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PubMed code 10888329

Compile data set for download or QSAR
Found 22 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089514
PNG
(1-Amino-3-phosphono-cyclopent-2-enecarboxylic acid...)
Show SMILES NC1(CCC(=C1)P(O)(O)=O)C(O)=O |c:4|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h3H,1-2,7H2,(H,8,9)(H2,10,11,12)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was tested on Human mGlu4 receptor expressed in recombinant mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089514
PNG
(1-Amino-3-phosphono-cyclopent-2-enecarboxylic acid...)
Show SMILES NC1(CCC(=C1)P(O)(O)=O)C(O)=O |c:4|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h3H,1-2,7H2,(H,8,9)(H2,10,11,12)
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Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity of the compound was tested on Human mGlu4a receptor expressed in recombinant mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089515
PNG
(1-Amino-3-phosphono-cyclopent-3-enecarboxylic acid...)
Show SMILES NC1(CC=C(C1)P(O)(O)=O)C(O)=O |c:3|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h1H,2-3,7H2,(H,8,9)(H2,10,11,12)
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Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity of the compound was tested on Human mGlu4a receptor expressed in recombinant mammalian cells by GTPgammaS binding assay; Partial a...

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089515
PNG
(1-Amino-3-phosphono-cyclopent-3-enecarboxylic acid...)
Show SMILES NC1(CC=C(C1)P(O)(O)=O)C(O)=O |c:3|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h1H,2-3,7H2,(H,8,9)(H2,10,11,12)
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Università di Perugia

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was tested on Human mGlu4 receptor expressed in recombinant mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50089514
PNG
(1-Amino-3-phosphono-cyclopent-2-enecarboxylic acid...)
Show SMILES NC1(CCC(=C1)P(O)(O)=O)C(O)=O |c:4|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h3H,1-2,7H2,(H,8,9)(H2,10,11,12)
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n/an/a>2.00E+5n/an/an/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was tested on Human mGlu2 receptor expressed in recombinant mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50089515
PNG
(1-Amino-3-phosphono-cyclopent-3-enecarboxylic acid...)
Show SMILES NC1(CC=C(C1)P(O)(O)=O)C(O)=O |c:3|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h1H,2-3,7H2,(H,8,9)(H2,10,11,12)
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Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing hmGlu4a

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM17664
PNG
((2S)-2-amino-3-(phosphonooxy)propanoic acid | CHEM...)
Show SMILES N[C@@H](COP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C3H8NO6P/c4-2(3(5)6)1-10-11(7,8)9/h2H,1,4H2,(H,5,6)(H2,7,8,9)/t2-/m0/s1
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n/an/an/an/a 1.00E+3n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50060137
PNG
((1R,2S)-4-aminocyclopentane-1,2,4-tricarboxylic ac...)
Show SMILES N[C@]1(C[C@@H]([C@@H](C1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4+,8-
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n/an/an/an/a 7.00E+3n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50004881
PNG
((RS) PPG | Amino-(4-phosphono-phenyl)-acetic acid ...)
Show SMILES NC(C(O)=O)c1ccc(cc1)P(O)(O)=O
Show InChI InChI=1S/C8H10NO5P/c9-7(8(10)11)5-1-3-6(4-2-5)15(12,13)14/h1-4,7H,9H2,(H,10,11)(H2,12,13,14)
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n/an/an/an/a 4.70E+3n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50021548
PNG
((1S,3S)-1-amino-3-phosphonocyclopentanecarboxylic ...)
Show SMILES N[C@]1(CC[C@@H](C1)P(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H12NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h4H,1-3,7H2,(H,8,9)(H2,10,11,12)/t4-,6-/m0/s1
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n/an/an/an/a 8.60E+4n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089517
PNG
((1R,2R)-4-Amino-cyclopentane-1,2,4-tricarboxylic a...)
Show SMILES NC1(C[C@H]([C@@H](C1)C(O)=O)C(O)=O)C(O)=O
Show InChI InChI=1S/C8H11NO6/c9-8(7(14)15)1-3(5(10)11)4(2-8)6(12)13/h3-4H,1-2,9H2,(H,10,11)(H,12,13)(H,14,15)/t3-,4-/m1/s1
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n/an/an/an/a 9.00E+3n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089105
PNG
(1-Amino-3-phosphonomethylene-cyclobutanecarboxylic...)
Show SMILES NC1(CC(C1)=CP(O)(O)=O)C(O)=O |(12.3,1,;12.3,-.54,;10.76,-.54,;10.76,-2.1,;12.3,-2.08,;9.68,-3.2,;8.14,-3.2,;7.05,-4.29,;8.54,-4.67,;7.73,-1.7,;13.84,-.54,;14.61,-1.85,;14.61,.79,)|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)1-4(2-6)3-13(10,11)12/h3H,1-2,7H2,(H,8,9)(H2,10,11,12)/b4-3-
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n/an/an/an/a 4.40E+3n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089515
PNG
(1-Amino-3-phosphono-cyclopent-3-enecarboxylic acid...)
Show SMILES NC1(CC=C(C1)P(O)(O)=O)C(O)=O |c:3|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h1H,2-3,7H2,(H,8,9)(H2,10,11,12)
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n/an/an/an/a 1.70E+4n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing hmGlu4a

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089516
PNG
((1R,2S)-1-amino-2-(phosphonomethyl)cyclopropanecar...)
Show SMILES N[C@@]1(C[C@@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5-/m1/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089518
PNG
((1R,2R)-1-amino-2-(phosphonomethyl)cyclopropanecar...)
Show SMILES N[C@@]1(C[C@H]1CP(O)(O)=O)C(O)=O
Show InChI InChI=1S/C5H10NO5P/c6-5(4(7)8)1-3(5)2-12(9,10)11/h3H,1-2,6H2,(H,7,8)(H2,9,10,11)/t3-,5+/m0/s1
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n/an/an/an/a 7.90E+3n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50007548
PNG
((S)-2-Amino-4-phosphono-butyric acid | (S)-2-amino...)
Show SMILES N[C@@H](CCP(O)(O)=O)C(O)=O |r|
Show InChI InChI=1S/C4H10NO5P/c5-3(4(6)7)1-2-11(8,9)10/h3H,1-2,5H2,(H,6,7)(H2,8,9,10)/t3-/m0/s1
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Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50089515
PNG
(1-Amino-3-phosphono-cyclopent-3-enecarboxylic acid...)
Show SMILES NC1(CC=C(C1)P(O)(O)=O)C(O)=O |c:3|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h1H,2-3,7H2,(H,8,9)(H2,10,11,12)
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Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity of the compound was tested on Human Metabotropic glutamate receptor 2 expressed in recombinant mammalian cells by GTPgammaS bindin...

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089514
PNG
(1-Amino-3-phosphono-cyclopent-2-enecarboxylic acid...)
Show SMILES NC1(CCC(=C1)P(O)(O)=O)C(O)=O |c:4|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h3H,1-2,7H2,(H,8,9)(H2,10,11,12)
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Università di Perugia

Curated by ChEMBL


Assay Description
Inhibitory concentration of the compound was tested on Human Metabotropic glutamate receptor 2 expressed in recombinant mammalian cells by GTPgammaS ...

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50089514
PNG
(1-Amino-3-phosphono-cyclopent-2-enecarboxylic acid...)
Show SMILES NC1(CCC(=C1)P(O)(O)=O)C(O)=O |c:4|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h3H,1-2,7H2,(H,8,9)(H2,10,11,12)
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Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity of the compound was tested on Human mGlu2 receptor expressed in recombinant mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 2


(Homo sapiens (Human))		BDBM50089514
PNG
(1-Amino-3-phosphono-cyclopent-2-enecarboxylic acid...)
Show SMILES NC1(CCC(=C1)P(O)(O)=O)C(O)=O |c:4|
Show InChI InChI=1S/C6H10NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h3H,1-2,7H2,(H,8,9)(H2,10,11,12)
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n/an/an/an/a>3.00E+5n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Inhibition of forskolin-stimulated cAMP accumulation in CHO cells expressing hmGlu4a

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM66976
PNG
((1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid;...)
Show SMILES N[C@]1(CC[C@H](C1)C(O)=O)C(O)=O
Show InChI InChI=1S/C7H11NO4/c8-7(6(11)12)2-1-4(3-7)5(9)10/h4H,1-3,8H2,(H,9,10)(H,11,12)/t4-,7+/m1/s1
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n/an/an/an/a 3.90E+4n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
Metabotropic glutamate receptor 4


(Homo sapiens (Human))		BDBM50021550
PNG
((1S,3S)-1-amino-3-phosphonocyclopentanecarboxylic ...)
Show SMILES N[C@]1(CC[C@H](C1)P(O)(O)=O)C(O)=O
Show InChI InChI=1S/C6H12NO5P/c7-6(5(8)9)2-1-4(3-6)13(10,11)12/h4H,1-3,7H2,(H,8,9)(H2,10,11,12)/t4-,6+/m1/s1
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n/an/an/an/a 2.70E+4n/an/an/an/a



Università di Perugia

Curated by ChEMBL


Assay Description
Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay

Bioorg Med Chem Lett 10: 1447-50 (2000)


BindingDB Entry DOI: 10.7270/Q2VT1R95
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%