Found 10 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucagon receptor
(Rattus norvegicus) | BDBM50098571
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50087848
(CHEMBL427644 | c[Asp15, Lys18,] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C154H226N40O47S/c1-75(2)56-101(138(225)175-100(51-55-242-11)137(224)183-108(64-118(161)207)147(234)193-124(79(8)199)127(162)214)178-142(229)107(62-86-67-165-92-31-19-18-30-90(86)92)182-135(222)98(45-49-117(160)206)176-152(239)123(77(5)6)192-145(232)105(58-82-26-14-12-15-27-82)180-136(223)99-46-50-119(208)164-54-25-22-34-93(131(218)168-78(7)128(215)169-97(134(221)174-99)44-48-116(159)205)170-132(219)94(32-20-23-52-155)171-150(237)113(72-197)189-144(231)110(66-122(212)213)184-139(226)102(57-76(3)4)177-140(227)103(60-84-35-39-88(202)40-36-84)179-133(220)95(33-21-24-53-156)172-149(236)112(71-196)188-141(228)104(61-85-37-41-89(203)42-38-85)181-143(230)109(65-121(210)211)185-151(238)114(73-198)190-154(241)126(81(10)201)194-146(233)106(59-83-28-16-13-17-29-83)186-153(240)125(80(9)200)191-120(209)69-166-130(217)96(43-47-115(158)204)173-148(235)111(70-195)187-129(216)91(157)63-87-68-163-74-167-87/h12-19,26-31,35-42,67-68,74-81,91,93-114,123-126,165,195-203H,20-25,32-34,43-66,69-73,155-157H2,1-11H3,(H2,158,204)(H2,159,205)(H2,160,206)(H2,161,207)(H2,162,214)(H,163,167)(H,164,208)(H,166,217)(H,168,218)(H,169,215)(H,170,219)(H,171,237)(H,172,236)(H,173,235)(H,174,221)(H,175,225)(H,176,239)(H,177,227)(H,178,229)(H,179,220)(H,180,223)(H,181,230)(H,182,222)(H,183,224)(H,184,226)(H,185,238)(H,186,240)(H,187,216)(H,188,228)(H,189,231)(H,190,241)(H,191,209)(H,192,232)(H,193,234)(H,194,233)(H,210,211)(H,212,213)/t78-,79-,80-,81-,91+,93-,94-,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105-,106+,107+,108+,109+,110+,111+,112+,113+,114+,123+,124+,125+,126+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50087843
(CHEMBL429724 | c[Asp9, Lys12,] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CCCNC(N)=N)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](CO)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C153H224N44O47S/c1-72(2)52-97(134(227)177-96(47-51-245-11)133(226)185-104(60-115(158)210)144(237)196-121(76(8)202)124(159)217)180-138(231)103(58-83-64-168-89-29-19-18-28-87(83)89)184-132(225)95(43-46-114(157)209)178-149(242)120(74(5)6)195-142(235)101(54-79-24-14-12-15-25-79)183-140(233)106(62-118(213)214)187-131(224)94(42-45-113(156)208)172-125(218)75(7)171-128(221)91(31-22-49-166-152(160)161)173-129(222)92(32-23-50-167-153(162)163)175-147(240)110(69-200)192-141(234)107(63-119(215)216)188-135(228)98(53-73(3)4)179-136(229)99(56-81-33-37-85(205)38-34-81)181-130(223)90-30-20-21-48-165-116(211)61-105(139(232)182-100(57-82-35-39-86(206)40-36-82)137(230)191-109(68-199)146(239)174-90)186-148(241)111(70-201)193-151(244)123(78(10)204)197-143(236)102(55-80-26-16-13-17-27-80)189-150(243)122(77(9)203)194-117(212)66-169-127(220)93(41-44-112(155)207)176-145(238)108(67-198)190-126(219)88(154)59-84-65-164-71-170-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,168,198-206H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,207)(H2,156,208)(H2,157,209)(H2,158,210)(H2,159,217)(H,164,170)(H,165,211)(H,169,220)(H,171,221)(H,172,218)(H,173,222)(H,174,239)(H,175,240)(H,176,238)(H,177,227)(H,178,242)(H,179,229)(H,180,231)(H,181,223)(H,182,232)(H,183,233)(H,184,225)(H,185,226)(H,186,241)(H,187,224)(H,188,228)(H,189,243)(H,190,219)(H,191,230)(H,192,234)(H,193,244)(H,194,212)(H,195,235)(H,196,237)(H,197,236)(H,213,214)(H,215,216)(H4,160,161,166)(H4,162,163,167)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99+,100+,101-,102-,103-,104-,105+,106-,107-,108-,109-,110-,111+,120-,121-,122-,123-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50087844
(CHEMBL266411 | c[ Lys12, Asp21] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2c[nH]cn2)[C@H](C)O)[C@H](C)O)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C153H224N44O47S/c1-72(2)52-97(134(227)177-96(47-51-245-11)133(226)185-104(60-115(158)210)144(237)196-121(76(8)202)124(159)217)180-138(231)103(58-83-64-168-89-29-19-18-28-87(83)89)184-132(225)95(43-46-114(157)209)178-149(242)120(74(5)6)195-142(235)101(54-79-24-14-12-15-25-79)183-139(232)105-61-116(211)165-48-21-20-30-90(130(223)181-99(56-81-33-37-85(205)38-34-81)136(229)179-98(53-73(3)4)135(228)187-107(63-119(215)216)141(234)192-110(69-200)147(240)175-92(32-23-50-167-153(162)163)129(222)173-91(31-22-49-166-152(160)161)128(221)171-75(7)125(218)172-94(131(224)186-105)42-45-113(156)208)174-146(239)109(68-199)191-137(230)100(57-82-35-39-86(206)40-36-82)182-140(233)106(62-118(213)214)188-148(241)111(70-201)193-151(244)123(78(10)204)197-143(236)102(55-80-26-16-13-17-27-80)189-150(243)122(77(9)203)194-117(212)66-169-127(220)93(41-44-112(155)207)176-145(238)108(67-198)190-126(219)88(154)59-84-65-164-71-170-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,168,198-206H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,207)(H2,156,208)(H2,157,209)(H2,158,210)(H2,159,217)(H,164,170)(H,165,211)(H,169,220)(H,171,221)(H,172,218)(H,173,222)(H,174,239)(H,175,240)(H,176,238)(H,177,227)(H,178,242)(H,179,229)(H,180,231)(H,181,223)(H,182,233)(H,183,232)(H,184,225)(H,185,226)(H,186,224)(H,187,228)(H,188,241)(H,189,243)(H,190,219)(H,191,230)(H,192,234)(H,193,244)(H,194,212)(H,195,235)(H,196,237)(H,197,236)(H,213,214)(H,215,216)(H4,160,161,166)(H4,162,163,167)/t75-,76+,77+,78+,88-,90-,91+,92-,93-,94+,95-,96-,97-,98+,99-,100-,101+,102-,103-,104-,105+,106-,107-,108-,109+,110+,111-,120-,121-,122-,123-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50087847
(CHEMBL413030 | c[Asp9, Lys12,] [Lys17,18, Glu21]-g...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H]2CCCCNC(=O)C[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc3ccccc3)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc3cnc[nH]3)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](Cc3ccc(O)cc3)C(=O)N[C@H](CO)C(=O)N2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O Show InChI InChI=1S/C154H224N40O46S/c1-75(2)56-101(138(224)175-100(51-55-241-11)137(223)183-108(64-118(160)207)147(233)193-124(79(8)199)127(161)213)178-142(228)107(62-86-67-165-92-31-19-18-30-90(86)92)182-135(221)98(45-49-117(159)206)176-152(238)123(77(5)6)192-145(231)105(58-82-26-14-12-15-27-82)180-136(222)99-46-50-119(208)163-53-24-21-33-94(132(218)170-93(32-20-23-52-155)131(217)168-78(7)128(214)169-97(134(220)174-99)44-48-116(158)205)171-150(236)113(72-197)189-144(230)110(66-122(211)212)185-139(225)102(57-76(3)4)177-140(226)103(60-84-35-39-88(202)40-36-84)179-133(219)95-34-22-25-54-164-120(209)65-109(143(229)181-104(61-85-37-41-89(203)42-38-85)141(227)188-112(71-196)149(235)172-95)184-151(237)114(73-198)190-154(240)126(81(10)201)194-146(232)106(59-83-28-16-13-17-29-83)186-153(239)125(80(9)200)191-121(210)69-166-130(216)96(43-47-115(157)204)173-148(234)111(70-195)187-129(215)91(156)63-87-68-162-74-167-87/h12-19,26-31,35-42,67-68,74-81,91,93-114,123-126,165,195-203H,20-25,32-34,43-66,69-73,155-156H2,1-11H3,(H2,157,204)(H2,158,205)(H2,159,206)(H2,160,207)(H2,161,213)(H,162,167)(H,163,208)(H,164,209)(H,166,216)(H,168,217)(H,169,214)(H,170,218)(H,171,236)(H,172,235)(H,173,234)(H,174,220)(H,175,224)(H,176,238)(H,177,226)(H,178,228)(H,179,219)(H,180,222)(H,181,229)(H,182,221)(H,183,223)(H,184,237)(H,185,225)(H,186,239)(H,187,215)(H,188,227)(H,189,230)(H,190,240)(H,191,210)(H,192,231)(H,193,233)(H,194,232)(H,211,212)/t78-,79-,80+,81+,91-,93+,94+,95-,96-,97+,98+,99+,100+,101+,102-,103+,104+,105-,106-,107+,108+,109+,110-,111-,112-,113+,114+,123+,124+,125-,126-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 250 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50087849
(CHEMBL268534 | c[ Lys12, Asp15] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@@H](Cc1ccccc1)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H]1CC(=O)NCCCC[C@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2c[nH]cn2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](Cc2ccc(O)cc2)C(=O)N[C@H](CC(C)C)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C153H224N44O47S/c1-72(2)52-97(134(227)177-96(47-51-245-11)133(226)185-104(60-115(158)210)144(237)196-121(76(8)202)124(159)217)180-138(231)103(58-83-64-168-89-29-19-18-28-87(83)89)184-132(225)95(43-46-114(157)209)178-149(242)120(74(5)6)195-142(235)101(54-79-24-14-12-15-25-79)183-140(233)106(62-118(213)214)187-131(224)94(42-45-113(156)208)172-125(218)75(7)171-128(221)91(31-22-49-166-152(160)161)173-129(222)92(32-23-50-167-153(162)163)175-147(240)110(69-200)192-139(232)105-61-116(211)165-48-21-20-30-90(130(223)181-99(56-81-33-37-85(205)38-34-81)136(229)179-98(53-73(3)4)135(228)186-105)174-146(239)109(68-199)191-137(230)100(57-82-35-39-86(206)40-36-82)182-141(234)107(63-119(215)216)188-148(241)111(70-201)193-151(244)123(78(10)204)197-143(236)102(55-80-26-16-13-17-27-80)189-150(243)122(77(9)203)194-117(212)66-169-127(220)93(41-44-112(155)207)176-145(238)108(67-198)190-126(219)88(154)59-84-65-164-71-170-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,168,198-206H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,207)(H2,156,208)(H2,157,209)(H2,158,210)(H2,159,217)(H,164,170)(H,165,211)(H,169,220)(H,171,221)(H,172,218)(H,173,222)(H,174,239)(H,175,240)(H,176,238)(H,177,227)(H,178,242)(H,179,229)(H,180,231)(H,181,223)(H,182,234)(H,183,233)(H,184,225)(H,185,226)(H,186,228)(H,187,224)(H,188,241)(H,189,243)(H,190,219)(H,191,230)(H,192,232)(H,193,244)(H,194,212)(H,195,235)(H,196,237)(H,197,236)(H,213,214)(H,215,216)(H4,160,161,166)(H4,162,163,167)/t75-,76+,77+,78+,88-,90+,91-,92-,93-,94-,95-,96-,97-,98-,99+,100-,101-,102-,103-,104-,105-,106-,107-,108-,109+,110+,111-,120-,121-,122-,123-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50087846
(CHEMBL266412 | c[Asp15, Lys18,] glucagon-NH2)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)C(C)NC(=O)[C@H]1CCCCNC(=O)C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2c[nH]cn2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCN=C(N)N)C(=O)N1)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O Show InChI InChI=1S/C153H224N42O47S/c1-73(2)53-98(135(225)175-97(48-52-243-11)134(224)183-105(61-116(159)208)145(235)194-122(77(8)200)125(160)215)178-139(229)104(59-84-65-166-90-30-19-18-29-88(84)90)182-133(223)96(44-47-115(158)207)176-150(240)121(75(5)6)193-143(233)102(55-80-25-14-12-15-26-80)181-141(231)107(63-119(211)212)185-132(222)95(43-46-114(157)206)170-126(216)76(7)169-129(219)91-32-21-23-50-164-117(209)62-106(140(230)190-111(70-198)148(238)173-93(130(220)171-91)33-24-51-165-153(161)162)184-136(226)99(54-74(3)4)177-137(227)100(57-82-34-38-86(203)39-35-82)179-131(221)92(31-20-22-49-154)172-147(237)110(69-197)189-138(228)101(58-83-36-40-87(204)41-37-83)180-142(232)108(64-120(213)214)186-149(239)112(71-199)191-152(242)124(79(10)202)195-144(234)103(56-81-27-16-13-17-28-81)187-151(241)123(78(9)201)192-118(210)67-167-128(218)94(42-45-113(156)205)174-146(236)109(68-196)188-127(217)89(155)60-85-66-163-72-168-85/h12-19,25-30,34-41,65-66,72-79,89,91-112,121-124,166,196-204H,20-24,31-33,42-64,67-71,154-155H2,1-11H3,(H2,156,205)(H2,157,206)(H2,158,207)(H2,159,208)(H2,160,215)(H,163,168)(H,164,209)(H,167,218)(H,169,219)(H,170,216)(H,171,220)(H,172,237)(H,173,238)(H,174,236)(H,175,225)(H,176,240)(H,177,227)(H,178,229)(H,179,221)(H,180,232)(H,181,231)(H,182,223)(H,183,224)(H,184,226)(H,185,222)(H,186,239)(H,187,241)(H,188,217)(H,189,228)(H,190,230)(H,191,242)(H,192,210)(H,193,233)(H,194,235)(H,195,234)(H,211,212)(H,213,214)(H4,161,162,165)/t76?,77-,78+,79+,89-,91-,92-,93-,94-,95+,96+,97+,98+,99-,100-,101-,102+,103-,104+,105+,106+,107+,108-,109-,110-,111+,112-,121+,122+,123-,124-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50087844
(CHEMBL266411 | c[ Lys12, Asp21] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CC(=O)NCCCC[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2c[nH]cn2)[C@H](C)O)[C@H](C)O)C(=O)N[C@H](Cc2ccc(O)cc2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C153H224N44O47S/c1-72(2)52-97(134(227)177-96(47-51-245-11)133(226)185-104(60-115(158)210)144(237)196-121(76(8)202)124(159)217)180-138(231)103(58-83-64-168-89-29-19-18-28-87(83)89)184-132(225)95(43-46-114(157)209)178-149(242)120(74(5)6)195-142(235)101(54-79-24-14-12-15-25-79)183-139(232)105-61-116(211)165-48-21-20-30-90(130(223)181-99(56-81-33-37-85(205)38-34-81)136(229)179-98(53-73(3)4)135(228)187-107(63-119(215)216)141(234)192-110(69-200)147(240)175-92(32-23-50-167-153(162)163)129(222)173-91(31-22-49-166-152(160)161)128(221)171-75(7)125(218)172-94(131(224)186-105)42-45-113(156)208)174-146(239)109(68-199)191-137(230)100(57-82-35-39-86(206)40-36-82)182-140(233)106(62-118(213)214)188-148(241)111(70-201)193-151(244)123(78(10)204)197-143(236)102(55-80-26-16-13-17-27-80)189-150(243)122(77(9)203)194-117(212)66-169-127(220)93(41-44-112(155)207)176-145(238)108(67-198)190-126(219)88(154)59-84-65-164-71-170-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,168,198-206H,20-23,30-32,41-63,66-70,154H2,1-11H3,(H2,155,207)(H2,156,208)(H2,157,209)(H2,158,210)(H2,159,217)(H,164,170)(H,165,211)(H,169,220)(H,171,221)(H,172,218)(H,173,222)(H,174,239)(H,175,240)(H,176,238)(H,177,227)(H,178,242)(H,179,229)(H,180,231)(H,181,223)(H,182,233)(H,183,232)(H,184,225)(H,185,226)(H,186,224)(H,187,228)(H,188,241)(H,189,243)(H,190,219)(H,191,230)(H,192,234)(H,193,244)(H,194,212)(H,195,235)(H,196,237)(H,197,236)(H,213,214)(H,215,216)(H4,160,161,166)(H4,162,163,167)/t75-,76+,77+,78+,88-,90-,91+,92-,93-,94+,95-,96-,97-,98+,99-,100-,101+,102-,103-,104-,105+,106-,107-,108-,109+,110+,111-,120-,121-,122-,123-/m1/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 794 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50098571
(CHEMBL266481 | GLUCAGON | His-Ser-Gln-Gly-Thr-Phe-...)Show SMILES CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]cn1)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O Show InChI InChI=1S/C153H225N43O49S/c1-72(2)52-97(133(226)176-96(47-51-246-11)132(225)184-104(60-115(159)209)143(236)196-123(78(10)203)151(244)245)179-137(230)103(58-83-64-167-89-29-19-18-28-87(83)89)183-131(224)95(43-46-114(158)208)177-148(241)120(74(5)6)194-141(234)101(54-79-24-14-12-15-25-79)182-138(231)105(61-117(211)212)185-130(223)94(42-45-113(157)207)171-124(217)75(7)170-127(220)91(31-22-49-165-152(160)161)172-128(221)92(32-23-50-166-153(162)163)174-146(239)110(69-199)191-140(233)107(63-119(215)216)186-134(227)98(53-73(3)4)178-135(228)99(56-81-33-37-85(204)38-34-81)180-129(222)90(30-20-21-48-154)173-145(238)109(68-198)190-136(229)100(57-82-35-39-86(205)40-36-82)181-139(232)106(62-118(213)214)187-147(240)111(70-200)192-150(243)122(77(9)202)195-142(235)102(55-80-26-16-13-17-27-80)188-149(242)121(76(8)201)193-116(210)66-168-126(219)93(41-44-112(156)206)175-144(237)108(67-197)189-125(218)88(155)59-84-65-164-71-169-84/h12-19,24-29,33-40,64-65,71-78,88,90-111,120-123,167,197-205H,20-23,30-32,41-63,66-70,154-155H2,1-11H3,(H2,156,206)(H2,157,207)(H2,158,208)(H2,159,209)(H,164,169)(H,168,219)(H,170,220)(H,171,217)(H,172,221)(H,173,238)(H,174,239)(H,175,237)(H,176,226)(H,177,241)(H,178,228)(H,179,230)(H,180,222)(H,181,232)(H,182,231)(H,183,224)(H,184,225)(H,185,223)(H,186,227)(H,187,240)(H,188,242)(H,189,218)(H,190,229)(H,191,233)(H,192,243)(H,193,210)(H,194,234)(H,195,235)(H,196,236)(H,211,212)(H,213,214)(H,215,216)(H,244,245)(H4,160,161,165)(H4,162,163,166)/t75-,76+,77+,78+,88-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,120-,121-,122-,123-/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 5 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
Glucagon receptor
(Rattus norvegicus) | BDBM50087848
(CHEMBL427644 | c[Asp15, Lys18,] glucagon-NH2)Show SMILES CSCC[C@@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H](CCC(N)=O)NC(=O)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H]1CCC(=O)NCCCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CCCCN)NC(=O)[C@@H](CO)NC(=O)[C@@H](Cc2ccc(O)cc2)NC(=O)[C@@H](CC(O)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](CCC(N)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)Cc2cnc[nH]2)[C@H](C)O)[C@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H](CCC(N)=O)C(=O)N1)C(C)C)C(=O)N[C@H](CC(N)=O)C(=O)N[C@H]([C@H](C)O)C(N)=O Show InChI InChI=1S/C154H226N40O47S/c1-75(2)56-101(138(225)175-100(51-55-242-11)137(224)183-108(64-118(161)207)147(234)193-124(79(8)199)127(162)214)178-142(229)107(62-86-67-165-92-31-19-18-30-90(86)92)182-135(222)98(45-49-117(160)206)176-152(239)123(77(5)6)192-145(232)105(58-82-26-14-12-15-27-82)180-136(223)99-46-50-119(208)164-54-25-22-34-93(131(218)168-78(7)128(215)169-97(134(221)174-99)44-48-116(159)205)170-132(219)94(32-20-23-52-155)171-150(237)113(72-197)189-144(231)110(66-122(212)213)184-139(226)102(57-76(3)4)177-140(227)103(60-84-35-39-88(202)40-36-84)179-133(220)95(33-21-24-53-156)172-149(236)112(71-196)188-141(228)104(61-85-37-41-89(203)42-38-85)181-143(230)109(65-121(210)211)185-151(238)114(73-198)190-154(241)126(81(10)201)194-146(233)106(59-83-28-16-13-17-29-83)186-153(240)125(80(9)200)191-120(209)69-166-130(217)96(43-47-115(158)204)173-148(235)111(70-195)187-129(216)91(157)63-87-68-163-74-167-87/h12-19,26-31,35-42,67-68,74-81,91,93-114,123-126,165,195-203H,20-25,32-34,43-66,69-73,155-157H2,1-11H3,(H2,158,204)(H2,159,205)(H2,160,206)(H2,161,207)(H2,162,214)(H,163,167)(H,164,208)(H,166,217)(H,168,218)(H,169,215)(H,170,219)(H,171,237)(H,172,236)(H,173,235)(H,174,221)(H,175,225)(H,176,239)(H,177,227)(H,178,229)(H,179,220)(H,180,223)(H,181,230)(H,182,222)(H,183,224)(H,184,226)(H,185,238)(H,186,240)(H,187,216)(H,188,228)(H,189,231)(H,190,241)(H,191,209)(H,192,232)(H,193,234)(H,194,233)(H,210,211)(H,212,213)/t78-,79-,80-,81-,91+,93-,94-,95+,96+,97+,98+,99+,100+,101+,102+,103+,104+,105-,106+,107+,108+,109+,110+,111+,112+,113+,114+,123+,124+,125+,126+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
KEGG
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | n/a | n/a | 320 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
In vitro receptor binding affinity (95% CL) using rat liver plasma membrane bioassay |
J Med Chem 43: 1714-22 (2000)
BindingDB Entry DOI: 10.7270/Q2XG9RVJ |
More data for this
Ligand-Target Pair | |
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