BindingDB logo
myBDB logout

PubMed code 10406633

Compile data set for download or QSAR
Found 32 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50065115
PNG
(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Show SMILES Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 0.5n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078656
PNG
(CHEMBL46295 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES Cc1c(F)cccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C26H21FN4O2/c1-17-21(8-4-9-22(17)27)25(32)29-24-12-11-18(14-28-24)26(33)31-16-20-7-5-13-30(20)15-19-6-2-3-10-23(19)31/h2-14H,15-16H2,1H3,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078652
PNG
(CHEMBL301788 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Fc1ccc(C(=O)Nc2ccc(cn2)C(=O)N2Cc3cccn3Cc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C25H18ClFN4O2/c26-21-12-18(27)8-9-20(21)24(32)29-23-10-7-16(13-28-23)25(33)31-15-19-5-3-11-30(19)14-17-4-1-2-6-22(17)31/h1-13H,14-15H2,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.10n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078660
PNG
(CHEMBL299532 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Brc1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H19BrN4O2/c26-21-9-3-2-8-20(21)24(31)28-23-12-11-17(14-27-23)25(32)30-16-19-7-5-13-29(19)15-18-6-1-4-10-22(18)30/h1-14H,15-16H2,(H,27,28,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.60n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078651
PNG
(CHEMBL300963 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H19ClN4O2/c26-21-9-3-2-8-20(21)24(31)28-23-12-11-17(14-27-23)25(32)30-16-19-7-5-13-29(19)15-18-6-1-4-10-22(18)30/h1-14H,15-16H2,(H,27,28,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.80n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078654
PNG
(CHEMBL297990 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C26H22N4O2/c1-18-7-2-4-10-22(18)25(31)28-24-13-12-19(15-27-24)26(32)30-17-21-9-6-14-29(21)16-20-8-3-5-11-23(20)30/h2-15H,16-17H2,1H3,(H,27,28,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of (P[3H]-AVP binding towards isolated rat kidney medullary Vasopre ssin V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078655
PNG
(CHEMBL49824 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H18ClFN4O2/c26-19-7-3-8-20(27)23(19)24(32)29-22-11-10-16(13-28-22)25(33)31-15-18-6-4-12-30(18)14-17-5-1-2-9-21(17)31/h1-13H,14-15H2,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078663
PNG
(CHEMBL300946 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Cc1ccc(F)cc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C26H21FN4O2/c1-17-8-10-20(27)13-22(17)25(32)29-24-11-9-18(14-28-24)26(33)31-16-21-6-4-12-30(21)15-19-5-2-3-7-23(19)31/h2-14H,15-16H2,1H3,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of (P[3H]-AVP binding to isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078665
PNG
(CHEMBL298911 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Clc1ccc(Cl)c(c1)C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H18Cl2N4O2/c26-18-8-9-21(27)20(12-18)24(32)29-23-10-7-16(13-28-23)25(33)31-15-19-5-3-11-30(19)14-17-4-1-2-6-22(17)31/h1-13H,14-15H2,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 4.30n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078652
PNG
(CHEMBL301788 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Fc1ccc(C(=O)Nc2ccc(cn2)C(=O)N2Cc3cccn3Cc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C25H18ClFN4O2/c26-21-12-18(27)8-9-20(21)24(32)29-23-10-7-16(13-28-23)25(33)31-15-19-5-3-11-30(19)14-17-4-1-2-6-22(17)31/h1-13H,14-15H2,(H,28,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 6n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078660
PNG
(CHEMBL299532 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Brc1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H19BrN4O2/c26-21-9-3-2-8-20(21)24(31)28-23-12-11-17(14-27-23)25(32)30-16-19-7-5-13-29(19)15-18-6-1-4-10-22(18)30/h1-14H,15-16H2,(H,27,28,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 7n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078661
PNG
(CHEMBL300433 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Clc1ccc(Br)cc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H18BrClN4O2/c26-18-8-9-21(27)20(12-18)24(32)29-23-10-7-16(13-28-23)25(33)31-15-19-5-3-11-30(19)14-17-4-1-2-6-22(17)31/h1-13H,14-15H2,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 7.30n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078659
PNG
(Biphenyl-2-carboxylic acid [5-(5H,11H-benzo[e]pyrr...)
Show SMILES O=C(Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C31H24N4O2/c36-30(27-14-6-5-13-26(27)22-9-2-1-3-10-22)33-29-17-16-23(19-32-29)31(37)35-21-25-12-8-18-34(25)20-24-11-4-7-15-28(24)35/h1-19H,20-21H2,(H,32,33,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 8.30n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078656
PNG
(CHEMBL46295 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES Cc1c(F)cccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C26H21FN4O2/c1-17-21(8-4-9-22(17)27)25(32)29-24-12-11-18(14-28-24)26(33)31-16-20-7-5-13-30(20)15-19-6-2-3-10-23(19)31/h2-14H,15-16H2,1H3,(H,28,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 9n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078651
PNG
(CHEMBL300963 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Clc1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H19ClN4O2/c26-21-9-3-2-8-20(21)24(31)28-23-12-11-17(14-27-23)25(32)30-16-19-7-5-13-29(19)15-18-6-1-4-10-22(18)30/h1-14H,15-16H2,(H,27,28,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 11n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078654
PNG
(CHEMBL297990 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Cc1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C26H22N4O2/c1-18-7-2-4-10-22(18)25(31)28-24-13-12-19(15-27-24)26(32)30-17-21-9-6-14-29(21)16-20-8-3-5-11-23(20)30/h2-15H,16-17H2,1H3,(H,27,28,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 21n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
In vitro inhibition of (Phe-3,4,5 [3H]-) AVP binding towards isolated rat hepatic Vasopressin V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078659
PNG
(Biphenyl-2-carboxylic acid [5-(5H,11H-benzo[e]pyrr...)
Show SMILES O=C(Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C31H24N4O2/c36-30(27-14-6-5-13-26(27)22-9-2-1-3-10-22)33-29-17-16-23(19-32-29)31(37)35-21-25-12-8-18-34(25)20-24-11-4-7-15-28(24)35/h1-19H,20-21H2,(H,32,33,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 30n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078663
PNG
(CHEMBL300946 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Cc1ccc(F)cc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C26H21FN4O2/c1-17-8-10-20(27)13-22(17)25(32)29-24-11-9-18(14-28-24)26(33)31-16-21-6-4-12-30(21)15-19-5-2-3-7-23(19)31/h2-14H,15-16H2,1H3,(H,28,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 33n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078650
PNG
(CHEMBL51645 | N-[5-(3-Dimethylaminomethyl-5H,11H-b...)
Show SMILES CN(C)Cc1ccc2CN(C(=O)c3ccc(NC(=O)c4cc(F)ccc4C)nc3)c3ccccc3Cn12
Show InChI InChI=1S/C29H28FN5O2/c1-19-8-10-22(30)14-25(19)28(36)32-27-13-9-20(15-31-27)29(37)35-18-24-12-11-23(17-33(2)3)34(24)16-21-6-4-5-7-26(21)35/h4-15H,16-18H2,1-3H3,(H,31,32,36)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 33n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078655
PNG
(CHEMBL49824 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES Fc1cccc(Cl)c1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H18ClFN4O2/c26-19-7-3-8-20(27)23(19)24(32)29-22-11-10-16(13-28-22)25(33)31-15-18-6-4-12-30(18)14-17-5-1-2-9-21(17)31/h1-13H,14-15H2,(H,28,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 40n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078661
PNG
(CHEMBL300433 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Clc1ccc(Br)cc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H18BrClN4O2/c26-18-8-9-21(27)20(12-18)24(32)29-23-10-7-16(13-28-23)25(33)31-15-19-5-3-11-30(19)14-17-4-1-2-6-22(17)31/h1-13H,14-15H2,(H,28,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 82n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50065115
PNG
(3-chloro-4-(10,11-dihydro-5H-benzo[e]pyrrolo[1,2-a...)
Show SMILES Cc1ccc(F)cc1C(=O)Nc1ccc(C(=O)N2Cc3cccn3Cc3ccccc23)c(Cl)c1
Show InChI InChI=1S/C27H21ClFN3O2/c1-17-8-9-19(29)13-23(17)26(33)30-20-10-11-22(24(28)14-20)27(34)32-16-21-6-4-12-31(21)15-18-5-2-3-7-25(18)32/h2-14H,15-16H2,1H3,(H,30,33)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
Purchase

CHEMBL
MCE
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a 82n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078650
PNG
(CHEMBL51645 | N-[5-(3-Dimethylaminomethyl-5H,11H-b...)
Show SMILES CN(C)Cc1ccc2CN(C(=O)c3ccc(NC(=O)c4cc(F)ccc4C)nc3)c3ccccc3Cn12
Show InChI InChI=1S/C29H28FN5O2/c1-19-8-10-22(30)14-25(19)28(36)32-27-13-9-20(15-31-27)29(37)35-18-24-12-11-23(17-33(2)3)34(24)16-21-6-4-5-7-26(21)35/h4-15H,16-18H2,1-3H3,(H,31,32,36)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 99n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078665
PNG
(CHEMBL298911 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Clc1ccc(Cl)c(c1)C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H18Cl2N4O2/c26-18-8-9-21(27)20(12-18)24(32)29-23-10-7-16(13-28-23)25(33)31-15-19-5-3-11-30(19)14-17-4-1-2-6-22(17)31/h1-13H,14-15H2,(H,28,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 100n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078658
PNG
(CHEMBL49796 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES [O-][N+](=O)c1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H19N5O4/c31-24(20-8-2-4-10-22(20)30(33)34)27-23-12-11-17(14-26-23)25(32)29-16-19-7-5-13-28(19)15-18-6-1-3-9-21(18)29/h1-14H,15-16H2,(H,26,27,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 160n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078664
PNG
(2-Amino-N-[5-(5H,11H-benzo[e]pyrrolo[1,2-a][1,4]di...)
Show SMILES Nc1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H21N5O2/c26-21-9-3-2-8-20(21)24(31)28-23-12-11-17(14-27-23)25(32)30-16-19-7-5-13-29(19)15-18-6-1-4-10-22(18)30/h1-14H,15-16,26H2,(H,27,28,31)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 210n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078653
PNG
(CHEMBL49657 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES Fc1ccc(F)c(c1)C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H18F2N4O2/c26-18-8-9-21(27)20(12-18)24(32)29-23-10-7-16(13-28-23)25(33)31-15-19-5-3-11-30(19)14-17-4-1-2-6-22(17)31/h1-13H,14-15H2,(H,28,29,32)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 240n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078662
PNG
(CHEMBL296619 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Clc1ccc(cc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12)-c1ccccn1
Show InChI InChI=1S/C30H22ClN5O2/c31-25-12-10-20(26-8-3-4-14-32-26)16-24(25)29(37)34-28-13-11-21(17-33-28)30(38)36-19-23-7-5-15-35(23)18-22-6-1-2-9-27(22)36/h1-17H,18-19H2,(H,33,34,37)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 260n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078657
PNG
(CHEMBL49323 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES CN(C)CCCN(C(=O)c1cc(F)ccc1C)c1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C31H32FN5O2/c1-22-11-13-25(32)18-27(22)31(39)36(17-7-15-34(2)3)29-14-12-23(19-33-29)30(38)37-21-26-9-6-16-35(26)20-24-8-4-5-10-28(24)37/h4-6,8-14,16,18-19H,7,15,17,20-21H2,1-3H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 290n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078653
PNG
(CHEMBL49657 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES Fc1ccc(F)c(c1)C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H18F2N4O2/c26-18-8-9-21(27)20(12-18)24(32)29-23-10-7-16(13-28-23)25(33)31-15-19-5-3-11-30(19)14-17-4-1-2-6-22(17)31/h1-13H,14-15H2,(H,28,29,32)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 310n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V2 receptor


(Rattus norvegicus (Rat))		BDBM50078662
PNG
(CHEMBL296619 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a]...)
Show SMILES Clc1ccc(cc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12)-c1ccccn1
Show InChI InChI=1S/C30H22ClN5O2/c31-25-12-10-20(26-8-3-4-14-32-26)16-24(25)29(37)34-28-13-11-21(17-33-28)30(38)36-19-23-7-5-15-35(23)18-22-6-1-2-9-27(22)36/h1-17H,18-19H2,(H,33,34,37)
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 480n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of P[3H]-AVP from isolated rat kidney medullary V2 receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
Vasopressin V1a receptor


(RAT)		BDBM50078658
PNG
(CHEMBL49796 | N-[5-(5H,11H-Benzo[e]pyrrolo[1,2-a][...)
Show SMILES [O-][N+](=O)c1ccccc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2cccn2Cc2ccccc12
Show InChI InChI=1S/C25H19N5O4/c31-24(20-8-2-4-10-22(20)30(33)34)27-23-12-11-17(14-26-23)25(32)29-16-19-7-5-13-28(19)15-18-6-1-3-9-21(18)29/h1-14H,15-16H2,(H,26,27,31)
UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 920n/an/an/an/an/an/a



Wyeth-Ayerst Research

Curated by ChEMBL


Assay Description
Displacement of (Phe-3,4,5 [3H]-) AVP from isolated rat hepatic V1a receptor

Bioorg Med Chem Lett 9: 1737-40 (1999)


BindingDB Entry DOI: 10.7270/Q23B5ZBZ
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%