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PubMed code 10639287

Compile data set for download or QSAR
Found 62 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50056543
PNG
(4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-6-18-29-19-22(5)30(20-21(29)4)26(23-12-10-9-11-13-23)24-14-16-25(17-15-24)27(31)28(7-2)8-3/h6,9-17,21-22,26H,1,7-8,18-20H2,2-5H3/t21-,22+,26?/m1/s1
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0.5n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084252
PNG
(4-[(4-Benzyl-piperazin-1-yl)-phenyl-methyl]-N,N-di...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-3-31(4-2)29(33)27-17-15-26(16-18-27)28(25-13-9-6-10-14-25)32-21-19-30(20-22-32)23-24-11-7-5-8-12-24/h5-18,28H,3-4,19-23H2,1-2H3
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1.5n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50039029
PNG
((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084251
PNG
(CHEMBL338980 | N,N-Diethyl-4-(phenyl-piperazin-1-y...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C22H29N3O/c1-3-24(4-2)22(26)20-12-10-19(11-13-20)21(18-8-6-5-7-9-18)25-16-14-23-15-17-25/h5-13,21,23H,3-4,14-17H2,1-2H3
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4.90n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084244
PNG
(CHEMBL542267 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7]-[#6]-[#6]-1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C24H30N2O2/c1-4-26(5-2)24(27)20-11-9-18(10-12-20)23(19-13-15-25-16-14-19)21-7-6-8-22(17-21)28-3/h6-12,17,25H,4-5,13-16H2,1-3H3
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5n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50077066
PNG
(4-[(4-Allyl-piperazin-1-yl)-phenyl-methyl]-N,N-die...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h4,7-15,24H,1,5-6,16-20H2,2-3H3
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11n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084247
PNG
(4-[(1-Benzyl-piperidin-4-ylidene)-(3-methoxy-pheny...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7](-[#6]-c2ccccc2)-[#6]-[#6]-1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C31H36N2O2/c1-4-33(5-2)31(34)27-16-14-25(15-17-27)30(28-12-9-13-29(22-28)35-3)26-18-20-32(21-19-26)23-24-10-7-6-8-11-24/h6-17,22H,4-5,18-21,23H2,1-3H3
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12n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084242
PNG
(CHEMBL544638 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCNCC1)c1cccc(OC)c1
Show InChI InChI=1S/C24H32N2O2/c1-4-26(5-2)24(27)20-11-9-18(10-12-20)23(19-13-15-25-16-14-19)21-7-6-8-22(17-21)28-3/h6-12,17,19,23,25H,4-5,13-16H2,1-3H3
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20n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084246
PNG
(4-[(1-Allyl-piperidin-4-yl)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCN(CC=C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C27H36N2O2/c1-5-17-28-18-15-22(16-19-28)26(24-9-8-10-25(20-24)31-4)21-11-13-23(14-12-21)27(30)29(6-2)7-3/h5,8-14,20,22,26H,1,6-7,15-19H2,2-4H3
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27n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50077065
PNG
(4-[(4-Allyl-piperazin-1-yl)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-15-27-16-18-29(19-17-27)25(23-9-8-10-24(20-23)31-4)21-11-13-22(14-12-21)26(30)28(6-2)7-3/h5,8-14,20,25H,1,6-7,15-19H2,2-4H3
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27n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084248
PNG
(CHEMBL124642 | CHEMBL555571 | N,N-Diethyl-4-[(4-me...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(C)CC1)c1ccccc1
Show InChI InChI=1S/C23H31N3O/c1-4-25(5-2)23(27)21-13-11-20(12-14-21)22(19-9-7-6-8-10-19)26-17-15-24(3)16-18-26/h6-14,22H,4-5,15-18H2,1-3H3
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43n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50077082
PNG
(CHEMBL150430 | CHEMBL27944 | N,N-Diethyl-4-[phenyl...)
Show SMILES CCCN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C25H35N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h7-15,24H,4-6,16-20H2,1-3H3
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44n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084241
PNG
(4-[[(2-Dimethylamino-ethyl)-methyl-amino]-(3-metho...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N(C)CCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C24H35N3O2/c1-7-27(8-2)24(28)20-14-12-19(13-15-20)23(26(5)17-16-25(3)4)21-10-9-11-22(18-21)29-6/h9-15,18,23H,7-8,16-17H2,1-6H3
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248n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084243
PNG
(4-[(2-Dimethylamino-ethoxy)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(OCCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C23H32N2O3/c1-6-25(7-2)23(26)19-13-11-18(12-14-19)22(28-16-15-24(3)4)20-9-8-10-21(17-20)27-5/h8-14,17,22H,6-7,15-16H2,1-5H3
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258n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084250
PNG
(CHEMBL541349 | N,N-Diethyl-4-[(3-methoxy-phenyl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCN(C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C25H34N2O2/c1-5-27(6-2)25(28)21-12-10-19(11-13-21)24(20-14-16-26(3)17-15-20)22-8-7-9-23(18-22)29-4/h7-13,18,20,24H,5-6,14-17H2,1-4H3
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328n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084254
PNG
(4-[(2-Dimethylamino-ethylamino)-(3-methoxy-phenyl)...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(NCCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C23H33N3O2/c1-6-26(7-2)23(27)19-13-11-18(12-14-19)22(24-15-16-25(3)4)20-9-8-10-21(17-20)28-5/h8-14,17,22,24H,6-7,15-16H2,1-5H3
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622n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro binding affinity to Opioid receptor delta 1 in rat brain membranes by [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) displacement.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084252
PNG
(4-[(4-Benzyl-piperazin-1-yl)-phenyl-methyl]-N,N-di...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-3-31(4-2)29(33)27-17-15-26(16-18-27)28(25-13-9-6-10-14-25)32-21-19-30(20-22-32)23-24-11-7-5-8-12-24/h5-18,28H,3-4,19-23H2,1-2H3
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2.00E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084249
PNG
(CHEMBL127240 | N,N-Diethyl-4-(phenyl-piperidin-1-y...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-3-24(4-2)23(26)21-15-13-20(14-16-21)22(19-11-7-5-8-12-19)25-17-9-6-10-18-25/h5,7-8,11-16,22H,3-4,6,9-10,17-18H2,1-2H3
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3.00E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) binding to Opioid receptor delta 1, in rat brain membranes ...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50056543
PNG
(4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-6-18-29-19-22(5)30(20-21(29)4)26(23-12-10-9-11-13-23)24-14-16-25(17-15-24)27(31)28(7-2)8-3/h6,9-17,21-22,26H,1,7-8,18-20H2,2-5H3/t21-,22+,26?/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084239
PNG
(CHEMBL125626 | N,N-Diethyl-4-(morpholin-4-yl-pheny...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O2/c1-3-23(4-2)22(25)20-12-10-19(11-13-20)21(18-8-6-5-7-9-18)24-14-16-26-17-15-24/h5-13,21H,3-4,14-17H2,1-2H3
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3.00E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DADLE (Tyr-D-Ala-Gly-Phe-D-Leu) binding to Opioid receptor delta 1, in rat brain membranes ...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50056543
PNG
(4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-6-18-29-19-22(5)30(20-21(29)4)26(23-12-10-9-11-13-23)24-14-16-25(17-15-24)27(31)28(7-2)8-3/h6,9-17,21-22,26H,1,7-8,18-20H2,2-5H3/t21-,22+,26?/m1/s1
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3.00E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50039029
PNG
((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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3.97E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084247
PNG
(4-[(1-Benzyl-piperidin-4-ylidene)-(3-methoxy-pheny...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7](-[#6]-c2ccccc2)-[#6]-[#6]-1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C31H36N2O2/c1-4-33(5-2)31(34)27-16-14-25(15-17-27)30(28-12-9-13-29(22-28)35-3)26-18-20-32(21-19-26)23-24-10-7-6-8-11-24/h6-17,22H,4-5,18-21,23H2,1-3H3
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7.65E+3n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084239
PNG
(CHEMBL125626 | N,N-Diethyl-4-(morpholin-4-yl-pheny...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O2/c1-3-23(4-2)22(25)20-12-10-19(11-13-20)21(18-8-6-5-7-9-18)24-14-16-26-17-15-24/h5-13,21H,3-4,14-17H2,1-2H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084243
PNG
(4-[(2-Dimethylamino-ethoxy)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(OCCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C23H32N2O3/c1-6-25(7-2)23(26)19-13-11-18(12-14-19)22(28-16-15-24(3)4)20-9-8-10-21(17-20)27-5/h8-14,17,22H,6-7,15-16H2,1-5H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50077065
PNG
(4-[(4-Allyl-piperazin-1-yl)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-15-27-16-18-29(19-17-27)25(23-9-8-10-24(20-23)31-4)21-11-13-22(14-12-21)26(30)28(6-2)7-3/h5,8-14,20,25H,1,6-7,15-19H2,2-4H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084243
PNG
(4-[(2-Dimethylamino-ethoxy)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(OCCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C23H32N2O3/c1-6-25(7-2)23(26)19-13-11-18(12-14-19)22(28-16-15-24(3)4)20-9-8-10-21(17-20)27-5/h8-14,17,22H,6-7,15-16H2,1-5H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084247
PNG
(4-[(1-Benzyl-piperidin-4-ylidene)-(3-methoxy-pheny...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7](-[#6]-c2ccccc2)-[#6]-[#6]-1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C31H36N2O2/c1-4-33(5-2)31(34)27-16-14-25(15-17-27)30(28-12-9-13-29(22-28)35-3)26-18-20-32(21-19-26)23-24-10-7-6-8-11-24/h6-17,22H,4-5,18-21,23H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084252
PNG
(4-[(4-Benzyl-piperazin-1-yl)-phenyl-methyl]-N,N-di...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-3-31(4-2)29(33)27-17-15-26(16-18-27)28(25-13-9-6-10-14-25)32-21-19-30(20-22-32)23-24-11-7-5-8-12-24/h5-18,28H,3-4,19-23H2,1-2H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084254
PNG
(4-[(2-Dimethylamino-ethylamino)-(3-methoxy-phenyl)...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(NCCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C23H33N3O2/c1-6-26(7-2)23(27)19-13-11-18(12-14-19)22(24-15-16-25(3)4)20-9-8-10-21(17-20)28-5/h8-14,17,22,24H,6-7,15-16H2,1-5H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50077065
PNG
(4-[(4-Allyl-piperazin-1-yl)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-15-27-16-18-29(19-17-27)25(23-9-8-10-24(20-23)31-4)21-11-13-22(14-12-21)26(30)28(6-2)7-3/h5,8-14,20,25H,1,6-7,15-19H2,2-4H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084241
PNG
(4-[[(2-Dimethylamino-ethyl)-methyl-amino]-(3-metho...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N(C)CCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C24H35N3O2/c1-7-27(8-2)24(28)20-14-12-19(13-15-20)23(26(5)17-16-25(3)4)21-10-9-11-22(18-21)29-6/h9-15,18,23H,7-8,16-17H2,1-6H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084250
PNG
(CHEMBL541349 | N,N-Diethyl-4-[(3-methoxy-phenyl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCN(C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C25H34N2O2/c1-5-27(6-2)25(28)21-12-10-19(11-13-21)24(20-14-16-26(3)17-15-20)22-8-7-9-23(18-22)29-4/h7-13,18,20,24H,5-6,14-17H2,1-4H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084242
PNG
(CHEMBL544638 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCNCC1)c1cccc(OC)c1
Show InChI InChI=1S/C24H32N2O2/c1-4-26(5-2)24(27)20-11-9-18(10-12-20)23(19-13-15-25-16-14-19)21-7-6-8-22(17-21)28-3/h6-12,17,19,23,25H,4-5,13-16H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084246
PNG
(4-[(1-Allyl-piperidin-4-yl)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCN(CC=C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C27H36N2O2/c1-5-17-28-18-15-22(16-19-28)26(24-9-8-10-25(20-24)31-4)21-11-13-23(14-12-21)27(30)29(6-2)7-3/h5,8-14,20,22,26H,1,6-7,15-19H2,2-4H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084244
PNG
(CHEMBL542267 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7]-[#6]-[#6]-1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C24H30N2O2/c1-4-26(5-2)24(27)20-11-9-18(10-12-20)23(19-13-15-25-16-14-19)21-7-6-8-22(17-21)28-3/h6-12,17,25H,4-5,13-16H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084248
PNG
(CHEMBL124642 | CHEMBL555571 | N,N-Diethyl-4-[(4-me...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(C)CC1)c1ccccc1
Show InChI InChI=1S/C23H31N3O/c1-4-25(5-2)23(27)21-13-11-20(12-14-21)22(19-9-7-6-8-10-19)26-17-15-24(3)16-18-26/h6-14,22H,4-5,15-18H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084254
PNG
(4-[(2-Dimethylamino-ethylamino)-(3-methoxy-phenyl)...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(NCCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C23H33N3O2/c1-6-26(7-2)23(27)19-13-11-18(12-14-19)22(24-15-16-25(3)4)20-9-8-10-21(17-20)28-5/h8-14,17,22,24H,6-7,15-16H2,1-5H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084251
PNG
(CHEMBL338980 | N,N-Diethyl-4-(phenyl-piperazin-1-y...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCNCC1)c1ccccc1
Show InChI InChI=1S/C22H29N3O/c1-3-24(4-2)22(26)20-12-10-19(11-13-20)21(18-8-6-5-7-9-18)25-16-14-23-15-17-25/h5-13,21,23H,3-4,14-17H2,1-2H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50077082
PNG
(CHEMBL150430 | CHEMBL27944 | N,N-Diethyl-4-[phenyl...)
Show SMILES CCCN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C25H35N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h7-15,24H,4-6,16-20H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50084249
PNG
(CHEMBL127240 | N,N-Diethyl-4-(phenyl-piperidin-1-y...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-3-24(4-2)23(26)21-15-13-20(14-16-21)22(19-11-7-5-8-12-19)25-17-9-6-10-18-25/h5,7-8,11-16,22H,3-4,6,9-10,17-18H2,1-2H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes, at highest conce...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084244
PNG
(CHEMBL542267 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7]-[#6]-[#6]-1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C24H30N2O2/c1-4-26(5-2)24(27)20-11-9-18(10-12-20)23(19-13-15-25-16-14-19)21-7-6-8-22(17-21)28-3/h6-12,17,25H,4-5,13-16H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084250
PNG
(CHEMBL541349 | N,N-Diethyl-4-[(3-methoxy-phenyl)-(...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCN(C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C25H34N2O2/c1-5-27(6-2)25(28)21-12-10-19(11-13-21)24(20-14-16-26(3)17-15-20)22-8-7-9-23(18-22)29-4/h7-13,18,20,24H,5-6,14-17H2,1-4H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084249
PNG
(CHEMBL127240 | N,N-Diethyl-4-(phenyl-piperidin-1-y...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCCCC1)c1ccccc1
Show InChI InChI=1S/C23H30N2O/c1-3-24(4-2)23(26)21-15-13-20(14-16-21)22(19-11-7-5-8-12-19)25-17-9-6-10-18-25/h5,7-8,11-16,22H,3-4,6,9-10,17-18H2,1-2H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50077082
PNG
(CHEMBL150430 | CHEMBL27944 | N,N-Diethyl-4-[phenyl...)
Show SMILES CCCN1CCN(CC1)C(c1ccccc1)c1ccc(cc1)C(=O)N(CC)CC
Show InChI InChI=1S/C25H35N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h7-15,24H,4-6,16-20H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084246
PNG
(4-[(1-Allyl-piperidin-4-yl)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCN(CC=C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C27H36N2O2/c1-5-17-28-18-15-22(16-19-28)26(24-9-8-10-25(20-24)31-4)21-11-13-23(14-12-21)27(30)29(6-2)7-3/h5,8-14,20,22,26H,1,6-7,15-19H2,2-4H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084239
PNG
(CHEMBL125626 | N,N-Diethyl-4-(morpholin-4-yl-pheny...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCOCC1)c1ccccc1
Show InChI InChI=1S/C22H28N2O2/c1-3-23(4-2)22(25)20-12-10-19(11-13-20)21(18-8-6-5-7-9-18)24-14-16-26-17-15-24/h5-13,21H,3-4,14-17H2,1-2H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084242
PNG
(CHEMBL544638 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(C1CCNCC1)c1cccc(OC)c1
Show InChI InChI=1S/C24H32N2O2/c1-4-26(5-2)24(27)20-11-9-18(10-12-20)23(19-13-15-25-16-14-19)21-7-6-8-22(17-21)28-3/h6-12,17,19,23,25H,4-5,13-16H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50077066
PNG
(4-[(4-Allyl-piperazin-1-yl)-phenyl-methyl]-N,N-die...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1ccccc1
Show InChI InChI=1S/C25H33N3O/c1-4-16-26-17-19-28(20-18-26)24(21-10-8-7-9-11-21)22-12-14-23(15-13-22)25(29)27(5-2)6-3/h4,7-15,24H,1,5-6,16-20H2,2-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]-DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membran...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084241
PNG
(4-[[(2-Dimethylamino-ethyl)-methyl-amino]-(3-metho...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N(C)CCN(C)C)c1cccc(OC)c1
Show InChI InChI=1S/C24H35N3O2/c1-7-27(8-2)24(28)20-14-12-19(13-15-20)23(26(5)17-16-25(3)4)21-10-9-11-22(18-21)29-6/h9-15,18,23H,7-8,16-17H2,1-6H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Rattus norvegicus (rat))
BDBM50084248
PNG
(CHEMBL124642 | CHEMBL555571 | N,N-Diethyl-4-[(4-me...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(C)CC1)c1ccccc1
Show InChI InChI=1S/C23H31N3O/c1-4-25(5-2)23(27)21-13-11-20(12-14-21)22(19-9-7-6-8-10-19)26-17-15-24(3)16-18-26/h6-14,22H,4-5,15-18H2,1-3H3
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1.00E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]DAMGO (Tyr-D-Ala-Gly-(Me)-Phe-Gly-ol) binding to Opioid receptor mu 1 in rat brain membrane...


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50039029
PNG
((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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1.17E+4n/an/an/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
In vitro radioligand binding assay, for inhibition of [3H]U-69593 binding to Opioid receptor kappa 1, in guinea pig brain membranes.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)
BDBM50039029
PNG
((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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n/an/a 2.70n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using electrically induced smooth muscle contraction of mouse vas deferens.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)
BDBM50056543
PNG
(4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-6-18-29-19-22(5)30(20-21(29)4)26(23-12-10-9-11-13-23)24-14-16-25(17-15-24)27(31)28(7-2)8-3/h6,9-17,21-22,26H,1,7-8,18-20H2,2-5H3/t21-,22+,26?/m1/s1
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n/an/a 11n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using electrically induced smooth muscle contraction of mouse vas deferens.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)
BDBM50084252
PNG
(4-[(4-Benzyl-piperazin-1-yl)-phenyl-methyl]-N,N-di...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-3-31(4-2)29(33)27-17-15-26(16-18-27)28(25-13-9-6-10-14-25)32-21-19-30(20-22-32)23-24-11-7-5-8-12-24/h5-18,28H,3-4,19-23H2,1-2H3
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n/an/a 26n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using electrically induced smooth muscle contraction of mouse vas deferens.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)
BDBM50077065
PNG
(4-[(4-Allyl-piperazin-1-yl)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-15-27-16-18-29(19-17-27)25(23-9-8-10-24(20-23)31-4)21-11-13-22(14-12-21)26(30)28(6-2)7-3/h5,8-14,20,25H,1,6-7,15-19H2,2-4H3
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n/an/a 33n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using electrically induced smooth muscle contraction of mouse vas deferens.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(MOUSE)
BDBM50084244
PNG
(CHEMBL542267 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7]-[#6]-[#6]-1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C24H30N2O2/c1-4-26(5-2)24(27)20-11-9-18(10-12-20)23(19-13-15-25-16-14-19)21-7-6-8-22(17-21)28-3/h6-12,17,25H,4-5,13-16H2,1-3H3
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n/an/a 125n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using electrically induced smooth muscle contraction of mouse vas deferens.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50039029
PNG
((+)-4-((alpha R)-((2S,5R)-4-allyl-2,5-dimethylpipe...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)[C@@H](N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1cccc(OC)c1 |r|
Show InChI InChI=1S/C28H39N3O2/c1-7-17-30-19-22(5)31(20-21(30)4)27(25-11-10-12-26(18-25)33-6)23-13-15-24(16-14-23)28(32)29(8-2)9-3/h7,10-16,18,21-22,27H,1,8-9,17,19-20H2,2-6H3/t21-,22+,27-/m1/s1
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n/an/a 5.45E+3n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50056543
PNG
(4-[((1R,2S,5R)-4-Allyl-2,5-dimethyl-piperazin-1-yl...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1C[C@@H](C)N(CC=C)C[C@@H]1C)c1ccccc1
Show InChI InChI=1S/C27H37N3O/c1-6-18-29-19-22(5)30(20-21(29)4)26(23-12-10-9-11-13-23)24-14-16-25(17-15-24)27(31)28(7-2)8-3/h6,9-17,21-22,26H,1,7-8,18-20H2,2-5H3/t21-,22+,26?/m1/s1
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n/an/a 8.58E+3n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50084252
PNG
(4-[(4-Benzyl-piperazin-1-yl)-phenyl-methyl]-N,N-di...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(Cc2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C29H35N3O/c1-3-31(4-2)29(33)27-17-15-26(16-18-27)28(25-13-9-6-10-14-25)32-21-19-30(20-22-32)23-24-11-7-5-8-12-24/h5-18,28H,3-4,19-23H2,1-2H3
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n/an/a 9.85E+3n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50077065
PNG
(4-[(4-Allyl-piperazin-1-yl)-(3-methoxy-phenyl)-met...)
Show SMILES CCN(CC)C(=O)c1ccc(cc1)C(N1CCN(CC=C)CC1)c1cccc(OC)c1
Show InChI InChI=1S/C26H35N3O2/c1-5-15-27-16-18-29(19-17-27)25(23-9-8-10-24(20-23)31-4)21-11-13-22(14-12-21)26(30)28(6-2)7-3/h5,8-14,20,25H,1,6-7,15-19H2,2-4H3
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n/an/a 2.03E+4n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)
BDBM50084244
PNG
(CHEMBL542267 | N,N-Diethyl-4-[(3-methoxy-phenyl)-p...)
Show SMILES [#6]-[#6]-[#7](-[#6]-[#6])-[#6](=O)-c1ccc(cc1)-[#6](=[#6]-1/[#6]-[#6]-[#7]-[#6]-[#6]-1)\c1cccc(-[#8]-[#6])c1
Show InChI InChI=1S/C24H30N2O2/c1-4-26(5-2)24(27)20-11-9-18(10-12-20)23(19-13-15-25-16-14-19)21-7-6-8-22(17-21)28-3/h6-12,17,25H,4-5,13-16H2,1-3H3
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n/an/a 2.77E+4n/an/an/an/an/an/a



National Institute of Diabetes and Digestive and Kidney Diseases

Curated by ChEMBL


Assay Description
Agonist activity using strips of guinea pig ileum longitudinal muscle myenteric plexus.


J Med Chem 42: 5455-63 (2000)


BindingDB Entry DOI: 10.7270/Q2QJ7J0X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%