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PubMed code 10479303

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080809
PNG
(7-(4-Phenyl-3,6-dihydro-2H-pyridin-1-ylmethyl)-chr...)
Show SMILES O=c1ccc2ccc(CN3CCC(=CC3)c3ccccc3)cc2o1 |c:12|
Show InChI InChI=1S/C21H19NO2/c23-21-9-8-19-7-6-16(14-20(19)24-21)15-22-12-10-18(11-13-22)17-4-2-1-3-5-17/h1-10,14H,11-13,15H2
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 4.40n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080797
PNG
(7-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-on...)
Show SMILES O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1
Show InChI InChI=1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
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 5.80n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080796
PNG
(7-[4-(3-Chloro-4-methyl-phenyl)-piperazin-1-ylmeth...)
Show SMILES Cc1ccc(cc1Cl)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C21H21ClN2O2/c1-15-2-6-18(13-19(15)22)24-10-8-23(9-11-24)14-16-3-4-17-5-7-21(25)26-20(17)12-16/h2-7,12-13H,8-11,14H2,1H3
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 6.90n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity using [3H]spiperone displacement from cloned human Dopamine receptor D4.2 expressed in CHO-K1 cells

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080794
PNG
(7-[(2-p-Tolylamino-ethylamino)-methyl]-chromen-2-o...)
Show SMILES Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1
Show InChI InChI=1S/C19H20N2O2/c1-14-2-7-17(8-3-14)21-11-10-20-13-15-4-5-16-6-9-19(22)23-18(16)12-15/h2-9,12,20-21H,10-11,13H2,1H3
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 10n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity using [3H]spiperone displacement from cloned human Dopamine receptor D4.2 expressed in CHO-K1 cells

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080787
PNG
(6-(4-p-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...)
Show SMILES Cc1ccc(cc1)N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1
Show InChI InChI=1S/C21H22N2O2/c1-16-2-6-19(7-3-16)23-12-10-22(11-13-23)15-17-4-8-20-18(14-17)5-9-21(24)25-20/h2-9,14H,10-13,15H2,1H3
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 11n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Binding affinity using [3H]spiperone displacement from cloned human Dopamine receptor D4.2 expressed in CHO-K1 cells

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080810
PNG
(7-[4-(3,4-Dimethyl-phenyl)-piperazin-1-ylmethyl]-c...)
Show SMILES Cc1ccc(cc1C)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C22H24N2O2/c1-16-3-7-20(13-17(16)2)24-11-9-23(10-12-24)15-18-4-5-19-6-8-22(25)26-21(19)14-18/h3-8,13-14H,9-12,15H2,1-2H3
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 14n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080798
PNG
(7-{[2-(4-Chloro-phenylamino)-ethylamino]-methyl}-c...)
Show SMILES Clc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1
Show InChI InChI=1S/C18H17ClN2O2/c19-15-4-6-16(7-5-15)21-10-9-20-12-13-1-2-14-3-8-18(22)23-17(14)11-13/h1-8,11,20-21H,9-10,12H2
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 14n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080800
PNG
(7-{[2-(3-Chloro-4-methyl-phenylamino)-ethylamino]-...)
Show SMILES Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1Cl
Show InChI InChI=1S/C19H19ClN2O2/c1-13-2-6-16(11-17(13)20)22-9-8-21-12-14-3-4-15-5-7-19(23)24-18(15)10-14/h2-7,10-11,21-22H,8-9,12H2,1H3
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 16n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080788
PNG
(7-(4-o-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...)
Show SMILES Cc1ccccc1N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C21H22N2O2/c1-16-4-2-3-5-19(16)23-12-10-22(11-13-23)15-17-6-7-18-8-9-21(24)25-20(18)14-17/h2-9,14H,10-13,15H2,1H3
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 16n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080790
PNG
(7-(4-p-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...)
Show SMILES Cc1ccc(cc1)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C21H22N2O2/c1-16-2-7-19(8-3-16)23-12-10-22(11-13-23)15-17-4-5-18-6-9-21(24)25-20(18)14-17/h2-9,14H,10-13,15H2,1H3
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 17n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080786
PNG
(7-(4-Phenyl-piperidin-1-ylmethyl)-chromen-2-one | ...)
Show SMILES O=c1ccc2ccc(CN3CCC(CC3)c3ccccc3)cc2o1
Show InChI InChI=1S/C21H21NO2/c23-21-9-8-19-7-6-16(14-20(19)24-21)15-22-12-10-18(11-13-22)17-4-2-1-3-5-17/h1-9,14,18H,10-13,15H2
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 19n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080806
PNG
(7-{[2-(3,4-Dimethyl-phenylamino)-ethylamino]-methy...)
Show SMILES Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1C
Show InChI InChI=1S/C20H22N2O2/c1-14-3-7-18(11-15(14)2)22-10-9-21-13-16-4-5-17-6-8-20(23)24-19(17)12-16/h3-8,11-12,21-22H,9-10,13H2,1-2H3
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 21n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080808
PNG
(7-(4-Phenyl-piperazin-1-ylmethyl)-chromen-2-one | ...)
Show SMILES O=c1ccc2ccc(CN3CCN(CC3)c3ccccc3)cc2o1
Show InChI InChI=1S/C20H20N2O2/c23-20-9-8-17-7-6-16(14-19(17)24-20)15-21-10-12-22(13-11-21)18-4-2-1-3-5-18/h1-9,14H,10-13,15H2
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 27n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080801
PNG
(6-(4-Phenyl-piperazin-1-ylmethyl)-chromen-2-one | ...)
Show SMILES O=c1ccc2cc(CN3CCN(CC3)c3ccccc3)ccc2o1
Show InChI InChI=1S/C20H20N2O2/c23-20-9-7-17-14-16(6-8-19(17)24-20)15-21-10-12-22(13-11-21)18-4-2-1-3-5-18/h1-9,14H,10-13,15H2
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 30n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080805
PNG
(7-[(3-Phenylamino-propylamino)-methyl]-chromen-2-o...)
Show SMILES O=c1ccc2ccc(CNCCCNc3ccccc3)cc2o1
Show InChI InChI=1S/C19H20N2O2/c22-19-10-9-16-8-7-15(13-18(16)23-19)14-20-11-4-12-21-17-5-2-1-3-6-17/h1-3,5-10,13,20-21H,4,11-12,14H2
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 31n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080795
PNG
(7-(4-m-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...)
Show SMILES Cc1cccc(c1)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C21H22N2O2/c1-16-3-2-4-19(13-16)23-11-9-22(10-12-23)15-17-5-6-18-7-8-21(24)25-20(18)14-17/h2-8,13-14H,9-12,15H2,1H3
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 32n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080792
PNG
(7-[(2-Phenoxy-ethylamino)-methyl]-chromen-2-one | ...)
Show SMILES O=c1ccc2ccc(CNCCOc3ccccc3)cc2o1
Show InChI InChI=1S/C18H17NO3/c20-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-21-16-4-2-1-3-5-16/h1-9,12,19H,10-11,13H2
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 43n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080812
PNG
(7-[4-(4-Fluoro-phenyl)-piperazin-1-ylmethyl]-chrom...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C20H19FN2O2/c21-17-4-6-18(7-5-17)23-11-9-22(10-12-23)14-15-1-2-16-3-8-20(24)25-19(16)13-15/h1-8,13H,9-12,14H2
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 59n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080793
PNG
(6-(4-o-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...)
Show SMILES Cc1ccccc1N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1
Show InChI InChI=1S/C21H22N2O2/c1-16-4-2-3-5-19(16)23-12-10-22(11-13-23)15-17-6-8-20-18(14-17)7-9-21(24)25-20/h2-9,14H,10-13,15H2,1H3
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 63n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080799
PNG
(6-(4-m-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...)
Show SMILES Cc1cccc(c1)N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1
Show InChI InChI=1S/C21H22N2O2/c1-16-3-2-4-19(13-16)23-11-9-22(10-12-23)15-17-5-7-20-18(14-17)6-8-21(24)25-20/h2-8,13-14H,9-12,15H2,1H3
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 74n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080804
PNG
(7-[4-(4-Methoxy-phenyl)-piperazin-1-ylmethyl]-chro...)
Show SMILES COc1ccc(cc1)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C21H22N2O3/c1-25-19-7-5-18(6-8-19)23-12-10-22(11-13-23)15-16-2-3-17-4-9-21(24)26-20(17)14-16/h2-9,14H,10-13,15H2,1H3
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 75n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080791
PNG
(7-[4-(4-Chloro-phenyl)-piperazin-1-ylmethyl]-chrom...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C20H19ClN2O2/c21-17-4-6-18(7-5-17)23-11-9-22(10-12-23)14-15-1-2-16-3-8-20(24)25-19(16)13-15/h1-8,13H,9-12,14H2
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 93n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080802
PNG
(7-[4-(4-tert-Butyl-phenyl)-piperazin-1-ylmethyl]-c...)
Show SMILES CC(C)(C)c1ccc(cc1)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C24H28N2O2/c1-24(2,3)20-7-9-21(10-8-20)26-14-12-25(13-15-26)17-18-4-5-19-6-11-23(27)28-22(19)16-18/h4-11,16H,12-15,17H2,1-3H3
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 227n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080803
PNG
(6-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-on...)
Show SMILES O=c1ccc2cc(CNCCNc3ccccc3)ccc2o1
Show InChI InChI=1S/C18H18N2O2/c21-18-9-7-15-12-14(6-8-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
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 311n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080811
PNG
(7-{[Ethyl-(2-phenylamino-ethyl)-amino]-methyl}-chr...)
Show SMILES CCN(CCNc1ccccc1)Cc1ccc2ccc(=O)oc2c1
Show InChI InChI=1S/C20H22N2O2/c1-2-22(13-12-21-18-6-4-3-5-7-18)15-16-8-9-17-10-11-20(23)24-19(17)14-16/h3-11,14,21H,2,12-13,15H2,1H3
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 410n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))		BDBM50080797
PNG
(7-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-on...)
Show SMILES O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1
Show InChI InChI=1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
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 424n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity using [3H]spiperone against cloned human Dopamine receptor D3 expressed in CHO-K1 cells

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080789
PNG
(7-{[2-(Ethyl-phenyl-amino)-ethylamino]-methyl}-chr...)
Show SMILES CCN(CCNCc1ccc2ccc(=O)oc2c1)c1ccccc1
Show InChI InChI=1S/C20H22N2O2/c1-2-22(18-6-4-3-5-7-18)13-12-21-15-16-8-9-17-10-11-20(23)24-19(17)14-16/h3-11,14,21H,2,12-13,15H2,1H3
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 2.66E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]


(Rattus norvegicus (rat))		BDBM50080797
PNG
(7-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-on...)
Show SMILES O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1
Show InChI InChI=1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
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 2.67E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity using [3H]prazosin against Alpha-1 adrenergic receptor

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080807
PNG
(7-(4-Benzyl-piperazin-1-ylmethyl)-chromen-2-one | ...)
Show SMILES O=c1ccc2ccc(CN3CCN(Cc4ccccc4)CC3)cc2o1
Show InChI InChI=1S/C21H22N2O2/c24-21-9-8-19-7-6-18(14-20(19)25-21)16-23-12-10-22(11-13-23)15-17-4-2-1-3-5-17/h1-9,14H,10-13,15-16H2
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 2.70E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A


(Mus musculus (Mouse))		BDBM50080797
PNG
(7-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-on...)
Show SMILES O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1
Show InChI InChI=1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
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 3.71E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity using [3H]8-OH-DPAT against 5-hydroxytryptamine 1A receptor

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(BOVINE)		BDBM50080797
PNG
(7-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-on...)
Show SMILES O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1
Show InChI InChI=1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
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>4.35E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity using [3H]ketanserin against 5-hydroxytryptamine 2 receptor

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
Adenosine receptor A2b


(Rattus norvegicus)		BDBM50080797
PNG
(7-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-on...)
Show SMILES O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1
Show InChI InChI=1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
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>4.70E+3n/an/an/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for binding affinity using [3H]MK-912 against Alpha-2 adrenergic receptor

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080797
PNG
(7-[(2-Phenylamino-ethylamino)-methyl]-chromen-2-on...)
Show SMILES O=c1ccc2ccc(CNCCNc3ccccc3)cc2o1
Show InChI InChI=1S/C18H18N2O2/c21-18-9-8-15-7-6-14(12-17(15)22-18)13-19-10-11-20-16-4-2-1-3-5-16/h1-9,12,19-20H,10-11,13H2
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n/an/a 1.30n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]-thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080796
PNG
(7-[4-(3-Chloro-4-methyl-phenyl)-piperazin-1-ylmeth...)
Show SMILES Cc1ccc(cc1Cl)N1CCN(Cc2ccc3ccc(=O)oc3c2)CC1
Show InChI InChI=1S/C21H21ClN2O2/c1-15-2-6-18(13-19(15)22)24-10-8-23(9-11-24)14-16-3-4-17-5-7-21(25)26-20(17)12-16/h2-7,12-13H,8-11,14H2,1H3
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n/an/a 5.40n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]-thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080794
PNG
(7-[(2-p-Tolylamino-ethylamino)-methyl]-chromen-2-o...)
Show SMILES Cc1ccc(NCCNCc2ccc3ccc(=O)oc3c2)cc1
Show InChI InChI=1S/C19H20N2O2/c1-14-2-7-17(8-3-14)21-11-10-20-13-15-4-5-16-6-9-19(22)23-18(16)12-15/h2-9,12,20-21H,10-11,13H2,1H3
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n/an/a 98n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]-thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
D(4) dopamine receptor


(Homo sapiens (Human))		BDBM50080787
PNG
(6-(4-p-Tolyl-piperazin-1-ylmethyl)-chromen-2-one |...)
Show SMILES Cc1ccc(cc1)N1CCN(Cc2ccc3oc(=O)ccc3c2)CC1
Show InChI InChI=1S/C21H22N2O2/c1-16-2-6-19(7-3-16)23-12-10-22(11-13-23)15-17-4-8-20-18(14-17)5-9-21(24)25-20/h2-9,14H,10-13,15H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Compound was tested for the inhibition of [3H]-thymidine uptake in CHO p-5 cells transfected with human Dopamine receptor D4.2

J Med Chem 42: 3718-25 (1999)


Article DOI: 10.1021/jm990266k
BindingDB Entry DOI: 10.7270/Q2RN371G
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%