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PubMed code 10978184

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50017702
PNG
(1-(bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine...)
Show SMILES Fc1ccc(cc1)C(N1CCN(C\C=C\c2ccccc2)CC1)c1ccc(F)cc1
Show InChI InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+
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PubMed
n/an/a 228n/an/an/an/an/an/a



Suntory Biomedical Research Limited

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibitory effect on Dopamine receptor D2 determined in competition experiments with [3H]raclopride

J Med Chem 43: 3372-6 (2000)


BindingDB Entry DOI: 10.7270/Q27945CD
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50091592
PNG
(7-{4-[Bis-(4-fluoro-phenyl)-methyl]-piperazin-1-yl...)
Show SMILES CC(C)c1ccc(CN2CCN(CC2)C(c2ccc(F)cc2)c2ccc(F)cc2)c(O)\c(c1)=N\CCO
Show InChI InChI=1S/C30H35F2N3O2/c1-21(2)24-3-4-25(30(37)28(19-24)33-13-18-36)20-34-14-16-35(17-15-34)29(22-5-9-26(31)10-6-22)23-7-11-27(32)12-8-23/h3-12,19,21,29,36H,13-18,20H2,1-2H3,(H,33,37)
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n/an/a 1.69E+3n/an/an/an/an/an/a



Suntory Biomedical Research Limited

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibitory effect on Dopamine receptor D2 determined in competition experiments with [3H]raclopride

J Med Chem 43: 3372-6 (2000)


BindingDB Entry DOI: 10.7270/Q27945CD
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))		BDBM50091591
PNG
((2S)-1-(4-amino-2,3,5-trimethylphenoxy)-3-{4-[4-(4...)
Show SMILES Cc1cc(OC[C@@H](O)CN2CCN(CC2)c2ccc(Cc3ccc(F)cc3)cc2)c(C)c(C)c1N
Show InChI InChI=1S/C29H36FN3O2/c1-20-16-28(21(2)22(3)29(20)31)35-19-27(34)18-32-12-14-33(15-13-32)26-10-6-24(7-11-26)17-23-4-8-25(30)9-5-23/h4-11,16,27,34H,12-15,17-19,31H2,1-3H3/t27-/m0/s1
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n/an/a>1.00E+4n/an/an/an/an/an/a



Suntory Biomedical Research Limited

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibitory effect on Dopamine receptor D2 determined in competition experiments with [3H]raclopride

J Med Chem 43: 3372-6 (2000)


BindingDB Entry DOI: 10.7270/Q27945CD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%