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PubMed code 10794701

Compile data set for download or QSAR
Found 48 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50026888
PNG
(CHEMBL2113671)
Show SMILES [H][C@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21+,23-,26+,27-,28?,29-/s2
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0.160n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human Opioid receptor delta 1 transfected onto CHO cells using [3H]Cl-DPDPE


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50026890
PNG
(CHEMBL2113670)
Show SMILES [H][C@](C)(OCC)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:10,TLB:18:19:9:24.26.27,1:6:28.15:11.10,25:24:19.20.21:9,THB:8:9:19.20.21:24.26.27,10:9:19.20.21:24.26.27|
Show InChI InChI=1/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16+,18-,21+,22-,23?,24-/s2
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0.300n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50369822
PNG
(CHEMBL1169580)
Show SMILES CCC[C@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22-,23?,24?,25+/m0/s1
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0.5n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50026890
PNG
(CHEMBL2113670)
Show SMILES [H][C@](C)(OCC)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:10,TLB:18:19:9:24.26.27,1:6:28.15:11.10,25:24:19.20.21:9,THB:8:9:19.20.21:24.26.27,10:9:19.20.21:24.26.27|
Show InChI InChI=1/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16+,18-,21+,22-,23?,24-/s2
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0.5n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50026888
PNG
(CHEMBL2113671)
Show SMILES [H][C@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21+,23-,26+,27-,28?,29-/s2
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0.640n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human Opioid receptor mu 1 transfected onto CHO cells using [3H]DAMGO


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50026889
PNG
(CHEMBL2113672)
Show SMILES [H][C@@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21-,23+,26-,27+,28?,29+/s2
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0.670n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human opioid Opioid receptor mu 1 transfected onto CHO cells using [3H]DAMGO


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369821
PNG
(CHEMBL1169585)
Show SMILES CCC[C@@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22+,23?,24?,25+/m0/s1
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0.700n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor delta 1 in guinea pig brain membranes using [3H]Cl-DPDPE


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50369821
PNG
(CHEMBL1169585)
Show SMILES CCC[C@@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22+,23?,24?,25+/m0/s1
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0.800n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50026888
PNG
(CHEMBL2113671)
Show SMILES [H][C@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21+,23-,26+,27-,28?,29-/s2
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0.840n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human opioid Opioid receptor kappa 1 transfected onto CHO cells using [3H]U-69593


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50369820
PNG
(CHEMBL1169584)
Show SMILES CCO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:8,TLB:15:16:7:20.22.23,3:5:24.13:9.8,23:24:6.5:9.8,21:20:16.17.18:7,THB:16:24:6.5:9.8,6:7:16.17.18:20.22.23,8:7:16.17.18:20.22.23,14:13:6.5:9.8|
Show InChI InChI=1S/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16-,18?,21-,22?,23?,24+/m0/s1
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1n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50026889
PNG
(CHEMBL2113672)
Show SMILES [H][C@@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21-,23+,26-,27+,28?,29+/s2
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1.10n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human Opioid receptor kappa 1 transfected onto CHO cells using [3H]U-69593


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369822
PNG
(CHEMBL1169580)
Show SMILES CCC[C@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22-,23?,24?,25+/m0/s1
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1.10n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor delta 1 in guinea pig brain membranes using [3H]Cl-DPDPE


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
mu/kappa opioid receptor


(GUINEA PIG)
BDBM50369821
PNG
(CHEMBL1169585)
Show SMILES CCC[C@@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22+,23?,24?,25+/m0/s1
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1.5n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor mu 1 in guinea pig brain membranes using [3H]DAMGO


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50369826
PNG
(CHEMBL1169583)
Show SMILES CO[C@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15+,17?,20+,21?,22?,23-/m1/s1
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1.60n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human opioid mu receptors transfected onto CHO cells using [3H]DAMGO


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50369822
PNG
(CHEMBL1169580)
Show SMILES CCC[C@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22-,23?,24?,25+/m0/s1
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2.30n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50026890
PNG
(CHEMBL2113670)
Show SMILES [H][C@](C)(OCC)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:10,TLB:18:19:9:24.26.27,1:6:28.15:11.10,25:24:19.20.21:9,THB:8:9:19.20.21:24.26.27,10:9:19.20.21:24.26.27|
Show InChI InChI=1/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16+,18-,21+,22-,23?,24-/s2
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2.70n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor delta 1 in guinea pig brain membranes using [3H]Cl-DPDPE


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50369826
PNG
(CHEMBL1169583)
Show SMILES CO[C@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15+,17?,20+,21?,22?,23-/m1/s1
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3.90n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human Opioid receptor kappa 1 transfected onto CHO cells using [3H]U-69593


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50026889
PNG
(CHEMBL2113672)
Show SMILES [H][C@@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21-,23+,26-,27+,28?,29+/s2
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4.60n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human Opioid receptor delta 1 transfected onto CHO cells using [3H]Cl-DPDPE


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50369823
PNG
(CHEMBL1169582)
Show SMILES CO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15-,17?,20-,21?,22?,23+/m0/s1
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4.80n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human Opioid receptor mu 1 transfected onto CHO cells using [3H]DAMGO


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369820
PNG
(CHEMBL1169584)
Show SMILES CCO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:8,TLB:15:16:7:20.22.23,3:5:24.13:9.8,23:24:6.5:9.8,21:20:16.17.18:7,THB:16:24:6.5:9.8,6:7:16.17.18:20.22.23,8:7:16.17.18:20.22.23,14:13:6.5:9.8|
Show InChI InChI=1S/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16-,18?,21-,22?,23?,24+/m0/s1
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7n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor delta 1 in guinea pig brain membranes using [3H]Cl-DPDPE


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369826
PNG
(CHEMBL1169583)
Show SMILES CO[C@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15+,17?,20+,21?,22?,23-/m1/s1
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13n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human Opioid receptor delta 1 transfected onto CHO cells using [3H]Cl-DPDPE


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))
BDBM50369820
PNG
(CHEMBL1169584)
Show SMILES CCO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:8,TLB:15:16:7:20.22.23,3:5:24.13:9.8,23:24:6.5:9.8,21:20:16.17.18:7,THB:16:24:6.5:9.8,6:7:16.17.18:20.22.23,8:7:16.17.18:20.22.23,14:13:6.5:9.8|
Show InChI InChI=1S/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16-,18?,21-,22?,23?,24+/m0/s1
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14n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against Opioid receptor kappa 1 in guinea pig brain membranes using [3H]U-69593


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50369823
PNG
(CHEMBL1169582)
Show SMILES CO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15-,17?,20-,21?,22?,23+/m0/s1
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43n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human opioid Opioid receptor kappa 1 transfected onto CHO cells using [3H]U-69593


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369823
PNG
(CHEMBL1169582)
Show SMILES CO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15-,17?,20-,21?,22?,23+/m0/s1
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78n/an/an/an/an/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
Binding affinity against cloned human Opioid receptor delta 1 transfected onto CHO cells using [3H]Cl-DPDPE


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50369823
PNG
(CHEMBL1169582)
Show SMILES CO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15-,17?,20-,21?,22?,23+/m0/s1
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n/an/an/an/a 35n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor mu 1 (DAMGO) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50026890
PNG
(CHEMBL2113670)
Show SMILES [H][C@](C)(OCC)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:10,TLB:18:19:9:24.26.27,1:6:28.15:11.10,25:24:19.20.21:9,THB:8:9:19.20.21:24.26.27,10:9:19.20.21:24.26.27|
Show InChI InChI=1/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16+,18-,21+,22-,23?,24-/s2
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n/an/an/an/a 0.610n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor kappa 1 (U-69,593) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50026889
PNG
(CHEMBL2113672)
Show SMILES [H][C@@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21-,23+,26-,27+,28?,29+/s2
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n/an/an/an/a 0.800n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor kappa 1 (U-69,593) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50026890
PNG
(CHEMBL2113670)
Show SMILES [H][C@](C)(OCC)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:10,TLB:18:19:9:24.26.27,1:6:28.15:11.10,25:24:19.20.21:9,THB:8:9:19.20.21:24.26.27,10:9:19.20.21:24.26.27|
Show InChI InChI=1/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16+,18-,21+,22-,23?,24-/s2
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n/an/an/an/a 24n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human oOpioid receptor delta 1 (Cl-DPDPE) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50369820
PNG
(CHEMBL1169584)
Show SMILES CCO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:8,TLB:15:16:7:20.22.23,3:5:24.13:9.8,23:24:6.5:9.8,21:20:16.17.18:7,THB:16:24:6.5:9.8,6:7:16.17.18:20.22.23,8:7:16.17.18:20.22.23,14:13:6.5:9.8|
Show InChI InChI=1S/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16-,18?,21-,22?,23?,24+/m0/s1
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n/an/an/an/a 14n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor mu 1 (DAMGO) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50369822
PNG
(CHEMBL1169580)
Show SMILES CCC[C@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22-,23?,24?,25+/m0/s1
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n/an/an/an/a 14n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor kappa 1 (U-69,593) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50369823
PNG
(CHEMBL1169582)
Show SMILES CO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15-,17?,20-,21?,22?,23+/m0/s1
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n/an/an/an/a 161n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor kappa 1 (U-69,593) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50026890
PNG
(CHEMBL2113670)
Show SMILES [H][C@](C)(OCC)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:10,TLB:18:19:9:24.26.27,1:6:28.15:11.10,25:24:19.20.21:9,THB:8:9:19.20.21:24.26.27,10:9:19.20.21:24.26.27|
Show InChI InChI=1/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16+,18-,21+,22-,23?,24-/s2
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n/an/an/an/a 4.90n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor mu 1 (DAMGO) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50026889
PNG
(CHEMBL2113672)
Show SMILES [H][C@@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21-,23+,26-,27+,28?,29+/s2
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n/an/an/an/a 1.80n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor mu 1 (DAMGO) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369823
PNG
(CHEMBL1169582)
Show SMILES CO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15-,17?,20-,21?,22?,23+/m0/s1
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n/an/an/an/a 160n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor delta 1 (Cl-DPDPE) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369826
PNG
(CHEMBL1169583)
Show SMILES CO[C@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15+,17?,20+,21?,22?,23-/m1/s1
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n/an/an/an/a 37n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor delta 1 (Cl-DPDPE) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50369820
PNG
(CHEMBL1169584)
Show SMILES CCO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:8,TLB:15:16:7:20.22.23,3:5:24.13:9.8,23:24:6.5:9.8,21:20:16.17.18:7,THB:16:24:6.5:9.8,6:7:16.17.18:20.22.23,8:7:16.17.18:20.22.23,14:13:6.5:9.8|
Show InChI InChI=1S/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16-,18?,21-,22?,23?,24+/m0/s1
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n/an/an/an/a 559n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor kappa 1 (U-69,593) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50026889
PNG
(CHEMBL2113672)
Show SMILES [H][C@@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21-,23+,26-,27+,28?,29+/s2
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n/an/an/an/a 19n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor delta 1 (Cl-DPDPE) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50369821
PNG
(CHEMBL1169585)
Show SMILES CCC[C@@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22+,23?,24?,25+/m0/s1
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n/an/an/an/a 0.660n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human oOpioid receptor mu 1 (DAMGO) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50026888
PNG
(CHEMBL2113671)
Show SMILES [H][C@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21+,23-,26+,27-,28?,29-/s2
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n/an/an/an/a 0.600n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor mu 1 (DAMGO) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50369826
PNG
(CHEMBL1169583)
Show SMILES CO[C@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15+,17?,20+,21?,22?,23-/m1/s1
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n/an/an/an/a 16n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human opioid mu receptor transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50369821
PNG
(CHEMBL1169585)
Show SMILES CCC[C@@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22+,23?,24?,25+/m0/s1
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n/an/an/an/a 2n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor kappa 1 (U-69,593) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50369826
PNG
(CHEMBL1169583)
Show SMILES CO[C@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:7,TLB:14:15:6:19.21.22,2:4:23.12:8.7,22:23:5.4:8.7,20:19:15.16.17:6,THB:15:23:5.4:8.7,5:6:15.16.17:19.21.22,7:6:15.16.17:19.21.22,13:12:5.4:8.7|
Show InChI InChI=1S/C23H29NO4/c1-13(26-3)15-12-21-7-8-23(15,27-4)20-22(21)9-10-24(2)17(21)11-14-5-6-16(25)19(28-20)18(14)22/h5-8,13,15,17,20,25H,9-12H2,1-4H3/t13-,15+,17?,20+,21?,22?,23-/m1/s1
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n/an/an/an/a 18n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor kappa 1 (U-69,593) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50026888
PNG
(CHEMBL2113671)
Show SMILES [H][C@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21+,23-,26+,27-,28?,29-/s2
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n/an/an/an/a 0.100n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor kappa 1 (U-69,593) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369821
PNG
(CHEMBL1169585)
Show SMILES CCC[C@@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22+,23?,24?,25+/m0/s1
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n/an/an/an/a 1.5n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor delta 1 (Cl-DPDPE) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50369822
PNG
(CHEMBL1169580)
Show SMILES CCC[C@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22-,23?,24?,25+/m0/s1
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n/an/an/an/a 7.30n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human opioid mu receptors (DAMGO) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369820
PNG
(CHEMBL1169584)
Show SMILES CCO[C@@H](C)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:8,TLB:15:16:7:20.22.23,3:5:24.13:9.8,23:24:6.5:9.8,21:20:16.17.18:7,THB:16:24:6.5:9.8,6:7:16.17.18:20.22.23,8:7:16.17.18:20.22.23,14:13:6.5:9.8|
Show InChI InChI=1S/C24H31NO4/c1-5-28-14(2)16-13-22-8-9-24(16,27-4)21-23(22)10-11-25(3)18(22)12-15-6-7-17(26)20(29-21)19(15)23/h6-9,14,16,18,21,26H,5,10-13H2,1-4H3/t14-,16-,18?,21-,22?,23?,24+/m0/s1
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n/an/an/an/a 58n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor delta 1 (Cl-DPDPE) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50369822
PNG
(CHEMBL1169580)
Show SMILES CCC[C@](C)(O)[C@@H]1CC23C=C[C@]1(OC)[C@H]1Oc4c5c(CC2N(C)CCC315)ccc4O |r,c:9,TLB:16:17:8:21.23.24,3:6:25.14:10.9,24:25:7.6:10.9,22:21:17.18.19:8,THB:17:25:7.6:10.9,7:8:17.18.19:21.23.24,9:8:17.18.19:21.23.24,15:14:7.6:10.9|
Show InChI InChI=1S/C25H33NO4/c1-5-8-22(2,28)17-14-23-9-10-25(17,29-4)21-24(23)11-12-26(3)18(23)13-15-6-7-16(27)20(30-21)19(15)24/h6-7,9-10,17-18,21,27-28H,5,8,11-14H2,1-4H3/t17-,18?,21-,22-,23?,24?,25+/m0/s1
PDB

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PC cid
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PubMed
n/an/an/an/a 13n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor delta 1 (Cl-DPDPE) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50026888
PNG
(CHEMBL2113671)
Show SMILES [H][C@](C)(OCc1ccccc1)[C@]1([H])C[C@]23C=C[C@]1(OC)[C@@]1([H])Oc4c5c(C[C@@]2([H])N(C)CCC315)ccc4O |r,c:16,TLB:23:24:14:29.31.32,1:11:33.20:16.15,30:29:24.25.26:14,THB:13:14:24.25.26:29.31.32,15:14:24.25.26:29.31.32|
Show InChI InChI=1/C29H33NO4/c1-18(33-17-19-7-5-4-6-8-19)21-16-27-11-12-29(21,32-3)26-28(27)13-14-30(2)23(27)15-20-9-10-22(31)25(34-26)24(20)28/h4-12,18,21,23,26,31H,13-17H2,1-3H3/t18-,21+,23-,26+,27-,28?,29-/s2
PDB

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n/an/an/an/a 1.10n/an/an/an/a



University of Bristol

Curated by ChEMBL


Assay Description
EC50 for binding of [35S]- GTPdeltaS in cloned human Opioid receptor delta 1 (Cl-DPDPE) transfected onto CHO cells


J Med Chem 43: 1852-7 (2000)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%