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PubMed code 10543880

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081969
PNG
(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(C)c2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-3-6-14-16(13)21-8-4-7-15(21)17(18-14)20-11-9-19(2)10-12-20/h3-8H,9-12H2,1-2H3
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n/an/a 0.260n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 3 receptor from NG108-15 cells using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081973
PNG
(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Show SMILES CN1CCN(CC1)c1nc2cc(O)ccc2n2cccc12
Show InChI InChI=1S/C16H18N4O/c1-18-7-9-19(10-8-18)16-15-3-2-6-20(15)14-5-4-12(21)11-13(14)17-16/h2-6,11,21H,7-10H2,1H3
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n/an/a 0.670n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081969
PNG
(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(C)c2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-3-6-14-16(13)21-8-4-7-15(21)17(18-14)20-11-9-19(2)10-12-20/h3-8H,9-12H2,1-2H3
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n/an/a 0.790n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50060688
PNG
(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-7-9-20(10-8-19)16-15-3-2-6-21(15)14-5-4-12(17)11-13(14)18-16/h2-6,11H,7-10H2,1H3
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n/an/a 0.810n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 1n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081972
PNG
(9-Methyl-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Cc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C16H18N4/c1-12-4-2-5-13-15(12)20-9-3-6-14(20)16(18-13)19-10-7-17-8-11-19/h2-6,9,17H,7-8,10-11H2,1H3
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n/an/a 1.13n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081989
PNG
(5-(4-Methyl-piperazin-1-yl)-pyrazolo[1,5-c]quinazo...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2ccnn12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-17-13-5-3-2-4-12(13)14-6-7-16-20(14)15/h2-7H,8-11H2,1H3
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Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081968
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2ncccc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)18-8-4-10-22-20(18)23-21/h1-11H,12-16H2
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n/an/a 2.20n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/a 2.30n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081999
PNG
(2-[4-(7-Fluoro-pyrrolo[1,2-a]quinoxalin-4-yl)-pipe...)
Show SMILES OCCN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C17H19FN4O/c18-13-3-4-15-14(12-13)19-17(16-2-1-5-22(15)16)21-8-6-20(7-9-21)10-11-23/h1-5,12,23H,6-11H2
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Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50082004
PNG
(6-Piperazin-1-yl-pyrido[2,3-e]pyrrolo[1,2-a]pyrazi...)
Show SMILES C1CN(CCN1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C14H15N5/c1-3-11-13(16-5-1)17-14(12-4-2-8-19(11)12)18-9-6-15-7-10-18/h1-5,8,15H,6-7,9-10H2
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n/an/a 3.10n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081976
PNG
(6-(4-Thiophen-2-ylmethyl-piperazin-1-yl)-pyrido[3,...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1cccs1
Show InChI InChI=1S/C19H19N5S/c1-5-16-18(20-7-1)24-8-2-6-17(24)19(21-16)23-11-9-22(10-12-23)14-15-4-3-13-25-15/h1-8,13H,9-12,14H2
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Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50014407
PNG
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
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Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081983
PNG
(4-(4-Methyl-piperazin-1-yl)-imidazo[1,2-a]quinoxal...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2n2ccnc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-14-16-6-7-20(14)13-5-3-2-4-12(13)17-15/h2-7H,8-11H2,1H3
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Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081986
PNG
(7-Fluoro-4-(4-methyl-piperazin-1-yl)-imidazo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2ccnc12
Show InChI InChI=1S/C15H16FN5/c1-19-6-8-20(9-7-19)15-14-17-4-5-21(14)13-3-2-11(16)10-12(13)18-15/h2-5,10H,6-9H2,1H3
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n/an/a 5.20n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081975
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)14-12(17-15)4-2-6-16-14/h2-7H,8-11H2,1H3
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n/an/a 5.40n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 3 receptor from NG108-15 cells using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081976
PNG
(6-(4-Thiophen-2-ylmethyl-piperazin-1-yl)-pyrido[3,...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1cccs1
Show InChI InChI=1S/C19H19N5S/c1-5-16-18(20-7-1)24-8-2-6-17(24)19(21-16)23-11-9-22(10-12-23)14-15-4-3-13-25-15/h1-8,13H,9-12,14H2
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n/an/a 6.40n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 3 receptor from NG108-15 cells using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081997
PNG
(4-(4-Methyl-piperazin-1-yl)-3,5,9,9b-tetraaza-cycl...)
Show SMILES CN1CCN(CC1)c1nc2cccnc2n2ccnc12
Show InChI InChI=1S/C14H16N6/c1-18-7-9-19(10-8-18)14-13-16-5-6-20(13)12-11(17-14)3-2-4-15-12/h2-6H,7-10H2,1H3
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Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM85330
PNG
(CAS_68647 | NSC_68647 | ONDANSETRON | Ondansetron ...)
Show SMILES Cc1nccn1CC1CCc2c(C1=O)c1ccccc1n2C
Show InChI InChI=1S/C18H19N3O/c1-12-19-9-10-21(12)11-13-7-8-16-17(18(13)22)14-5-3-4-6-15(14)20(16)2/h3-6,9-10,13H,7-8,11H2,1-2H3
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n/an/a 6.80n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081977
PNG
(2-[4-(9-Fluoro-pyrrolo[1,2-a]quinoxalin-4-yl)-pipe...)
Show SMILES OCCN1CCN(CC1)c1nc2cccc(F)c2n2cccc12
Show InChI InChI=1S/C17H19FN4O/c18-13-3-1-4-14-16(13)22-6-2-5-15(22)17(19-14)21-9-7-20(8-10-21)11-12-23/h1-6,23H,7-12H2
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n/an/a 8.20n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081981
PNG
(4-(4-Benzyl-piperazin-1-yl)-9-methyl-pyrrolo[1,2-a...)
Show SMILES Cc1cccc2nc(N3CCN(Cc4ccccc4)CC3)c3cccn3c12
Show InChI InChI=1S/C23H24N4/c1-18-7-5-10-20-22(18)27-12-6-11-21(27)23(24-20)26-15-13-25(14-16-26)17-19-8-3-2-4-9-19/h2-12H,13-17H2,1H3
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Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081970
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)12-4-2-6-16-14(12)17-15/h2-7H,8-11H2,1H3
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n/an/a 9.30n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
The compound was tested for binding affinity against 5-hydroxytryptamine 3 receptor from NG108-15 cells (using [3H]-zacopride as radioligand)

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081971
PNG
(7-Fluoro-4-(4-furan-2-ylmethyl-piperazin-1-yl)-pyr...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3ccco3)CC1)c1cccn21
Show InChI InChI=1S/C20H19FN4O/c21-15-5-6-18-17(13-15)22-20(19-4-1-7-25(18)19)24-10-8-23(9-11-24)14-16-3-2-12-26-16/h1-7,12-13H,8-11,14H2
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n/an/a 11n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081967
PNG
(7-Fluoro-4-(4-thiophen-2-ylmethyl-piperazin-1-yl)-...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3cccs3)CC1)c1cccn21
Show InChI InChI=1S/C20H19FN4S/c21-15-5-6-18-17(13-15)22-20(19-4-1-7-25(18)19)24-10-8-23(9-11-24)14-16-3-2-12-26-16/h1-7,12-13H,8-11,14H2
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n/an/a 12n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081974
PNG
(4-(4-Benzyl-piperazin-1-yl)-7-fluoro-pyrrolo[1,2-a...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3ccccc3)CC1)c1cccn21
Show InChI InChI=1S/C22H21FN4/c23-18-8-9-20-19(15-18)24-22(21-7-4-10-27(20)21)26-13-11-25(12-14-26)16-17-5-2-1-3-6-17/h1-10,15H,11-14,16H2
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n/an/a 13n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081984
PNG
(7-Methyl-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Cc1ccc2c(c1)nc(N1CCNCC1)c1cccn21
Show InChI InChI=1S/C16H18N4/c1-12-4-5-14-13(11-12)18-16(15-3-2-8-20(14)15)19-9-6-17-7-10-19/h2-5,8,11,17H,6-7,9-10H2,1H3
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n/an/a 16.4n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081993
PNG
(7-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(C)ccc2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-6-15-14(12-13)18-17(16-4-3-7-21(15)16)20-10-8-19(2)9-11-20/h3-7,12H,8-11H2,1-2H3
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n/an/a 18n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081991
PNG
(4-(4-Thiophen-2-ylmethyl-piperazin-1-yl)-pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2ccccc2n2cccc12)c1cccs1
Show InChI InChI=1S/C20H20N4S/c1-2-7-18-17(6-1)21-20(19-8-3-9-24(18)19)23-12-10-22(11-13-23)15-16-5-4-14-25-16/h1-9,14H,10-13,15H2
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n/an/a 22n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081985
PNG
(4-(4-Benzyl-piperazin-1-yl)-7-methyl-pyrrolo[1,2-a...)
Show SMILES Cc1ccc2c(c1)nc(N1CCN(Cc3ccccc3)CC1)c1cccn21
Show InChI InChI=1S/C23H24N4/c1-18-9-10-21-20(16-18)24-23(22-8-5-11-27(21)22)26-14-12-25(13-15-26)17-19-6-3-2-4-7-19/h2-11,16H,12-15,17H2,1H3
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n/an/a 24n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081998
PNG
(7,8-Dimethyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cc(C)c(C)cc2n2cccc12
Show InChI InChI=1S/C18H22N4/c1-13-11-15-17(12-14(13)2)22-6-4-5-16(22)18(19-15)21-9-7-20(3)8-10-21/h4-6,11-12H,7-10H2,1-3H3
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n/an/a 30n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50082005
PNG
(2-[4-(3,5,9,9b-Tetraaza-cyclopenta[a]naphthalen-4-...)
Show SMILES OCCN1CCN(CC1)c1nc2cccnc2n2ccnc12
Show InChI InChI=1S/C15H18N6O/c22-11-10-19-6-8-20(9-7-19)15-14-17-4-5-21(14)13-12(18-15)2-1-3-16-13/h1-5,22H,6-11H2
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n/an/a 38n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081992
PNG
(4-(4-Benzyl-piperazin-1-yl)-7,8-dimethyl-pyrrolo[1...)
Show SMILES Cc1cc2nc(N3CCN(Cc4ccccc4)CC3)c3cccn3c2cc1C
Show InChI InChI=1S/C24H26N4/c1-18-15-21-23(16-19(18)2)28-10-6-9-22(28)24(25-21)27-13-11-26(12-14-27)17-20-7-4-3-5-8-20/h3-10,15-16H,11-14,17H2,1-2H3
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n/an/a 44n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50082001
PNG
(9-Fluoro-4-(4-thiophen-2-ylmethyl-piperazin-1-yl)-...)
Show SMILES Fc1cccc2nc(N3CCN(Cc4cccs4)CC3)c3cccn3c12
Show InChI InChI=1S/C20H19FN4S/c21-16-5-1-6-17-19(16)25-8-2-7-18(25)20(22-17)24-11-9-23(10-12-24)14-15-4-3-13-26-15/h1-8,13H,9-12,14H2
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n/an/a 60n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50082003
PNG
(7,8-Dichloro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2cc(Cl)c(Cl)cc2n2cccc12
Show InChI InChI=1S/C16H16Cl2N4/c1-20-5-7-21(8-6-20)16-14-3-2-4-22(14)15-10-12(18)11(17)9-13(15)19-16/h2-4,9-10H,5-8H2,1H3
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n/an/a 97n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081988
PNG
(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Show SMILES CN1CCN(CC1)c1nc2cc(ccc2n2cccc12)C#N
Show InChI InChI=1S/C17H17N5/c1-20-7-9-21(10-8-20)17-16-3-2-6-22(16)15-5-4-13(12-18)11-14(15)19-17/h2-6,11H,7-10H2,1H3
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n/an/a 104n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081979
PNG
(4-[4-(5-Bromo-thiophen-2-ylmethyl)-piperazin-1-yl]...)
Show SMILES Cc1cccc2nc(N3CCN(Cc4ccc(Br)s4)CC3)c3cccn3c12
Show InChI InChI=1S/C21H21BrN4S/c1-15-4-2-5-17-20(15)26-9-3-6-18(26)21(23-17)25-12-10-24(11-13-25)14-16-7-8-19(22)27-16/h2-9H,10-14H2,1H3
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n/an/a 104n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50082000
PNG
(7,8-Dimethyl-4-piperazin-1-yl-pyrrolo[1,2-a]quinox...)
Show SMILES Cc1cc2nc(N3CCNCC3)c3cccn3c2cc1C
Show InChI InChI=1S/C17H20N4/c1-12-10-14-16(11-13(12)2)21-7-3-4-15(21)17(19-14)20-8-5-18-6-9-20/h3-4,7,10-11,18H,5-6,8-9H2,1-2H3
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n/an/a 113n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081996
PNG
(4-(4-Benzyl-piperazin-1-yl)-7,8-dichloro-pyrrolo[1...)
Show SMILES Clc1cc2nc(N3CCN(Cc4ccccc4)CC3)c3cccn3c2cc1Cl
Show InChI InChI=1S/C22H20Cl2N4/c23-17-13-19-21(14-18(17)24)28-8-4-7-20(28)22(25-19)27-11-9-26(10-12-27)15-16-5-2-1-3-6-16/h1-8,13-14H,9-12,15H2
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n/an/a 118n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081990
PNG
(4-[4-(5-Bromo-furan-2-ylmethyl)-piperazin-1-yl]-7-...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3ccc(Br)o3)CC1)c1cccn21
Show InChI InChI=1S/C20H18BrFN4O/c21-19-6-4-15(27-19)13-24-8-10-25(11-9-24)20-18-2-1-7-26(18)17-5-3-14(22)12-16(17)23-20/h1-7,12H,8-11,13H2
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n/an/a 148n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081978
PNG
(7-Benzyloxy-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,...)
Show SMILES CN1CCN(CC1)c1nc2cc(OCc3ccccc3)ccc2n2cccc12
Show InChI InChI=1S/C23H24N4O/c1-25-12-14-26(15-13-25)23-22-8-5-11-27(22)21-10-9-19(16-20(21)24-23)28-17-18-6-3-2-4-7-18/h2-11,16H,12-15,17H2,1H3
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n/an/a 225n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081982
PNG
(9-Fluoro-4-[4-(5H-tetrazol-5-ylmethyl)-piperazin-1...)
Show SMILES Fc1cccc2nc(N3CCN(Cc4nnn[nH]4)CC3)c3cccn3c12
Show InChI InChI=1S/C17H17FN8/c18-12-3-1-4-13-16(12)26-6-2-5-14(26)17(19-13)25-9-7-24(8-10-25)11-15-20-22-23-21-15/h1-6H,7-11H2,(H,20,21,22,23)
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n/an/a 690n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081987
PNG
(9-Fluoro-4-(4-naphthalen-2-ylmethyl-piperazin-1-yl...)
Show SMILES Fc1cccc2nc(N3CCN(Cc4ccc5ccccc5c4)CC3)c3cccn3c12
Show InChI InChI=1S/C26H23FN4/c27-22-7-3-8-23-25(22)31-12-4-9-24(31)26(28-23)30-15-13-29(14-16-30)18-19-10-11-20-5-1-2-6-21(20)17-19/h1-12,17H,13-16,18H2
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n/an/a 780n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081995
PNG
(2-(4-(9-fluoropyrrolo[1,2-a]quinoxalin-4-yl)pipera...)
Show SMILES OC(=O)CN1CCN(CC1)c1nc2cccc(F)c2n2cccc12
Show InChI InChI=1S/C17H17FN4O2/c18-12-3-1-4-13-16(12)22-6-2-5-14(22)17(19-13)21-9-7-20(8-10-21)11-15(23)24/h1-6H,7-11H2,(H,23,24)
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n/an/a 920n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081994
PNG
(1-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]pyrazine...)
Show SMILES CN1CCN(CC1)c1nccn2cccc12
Show InChI InChI=1S/C12H16N4/c1-14-7-9-16(10-8-14)12-11-3-2-5-15(11)6-4-13-12/h2-6H,7-10H2,1H3
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n/an/a 1.93E+3n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50081980
PNG
(8-(4-Methyl-piperazin-1-yl)-2,3-dihydro-imidazo[1,...)
Show SMILES CN1CCN(CC1)C1=NC=CN2CCN=C12 |c:10,t:8,15|
Show InChI InChI=1S/C11H17N5/c1-14-6-8-16(9-7-14)11-10-12-2-4-15(10)5-3-13-11/h3,5H,2,4,6-9H2,1H3
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n/an/a 3.65E+3n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Rattus norvegicus-RAT)		BDBM50082002
PNG
(CHEMBL336699 | [4-(9-Fluoro-pyrrolo[1,2-a]quinoxal...)
Show SMILES Fc1cccc2nc(N3CCN(CC#N)CC3)c3cccn3c12
Show InChI InChI=1S/C17H16FN5/c18-13-3-1-4-14-16(13)23-7-2-5-15(23)17(20-14)22-11-9-21(8-6-19)10-12-22/h1-5,7H,8-12H2
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n/an/a 3.80E+3n/an/an/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Binding affinity against 5-hydroxytryptamine 3 (5-HT3) receptor from rat cortical homogenate using [3H]-zacopride as radioligand

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081973
PNG
(4-(4-Methyl-piperazin-1-yl)-pyrrolo[1,2-a]quinoxal...)
Show SMILES CN1CCN(CC1)c1nc2cc(O)ccc2n2cccc12
Show InChI InChI=1S/C16H18N4O/c1-18-7-9-19(10-8-18)16-15-3-2-6-20(15)14-5-4-12(21)11-13(14)17-16/h2-6,11,21H,7-10H2,1H3
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n/an/an/an/a 1.60n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081970
PNG
(6-(4-Methyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES CN1CCN(CC1)c1nc2ncccc2n2cccc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-13-5-3-7-20(13)12-4-2-6-16-14(12)17-15/h2-7H,8-11H2,1H3
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n/an/an/an/a 1.70n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081983
PNG
(4-(4-Methyl-piperazin-1-yl)-imidazo[1,2-a]quinoxal...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2n2ccnc12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-14-16-6-7-20(14)13-5-3-2-4-12(13)17-15/h2-7H,8-11H2,1H3
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n/an/an/an/a 15n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50060688
PNG
(7-Fluoro-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C16H17FN4/c1-19-7-9-20(10-8-19)16-15-3-2-6-21(15)14-5-4-12(17)11-13(14)18-16/h2-6,11H,7-10H2,1H3
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n/an/an/an/a 3n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50014407
PNG
(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Show SMILES C1CN(CCN1)c1ccc2ccccc2n1
Show InChI InChI=1S/C13H15N3/c1-2-4-12-11(3-1)5-6-13(15-12)16-9-7-14-8-10-16/h1-6,14H,7-10H2
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n/an/an/an/a 1n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081977
PNG
(2-[4-(9-Fluoro-pyrrolo[1,2-a]quinoxalin-4-yl)-pipe...)
Show SMILES OCCN1CCN(CC1)c1nc2cccc(F)c2n2cccc12
Show InChI InChI=1S/C17H19FN4O/c18-13-3-1-4-14-16(13)22-6-2-5-15(22)17(19-14)21-9-7-20(8-10-21)11-12-23/h1-6,23H,7-12H2
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n/an/an/an/a 54n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081969
PNG
(9-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cccc(C)c2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-3-6-14-16(13)21-8-4-7-15(21)17(18-14)20-11-9-19(2)10-12-20/h3-8H,9-12H2,1-2H3
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n/an/an/an/a 3.80n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081989
PNG
(5-(4-Methyl-piperazin-1-yl)-pyrazolo[1,5-c]quinazo...)
Show SMILES CN1CCN(CC1)c1nc2ccccc2c2ccnn12
Show InChI InChI=1S/C15H17N5/c1-18-8-10-19(11-9-18)15-17-13-5-3-2-4-12(13)14-6-7-16-20(14)15/h2-7H,8-11H2,1H3
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n/an/an/an/a 2.70n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50058283
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[3,2-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2cccnc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)20-18(23-21)8-4-10-22-20/h1-11H,12-16H2
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n/an/an/an/a 32n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081974
PNG
(4-(4-Benzyl-piperazin-1-yl)-7-fluoro-pyrrolo[1,2-a...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3ccccc3)CC1)c1cccn21
Show InChI InChI=1S/C22H21FN4/c23-18-8-9-20-19(15-18)24-22(21-7-4-10-27(20)21)26-13-11-25(12-14-26)16-17-5-2-1-3-6-17/h1-10,15H,11-14,16H2
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n/an/an/an/a 4.20n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081999
PNG
(2-[4-(7-Fluoro-pyrrolo[1,2-a]quinoxalin-4-yl)-pipe...)
Show SMILES OCCN1CCN(CC1)c1nc2cc(F)ccc2n2cccc12
Show InChI InChI=1S/C17H19FN4O/c18-13-3-4-15-14(12-13)19-17(16-2-1-5-22(15)16)21-8-6-20(7-9-21)10-11-23/h1-5,12,23H,6-11H2
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n/an/an/an/a 2.40n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081972
PNG
(9-Methyl-4-piperazin-1-yl-pyrrolo[1,2-a]quinoxalin...)
Show SMILES Cc1cccc2nc(N3CCNCC3)c3cccn3c12
Show InChI InChI=1S/C16H18N4/c1-12-4-2-5-13-15(12)20-9-3-6-14(20)16(18-13)19-10-7-17-8-11-19/h2-6,9,17H,7-8,10-11H2,1H3
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n/an/an/an/a 9.5n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081986
PNG
(7-Fluoro-4-(4-methyl-piperazin-1-yl)-imidazo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(F)ccc2n2ccnc12
Show InChI InChI=1S/C15H16FN5/c1-19-6-8-20(9-7-19)15-14-17-4-5-21(14)13-3-2-11(16)10-12(13)18-15/h2-5,10H,6-9H2,1H3
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n/an/an/an/a 7.20n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081968
PNG
(6-(4-Benzyl-piperazin-1-yl)-pyrido[2,3-e]pyrrolo[1...)
Show SMILES C(N1CCN(CC1)c1nc2ncccc2n2cccc12)c1ccccc1
Show InChI InChI=1S/C21H21N5/c1-2-6-17(7-3-1)16-24-12-14-25(15-13-24)21-19-9-5-11-26(19)18-8-4-10-22-20(18)23-21/h1-11H,12-16H2
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n/an/an/an/a 4.20n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081981
PNG
(4-(4-Benzyl-piperazin-1-yl)-9-methyl-pyrrolo[1,2-a...)
Show SMILES Cc1cccc2nc(N3CCN(Cc4ccccc4)CC3)c3cccn3c12
Show InChI InChI=1S/C23H24N4/c1-18-7-5-10-20-22(18)27-12-6-11-21(27)23(24-20)26-15-13-25(14-16-26)17-19-8-3-2-4-9-19/h2-12H,13-17H2,1H3
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n/an/an/an/a 12n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081993
PNG
(7-Methyl-4-(4-methyl-piperazin-1-yl)-pyrrolo[1,2-a...)
Show SMILES CN1CCN(CC1)c1nc2cc(C)ccc2n2cccc12
Show InChI InChI=1S/C17H20N4/c1-13-5-6-15-14(12-13)18-17(16-4-3-7-21(15)16)20-10-8-19(2)9-11-20/h3-7,12H,8-11H2,1-2H3
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n/an/an/an/a 14n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 3A/3B


(Homo sapiens (Human))		BDBM50081971
PNG
(7-Fluoro-4-(4-furan-2-ylmethyl-piperazin-1-yl)-pyr...)
Show SMILES Fc1ccc2c(c1)nc(N1CCN(Cc3ccco3)CC1)c1cccn21
Show InChI InChI=1S/C20H19FN4O/c21-15-5-6-18-17(13-15)22-20(19-4-1-7-25(18)19)24-10-8-23(9-11-24)14-16-3-2-12-26-16/h1-7,12-13H,8-11,14H2
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n/an/an/an/a 6.60n/an/an/an/a



Universita' degli Studi di Salerno

Curated by ChEMBL


Assay Description
Effective concentration against 5-Hydroxytryptamine 3 receptor by measuring [14C]-guanidinium uptake on NG108-15 cells.

J Med Chem 42: 4362-79 (1999)


BindingDB Entry DOI: 10.7270/Q2S75FJM
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%