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PubMed code 10891107

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50089779
PNG
(4-cyclopropylmethyl-14-(3,4-diformylphenylcarboxam...)
Show SMILES Oc1ccc2CC3N(CC4CC4)CCC45C(Oc1c24)[C@@H](CC[C@@]35O)NC(=O)CNC(=O)c1ccc(C=O)c(C=O)c1 |TLB:23:22:18.4.5:7.13.12,THB:8:7:22:18.4.5,17:18:22:7.13.12|
Show InChI InChI=1S/C31H33N3O7/c35-15-20-4-3-19(11-21(20)16-36)29(39)32-13-25(38)33-22-7-8-31(40)24-12-18-5-6-23(37)27-26(18)30(31,28(22)41-27)9-10-34(24)14-17-1-2-17/h3-6,11,15-17,22,24,28,37,40H,1-2,7-10,12-14H2,(H,32,39)(H,33,38)/t22-,24?,28?,30?,31-/m1/s1
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PC cid
PC sid
UniChem
PubMed
0.450n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of [3H]- diprenorphine binding to Opioid receptor mu 1 (83 fmol/mg protein) stably expressed in membranes from CHO cells


J Med Chem 43: 2489-92 (2000)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50089779
PNG
(4-cyclopropylmethyl-14-(3,4-diformylphenylcarboxam...)
Show SMILES Oc1ccc2CC3N(CC4CC4)CCC45C(Oc1c24)[C@@H](CC[C@@]35O)NC(=O)CNC(=O)c1ccc(C=O)c(C=O)c1 |TLB:23:22:18.4.5:7.13.12,THB:8:7:22:18.4.5,17:18:22:7.13.12|
Show InChI InChI=1S/C31H33N3O7/c35-15-20-4-3-19(11-21(20)16-36)29(39)32-13-25(38)33-22-7-8-31(40)24-12-18-5-6-23(37)27-26(18)30(31,28(22)41-27)9-10-34(24)14-17-1-2-17/h3-6,11,15-17,22,24,28,37,40H,1-2,7-10,12-14H2,(H,32,39)(H,33,38)/t22-,24?,28?,30?,31-/m1/s1
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PC cid
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UniChem
PubMed
0.700n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of [3H]diprenorphine binding to Opioid receptor kappa 1


J Med Chem 43: 2489-92 (2000)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50089779
PNG
(4-cyclopropylmethyl-14-(3,4-diformylphenylcarboxam...)
Show SMILES Oc1ccc2CC3N(CC4CC4)CCC45C(Oc1c24)[C@@H](CC[C@@]35O)NC(=O)CNC(=O)c1ccc(C=O)c(C=O)c1 |TLB:23:22:18.4.5:7.13.12,THB:8:7:22:18.4.5,17:18:22:7.13.12|
Show InChI InChI=1S/C31H33N3O7/c35-15-20-4-3-19(11-21(20)16-36)29(39)32-13-25(38)33-22-7-8-31(40)24-12-18-5-6-23(37)27-26(18)30(31,28(22)41-27)9-10-34(24)14-17-1-2-17/h3-6,11,15-17,22,24,28,37,40H,1-2,7-10,12-14H2,(H,32,39)(H,33,38)/t22-,24?,28?,30?,31-/m1/s1
PDB

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UniProtKB/SwissProt

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PC cid
PC sid
UniChem
PubMed
2.60n/an/an/an/an/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Inhibition of [3H]- diprenorphine binding to Opioid receptor delta 1


J Med Chem 43: 2489-92 (2000)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%