Found 33 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089127
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-11(2-4-13)14-15(12-5-9-19-10-6-12)21-16(20-14)17(22)7-8-17/h1-6,9-10,22H,7-8H2,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089122
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H22FN3O/c22-17-7-5-15(6-8-17)18-19(16-9-13-23-14-10-16)25-20(24-18)21(26)11-3-1-2-4-12-21/h5-10,13-14,26H,1-4,11-12H2,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089123
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C19H18FN3O/c20-15-5-3-13(4-6-15)16-17(14-7-11-21-12-8-14)23-18(22-16)19(24)9-1-2-10-19/h3-8,11-12,24H,1-2,9-10H2,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 80 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089125
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)Show SMILES CN1CCC(O)(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H21FN4O/c1-25-12-8-20(26,9-13-25)19-23-17(14-2-4-16(21)5-3-14)18(24-19)15-6-10-22-11-7-15/h2-7,10-11,26H,8-9,12-13H2,1H3,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089130
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H20FN3O/c21-16-6-4-14(5-7-16)17-18(15-8-12-22-13-9-15)24-19(23-17)20(25)10-2-1-3-11-20/h4-9,12-13,25H,1-3,10-11H2,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089124
(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-...)Show SMILES CN1CCC(O)(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H22FN3O/c1-25-12-8-21(26,9-13-25)19-14-18(15-6-10-23-11-7-15)20(24-19)16-2-4-17(22)5-3-16/h2-7,10-11,14,24,26H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089132
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C18H16FN3O/c19-14-4-2-12(3-5-14)15-16(13-6-10-20-11-7-13)22-17(21-15)18(23)8-1-9-18/h2-7,10-11,23H,1,8-9H2,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089122
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H22FN3O/c22-17-7-5-15(6-8-17)18-19(16-9-13-23-14-10-16)25-20(24-18)21(26)11-3-1-2-4-12-21/h5-10,13-14,26H,1-4,11-12H2,(H,24,25) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089128
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-thiazol-2-yl...)Show SMILES CN1CCC(O)(CC1)c1nc(c(s1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3OS/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089131
(4-(2-tert-Butyl-5-phenyl-1H-imidazol-4-yl)-pyridin...)Show InChI InChI=1S/C18H19N3/c1-18(2,3)17-20-15(13-7-5-4-6-8-13)16(21-17)14-9-11-19-12-10-14/h4-12H,1-3H3,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089133
(2-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES CC(C)(O)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C17H16FN3O/c1-17(2,22)16-20-14(11-3-5-13(18)6-4-11)15(21-16)12-7-9-19-10-8-12/h3-10,22H,1-2H3,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 797 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of EGFR kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 14
(Mus musculus (mouse)) | BDBM50089129
(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-6-10-22-11-7-14)18(26-19)15-2-4-16(21)5-3-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of murine p38 alpha MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 11
(Homo sapiens (Human)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.41E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human p38 beta MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089123
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C19H18FN3O/c20-15-5-3-13(4-6-15)16-17(14-7-11-21-12-8-14)23-18(22-16)19(24)9-1-2-10-19/h3-8,11-12,24H,1-2,9-10H2,(H,22,23) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089131
(4-(2-tert-Butyl-5-phenyl-1H-imidazol-4-yl)-pyridin...)Show InChI InChI=1S/C18H19N3/c1-18(2,3)17-20-15(13-7-5-4-6-8-13)16(21-17)14-9-11-19-12-10-14/h4-12H,1-3H3,(H,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089130
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H20FN3O/c21-16-6-4-14(5-7-16)17-18(15-8-12-22-13-9-15)24-19(23-17)20(25)10-2-1-3-11-20/h4-9,12-13,25H,1-3,10-11H2,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 6.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 9
(Homo sapiens (Human)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of JNK2 kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 1
(Mus musculus (Mouse)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of ERK2 kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 13
(Homo sapiens (Human)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of human p38 delta MAP kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Mitogen-activated protein kinase 8
(Homo sapiens (Human)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of JNK1 kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089132
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C18H16FN3O/c19-14-4-2-12(3-5-14)15-16(13-6-10-20-11-7-13)22-17(21-15)18(23)8-1-9-18/h2-7,10-11,23H,1,8-9H2,(H,21,22) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Proto-oncogene tyrosine-protein kinase Src
(Gallus gallus (Chicken)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.27E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of c-src kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089127
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES OC1(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-11(2-4-13)14-15(12-5-9-19-10-6-12)21-16(20-14)17(22)7-8-17/h1-6,9-10,22H,7-8H2,(H,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Protein kinase C alpha type
(Bos taurus (bovine)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5.11E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of PKCalpha kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089128
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-thiazol-2-yl...)Show SMILES CN1CCC(O)(CC1)c1nc(c(s1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3OS/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase ABL1
(Mus musculus) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 8.68E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of c-abl kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089133
(2-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)Show SMILES CC(C)(O)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C17H16FN3O/c1-17(2,22)16-20-14(11-3-5-13(18)6-4-11)15(21-16)12-7-9-19-10-8-12/h3-10,22H,1-2H3,(H,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 8.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089124
(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-...)Show SMILES CN1CCC(O)(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C21H22FN3O/c1-25-12-8-21(26,9-13-25)19-14-18(15-6-10-23-11-7-15)20(24-19)16-2-4-17(22)5-3-16/h2-7,10-11,14,24,26H,8-9,12-13H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089125
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)Show SMILES CN1CCC(O)(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1 Show InChI InChI=1S/C20H21FN4O/c1-25-12-8-20(26,9-13-25)19-23-17(14-2-4-16(21)5-3-14)18(24-19)15-6-10-22-11-7-15/h2-7,10-11,26H,8-9,12-13H2,1H3,(H,23,24) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Dual specificity mitogen-activated protein kinase kinase 6
(Homo sapiens (Human)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of MKK6b kinase |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Prostaglandin G/H synthase 1
(Ovis aries (Sheep)) | BDBM50089126
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1 Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Pharma AG
Curated by ChEMBL
| Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1 |
Bioorg Med Chem Lett 10: 1261-4 (2000)
BindingDB Entry DOI: 10.7270/Q2XS5TMT |
More data for this
Ligand-Target Pair | |
Search and Browse
