Found 27 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080764
((S)-2-({5-[(Benzyl-pyridin-3-yl-amino)-methyl]-2'-...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H33N3O3S/c1-23-9-6-7-13-27(23)29-19-25(14-15-28(29)31(36)34-30(32(37)38)16-18-39-2)22-35(26-12-8-17-33-20-26)21-24-10-4-3-5-11-24/h3-15,17,19-20,30H,16,18,21-22H2,1-2H3,(H,34,36)(H,37,38)/t30-/m0/s1 | PDB
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PubMed
| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080765
((S)-2-({5-[(Cyclohexylmethyl-pyridin-3-yl-amino)-m...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(CC2CCCCC2)c2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H39N3O3S/c1-23-9-6-7-13-27(23)29-19-25(14-15-28(29)31(36)34-30(32(37)38)16-18-39-2)22-35(26-12-8-17-33-20-26)21-24-10-4-3-5-11-24/h6-9,12-15,17,19-20,24,30H,3-5,10-11,16,18,21-22H2,1-2H3,(H,34,36)(H,37,38)/t30-/m0/s1 | PDB
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080742
((S)-2-[(5-{[Benzyl-(5-fluoro-pyridin-3-yl)-amino]-...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cncc(F)c2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H32FN3O3S/c1-22-8-6-7-11-27(22)29-16-24(12-13-28(29)31(37)35-30(32(38)39)14-15-40-2)21-36(20-23-9-4-3-5-10-23)26-17-25(33)18-34-19-26/h3-13,16-19,30H,14-15,20-21H2,1-2H3,(H,35,37)(H,38,39)/t30-/m0/s1 | PDB
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| n/a | n/a | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080748
((S)-2-[(5-{[(3,5-Difluoro-benzyl)-thiazol-5-ylmeth...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2cncs2)Cc2cc(F)cc(F)c2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H31F2N3O3S2/c1-20-5-3-4-6-26(20)28-13-21(7-8-27(28)30(37)35-29(31(38)39)9-10-40-2)16-36(18-25-15-34-19-41-25)17-22-11-23(32)14-24(33)12-22/h3-8,11-15,19,29H,9-10,16-18H2,1-2H3,(H,35,37)(H,38,39)/t29-/m0/s1 | PDB
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| n/a | n/a | 0.200 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067581
((S)-2-{[2'-Methyl-5-(pyridin-3-ylaminomethyl)-biph...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CNc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C25H27N3O3S/c1-17-6-3-4-8-20(17)22-14-18(15-27-19-7-5-12-26-16-19)9-10-21(22)24(29)28-23(25(30)31)11-13-32-2/h3-10,12,14,16,23,27H,11,13,15H2,1-2H3,(H,28,29)(H,30,31)/t23-/m0/s1 | PDB
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| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080750
((S)-2-({5-[(Benzyl-pyrimidin-5-yl-amino)-methyl]-2...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cncnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H32N4O3S/c1-22-8-6-7-11-26(22)28-16-24(12-13-27(28)30(36)34-29(31(37)38)14-15-39-2)20-35(25-17-32-21-33-18-25)19-23-9-4-3-5-10-23/h3-13,16-18,21,29H,14-15,19-20H2,1-2H3,(H,34,36)(H,37,38)/t29-/m0/s1 | PDB
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| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50067563
((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-biphen...)Show SMILES CSCC[C@H](NC(=O)c1ccc(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C25H26N2O4S/c1-17-6-3-4-8-20(17)22-14-18(16-31-19-7-5-12-26-15-19)9-10-21(22)24(28)27-23(25(29)30)11-13-32-2/h3-10,12,14-15,23H,11,13,16H2,1-2H3,(H,27,28)(H,29,30)/t23-/m0/s1 | PDB
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| n/a | n/a | 0.400 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080747
((S)-2-[(5-{[(3,5-Difluoro-benzyl)-phenyl-amino]-me...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2cc(F)cc(F)c2)c2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C33H32F2N2O3S/c1-22-8-6-7-11-28(22)30-18-23(12-13-29(30)32(38)36-31(33(39)40)14-15-41-2)20-37(27-9-4-3-5-10-27)21-24-16-25(34)19-26(35)17-24/h3-13,16-19,31H,14-15,20-21H2,1-2H3,(H,36,38)(H,39,40)/t31-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080743
((S)-2-({5-[(Benzyl-thiazol-5-ylmethyl-amino)-methy...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2cncs2)Cc2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H33N3O3S2/c1-22-8-6-7-11-26(22)28-16-24(12-13-27(28)30(35)33-29(31(36)37)14-15-38-2)19-34(20-25-17-32-21-39-25)18-23-9-4-3-5-10-23/h3-13,16-17,21,29H,14-15,18-20H2,1-2H3,(H,33,35)(H,36,37)/t29-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080759
((S)-2-{[2'-Methyl-4-phenethyl-5-(pyridin-3-yloxyme...)Show SMILES CSCC[C@H](NC(=O)c1cc(CCc2ccccc2)c(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C33H34N2O4S/c1-23-9-6-7-13-28(23)29-20-26(22-39-27-12-8-17-34-21-27)25(15-14-24-10-4-3-5-11-24)19-30(29)32(36)35-31(33(37)38)16-18-40-2/h3-13,17,19-21,31H,14-16,18,22H2,1-2H3,(H,35,36)(H,37,38)/t31-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080744
((S)-2-({5-[(Benzyl-pyrazin-2-yl-amino)-methyl]-2'-...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2cnccn2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H32N4O3S/c1-22-8-6-7-11-25(22)27-18-24(12-13-26(27)30(36)34-28(31(37)38)14-17-39-2)21-35(29-19-32-15-16-33-29)20-23-9-4-3-5-10-23/h3-13,15-16,18-19,28H,14,17,20-21H2,1-2H3,(H,34,36)(H,37,38)/t28-/m0/s1 | PDB
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| n/a | n/a | 0.800 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080762
((S)-2-{[4-Benzyl-2'-methyl-5-(pyridin-3-yloxymethy...)Show SMILES CSCC[C@H](NC(=O)c1cc(Cc2ccccc2)c(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H32N2O4S/c1-22-9-6-7-13-27(22)28-19-25(21-38-26-12-8-15-33-20-26)24(17-23-10-4-3-5-11-23)18-29(28)31(35)34-30(32(36)37)14-16-39-2/h3-13,15,18-20,30H,14,16-17,21H2,1-2H3,(H,34,35)(H,36,37)/t30-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080745
((S)-2-({5-[(Benzyl-phenyl-amino)-methyl]-2'-methyl...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2ccccc2)c2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C33H34N2O3S/c1-24-11-9-10-16-28(24)30-21-26(17-18-29(30)32(36)34-31(33(37)38)19-20-39-2)23-35(27-14-7-4-8-15-27)22-25-12-5-3-6-13-25/h3-18,21,31H,19-20,22-23H2,1-2H3,(H,34,36)(H,37,38)/t31-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080763
((S)-2-[(5-{[(3,5-Difluoro-benzyl)-pyridin-3-yl-ami...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2cc(F)cc(F)c2)c2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H31F2N3O3S/c1-21-6-3-4-8-27(21)29-16-22(9-10-28(29)31(38)36-30(32(39)40)11-13-41-2)19-37(26-7-5-12-35-18-26)20-23-14-24(33)17-25(34)15-23/h3-10,12,14-18,30H,11,13,19-20H2,1-2H3,(H,36,38)(H,39,40)/t30-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080761
((S)-2-{[2'-Methyl-4-pentyl-5-(pyridin-3-yloxymethy...)Show SMILES CCCCCc1cc(C(=O)N[C@@H](CCSC)C(O)=O)c(cc1COc1cccnc1)-c1ccccc1C Show InChI InChI=1S/C30H36N2O4S/c1-4-5-6-11-22-17-27(29(33)32-28(30(34)35)14-16-37-3)26(25-13-8-7-10-21(25)2)18-23(22)20-36-24-12-9-15-31-19-24/h7-10,12-13,15,17-19,28H,4-6,11,14,16,20H2,1-3H3,(H,32,33)(H,34,35)/t28-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080760
((S)-2-{[4-Ethyl-2'-methyl-5-(pyridin-3-yloxymethyl...)Show SMILES CCc1cc(C(=O)N[C@@H](CCSC)C(O)=O)c(cc1COc1cccnc1)-c1ccccc1C Show InChI InChI=1S/C27H30N2O4S/c1-4-19-14-24(26(30)29-25(27(31)32)11-13-34-3)23(22-10-6-5-8-18(22)2)15-20(19)17-33-21-9-7-12-28-16-21/h5-10,12,14-16,25H,4,11,13,17H2,1-3H3,(H,29,30)(H,31,32)/t25-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080752
((S)-2-({5-[(Benzyl-thiazol-2-ylmethyl-amino)-methy...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2nccs2)Cc2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H33N3O3S2/c1-22-8-6-7-11-25(22)27-18-24(12-13-26(27)30(35)33-28(31(36)37)14-16-38-2)20-34(21-29-32-15-17-39-29)19-23-9-4-3-5-10-23/h3-13,15,17-18,28H,14,16,19-21H2,1-2H3,(H,33,35)(H,36,37)/t28-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080751
((S)-2-({5-[(Benzenesulfonyl-pyridin-3-yl-amino)-me...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(c2cccnc2)S(=O)(=O)c2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H31N3O5S2/c1-22-9-6-7-13-26(22)28-19-23(14-15-27(28)30(35)33-29(31(36)37)16-18-40-2)21-34(24-10-8-17-32-20-24)41(38,39)25-11-4-3-5-12-25/h3-15,17,19-20,29H,16,18,21H2,1-2H3,(H,33,35)(H,36,37)/t29-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080749
((S)-2-{[4-Butyl-2'-methyl-5-(pyridin-3-yloxymethyl...)Show SMILES CCCCc1cc(C(=O)N[C@@H](CCSC)C(O)=O)c(cc1COc1cccnc1)-c1ccccc1C Show InChI InChI=1S/C29H34N2O4S/c1-4-5-10-21-16-26(28(32)31-27(29(33)34)13-15-36-3)25(24-12-7-6-9-20(24)2)17-22(21)19-35-23-11-8-14-30-18-23/h6-9,11-12,14,16-18,27H,4-5,10,13,15,19H2,1-3H3,(H,31,32)(H,33,34)/t27-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080756
((S)-2-{[4-Cyclohexylmethyl-2'-methyl-5-(pyridin-3-...)Show SMILES CSCC[C@H](NC(=O)c1cc(CC2CCCCC2)c(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H38N2O4S/c1-22-9-6-7-13-27(22)28-19-25(21-38-26-12-8-15-33-20-26)24(17-23-10-4-3-5-11-23)18-29(28)31(35)34-30(32(36)37)14-16-39-2/h6-9,12-13,15,18-20,23,30H,3-5,10-11,14,16-17,21H2,1-2H3,(H,34,35)(H,36,37)/t30-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080753
((S)-2-({5-[(Benzyl-thiazol-4-ylmethyl-amino)-methy...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(Cc2cscn2)Cc2ccccc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C31H33N3O3S2/c1-22-8-6-7-11-26(22)28-16-24(12-13-27(28)30(35)33-29(31(36)37)14-15-38-2)18-34(19-25-20-39-21-32-25)17-23-9-4-3-5-10-23/h3-13,16,20-21,29H,14-15,17-19H2,1-2H3,(H,33,35)(H,36,37)/t29-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080755
((S)-2-{[4-Isobutyl-2'-methyl-5-(pyridin-3-yloxymet...)Show SMILES CSCC[C@H](NC(=O)c1cc(CC(C)C)c(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C29H34N2O4S/c1-19(2)14-21-15-26(28(32)31-27(29(33)34)11-13-36-4)25(24-10-6-5-8-20(24)3)16-22(21)18-35-23-9-7-12-30-17-23/h5-10,12,15-17,19,27H,11,13-14,18H2,1-4H3,(H,31,32)(H,33,34)/t27-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080754
((S)-2-({2'-Methyl-5-[(phenylacetyl-pyridin-3-yl-am...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(C(=O)Cc2ccccc2)c2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C33H33N3O4S/c1-23-9-6-7-13-27(23)29-19-25(14-15-28(29)32(38)35-30(33(39)40)16-18-41-2)22-36(26-12-8-17-34-21-26)31(37)20-24-10-4-3-5-11-24/h3-15,17,19,21,30H,16,18,20,22H2,1-2H3,(H,35,38)(H,39,40)/t30-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080757
((S)-2-({5-[(Benzoyl-pyridin-3-yl-amino)-methyl]-2'...)Show SMILES CSCC[C@H](NC(=O)c1ccc(CN(C(=O)c2ccccc2)c2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C32H31N3O4S/c1-22-9-6-7-13-26(22)28-19-23(14-15-27(28)30(36)34-29(32(38)39)16-18-40-2)21-35(25-12-8-17-33-20-25)31(37)24-10-4-3-5-11-24/h3-15,17,19-20,29H,16,18,21H2,1-2H3,(H,34,36)(H,38,39)/t29-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080758
((S)-2-{[3'',5''-Dichloro-2-methyl-5'-(pyridin-3-yl...)Show SMILES CSCC[C@H](NC(=O)c1cc(c(COc2cccnc2)cc1-c1ccccc1C)-c1cc(Cl)cc(Cl)c1)C(O)=O Show InChI InChI=1S/C31H28Cl2N2O4S/c1-19-6-3-4-8-25(19)27-14-21(18-39-24-7-5-10-34-17-24)26(20-12-22(32)15-23(33)13-20)16-28(27)30(36)35-29(31(37)38)9-11-40-2/h3-8,10,12-17,29H,9,11,18H2,1-2H3,(H,35,36)(H,37,38)/t29-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080746
((S)-2-{[2,4''-Dimethyl-5'-(pyridin-3-yloxymethyl)-...)Show SMILES CSCC[C@H](NC(=O)c1cc(c(COc2cccnc2)cc1-c1ccccc1C)-c1ccc(C)cc1)C(O)=O Show InChI InChI=1S/C32H32N2O4S/c1-21-10-12-23(13-11-21)27-18-29(31(35)34-30(32(36)37)14-16-39-3)28(26-9-5-4-7-22(26)2)17-24(27)20-38-25-8-6-15-33-19-25/h4-13,15,17-19,30H,14,16,20H2,1-3H3,(H,34,35)(H,36,37)/t30-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Bos taurus (bovine)) | BDBM50080766
((S)-2-{[2'-Methyl-5-(pyridin-3-yloxymethyl)-4-thio...)Show SMILES CSCC[C@H](NC(=O)c1cc(-c2cccs2)c(COc2cccnc2)cc1-c1ccccc1C)C(O)=O Show InChI InChI=1S/C29H28N2O4S2/c1-19-7-3-4-9-22(19)24-15-20(18-35-21-8-5-12-30-17-21)23(27-10-6-13-37-27)16-25(24)28(32)31-26(29(33)34)11-14-36-2/h3-10,12-13,15-17,26H,11,14,18H2,1-2H3,(H,31,32)(H,33,34)/t26-/m0/s1 | PDB
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Abbott Laboratories
Curated by ChEMBL
| Assay Description
In vitro inhibition of farnesyltransferase purified from bovine brain using scintillation proximity assay |
J Med Chem 42: 3701-10 (1999)
Article DOI: 10.1021/jm9901935
BindingDB Entry DOI: 10.7270/Q2W958DC |
More data for this
Ligand-Target Pair | |
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