Affinity Data by PubMed id=10450949

PubMed code 10450949

Found 24 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Muscarinic acetylcholine receptor M1 (RAT)	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity against M1 receptor was determined by displacing [3H]OXO-M in rat cortical homogenate				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	2	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	3.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity towards human muscarinic M2 receptor				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079592 (3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079592 (3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	7	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50079584 (3-(3-Hexyloxy-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity towards human muscarinic M2 receptor				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079586 (3-(6-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicyclo[...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	22	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079584 (3-(3-Hexyloxy-pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079589 (3-(3-Hexylsulfanyl-pyrazin-2-ylsulfanyl)-1-aza-bic...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50079590 ((S)-3-(Pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptan...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Binding affinity towards human muscarinic M2 receptor				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50003359 (5-(4-Hexyloxy-[1,2,5]thiadiazol-3-yl)-1-methyl-1,2...) Show SMILES CCCCCCOc1nsnc1C1=CCCN(C)C1 \|t:13\| Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	42	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079594 ((S)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	75	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079591 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	124	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079585 (3-(3-Hexyloxy-pyrazin-2-ylsulfanyl)-1-aza-bicyclo[...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	292	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079588 ((S)-3-(3-Hexyloxy-pyrazin-2-yloxy)-1-aza-bicyclo[2...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	465	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079588 ((S)-3-(3-Hexyloxy-pyrazin-2-yloxy)-1-aza-bicyclo[2...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	465	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079593 ((R)-3-(3-Hexyloxy-pyrazin-2-yloxy)-1-aza-bicyclo[2...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	690	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079590 ((S)-3-(Pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptan...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079590 ((S)-3-(Pyrazin-2-yloxy)-1-aza-bicyclo[2.2.1]heptan...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	5.60E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079587 (CHEMBL301826 \| Methyl-carbamic acid (S)-(1-aza-bic...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	2.60E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligand				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M3 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.70	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description In vitro functional agonism against M3 muscarinic receptor (PI)				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M2 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	8	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description In vitro functional agonism against M2 muscarinic receptor (cAMP)				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair
Muscarinic acetylcholine receptor M1 (Homo sapiens (Human))	BDBM50079583 ((R)-3-(3-Hexylsulfanyl-pyrazin-2-yloxy)-1-aza-bicy...) Show SMILES Show InChI	UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.10	n/a	n/a	n/a	n/a
Wyeth-Ayerst Research Curated by ChEMBL					Assay Description In vitro functional agonism against M1 muscarinic receptor (PI)				Bioorg Med Chem Lett 9: 1895-900 (1999) BindingDB Entry DOI: 10.7270/Q2G161CX
Wyeth-Ayerst Research Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%