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PubMed code 10980448

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM39807
PNG
(CP-526,423)
Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)NCCOCCOCCNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C25H27ClN4O4/c1-16-2-4-20-17(12-16)14-22(29-20)24(31)27-6-8-33-10-11-34-9-7-28-25(32)23-15-18-13-19(26)3-5-21(18)30-23/h2-5,12-15,29-30H,6-11H2,1H3,(H,27,31)(H,28,32)
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Article
PubMed
n/an/a 6n/an/an/an/a7.222



Pfizer Inc



Assay Description
Human liver glycogen phsphorylase (HLGP) activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phos...

Chem Biol 7: 677-82 (2000)


Article DOI: 10.1016/S1074-5521(00)00004-1
BindingDB Entry DOI: 10.7270/Q2H41PT2
More data for this
Ligand-Target Pair
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50136446
PNG
(1-{(S)-2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3...)
Show SMILES OC(=O)C1CN(C1)C(=O)[C@H](Cc1ccccc1)NC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C22H20ClN3O4/c23-16-6-7-17-14(9-16)10-18(24-17)20(27)25-19(8-13-4-2-1-3-5-13)21(28)26-11-15(12-26)22(29)30/h1-7,9-10,15,19,24H,8,11-12H2,(H,25,27)(H,29,30)/t19-/m0/s1
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Article
PubMed
n/an/a 45n/an/an/an/a7.222



Pfizer Inc



Assay Description
Human liver glycogen phsphorylase (HLGP) activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phos...

Chem Biol 7: 677-82 (2000)


Article DOI: 10.1016/S1074-5521(00)00004-1
BindingDB Entry DOI: 10.7270/Q2H41PT2
More data for this
Ligand-Target Pair		3D
3D Structure (crystal)
Glycogen phosphorylase, liver form


(Homo sapiens (Human))		BDBM50149237
PNG
(5-Chloro-1H-indole-2-carboxylic acid (2-methoxy-et...)
Show SMILES COCCNC(=O)c1cc2cc(Cl)ccc2[nH]1
Show InChI InChI=1S/C12H13ClN2O2/c1-17-5-4-14-12(16)11-7-8-6-9(13)2-3-10(8)15-11/h2-3,6-7,15H,4-5H2,1H3,(H,14,16)
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PC cid
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Article
PubMed
n/an/a 1.25E+4n/an/an/an/a7.222



Pfizer Inc



Assay Description
Human liver glycogen phsphorylase (HLGP) activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phos...

Chem Biol 7: 677-82 (2000)


Article DOI: 10.1016/S1074-5521(00)00004-1
BindingDB Entry DOI: 10.7270/Q2H41PT2
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%