Affinity Data by PubMed id=10999467

PubMed code 10999467

Found 19 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091927 (1-(2,6-Dichloro-phenyl)-1-(4'-fluoro-6-hydroxymeth...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM13336 (4-[4-(4-fluorophenyl)-2-(4-methanesulfinylphenyl)-...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091919 (1-(3-tert-Butyl-isoxazol-5-yl)-3-(2,3-dichloro-phe...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)on1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	36	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091923 (1-(5-tert-Butyl-2-methyl-2H-pyrazol-3-yl)-3-(2,3-d...) Show SMILES Cn1nc(cc1NC(=O)Nc1cccc(Cl)c1Cl)C(C)(C)C Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	53	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091917 (1-(5-tert-Butyl-isoxazol-3-yl)-3-(2,3-dichloro-phe...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)no1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	58	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091929 (2-[3-(3,4-Dichloro-phenyl)-ureido]-benzamide \| CHE...) Show SMILES NC(=O)c1ccccc1NC(=O)Nc1ccc(Cl)c(Cl)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091920 (1-(5-tert-Butyl-thiophen-2-yl)-3-(2,3-dichloro-phe...) Show SMILES CC(C)(C)c1ccc(NC(=O)Nc2cccc(Cl)c2Cl)s1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091913 (1-(2,3-Dichloro-phenyl)-3-[3-(2,2-dimethyl-propyl)...) Show SMILES CC(C)(C)Cc1cc(NC(=O)Nc2cccc(Cl)c2Cl)on1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091916 (1-(2,3-Dichloro-phenyl)-3-[3-(1,1-dimethyl-propyl)...) Show SMILES CCC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)on1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091912 (1-(5-tert-Butyl-thiophen-3-yl)-3-(2,3-dichloro-phe...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)cs1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	160	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091914 (1-(5-tert-Butyl-isoxazol-3-yl)-3-(4-fluoro-phenyl)...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(F)cc2)no1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	190	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091926 (1-(3-tert-Butyl-isoxazol-5-yl)-3-(4-trifluoromethy...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091918 (1-(3-tert-Butyl-isoxazol-5-yl)-3-(3,4-dichloro-phe...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	220	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091921 (1-(3-tert-Butyl-isoxazol-5-yl)-3-(4-chloro-phenyl)...) Show SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(Cl)cc2)on1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091925 (1-(2,3-Dichloro-phenyl)-3-(3-isopropyl-isoxazol-5-...) Show SMILES CC(C)c1cc(NC(=O)Nc2cccc(Cl)c2Cl)on1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091915 (1-(3-Cyclobutyl-isoxazol-5-yl)-3-(2,3-dichloro-phe...) Show SMILES Clc1cccc(NC(=O)Nc2cc(no2)C2CCC2)c1Cl Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091924 (1-(5-tert-Butyl-isoxazol-3-yl)-3-(3,5-dibromo-phen...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091922 (1-(2,3-Dichloro-phenyl)-3-(3-isopropyl-4-methyl-is...) Show SMILES CC(C)c1noc(NC(=O)Nc2cccc(Cl)c2Cl)c1C Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	920	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50091928 (1-(3-Butyl-isoxazol-5-yl)-3-(2,3-dichloro-phenyl)-...) Show SMILES CCCCc1cc(NC(=O)Nc2cccc(Cl)c2Cl)on1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
Bayer Research Center Curated by ChEMBL					Assay Description Inhibitory activity against Mitogen-activated protein kinase p38 alpha 2 expressed in E. coli.				Bioorg Med Chem Lett 10: 2047-50 (2000) BindingDB Entry DOI: 10.7270/Q2FB526H
Bayer Research Center Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%