show SMILES Oc1ccc2n(cnc2c1O)-c1ccccc1
Show InChI InChI=1S/C13H10N2O2/c16-11-7-6-10-12(13(11)17)14-8-15(10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3923
PNG
(4-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]butan-1-o...)
Show SMILES OCCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H18N2O2/c20-10-4-5-11-21-15-8-9-17-16(12-15)18-13-19(17)14-6-2-1-3-7-14/h1-3,6-9,12-13,20H,4-5,10-11H2
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3923
PNG
(4-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]butan-1-o...)
Show SMILES OCCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H18N2O2/c20-10-4-5-11-21-15-8-9-17-16(12-15)18-13-19(17)14-6-2-1-3-7-14/h1-3,6-9,12-13,20H,4-5,10-11H2
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3946
PNG
(5,6-Dimethoxy-1-phenylbenzimidazole Hydrochloride ...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1OC
Show InChI InChI=1S/C15H14N2O2/c1-18-14-8-12-13(9-15(14)19-2)17(10-16-12)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a 2.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3918
PNG
(5-Ethoxy-1-phenylbenzimidazole Hydrochloride | 5-S...)
Show SMILES CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H14N2O/c1-2-18-13-8-9-15-14(10-13)16-11-17(15)12-6-4-3-5-7-12/h3-11H,2H2,1H3
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n/an/a 2.60E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3948
PNG
(12-phenyl-4,6-dioxa-10,12-diazatricyclo[7.3.0.0^{3...)
Show SMILES C1Oc2cc3ncn(-c4ccccc4)c3cc2O1
Show InChI InChI=1S/C14H10N2O2/c1-2-4-10(5-3-1)16-8-15-11-6-13-14(7-12(11)16)18-9-17-13/h1-8H,9H2
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3926
PNG
(5-(2-Aminoethoxy)-1-phenylbenzimidazole Dihydrochl...)
Show SMILES NCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H15N3O/c16-8-9-19-13-6-7-15-14(10-13)17-11-18(15)12-4-2-1-3-5-12/h1-7,10-11H,8-9,16H2
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3935
PNG
(5-(Methylthio)-1-phenylbenzimidazole Hydrochloride...)
Show SMILES CSc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2S/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a 2.70E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3930
PNG
(4-{2-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]ethyl}...)
Show SMILES C(CN1CCOCC1)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H21N3O2/c1-2-4-16(5-3-1)22-15-20-18-14-17(6-7-19(18)22)24-13-10-21-8-11-23-12-9-21/h1-7,14-15H,8-13H2
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3927
PNG
(5-Substituted 1-Phenylbenzimidazole 16 | 5-[2-(N,N...)
Show SMILES CN(C)CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H19N3O/c1-19(2)10-11-21-15-8-9-17-16(12-15)18-13-20(17)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3
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n/an/a 2.80E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3945
PNG
(11-methyl-5-phenyl-10-oxa-3,5-diazatricyclo[7.3.0....)
Show SMILES CC1Cc2c(O1)ccc1n(cnc21)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-11-9-13-15(19-11)8-7-14-16(13)17-10-18(14)12-5-3-2-4-6-12/h2-8,10-11H,9H2,1H3
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n/an/a 2.90E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3953
PNG
(5-Substituted 1-Phenylbenzimidazole 42 | Methyl 5-...)
Show SMILES COC(=O)c1cc2n(cnc2cc1OC)-c1ccccc1
Show InChI InChI=1S/C16H14N2O3/c1-20-15-9-13-14(8-12(15)16(19)21-2)18(10-17-13)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a 3.33E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3952
PNG
(5-Hydroxy-1-phenylbenzimidazole-6-carboxylic Acid ...)
Show SMILES OC(=O)c1cc2n(cnc2cc1O)-c1ccccc1
Show InChI InChI=1S/C14H10N2O3/c17-13-7-11-12(6-10(13)14(18)19)16(8-15-11)9-4-2-1-3-5-9/h1-8,17H,(H,18,19)
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n/an/a 3.35E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3922
PNG
(1-phenyl-5-(prop-2-en-1-yloxy)-1H-1,3-benzodiazole...)
Show SMILES C=CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-2-10-19-14-8-9-16-15(11-14)17-12-18(16)13-6-4-3-5-7-13/h2-9,11-12H,1,10H2
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n/an/a 3.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3919
PNG
(1-Phenyl-5-propoxybenzimidazole Hydrochloride | 1-...)
Show SMILES CCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O/c1-2-10-19-14-8-9-16-15(11-14)17-12-18(16)13-6-4-3-5-7-13/h3-9,11-12H,2,10H2,1H3
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n/an/a 3.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3939
PNG
(4-Hydroxy-5-methoxy-1-phenylbenzimidazole | 5-Subs...)
Show SMILES COc1ccc2n(cnc2c1O)-c1ccccc1
Show InChI InChI=1S/C14H12N2O2/c1-18-12-8-7-11-13(14(12)17)15-9-16(11)10-5-3-2-4-6-10/h2-9,17H,1H3
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3946
PNG
(5,6-Dimethoxy-1-phenylbenzimidazole Hydrochloride ...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1OC
Show InChI InChI=1S/C15H14N2O2/c1-18-14-8-12-13(9-15(14)19-2)17(10-16-12)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a 4.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3927
PNG
(5-Substituted 1-Phenylbenzimidazole 16 | 5-[2-(N,N...)
Show SMILES CN(C)CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H19N3O/c1-19(2)10-11-21-15-8-9-17-16(12-15)18-13-20(17)14-6-4-3-5-7-14/h3-9,12-13H,10-11H2,1-2H3
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n/an/a 4.50E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3941
PNG
(4,5-Dimethoxy-1-phenylbenzimidazole Hydrochloride ...)
Show SMILES COc1ccc2n(cnc2c1OC)-c1ccccc1
Show InChI InChI=1S/C15H14N2O2/c1-18-13-9-8-12-14(15(13)19-2)16-10-17(12)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3935
PNG
(5-(Methylthio)-1-phenylbenzimidazole Hydrochloride...)
Show SMILES CSc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2S/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3944
PNG
(1-phenyl-4-(prop-2-en-1-yl)-1H-1,3-benzodiazol-5-o...)
Show SMILES Oc1ccc2n(cnc2c1CC=C)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-2-6-13-15(19)10-9-14-16(13)17-11-18(14)12-7-4-3-5-8-12/h2-5,7-11,19H,1,6H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3947
PNG
(1-phenyl-1H-1,3-benzodiazole-5,6-diol | 5,6-Dihydr...)
Show SMILES Oc1cc2ncn(-c3ccccc3)c2cc1O
Show InChI InChI=1S/C13H10N2O2/c16-12-6-10-11(7-13(12)17)15(8-14-10)9-4-2-1-3-5-9/h1-8,16-17H
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3944
PNG
(1-phenyl-4-(prop-2-en-1-yl)-1H-1,3-benzodiazol-5-o...)
Show SMILES Oc1ccc2n(cnc2c1CC=C)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-2-6-13-15(19)10-9-14-16(13)17-11-18(14)12-7-4-3-5-8-12/h2-5,7-11,19H,1,6H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3839
PNG
(1-Phenylbenzimidazole 4 | 1-Phenylbenzimidazole de...)
Show SMILES Oc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-12-8-4-7-11-13(12)14-9-15(11)10-5-2-1-3-6-10/h1-9,16H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3920
PNG
(1-phenyl-5-(propan-2-yloxy)-1H-1,3-benzodiazole | ...)
Show SMILES CC(C)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O/c1-12(2)19-14-8-9-16-15(10-14)17-11-18(16)13-6-4-3-5-7-13/h3-12H,1-2H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3921
PNG
(5-Butoxy-1-phenylbenzimidazole Hydrochloride | 5-S...)
Show SMILES CCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H18N2O/c1-2-3-11-20-15-9-10-17-16(12-15)18-13-19(17)14-7-5-4-6-8-14/h4-10,12-13H,2-3,11H2,1H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3945
PNG
(11-methyl-5-phenyl-10-oxa-3,5-diazatricyclo[7.3.0....)
Show SMILES CC1Cc2c(O1)ccc1n(cnc21)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-11-9-13-15(19-11)8-7-14-16(13)17-10-18(14)12-5-3-2-4-6-12/h2-8,10-11H,9H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3949
PNG
(5-Methoxy-6-methyl-1-phenylbenzimidazole Hydrochlo...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C
Show InChI InChI=1S/C15H14N2O/c1-11-8-14-13(9-15(11)18-2)16-10-17(14)12-6-4-3-5-7-12/h3-10H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3954
PNG
((5-methoxy-1-phenyl-1H-1,3-benzodiazol-6-yl)methan...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1CO
Show InChI InChI=1S/C15H14N2O2/c1-19-15-8-13-14(7-11(15)9-18)17(10-16-13)12-5-3-2-4-6-12/h2-8,10,18H,9H2,1H3
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3925
PNG
(3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]propane-1...)
Show SMILES OCC(O)COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O3/c19-9-13(20)10-21-14-6-7-16-15(8-14)17-11-18(16)12-4-2-1-3-5-12/h1-8,11,13,19-20H,9-10H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3941
PNG
(4,5-Dimethoxy-1-phenylbenzimidazole Hydrochloride ...)
Show SMILES COc1ccc2n(cnc2c1OC)-c1ccccc1
Show InChI InChI=1S/C15H14N2O2/c1-18-13-9-8-12-14(15(13)19-2)16-10-17(12)11-6-4-3-5-7-11/h3-10H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3940
PNG
(4-methoxy-1-phenyl-1H-1,3-benzodiazol-5-ol | 5-Hyd...)
Show SMILES COc1c(O)ccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H12N2O2/c1-18-14-12(17)8-7-11-13(14)15-9-16(11)10-5-3-2-4-6-10/h2-9,17H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3942
PNG
(4-Bromo-5-hydroxy-1-phenylbenzimidazole Hydrochlor...)
Show SMILES Oc1ccc2n(cnc2c1Br)-c1ccccc1
Show InChI InChI=1S/C13H9BrN2O/c14-12-11(17)7-6-10-13(12)15-8-16(10)9-4-2-1-3-5-9/h1-8,17H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3937
PNG
(5-Substituted 1-Phenylbenzimidazole 26 | N,N-dimet...)
Show SMILES CN(C)C(=S)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H15N3OS/c1-18(2)16(21)20-13-8-9-15-14(10-13)17-11-19(15)12-6-4-3-5-7-12/h3-11H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3918
PNG
(5-Ethoxy-1-phenylbenzimidazole Hydrochloride | 5-S...)
Show SMILES CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H14N2O/c1-2-18-13-8-9-15-14(10-13)16-11-17(15)12-6-4-3-5-7-12/h3-11H,2H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3919
PNG
(1-Phenyl-5-propoxybenzimidazole Hydrochloride | 1-...)
Show SMILES CCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O/c1-2-10-19-14-8-9-16-15(11-14)17-12-18(16)13-6-4-3-5-7-13/h3-9,11-12H,2,10H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3920
PNG
(1-phenyl-5-(propan-2-yloxy)-1H-1,3-benzodiazole | ...)
Show SMILES CC(C)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H16N2O/c1-12(2)19-14-8-9-16-15(10-14)17-11-18(16)13-6-4-3-5-7-13/h3-12H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3924
PNG
(5-(2,3-Epoxypropoxy)-1-phenylbenzimidazole | 5-(ox...)
Show SMILES C(Oc1ccc2n(cnc2c1)-c1ccccc1)C1CO1
Show InChI InChI=1S/C16H14N2O2/c1-2-4-12(5-3-1)18-11-17-15-8-13(6-7-16(15)18)19-9-14-10-20-14/h1-8,11,14H,9-10H2
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3926
PNG
(5-(2-Aminoethoxy)-1-phenylbenzimidazole Dihydrochl...)
Show SMILES NCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C15H15N3O/c16-8-9-19-13-6-7-15-14(10-13)17-11-18(15)12-4-2-1-3-5-12/h1-7,10-11H,8-9,16H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3934
PNG
(1-phenyl-1H-1,3-benzodiazole-5-thiol | 5-Mercapto-...)
Show SMILES Sc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2S/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3951
PNG
(5-Methoxy-1-phenylbenzimidazole-6-carboxylic Acid ...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C15H12N2O3/c1-20-14-8-12-13(7-11(14)15(18)19)17(9-16-12)10-5-3-2-4-6-10/h2-9H,1H3,(H,18,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3955
PNG
(5-Methoxy-1-phenylbenzimidazole-6-carboxaldehyde H...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C=O
Show InChI InChI=1S/C15H12N2O2/c1-19-15-8-13-14(7-11(15)9-18)17(10-16-13)12-5-3-2-4-6-12/h2-10H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3942
PNG
(4-Bromo-5-hydroxy-1-phenylbenzimidazole Hydrochlor...)
Show SMILES Oc1ccc2n(cnc2c1Br)-c1ccccc1
Show InChI InChI=1S/C13H9BrN2O/c14-12-11(17)7-6-10-13(12)15-8-16(10)9-4-2-1-3-5-9/h1-8,17H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3944
PNG
(1-phenyl-4-(prop-2-en-1-yl)-1H-1,3-benzodiazol-5-o...)
Show SMILES Oc1ccc2n(cnc2c1CC=C)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-2-6-13-15(19)10-9-14-16(13)17-11-18(14)12-7-4-3-5-8-12/h2-5,7-11,19H,1,6H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3950
PNG
(5-Hydroxy-6-methyl-1-phenylbenzimidazole Hydrochlo...)
Show SMILES Cc1cc2n(cnc2cc1O)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-10-7-13-12(8-14(10)17)15-9-16(13)11-5-3-2-4-6-11/h2-9,17H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3922
PNG
(1-phenyl-5-(prop-2-en-1-yloxy)-1H-1,3-benzodiazole...)
Show SMILES C=CCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-2-10-19-14-8-9-16-15(11-14)17-12-18(16)13-6-4-3-5-7-13/h2-9,11-12H,1,10H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3930
PNG
(4-{2-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]ethyl}...)
Show SMILES C(CN1CCOCC1)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H21N3O2/c1-2-4-16(5-3-1)22-15-20-18-14-17(6-7-19(18)22)24-13-10-21-8-11-23-12-9-21/h1-7,14-15H,8-13H2
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3933
PNG
(1-(4-Aminophenyl)-5-methoxybenzimidazole Dihydroch...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccc(N)cc1
Show InChI InChI=1S/C14H13N3O/c1-18-12-6-7-14-13(8-12)16-9-17(14)11-4-2-10(15)3-5-11/h2-9H,15H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3948
PNG
(12-phenyl-4,6-dioxa-10,12-diazatricyclo[7.3.0.0^{3...)
Show SMILES C1Oc2cc3ncn(-c4ccccc4)c3cc2O1
Show InChI InChI=1S/C14H10N2O2/c1-2-4-10(5-3-1)16-8-15-11-6-13-14(7-12(11)16)18-9-17-13/h1-8H,9H2
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3949
PNG
(5-Methoxy-6-methyl-1-phenylbenzimidazole Hydrochlo...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C
Show InChI InChI=1S/C15H14N2O/c1-11-8-14-13(9-15(11)18-2)16-10-17(14)12-6-4-3-5-7-12/h3-10H,1-2H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3941
PNG
(4,5-Dimethoxy-1-phenylbenzimidazole Hydrochloride ...)
Show SMILES COc1ccc2n(cnc2c1OC)-c1ccccc1
Show InChI InChI=1S/C15H14N2O2/c1-18-13-9-8-12-14(15(13)19-2)16-10-17(12)11-6-4-3-5-7-11/h3-10H,1-2H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3953
PNG
(5-Substituted 1-Phenylbenzimidazole 42 | Methyl 5-...)
Show SMILES COC(=O)c1cc2n(cnc2cc1OC)-c1ccccc1
Show InChI InChI=1S/C16H14N2O3/c1-20-15-9-13-14(8-12(15)16(19)21-2)18(10-17-13)11-6-4-3-5-7-11/h3-10H,1-2H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3839
PNG
(1-Phenylbenzimidazole 4 | 1-Phenylbenzimidazole de...)
Show SMILES Oc1cccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-12-8-4-7-11-13(12)14-9-15(11)10-5-2-1-3-6-10/h1-9,16H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3847
PNG
(1-Phenylbenzimidazole deriv. 64 | 5-Substituted 1-...)
Show SMILES COc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-17-12-7-8-14-13(9-12)15-10-16(14)11-5-3-2-4-6-11/h2-10H,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3921
PNG
(5-Butoxy-1-phenylbenzimidazole Hydrochloride | 5-S...)
Show SMILES CCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C17H18N2O/c1-2-3-11-20-15-9-10-17-16(12-15)18-13-19(17)14-7-5-4-6-8-14/h4-10,12-13H,2-3,11H2,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3929
PNG
(5-Substituted 1-Phenylbenzimidazole 18 | 5-[4-(N,N...)
Show SMILES CN(C)CCCCOc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C19H23N3O/c1-21(2)12-6-7-13-23-17-10-11-19-18(14-17)20-15-22(19)16-8-4-3-5-9-16/h3-5,8-11,14-15H,6-7,12-13H2,1-2H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3937
PNG
(5-Substituted 1-Phenylbenzimidazole 26 | N,N-dimet...)
Show SMILES CN(C)C(=S)Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C16H15N3OS/c1-18(2)16(21)20-13-8-9-15-14(10-13)17-11-19(15)12-6-4-3-5-7-12/h3-11H,1-2H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3950
PNG
(5-Hydroxy-6-methyl-1-phenylbenzimidazole Hydrochlo...)
Show SMILES Cc1cc2n(cnc2cc1O)-c1ccccc1
Show InChI InChI=1S/C14H12N2O/c1-10-7-13-12(8-14(10)17)15-9-16(13)11-5-3-2-4-6-11/h2-9,17H,1H3
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3943
PNG
(4-Bromo-5-allyloxy-1-phenylbenzimidazole | 4-bromo...)
Show SMILES Brc1c(OCC=C)ccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C16H13BrN2O/c1-2-10-20-14-9-8-13-16(15(14)17)18-11-19(13)12-6-4-3-5-7-12/h2-9,11H,1,10H2
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3794
PNG
(1-Phenylbenzimidazole 3 | 1-Phenylbenzimidazole de...)
Show SMILES c1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2/c1-2-6-11(7-3-1)15-10-14-12-8-4-5-9-13(12)15/h1-10H
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University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3934
PNG
(1-phenyl-1H-1,3-benzodiazole-5-thiol | 5-Mercapto-...)
Show SMILES Sc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2S/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3940
PNG
(4-methoxy-1-phenyl-1H-1,3-benzodiazol-5-ol | 5-Hyd...)
Show SMILES COc1c(O)ccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H12N2O2/c1-18-14-12(17)8-7-11-13(14)15-9-16(11)10-5-3-2-4-6-10/h2-9,17H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3943
PNG
(4-Bromo-5-allyloxy-1-phenylbenzimidazole | 4-bromo...)
Show SMILES Brc1c(OCC=C)ccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C16H13BrN2O/c1-2-10-20-14-9-8-13-16(15(14)17)18-11-19(13)12-6-4-3-5-7-12/h2-9,11H,1,10H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3951
PNG
(5-Methoxy-1-phenylbenzimidazole-6-carboxylic Acid ...)
Show SMILES COc1cc2ncn(-c3ccccc3)c2cc1C(O)=O
Show InChI InChI=1S/C15H12N2O3/c1-20-14-8-12-13(7-11(14)15(18)19)17(9-16-12)10-5-3-2-4-6-10/h2-9H,1H3,(H,18,19)
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3794
PNG
(1-Phenylbenzimidazole 3 | 1-Phenylbenzimidazole de...)
Show SMILES c1nc2ccccc2n1-c1ccccc1
Show InChI InChI=1S/C13H10N2/c1-2-6-11(7-3-1)15-10-14-12-8-4-5-9-13(12)15/h1-10H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3931
PNG
(4-{3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)oxy]propyl...)
Show SMILES C(COc1ccc2n(cnc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C20H23N3O2/c1-2-5-17(6-3-1)23-16-21-19-15-18(7-8-20(19)23)25-12-4-9-22-10-13-24-14-11-22/h1-3,5-8,15-16H,4,9-14H2
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n/an/a 5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3936
PNG
(4-{3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)sulfanyl]p...)
Show SMILES C(CSc1ccc2n(cnc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C20H23N3OS/c1-2-5-17(6-3-1)23-16-21-19-15-18(7-8-20(19)23)25-14-4-9-22-10-12-24-13-11-22/h1-3,5-8,15-16H,4,9-14H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3940
PNG
(4-methoxy-1-phenyl-1H-1,3-benzodiazol-5-ol | 5-Hyd...)
Show SMILES COc1c(O)ccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C14H12N2O2/c1-18-14-12(17)8-7-11-13(14)15-9-16(11)10-5-3-2-4-6-10/h2-9,17H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3942
PNG
(4-Bromo-5-hydroxy-1-phenylbenzimidazole Hydrochlor...)
Show SMILES Oc1ccc2n(cnc2c1Br)-c1ccccc1
Show InChI InChI=1S/C13H9BrN2O/c14-12-11(17)7-6-10-13(12)15-8-16(10)9-4-2-1-3-5-9/h1-8,17H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM3936
PNG
(4-{3-[(1-phenyl-1H-1,3-benzodiazol-5-yl)sulfanyl]p...)
Show SMILES C(CSc1ccc2n(cnc2c1)-c1ccccc1)CN1CCOCC1
Show InChI InChI=1S/C20H23N3OS/c1-2-5-17(6-3-1)23-16-21-19-15-18(7-8-20(19)23)25-14-4-9-22-10-12-24-13-11-22/h1-3,5-8,15-16H,4,9-14H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (Human))
BDBM3939
PNG
(4-Hydroxy-5-methoxy-1-phenylbenzimidazole | 5-Subs...)
Show SMILES COc1ccc2n(cnc2c1O)-c1ccccc1
Show InChI InChI=1S/C14H12N2O2/c1-18-12-8-7-11-13(14(12)17)15-9-16(11)10-5-3-2-4-6-10/h2-9,17H,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3848
PNG
(1-Phenylbenzimidazole deriv. 65 | 1-phenyl-1H-1,3-...)
Show SMILES Oc1ccc2n(cnc2c1)-c1ccccc1
Show InChI InChI=1S/C13H10N2O/c16-11-6-7-13-12(8-11)14-9-15(13)10-4-2-1-3-5-10/h1-9,16H
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3943
PNG
(4-Bromo-5-allyloxy-1-phenylbenzimidazole | 4-bromo...)
Show SMILES Brc1c(OCC=C)ccc2n(cnc12)-c1ccccc1
Show InChI InChI=1S/C16H13BrN2O/c1-2-10-20-14-9-8-13-16(15(14)17)18-11-19(13)12-6-4-3-5-7-12/h2-9,11H,1,10H2
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM3945
PNG
(11-methyl-5-phenyl-10-oxa-3,5-diazatricyclo[7.3.0....)
Show SMILES CC1Cc2c(O1)ccc1n(cnc21)-c1ccccc1
Show InChI InChI=1S/C16H14N2O/c1-11-9-13-15(19-11)8-7-14-16(13)17-10-18(14)12-5-3-2-4-6-12/h2-8,10-11H,9H2,1H3
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n/an/a>5.00E+4n/an/an/an/an/an/a



University of Auckland



Assay Description
IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...


J Med Chem 42: 2373-82 (1999)


Article DOI: 10.1021/jm980658b
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%