Affinity Data by PubMed id=10741563

PubMed code 10741563

Found 4 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Inhibition of 1 nM [3H]RX-821002 binding to rat whole brain membrane Alpha-2 adrenergic receptors				Bioorg Med Chem Lett 10: 605-7 (2000) BindingDB Entry DOI: 10.7270/Q2PR7V63
University of Bristol Curated by ChEMBL					More data for this Ligand-Target Pair
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor (RAT-NEONATAL RAT-Rattus norvegicus (rat))	BDBM50086503 (2-(5-Thiocyanato-benzofuran-2-yl)-4,5-dihydro-1H-i...) Show SMILES N#CSc1ccc2oc(cc2c1)C1=NCCN1 \|t:14\| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	1.63E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Inhibition of 1 nM [3H]RX-821002 binding to rat whole brain membrane Alpha-2 adrenergic receptors				Bioorg Med Chem Lett 10: 605-7 (2000) BindingDB Entry DOI: 10.7270/Q2PR7V63
University of Bristol Curated by ChEMBL					More data for this Ligand-Target Pair
Nischarin (Homo sapiens (Human))	BDBM50086502 (2-BFi \| 2-Benzofuran-2-yl-4,5-dihydro-1H-imidazole...) Show SMILES C1CN=C(N1)c1cc2ccccc2o1 \|c:2\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	6.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Inhibition of 3 nM [3H]-clonidine binding to rat kidney membrane imidazoline receptor I-1 in presence of rauwolscine				Bioorg Med Chem Lett 10: 605-7 (2000) BindingDB Entry DOI: 10.7270/Q2PR7V63
University of Bristol Curated by ChEMBL					More data for this Ligand-Target Pair
Nischarin (Homo sapiens (Human))	BDBM50086503 (2-(5-Thiocyanato-benzofuran-2-yl)-4,5-dihydro-1H-i...) Show SMILES N#CSc1ccc2oc(cc2c1)C1=NCCN1 \|t:14\| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	8.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Bristol Curated by ChEMBL					Assay Description Inhibition of 3 nM [3H]-clonidine binding to rat kidney membrane imidazoline receptor I-1 in presence of rauwolscine				Bioorg Med Chem Lett 10: 605-7 (2000) BindingDB Entry DOI: 10.7270/Q2PR7V63
University of Bristol Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%