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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet  | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity of the compound towards Alpha1A human adrenergic receptors, using [125I]-HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.230 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards Alpha1A dog adrenergic receptors, using [125I]HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1A adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 0.360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards Alpha1A rat adrenergic receptors, using [125I]HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-2A adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards human alpha-2A-adrenergic receptor, using [3H]rauwolscine as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-2B adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards human alpha-2B-adrenergic receptor, using [3H]rauwolscine as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-2C adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards human alpha-2C-adrenergic receptor, using [3H]rauwolscine as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H1 receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 54 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards Histamine H1 receptor in human brain tissue preparation, using [3H]rauwolscine as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1D adrenergic receptor (Rattus norvegicus (Rat)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 62 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards Alpha1D rat adrenergic receptors, using [125I]HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1B adrenergic receptor (Rattus norvegicus (rat)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | Reactome pathway UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards Alpha1B rat adrenergic receptors, using [125I]HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1B adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 119 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity of the compound towards Alpha1B human adrenergic receptors, using [125I]-HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1B adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 121 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards Alpha1B dog adrenergic receptors, using [125I]HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 122 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards Alpha1D human adrenergic receptors, using [125I]HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Alpha-1D adrenergic receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | 133 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity of the compound towards Alpha1D dog adrenergic receptors, using [125I]-HEAT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1B (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1B receptor using [3H]5-HT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1D (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards 5-HT1D receptor, using [3H]5-HT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 1A (Mus musculus (Mouse)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 1A receptor receptor, using [3H]5-HT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| 5-hydroxytryptamine receptor 2A (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards 5-hydroxytryptamine 2A receptor using [3H]5-HT as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Histamine H2 receptor (Homo sapiens (Human)) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Binding affinity towards human Histamine H2 receptor, using [3H]tiotidine as radioligand. | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Voltage-dependent L-type calcium channel subunit alpha-1C/alpha-1D/alpha-1S (Rattus norvegicus-RAT) | BDBM50090647 ((4S,5S)-4-(3,4-Difluoro-phenyl)-5-methyl-2-oxo-oxa...) | PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | PubMed | >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Synaptic Pharmaceutical Corporation Curated by ChEMBL | Assay Description Inhibition of [3H]nitrendipine binding to rat L-type Ca-channel receptor | J Med Chem 43: 2775-8 (2000) BindingDB Entry DOI: 10.7270/Q2PZ582K | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
