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PubMed code 10741545

Compile data set for download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50000788
PNG
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r|
Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
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1.20n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086359
PNG
(CHEMBL147191 | N-Cyclohexylmethyl-2,2-dimethyl-3-m...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C19H30N2O/c1-19(2,17(20-3)16-12-8-5-9-13-16)18(22)21-14-15-10-6-4-7-11-15/h5,8-9,12-13,15,17,20H,4,6-7,10-11,14H2,1-3H3,(H,21,22)
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1.20n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086361
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCc1cccc2ccccc12
Show InChI InChI=1S/C23H26N2O2/c1-23(2,21(24-3)17-10-7-12-19(26)14-17)22(27)25-15-18-11-6-9-16-8-4-5-13-20(16)18/h4-14,21,24,26H,15H2,1-3H3,(H,25,27)
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1.30n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50000788
PNG
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r|
Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
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1.40n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086367
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C20H26N2O2/c1-20(2,18(21-3)16-10-7-11-17(23)14-16)19(24)22-13-12-15-8-5-4-6-9-15/h4-11,14,18,21,23H,12-13H2,1-3H3,(H,22,24)
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1.40n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086361
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCc1cccc2ccccc12
Show InChI InChI=1S/C23H26N2O2/c1-23(2,21(24-3)17-10-7-12-19(26)14-17)22(27)25-15-18-11-6-9-16-8-4-5-13-20(16)18/h4-14,21,24,26H,15H2,1-3H3,(H,25,27)
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1.40n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086363
PNG
(3-(Cyclopropylmethyl-methyl-amino)-3-(3-hydroxy-ph...)
Show SMILES CN(CC1CC1)C(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-24(2,23(28)25-15-14-18-8-5-4-6-9-18)22(26(3)17-19-12-13-19)20-10-7-11-21(27)16-20/h4-11,16,19,22,27H,12-15,17H2,1-3H3,(H,25,28)
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2.90n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086366
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C21H28N2O2/c1-21(2,19(22-3)17-12-7-13-18(24)15-17)20(25)23-14-8-11-16-9-5-4-6-10-16/h4-7,9-10,12-13,15,19,22,24H,8,11,14H2,1-3H3,(H,23,25)
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3.60n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086360
PNG
(CHEMBL347531 | N-Cyclohexylmethyl-3-(3-hydroxy-phe...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C19H30N2O2/c1-19(2,17(20-3)15-10-7-11-16(22)12-15)18(23)21-13-14-8-5-4-6-9-14/h7,10-12,14,17,20,22H,4-6,8-9,13H2,1-3H3,(H,21,23)
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4.40n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086364
PNG
(CHEMBL146750 | N-Benzyl-3-(3-hydroxy-phenyl)-2,2-d...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H24N2O2/c1-19(2,17(20-3)15-10-7-11-16(22)12-15)18(23)21-13-14-8-5-4-6-9-14/h4-12,17,20,22H,13H2,1-3H3,(H,21,23)
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5n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086360
PNG
(CHEMBL347531 | N-Cyclohexylmethyl-3-(3-hydroxy-phe...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C19H30N2O2/c1-19(2,17(20-3)15-10-7-11-16(22)12-15)18(23)21-13-14-8-5-4-6-9-14/h7,10-12,14,17,20,22H,4-6,8-9,13H2,1-3H3,(H,21,23)
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5.70n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086367
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C20H26N2O2/c1-20(2,18(21-3)16-10-7-11-17(23)14-16)19(24)22-13-12-15-8-5-4-6-9-15/h4-11,14,18,21,23H,12-13H2,1-3H3,(H,22,24)
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6.30n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086364
PNG
(CHEMBL146750 | N-Benzyl-3-(3-hydroxy-phenyl)-2,2-d...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H24N2O2/c1-19(2,17(20-3)15-10-7-11-16(22)12-15)18(23)21-13-14-8-5-4-6-9-14/h4-12,17,20,22H,13H2,1-3H3,(H,21,23)
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8.70n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086366
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C21H28N2O2/c1-21(2,19(22-3)17-12-7-13-18(24)15-17)20(25)23-14-8-11-16-9-5-4-6-10-16/h4-7,9-10,12-13,15,19,22,24H,8,11,14H2,1-3H3,(H,23,25)
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12n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086357
PNG
(2,2-Dimethyl-3-methylamino-N-phenethyl-3-phenyl-pr...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C20H26N2O/c1-20(2,18(21-3)17-12-8-5-9-13-17)19(23)22-15-14-16-10-6-4-7-11-16/h4-13,18,21H,14-15H2,1-3H3,(H,22,23)
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13n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086365
PNG
(3-(Butyl-methyl-amino)-3-(3-hydroxy-phenyl)-2,2-di...)
Show SMILES CCCCN(C)C(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H34N2O2/c1-5-6-17-26(4)22(20-13-10-14-21(27)18-20)24(2,3)23(28)25-16-15-19-11-8-7-9-12-19/h7-14,18,22,27H,5-6,15-17H2,1-4H3,(H,25,28)
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26n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086363
PNG
(3-(Cyclopropylmethyl-methyl-amino)-3-(3-hydroxy-ph...)
Show SMILES CN(CC1CC1)C(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-24(2,23(28)25-15-14-18-8-5-4-6-9-18)22(26(3)17-19-12-13-19)20-10-7-11-21(27)16-20/h4-11,16,19,22,27H,12-15,17H2,1-3H3,(H,25,28)
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28n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50000788
PNG
((morphine)4-methyl-(1S,5R,13R,14S,17R)-12-oxa-4-az...)
Show SMILES Oc1ccc2C[C@H]3N(CC=C)CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O |r|
Show InChI InChI=1S/C19H21NO4/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11/h2-4,14,17,21,23H,1,5-10H2/t14-,17+,18+,19-/m1/s1
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41n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086357
PNG
(2,2-Dimethyl-3-methylamino-N-phenethyl-3-phenyl-pr...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C20H26N2O/c1-20(2,18(21-3)17-12-8-5-9-13-17)19(23)22-15-14-16-10-6-4-7-11-16/h4-13,18,21H,14-15H2,1-3H3,(H,22,23)
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49n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086358
PNG
(CHEMBL347316 | N-Cyclopropylmethyl-3-(3-hydroxy-ph...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCC1CC1
Show InChI InChI=1S/C16H24N2O2/c1-16(2,15(20)18-10-11-7-8-11)14(17-3)12-5-4-6-13(19)9-12/h4-6,9,11,14,17,19H,7-8,10H2,1-3H3,(H,18,20)
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75n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086365
PNG
(3-(Butyl-methyl-amino)-3-(3-hydroxy-phenyl)-2,2-di...)
Show SMILES CCCCN(C)C(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H34N2O2/c1-5-6-17-26(4)22(20-13-10-14-21(27)18-20)24(2,3)23(28)25-16-15-19-11-8-7-9-12-19/h7-14,18,22,27H,5-6,15-17H2,1-4H3,(H,25,28)
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75n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086359
PNG
(CHEMBL147191 | N-Cyclohexylmethyl-2,2-dimethyl-3-m...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C19H30N2O/c1-19(2,17(20-3)16-12-8-5-9-13-16)18(22)21-14-15-10-6-4-7-11-15/h5,8-9,12-13,15,17,20H,4,6-7,10-11,14H2,1-3H3,(H,21,22)
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85n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086362
PNG
(CHEMBL149143 | N-Benzyl-2,2-dimethyl-3-methylamino...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H24N2O/c1-19(2,17(20-3)16-12-8-5-9-13-16)18(22)21-14-15-10-6-4-7-11-15/h4-13,17,20H,14H2,1-3H3,(H,21,22)
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95n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086361
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCc1cccc2ccccc12
Show InChI InChI=1S/C23H26N2O2/c1-23(2,21(24-3)17-10-7-12-19(26)14-17)22(27)25-15-18-11-6-9-16-8-4-5-13-20(16)18/h4-14,21,24,26H,15H2,1-3H3,(H,25,27)
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163n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086367
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C20H26N2O2/c1-20(2,18(21-3)16-10-7-11-17(23)14-16)19(24)22-13-12-15-8-5-4-6-9-15/h4-11,14,18,21,23H,12-13H2,1-3H3,(H,22,24)
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176n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Nociceptin/mu opioid receptor


(Rattus norvegicus (rat))
BDBM50086358
PNG
(CHEMBL347316 | N-Cyclopropylmethyl-3-(3-hydroxy-ph...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCC1CC1
Show InChI InChI=1S/C16H24N2O2/c1-16(2,15(20)18-10-11-7-8-11)14(17-3)12-5-4-6-13(19)9-12/h4-6,9,11,14,17,19H,7-8,10H2,1-3H3,(H,18,20)
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364n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-DAMGO binding to rat Opioid receptor mu 1


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50086362
PNG
(CHEMBL149143 | N-Benzyl-2,2-dimethyl-3-methylamino...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H24N2O/c1-19(2,17(20-3)16-12-8-5-9-13-16)18(22)21-14-15-10-6-4-7-11-15/h4-13,17,20H,14H2,1-3H3,(H,21,22)
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467n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]U-69,593 binding to human Opioid receptor kappa 1 expressed in HEK 293 cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086363
PNG
(3-(Cyclopropylmethyl-methyl-amino)-3-(3-hydroxy-ph...)
Show SMILES CN(CC1CC1)C(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H32N2O2/c1-24(2,23(28)25-15-14-18-8-5-4-6-9-18)22(26(3)17-19-12-13-19)20-10-7-11-21(27)16-20/h4-11,16,19,22,27H,12-15,17H2,1-3H3,(H,25,28)
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710n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086358
PNG
(CHEMBL347316 | N-Cyclopropylmethyl-3-(3-hydroxy-ph...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCC1CC1
Show InChI InChI=1S/C16H24N2O2/c1-16(2,15(20)18-10-11-7-8-11)14(17-3)12-5-4-6-13(19)9-12/h4-6,9,11,14,17,19H,7-8,10H2,1-3H3,(H,18,20)
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781n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086360
PNG
(CHEMBL347531 | N-Cyclohexylmethyl-3-(3-hydroxy-phe...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C19H30N2O2/c1-19(2,17(20-3)15-10-7-11-16(22)12-15)18(23)21-13-14-8-5-4-6-9-14/h7,10-12,14,17,20,22H,4-6,8-9,13H2,1-3H3,(H,21,23)
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881n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086359
PNG
(CHEMBL147191 | N-Cyclohexylmethyl-2,2-dimethyl-3-m...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCC1CCCCC1
Show InChI InChI=1S/C19H30N2O/c1-19(2,17(20-3)16-12-8-5-9-13-16)18(22)21-14-15-10-6-4-7-11-15/h5,8-9,12-13,15,17,20H,4,6-7,10-11,14H2,1-3H3,(H,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086365
PNG
(3-(Butyl-methyl-amino)-3-(3-hydroxy-phenyl)-2,2-di...)
Show SMILES CCCCN(C)C(c1cccc(O)c1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C24H34N2O2/c1-5-6-17-26(4)22(20-13-10-14-21(27)18-20)24(2,3)23(28)25-16-15-19-11-8-7-9-12-19/h7-14,18,22,27H,5-6,15-17H2,1-4H3,(H,25,28)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086357
PNG
(2,2-Dimethyl-3-methylamino-N-phenethyl-3-phenyl-pr...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCCc1ccccc1
Show InChI InChI=1S/C20H26N2O/c1-20(2,18(21-3)17-12-8-5-9-13-17)19(23)22-15-14-16-10-6-4-7-11-16/h4-13,18,21H,14-15H2,1-3H3,(H,22,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086362
PNG
(CHEMBL149143 | N-Benzyl-2,2-dimethyl-3-methylamino...)
Show SMILES CNC(c1ccccc1)C(C)(C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H24N2O/c1-19(2,17(20-3)16-12-8-5-9-13-16)18(22)21-14-15-10-6-4-7-11-15/h4-13,17,20H,14H2,1-3H3,(H,21,22)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086364
PNG
(CHEMBL146750 | N-Benzyl-3-(3-hydroxy-phenyl)-2,2-d...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCc1ccccc1
Show InChI InChI=1S/C19H24N2O2/c1-19(2,17(20-3)15-10-7-11-16(22)12-15)18(23)21-13-14-8-5-4-6-9-14/h4-12,17,20,22H,13H2,1-3H3,(H,21,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50086366
PNG
(3-(3-Hydroxy-phenyl)-2,2-dimethyl-3-methylamino-N-...)
Show SMILES CNC(c1cccc(O)c1)C(C)(C)C(=O)NCCCc1ccccc1
Show InChI InChI=1S/C21H28N2O2/c1-21(2,19(22-3)17-12-7-13-18(24)15-17)20(25)23-14-8-11-16-9-5-4-6-10-16/h4-7,9-10,12-13,15,19,22,24H,8,11,14H2,1-3H3,(H,23,25)
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>1.00E+4n/an/an/an/an/an/an/an/a



Pfizer Inc

Curated by ChEMBL


Assay Description
Inhibition of [3H]-naltrindole binding to human Opioid receptor delta 1 in CHO cells


Bioorg Med Chem Lett 10: 523-6 (2000)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%