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PubMed code 11000010

Compile data set for download or QSAR
Found 27 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50001023
PNG
((2R,6R,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CC1CC1 |TLB:16:15:1:10.4.3|
Show InChI InChI=1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3/t12-,17+,18+/m0/s1
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 0.0520n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50001023
PNG
((2R,6R,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CC1CC1 |TLB:16:15:1:10.4.3|
Show InChI InChI=1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3/t12-,17+,18+/m0/s1
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 0.100n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES [H][C@]12Cc3ccc(Nc4ccccc4)cc3[C@@](C)(CCN1CC1CC1)[C@H]2C |THB:21:20:25:15.3.2,14:15:25:20.18.19|
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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 0.540n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50001023
PNG
((2R,6R,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(O)cc3[C@]1(C)CCN2CC1CC1 |TLB:16:15:1:10.4.3|
Show InChI InChI=1S/C18H25NO/c1-12-17-9-14-5-6-15(20)10-16(14)18(12,2)7-8-19(17)11-13-3-4-13/h5-6,10,12-13,17,20H,3-4,7-9,11H2,1-2H3/t12-,17+,18+/m0/s1
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 0.580n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50000092
PNG
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1|
Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
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 0.880n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES [H][C@]12Cc3ccc(Nc4ccccc4)cc3[C@@](C)(CCN1CC1CC1)[C@H]2C |THB:21:20:25:15.3.2,14:15:25:20.18.19|
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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 1.10n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50092176
PNG
(3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexa...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(N)cc3[C@@]1(C)CCN2CC1CC1 |TLB:16:15:1:10.4.3|
Show InChI InChI=1S/C18H26N2/c1-12-17-9-14-5-6-15(19)10-16(14)18(12,2)7-8-20(17)11-13-3-4-13/h5-6,10,12-13,17H,3-4,7-9,11,19H2,1-2H3/t12-,17+,18-/m0/s1
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 1.20n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50092176
PNG
(3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexa...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(N)cc3[C@@]1(C)CCN2CC1CC1 |TLB:16:15:1:10.4.3|
Show InChI InChI=1S/C18H26N2/c1-12-17-9-14-5-6-15(19)10-16(14)18(12,2)7-8-20(17)11-13-3-4-13/h5-6,10,12-13,17H,3-4,7-9,11,19H2,1-2H3/t12-,17+,18-/m0/s1
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 1.80n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50085020
PNG
(((6S,11R)-3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,...)
Show SMILES [H][C@]12Cc3ccc(Nc4ccccc4)cc3[C@@](C)(CCN1CC1CC1)[C@H]2C |THB:21:20:25:15.3.2,14:15:25:20.18.19|
Show InChI InChI=1S/C24H30N2/c1-17-23-14-19-10-11-21(25-20-6-4-3-5-7-20)15-22(19)24(17,2)12-13-26(23)16-18-8-9-18/h3-7,10-11,15,17-18,23,25H,8-9,12-14,16H2,1-2H3/t17-,23?,24-/m0/s1
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 5.20n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50092176
PNG
(3-Cyclopropylmethyl-6,11-dimethyl-1,2,3,4,5,6-hexa...)
Show SMILES C[C@H]1[C@H]2Cc3ccc(N)cc3[C@@]1(C)CCN2CC1CC1 |TLB:16:15:1:10.4.3|
Show InChI InChI=1S/C18H26N2/c1-12-17-9-14-5-6-15(19)10-16(14)18(12,2)7-8-20(17)11-13-3-4-13/h5-6,10,12-13,17H,3-4,7-9,11,19H2,1-2H3/t12-,17+,18-/m0/s1
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 12n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50000092
PNG
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1|
Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
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 24n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50369589
PNG
(CHEMBL332927)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5NCc1ccccc1 |c:16|
Show InChI InChI=1S/C24H26N2O2/c1-26-12-11-24-17-8-10-20(27)23(24)28-22-18(25-14-15-5-3-2-4-6-15)9-7-16(21(22)24)13-19(17)26/h2-10,17,19-20,23,25,27H,11-14H2,1H3/t17-,19+,20-,23-,24-/m0/s1
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 33n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50369585
PNG
(CHEMBL333959)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5N |c:16|
Show InChI InChI=1S/C17H20N2O2/c1-19-7-6-17-10-3-5-13(20)16(17)21-15-11(18)4-2-9(14(15)17)8-12(10)19/h2-5,10,12-13,16,20H,6-8,18H2,1H3/t10-,12+,13-,16-,17-/m0/s1
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 53n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50369590
PNG
(CHEMBL333965)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5Nc1ccccc1 |c:16|
Show InChI InChI=1S/C23H24N2O2/c1-25-12-11-23-16-8-10-19(26)22(23)27-21-17(24-15-5-3-2-4-6-15)9-7-14(20(21)23)13-18(16)25/h2-10,16,18-19,22,24,26H,11-13H2,1H3/t16-,18+,19-,22-,23-/m0/s1
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 59n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50369587
PNG
(CHEMBL119692)
Show SMILES CNc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C |c:9|
Show InChI InChI=1S/C18H22N2O2/c1-19-12-5-3-10-9-13-11-4-6-14(21)17-18(11,7-8-20(13)2)15(10)16(12)22-17/h3-6,11,13-14,17,19,21H,7-9H2,1-2H3/t11-,13+,14-,17-,18-/m0/s1
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 63n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50000092
PNG
((-)-(etorphine) | (-)-morphine | (1S,5R,13R,14S)-1...)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5O |r,c:16,TLB:13:12:8.9.10:3.2.1|
Show InChI InChI=1S/C17H19NO3/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18/h2-5,10-11,13,16,19-20H,6-8H2,1H3/t10-,11+,13-,16-,17-/m0/s1
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 140n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Mu-type opioid receptor


(GUINEA PIG)		BDBM50369588
PNG
(CHEMBL119332)
Show SMILES CN(C)c1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C |c:10|
Show InChI InChI=1S/C19H24N2O2/c1-20(2)13-6-4-11-10-14-12-5-7-15(22)18-19(12,8-9-21(14)3)16(11)17(13)23-18/h4-7,12,14-15,18,22H,8-10H2,1-3H3/t12-,14+,15-,18-,19-/m0/s1
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 240n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]DAMGO on Opioid receptor mu 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50369590
PNG
(CHEMBL333965)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5Nc1ccccc1 |c:16|
Show InChI InChI=1S/C23H24N2O2/c1-25-12-11-23-16-8-10-19(26)22(23)27-21-17(24-15-5-3-2-4-6-15)9-7-14(20(21)23)13-18(16)25/h2-10,16,18-19,22,24,26H,11-13H2,1H3/t16-,18+,19-,22-,23-/m0/s1
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 240n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50369588
PNG
(CHEMBL119332)
Show SMILES CN(C)c1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C |c:10|
Show InChI InChI=1S/C19H24N2O2/c1-20(2)13-6-4-11-10-14-12-5-7-15(22)18-19(12,8-9-21(14)3)16(11)17(13)23-18/h4-7,12,14-15,18,22H,8-10H2,1-3H3/t12-,14+,15-,18-,19-/m0/s1
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 290n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50369585
PNG
(CHEMBL333959)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5N |c:16|
Show InChI InChI=1S/C17H20N2O2/c1-19-7-6-17-10-3-5-13(20)16(17)21-15-11(18)4-2-9(14(15)17)8-12(10)19/h2-5,10,12-13,16,20H,6-8,18H2,1H3/t10-,12+,13-,16-,17-/m0/s1
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 740n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50369590
PNG
(CHEMBL333965)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5Nc1ccccc1 |c:16|
Show InChI InChI=1S/C23H24N2O2/c1-25-12-11-23-16-8-10-19(26)22(23)27-21-17(24-15-5-3-2-4-6-15)9-7-14(20(21)23)13-18(16)25/h2-10,16,18-19,22,24,26H,11-13H2,1H3/t16-,18+,19-,22-,23-/m0/s1
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 1.50E+3n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50369588
PNG
(CHEMBL119332)
Show SMILES CN(C)c1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C |c:10|
Show InChI InChI=1S/C19H24N2O2/c1-20(2)13-6-4-11-10-14-12-5-7-15(22)18-19(12,8-9-21(14)3)16(11)17(13)23-18/h4-7,12,14-15,18,22H,8-10H2,1-3H3/t12-,14+,15-,18-,19-/m0/s1
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 1.60E+3n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50369585
PNG
(CHEMBL333959)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5N |c:16|
Show InChI InChI=1S/C17H20N2O2/c1-19-7-6-17-10-3-5-13(20)16(17)21-15-11(18)4-2-9(14(15)17)8-12(10)19/h2-5,10,12-13,16,20H,6-8,18H2,1H3/t10-,12+,13-,16-,17-/m0/s1
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 2.40E+3n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50369587
PNG
(CHEMBL119692)
Show SMILES CNc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C |c:9|
Show InChI InChI=1S/C18H22N2O2/c1-19-12-5-3-10-9-13-11-4-6-14(21)17-18(11,7-8-20(13)2)15(10)16(12)22-17/h3-6,11,13-14,17,19,21H,7-9H2,1-2H3/t11-,13+,14-,17-,18-/m0/s1
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 2.80E+3n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Cavia porcellus (domestic guinea pig))		BDBM50369589
PNG
(CHEMBL332927)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5NCc1ccccc1 |c:16|
Show InChI InChI=1S/C24H26N2O2/c1-26-12-11-24-17-8-10-20(27)23(24)28-22-18(25-14-15-5-3-2-4-6-15)9-7-16(21(22)24)13-19(17)26/h2-10,17,19-20,23,25,27H,11-14H2,1H3/t17-,19+,20-,23-,24-/m0/s1
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 3.40E+3n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]U-69593 on Opioid receptor kappa 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50369589
PNG
(CHEMBL332927)
Show SMILES CN1CC[C@@]23[C@H]4Oc5c2c(C[C@@H]1[C@@H]3C=C[C@@H]4O)ccc5NCc1ccccc1 |c:16|
Show InChI InChI=1S/C24H26N2O2/c1-26-12-11-24-17-8-10-20(27)23(24)28-22-18(25-14-15-5-3-2-4-6-15)9-7-16(21(22)24)13-19(17)26/h2-10,17,19-20,23,25,27H,11-14H2,1H3/t17-,19+,20-,23-,24-/m0/s1
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 5.50E+3n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))		BDBM50369587
PNG
(CHEMBL119692)
Show SMILES CNc1ccc2C[C@@H]3[C@@H]4C=C[C@H](O)[C@@H]5Oc1c2[C@]45CCN3C |c:9|
Show InChI InChI=1S/C18H22N2O2/c1-19-12-5-3-10-9-13-11-4-6-14(21)17-18(11,7-8-20(13)2)15(10)16(12)22-17/h3-6,11,13-14,17,19,21H,7-9H2,1-2H3/t11-,13+,14-,17-,18-/m0/s1
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 5.70E+3n/an/an/an/an/an/an/an/a



Rensselaer Polytechnic Institute

Curated by ChEMBL


Assay Description
Binding affinity to displace radioligand [3H]naltrindole on Opioid receptor delta 1 in guinea pig membranes.

J Med Chem 43: 3558-65 (2000)


BindingDB Entry DOI: 10.7270/Q269749X
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%