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PubMed code 10866395

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
MAP kinase p38


(Mus musculus (mouse))
BDBM50089127
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-11(2-4-13)14-15(12-5-9-19-10-6-12)21-16(20-14)17(22)7-8-17/h1-6,9-10,22H,7-8H2,(H,20,21)
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n/an/a 20n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089122
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H22FN3O/c22-17-7-5-15(6-8-17)18-19(16-9-13-23-14-10-16)25-20(24-18)21(26)11-3-1-2-4-12-21/h5-10,13-14,26H,1-4,11-12H2,(H,24,25)
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n/an/a 76n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089123
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C19H18FN3O/c20-15-5-3-13(4-6-15)16-17(14-7-11-21-12-8-14)23-18(22-16)19(24)9-1-2-10-19/h3-8,11-12,24H,1-2,9-10H2,(H,22,23)
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n/an/a 80n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089125
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES CN1CCC(O)(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H21FN4O/c1-25-12-8-20(26,9-13-25)19-23-17(14-2-4-16(21)5-3-14)18(24-19)15-6-10-22-11-7-15/h2-7,10-11,26H,8-9,12-13H2,1H3,(H,23,24)
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n/an/a 90n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089130
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H20FN3O/c21-16-6-4-14(5-7-16)17-18(15-8-12-22-13-9-15)24-19(23-17)20(25)10-2-1-3-11-20/h4-9,12-13,25H,1-3,10-11H2,(H,23,24)
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n/an/a 120n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089124
PNG
(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-...)
Show SMILES CN1CCC(O)(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H22FN3O/c1-25-12-8-21(26,9-13-25)19-14-18(15-6-10-23-11-7-15)20(24-19)16-2-4-17(22)5-3-16/h2-7,10-11,14,24,26H,8-9,12-13H2,1H3
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n/an/a 130n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089132
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C18H16FN3O/c19-14-4-2-12(3-5-14)15-16(13-6-10-20-11-7-13)22-17(21-15)18(23)8-1-9-18/h2-7,10-11,23H,1,8-9H2,(H,21,22)
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n/an/a 150n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089122
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H22FN3O/c22-17-7-5-15(6-8-17)18-19(16-9-13-23-14-10-16)25-20(24-18)21(26)11-3-1-2-4-12-21/h5-10,13-14,26H,1-4,11-12H2,(H,24,25)
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n/an/a 200n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 350n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089128
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-thiazol-2-yl...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(s1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3OS/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 450n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089131
PNG
(4-(2-tert-Butyl-5-phenyl-1H-imidazol-4-yl)-pyridin...)
Show SMILES CC(C)(C)c1nc(c([nH]1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C18H19N3/c1-18(2,3)17-20-15(13-7-5-4-6-8-13)16(21-17)14-9-11-19-12-10-14/h4-12H,1-3H3,(H,20,21)
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n/an/a 450n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089133
PNG
(2-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES CC(C)(O)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C17H16FN3O/c1-17(2,22)16-20-14(11-3-5-13(18)6-4-11)15(21-16)12-7-9-19-10-8-12/h3-10,22H,1-2H3,(H,20,21)
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n/an/a 470n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 797n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of EGFR kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Mus musculus (mouse))
BDBM50089129
PNG
(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-6-10-22-11-7-14)18(26-19)15-2-4-16(21)5-3-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 2.00E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of murine p38 alpha MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 2.41E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of human p38 beta MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089123
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C19H18FN3O/c20-15-5-3-13(4-6-15)16-17(14-7-11-21-12-8-14)23-18(22-16)19(24)9-1-2-10-19/h3-8,11-12,24H,1-2,9-10H2,(H,22,23)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089131
PNG
(4-(2-tert-Butyl-5-phenyl-1H-imidazol-4-yl)-pyridin...)
Show SMILES CC(C)(C)c1nc(c([nH]1)-c1ccccc1)-c1ccncc1
Show InChI InChI=1S/C18H19N3/c1-18(2,3)17-20-15(13-7-5-4-6-8-13)16(21-17)14-9-11-19-12-10-14/h4-12H,1-3H3,(H,20,21)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089130
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCCCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H20FN3O/c21-16-6-4-14(5-7-16)17-18(15-8-12-22-13-9-15)24-19(23-17)20(25)10-2-1-3-11-20/h4-9,12-13,25H,1-3,10-11H2,(H,23,24)
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n/an/a 6.30E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 9


(Homo sapiens (Human))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 8.09E+3n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of JNK2 kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
c-Jun N-terminal kinase, JNK


(Homo sapiens (Human))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of JNK1 kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 1


(Mus musculus (Mouse))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of ERK2 kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 13 (MAPK13)


(Homo sapiens (Human))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of human p38 delta MAP kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089132
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CCC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C18H16FN3O/c19-14-4-2-12(3-5-14)15-16(13-6-10-20-11-7-13)22-17(21-15)18(23)8-1-9-18/h2-7,10-11,23H,1,8-9H2,(H,21,22)
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n/an/a 2.00E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Gallus gallus (Chicken))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 2.27E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of c-src kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089127
PNG
(1-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES OC1(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C17H14FN3O/c18-13-3-1-11(2-4-13)14-15(12-5-9-19-10-6-12)21-16(20-14)17(22)7-8-17/h1-6,9-10,22H,7-8H2,(H,20,21)
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n/an/a 4.00E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Protein Kinase C, alpha


(Bos taurus (bovine))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 5.11E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of PKCalpha kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089128
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-thiazol-2-yl...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(s1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3OS/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 7.30E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1


(Mus musculus)
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a 8.68E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of c-abl kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089133
PNG
(2-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-imidazol-...)
Show SMILES CC(C)(O)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C17H16FN3O/c1-17(2,22)16-20-14(11-3-5-13(18)6-4-11)15(21-16)12-7-9-19-10-8-12/h3-10,22H,1-2H3,(H,20,21)
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n/an/a 8.70E+4n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089125
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-imidazol-...)
Show SMILES CN1CCC(O)(CC1)c1nc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C20H21FN4O/c1-25-12-8-20(26,9-13-25)19-23-17(14-2-4-16(21)5-3-14)18(24-19)15-6-10-22-11-7-15/h2-7,10-11,26H,8-9,12-13H2,1H3,(H,23,24)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089124
PNG
(4-[5-(4-Fluoro-phenyl)-4-pyridin-4-yl-1H-pyrrol-2-...)
Show SMILES CN1CCC(O)(CC1)c1cc(c([nH]1)-c1ccc(F)cc1)-c1ccncc1
Show InChI InChI=1S/C21H22FN3O/c1-25-12-8-21(26,9-13-25)19-14-18(15-6-10-23-11-7-15)20(24-19)16-2-4-17(22)5-3-16/h2-7,10-11,14,24,26H,8-9,12-13H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 6


(Homo sapiens (Human))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of MKK6b kinase


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
Prostaglandin G/H synthase (cyclooxygenase)


(Ovis aries (Sheep))
BDBM50089126
PNG
(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-oxazol-2-yl]...)
Show SMILES CN1CCC(O)(CC1)c1nc(c(o1)-c1ccncc1)-c1ccc(F)cc1
Show InChI InChI=1S/C20H20FN3O2/c1-24-12-8-20(25,9-13-24)19-23-17(14-2-4-16(21)5-3-14)18(26-19)15-6-10-22-11-7-15/h2-7,10-11,25H,8-9,12-13H2,1H3
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n/an/a>1.00E+5n/an/an/an/an/an/a



Novartis Pharma AG

Curated by ChEMBL


Assay Description
Inhibition of Prostaglandin G/H synthase 1, COX-1


Bioorg Med Chem Lett 10: 1261-4 (2000)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%