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PubMed code 10937720

Compile data set for download or QSAR
Found 24 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Neuromedin-K receptor


(GUINEA PIG)		BDBM50403793
PNG
(CHEMBL2115415)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)c2ccccc2C[S@@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45-/m0/s1
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n/an/a 0.720n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(GUINEA PIG)		BDBM50090485
PNG
(CHEMBL295615 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)[C@@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35-/m0/s1
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n/an/a 2.70n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-K receptor


(GUINEA PIG)		BDBM50403793
PNG
(CHEMBL2115415)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)c2ccccc2C[S@@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45-/m0/s1
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n/an/a 3.10n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-K receptor


(GUINEA PIG)		BDBM50090485
PNG
(CHEMBL295615 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)[C@@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35-/m0/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(GUINEA PIG)		BDBM50403790
PNG
(CHEMBL2114963)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)c2ccccc2C[S@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45+/m0/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(GUINEA PIG)		BDBM50090487
PNG
(CHEMBL298247 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)[C@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35+/m1/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-P receptor


(GUINEA PIG)		BDBM50403793
PNG
(CHEMBL2115415)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)c2ccccc2C[S@@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45-/m0/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-P receptor


(GUINEA PIG)		BDBM50090485
PNG
(CHEMBL295615 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)[C@@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35-/m0/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-K receptor


(GUINEA PIG)		BDBM50090487
PNG
(CHEMBL298247 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)[C@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35+/m1/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-K receptor


(GUINEA PIG)		BDBM50403790
PNG
(CHEMBL2114963)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)c2ccccc2C[S@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45+/m0/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-P receptor


(GUINEA PIG)		BDBM50403790
PNG
(CHEMBL2114963)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)c2ccccc2C[S@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45+/m0/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-P receptor


(GUINEA PIG)		BDBM50090487
PNG
(CHEMBL298247 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@@](CCN2CCC3(CC2)[C@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35+/m1/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(GUINEA PIG)		BDBM50403791
PNG
(CHEMBL2114965)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)c2ccccc2C[S@@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45+/m1/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(GUINEA PIG)		BDBM50403792
PNG
(CHEMBL2115416)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)c2ccccc2C[S@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45-/m1/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(GUINEA PIG)		BDBM50090482
PNG
(CHEMBL295785 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)[C@@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-K receptor


(GUINEA PIG)		BDBM50090484
PNG
(CHEMBL46795 | spiro[(2-hydroxy)indane-1,40-piperid...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)[C@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35-/m1/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Neuromedin-K receptor


(GUINEA PIG)		BDBM50090484
PNG
(CHEMBL46795 | spiro[(2-hydroxy)indane-1,40-piperid...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)[C@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35-/m1/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 3 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-K receptor


(GUINEA PIG)		BDBM50090482
PNG
(CHEMBL295785 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)[C@@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-P receptor


(GUINEA PIG)		BDBM50090484
PNG
(CHEMBL46795 | spiro[(2-hydroxy)indane-1,40-piperid...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)[C@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-P receptor


(GUINEA PIG)		BDBM50403791
PNG
(CHEMBL2114965)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)c2ccccc2C[S@@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45+/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-K receptor


(GUINEA PIG)		BDBM50403792
PNG
(CHEMBL2115416)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)c2ccccc2C[S@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-K receptor


(GUINEA PIG)		BDBM50403791
PNG
(CHEMBL2114965)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)c2ccccc2C[S@@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45+/m1/s1
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Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 2 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-P receptor


(GUINEA PIG)		BDBM50403792
PNG
(CHEMBL2115416)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)c2ccccc2C[S@]3=O)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C34H38Cl2N2O6S/c1-41-29-18-24(19-30(42-2)31(29)43-3)32(39)38-16-17-44-33(22-38,25-8-9-27(35)28(36)20-25)10-13-37-14-11-34(12-15-37)26-7-5-4-6-23(26)21-45(34)40/h4-9,18-20H,10-17,21-22H2,1-3H3/t33-,45-/m1/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
Substance-P receptor


(GUINEA PIG)		BDBM50090482
PNG
(CHEMBL295785 | spiro[(2-hydroxy)indane-1,40-piperi...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)N1CCO[C@](CCN2CCC3(CC2)[C@@H](O)Cc2ccccc32)(C1)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C35H40Cl2N2O6/c1-42-29-18-24(19-30(43-2)32(29)44-3)33(41)39-16-17-45-35(22-39,25-8-9-27(36)28(37)21-25)12-15-38-13-10-34(11-14-38)26-7-5-4-6-23(26)20-31(34)40/h4-9,18-19,21,31,40H,10-17,20,22H2,1-3H3/t31-,35+/m0/s1
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n/an/a>1.00E+3n/an/an/an/an/an/a



Sankyo Co., Ltd.

Curated by ChEMBL


Assay Description
The compound was evaluated in vitro for its ability to displace [3H]-SP from Tachykinin receptor 1 of male guinea pig lung membrane

Bioorg Med Chem Lett 10: 1665-8 (2000)


BindingDB Entry DOI: 10.7270/Q2QZ297D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%