Found 65 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097096
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrClNO2/c1-9-6-12(19)7-13-14(17(21)22)8-15(20-16(9)13)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097096
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrClNO2/c1-9-6-12(19)7-13-14(17(21)22)8-15(20-16(9)13)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Binding affinity towards 5-hydroxytryptamine 3 receptor |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097096
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrClNO2/c1-9-6-12(19)7-13-14(17(21)22)8-15(20-16(9)13)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097082
(2-(4-Bromo-phenyl)-6-iodo-quinoline-4-carboxylic a...)Show InChI InChI=1S/C16H9BrINO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097095
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show SMILES Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H15BrCl3NO2/c1-13-8-17(26)10-18-19(24(30)31-12-14-2-7-20(27)21(28)9-14)11-22(29-23(13)18)15-3-5-16(25)6-4-15/h2-11H,12H2,1H3 | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097106
(2-(4-Bromo-phenyl)-8-chloro-6-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrClNO2/c1-9-6-12-13(17(21)22)8-15(20-16(12)14(19)7-9)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097105
(6-Bromo-2-(4-bromo-phenyl)-quinoline-4-carboxylic ...)Show InChI InChI=1S/C16H9Br2NO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) | UniProtKB/SwissProt
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CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097090
(2-(4-Bromo-phenyl)-6-chloro-quinoline-4-carboxylic...)Show InChI InChI=1S/C16H9BrClNO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) | UniProtKB/SwissProt
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PC sid
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| PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097086
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show SMILES Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)Oc1nnn[nH]1 Show InChI InChI=1S/C18H11BrClN5O2/c1-9-6-12(20)7-13-14(17(26)27-18-22-24-25-23-18)8-15(21-16(9)13)10-2-4-11(19)5-3-10/h2-8H,1H3,(H,22,23,24,25) | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097113
(2-(4-Bromo-phenyl)-6-trifluoromethoxy-quinoline-4-...)Show SMILES OC(=O)c1cc(nc2ccc(OC(F)(F)F)cc12)-c1ccc(Br)cc1 Show InChI InChI=1S/C17H9BrF3NO3/c18-10-3-1-9(2-4-10)15-8-13(16(23)24)12-7-11(25-17(19,20)21)5-6-14(12)22-15/h1-8H,(H,23,24) | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 53 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097102
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show SMILES Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccco1 Show InChI InChI=1S/C22H15BrClNO3/c1-13-9-16(24)10-18-19(22(26)28-12-17-3-2-8-27-17)11-20(25-21(13)18)14-4-6-15(23)7-5-14/h2-11H,12H2,1H3 | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097107
(2-(4-Bromo-phenyl)-7-fluoro-8-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrFNO2/c1-9-14(19)7-6-12-13(17(21)22)8-15(20-16(9)12)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097091
(2-(4-Bromo-phenyl)-5,7-dichloro-quinoline-4-carbox...)Show SMILES OC(=O)c1cc(nc2cc(Cl)cc(Cl)c12)-c1ccc(Br)cc1 Show InChI InChI=1S/C16H8BrCl2NO2/c17-9-3-1-8(2-4-9)13-7-11(16(21)22)15-12(19)5-10(18)6-14(15)20-13/h1-7H,(H,21,22) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097093
(7-Bromo-2-(4-bromo-phenyl)-8-methyl-quinoline-4-ca...)Show InChI InChI=1S/C17H11Br2NO2/c1-9-14(19)7-6-12-13(17(21)22)8-15(20-16(9)12)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097104
(6-Bromo-2-(4-bromo-phenyl)-8-trifluoromethyl-quino...)Show SMILES OC(=O)c1cc(nc2c(cc(Br)cc12)C(F)(F)F)-c1ccc(Br)cc1 Show InChI InChI=1S/C17H8Br2F3NO2/c18-9-3-1-8(2-4-9)14-7-12(16(24)25)11-5-10(19)6-13(15(11)23-14)17(20,21)22/h1-7H,(H,24,25) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 220 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097103
(2-(4-Bromo-phenyl)-6-(4-hydroxy-phenyl)-quinoline-...)Show SMILES OC(=O)c1cc(nc2ccc(cc12)-c1ccc(O)cc1)-c1ccc(Br)cc1 Show InChI InChI=1S/C22H14BrNO3/c23-16-6-1-14(2-7-16)21-12-19(22(26)27)18-11-15(5-10-20(18)24-21)13-3-8-17(25)9-4-13/h1-12,25H,(H,26,27) | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097094
(2-(4-Bromo-phenyl)-quinoline-4-carboxylic acid | C...)Show InChI InChI=1S/C16H10BrNO2/c17-11-7-5-10(6-8-11)15-9-13(16(19)20)12-3-1-2-4-14(12)18-15/h1-9H,(H,19,20) | UniProtKB/SwissProt
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MCE
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097087
(2-(4-Bromo-phenyl)-6-((E)-2-carboxy-vinyl)-quinoli...)Show SMILES OC(=O)\C=C\c1ccc2nc(cc(C(O)=O)c2c1)-c1ccc(Br)cc1 Show InChI InChI=1S/C19H12BrNO4/c20-13-5-3-12(4-6-13)17-10-15(19(24)25)14-9-11(2-8-18(22)23)1-7-16(14)21-17/h1-10H,(H,22,23)(H,24,25)/b8-2+ | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097084
(2-(4-Bromo-phenyl)-7-chloro-5-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrClNO2/c1-9-6-12(19)7-15-16(9)13(17(21)22)8-14(20-15)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | UniProtKB/SwissProt
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| CHEMBL
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PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097109
(2-(4-Bromo-phenyl)-6-chloro-8-hydroxymethyl-quinol...)Show SMILES OCc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(O)=O Show InChI InChI=1S/C17H11BrClNO3/c18-11-3-1-9(2-4-11)15-7-14(17(22)23)13-6-12(19)5-10(8-21)16(13)20-15/h1-7,21H,8H2,(H,22,23) | UniProtKB/SwissProt
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097111
(CHEMBL150305 | Sulfamic acid 2-(4-bromo-phenyl)-6-...)Show SMILES Cc1cc(Cl)cc2c(COS(N)(=O)=O)cc(nc12)-c1ccc(Br)cc1 Show InChI InChI=1S/C17H14BrClN2O3S/c1-10-6-14(19)8-15-12(9-24-25(20,22)23)7-16(21-17(10)15)11-2-4-13(18)5-3-11/h2-8H,9H2,1H3,(H2,20,22,23) | UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 2.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097099
(6-Amino-2-(4-bromo-phenyl)-quinoline-4-carboxylic ...)Show InChI InChI=1S/C16H11BrN2O2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,18H2,(H,20,21) | UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097101
(2-Naphthalen-2-yl-quinoline-4-carboxylic acid | CH...)Show InChI InChI=1S/C20H13NO2/c22-20(23)17-12-19(21-18-8-4-3-7-16(17)18)15-10-9-13-5-1-2-6-14(13)11-15/h1-12H,(H,22,23) | UniProtKB/SwissProt
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CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 3.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097092
(2-{[2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline...)Show SMILES COC(=O)C(Cc1ccccc1)NC(=O)c1cc(nc2c(C)cc(Cl)cc12)-c1ccc(Br)cc1 Show InChI InChI=1S/C27H22BrClN2O3/c1-16-12-20(29)14-21-22(15-23(30-25(16)21)18-8-10-19(28)11-9-18)26(32)31-24(27(33)34-2)13-17-6-4-3-5-7-17/h3-12,14-15,24H,13H2,1-2H3,(H,31,32) | UniProtKB/SwissProt
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UniChem
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| n/a | n/a | 5.70E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097108
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show SMILES Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C30H21BrClNO2/c1-19-15-25(32)16-26-27(17-28(33-29(19)26)23-11-13-24(31)14-12-23)30(34)35-18-20-7-9-22(10-8-20)21-5-3-2-4-6-21/h2-17H,18H2,1H3 | UniProtKB/SwissProt
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UniChem
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| n/a | n/a | 8.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097085
(2-(4-Bromo-phenyl)-6-sulfo-quinoline-4-carboxylic ...)Show SMILES OC(=O)c1cc(nc2ccc(cc12)S(O)(=O)=O)-c1ccc(Br)cc1 Show InChI InChI=1S/C16H10BrNO5S/c17-10-3-1-9(2-4-10)15-8-13(16(19)20)12-7-11(24(21,22)23)5-6-14(12)18-15/h1-8H,(H,19,20)(H,21,22,23) | UniProtKB/SwissProt
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| n/a | n/a | 1.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097083
(2-(3,4-Dichloro-phenyl)-quinoline-4-carboxylic aci...)Show InChI InChI=1S/C16H9Cl2NO2/c17-12-6-5-9(7-13(12)18)15-8-11(16(20)21)10-3-1-2-4-14(10)19-15/h1-8H,(H,20,21) | UniProtKB/SwissProt
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| n/a | n/a | 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097096
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrClNO2/c1-9-6-12(19)7-13-14(17(21)22)8-15(20-16(9)13)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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| CHEMBL
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UniChem
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097090
(2-(4-Bromo-phenyl)-6-chloro-quinoline-4-carboxylic...)Show InChI InChI=1S/C16H9BrClNO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097105
(6-Bromo-2-(4-bromo-phenyl)-quinoline-4-carboxylic ...)Show InChI InChI=1S/C16H9Br2NO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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CHEMBL
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UniChem
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| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097106
(2-(4-Bromo-phenyl)-8-chloro-6-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrClNO2/c1-9-6-12-13(17(21)22)8-15(20-16(12)14(19)7-9)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097088
(2-(4-Bromo-phenyl)-6,8-dimethyl-quinoline-4-carbox...)Show InChI InChI=1S/C18H14BrNO2/c1-10-7-11(2)17-14(8-10)15(18(21)22)9-16(20-17)12-3-5-13(19)6-4-12/h3-9H,1-2H3,(H,21,22) | UniProtKB/SwissProt
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| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097098
(2-(5-Chloro-thiophen-2-yl)-quinoline-4-carboxylic ...)Show InChI InChI=1S/C14H8ClNO2S/c15-13-6-5-12(19-13)11-7-9(14(17)18)8-3-1-2-4-10(8)16-11/h1-7H,(H,17,18) | UniProtKB/SwissProt
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| n/a | n/a | 3.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097103
(2-(4-Bromo-phenyl)-6-(4-hydroxy-phenyl)-quinoline-...)Show SMILES OC(=O)c1cc(nc2ccc(cc12)-c1ccc(O)cc1)-c1ccc(Br)cc1 Show InChI InChI=1S/C22H14BrNO3/c23-16-6-1-14(2-7-16)21-12-19(22(26)27)18-11-15(5-10-20(18)24-21)13-3-8-17(25)9-4-13/h1-12,25H,(H,26,27) | PDB
MMDB
Reactome pathway
KEGG
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| CHEMBL
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UniChem
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| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097104
(6-Bromo-2-(4-bromo-phenyl)-8-trifluoromethyl-quino...)Show SMILES OC(=O)c1cc(nc2c(cc(Br)cc12)C(F)(F)F)-c1ccc(Br)cc1 Show InChI InChI=1S/C17H8Br2F3NO2/c18-9-3-1-8(2-4-9)14-7-12(16(24)25)11-5-10(19)6-13(15(11)23-14)17(20,21)22/h1-7H,(H,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 5.60E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097107
(2-(4-Bromo-phenyl)-7-fluoro-8-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrFNO2/c1-9-14(19)7-6-12-13(17(21)22)8-15(20-16(9)12)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
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| n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097093
(7-Bromo-2-(4-bromo-phenyl)-8-methyl-quinoline-4-ca...)Show InChI InChI=1S/C17H11Br2NO2/c1-9-14(19)7-6-12-13(17(21)22)8-15(20-16(9)12)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 7.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097087
(2-(4-Bromo-phenyl)-6-((E)-2-carboxy-vinyl)-quinoli...)Show SMILES OC(=O)\C=C\c1ccc2nc(cc(C(O)=O)c2c1)-c1ccc(Br)cc1 Show InChI InChI=1S/C19H12BrNO4/c20-13-5-3-12(4-6-13)17-10-15(19(24)25)14-9-11(2-8-18(22)23)1-7-16(14)21-17/h1-10H,(H,22,23)(H,24,25)/b8-2+ | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| CHEMBL
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PC sid
UniChem
Similars
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| n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097099
(6-Amino-2-(4-bromo-phenyl)-quinoline-4-carboxylic ...)Show InChI InChI=1S/C16H11BrN2O2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,18H2,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097083
(2-(3,4-Dichloro-phenyl)-quinoline-4-carboxylic aci...)Show InChI InChI=1S/C16H9Cl2NO2/c17-12-6-5-9(7-13(12)18)15-8-11(16(20)21)10-3-1-2-4-14(10)19-15/h1-8H,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM35453
(2-(2-furanyl)-4-quinolinecarboxylic acid | 2-(2-fu...)Show InChI InChI=1S/C14H9NO3/c16-14(17)10-8-12(13-6-3-7-18-13)15-11-5-2-1-4-9(10)11/h1-8H,(H,16,17) | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097091
(2-(4-Bromo-phenyl)-5,7-dichloro-quinoline-4-carbox...)Show SMILES OC(=O)c1cc(nc2cc(Cl)cc(Cl)c12)-c1ccc(Br)cc1 Show InChI InChI=1S/C16H8BrCl2NO2/c17-9-3-1-8(2-4-9)13-7-11(16(21)22)15-12(19)5-10(18)6-14(15)20-13/h1-7H,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097102
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show SMILES Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccco1 Show InChI InChI=1S/C22H15BrClNO3/c1-13-9-16(24)10-18-19(22(26)28-12-17-3-2-8-27-17)11-20(25-21(13)18)14-4-6-15(23)7-5-14/h2-11H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097098
(2-(5-Chloro-thiophen-2-yl)-quinoline-4-carboxylic ...)Show InChI InChI=1S/C14H8ClNO2S/c15-13-6-5-12(19-13)11-7-9(14(17)18)8-3-1-2-4-10(8)16-11/h1-7H,(H,17,18) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097100
(2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...)Show InChI InChI=1S/C16H11NO2/c18-16(19)13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H,18,19) | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097109
(2-(4-Bromo-phenyl)-6-chloro-8-hydroxymethyl-quinol...)Show SMILES OCc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(O)=O Show InChI InChI=1S/C17H11BrClNO3/c18-11-3-1-9(2-4-11)15-7-14(17(22)23)13-6-12(19)5-10(8-21)16(13)20-15/h1-7,21H,8H2,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| CHEMBL
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UniChem
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097110
(2-(4-Trifluoromethyl-phenyl)-quinoline-4-carboxyli...)Show InChI InChI=1S/C17H10F3NO2/c18-17(19,20)11-7-5-10(6-8-11)15-9-13(16(22)23)12-3-1-2-4-14(12)21-15/h1-9H,(H,22,23) | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097082
(2-(4-Bromo-phenyl)-6-iodo-quinoline-4-carboxylic a...)Show InChI InChI=1S/C16H9BrINO2/c17-10-3-1-9(2-4-10)15-8-13(16(20)21)12-7-11(18)5-6-14(12)19-15/h1-8H,(H,20,21) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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DrugBank
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| CHEMBL
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UniChem
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097094
(2-(4-Bromo-phenyl)-quinoline-4-carboxylic acid | C...)Show InChI InChI=1S/C16H10BrNO2/c17-11-7-5-10(6-8-11)15-9-13(16(19)20)12-3-1-2-4-14(12)18-15/h1-9H,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
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antibodypedia
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097084
(2-(4-Bromo-phenyl)-7-chloro-5-methyl-quinoline-4-c...)Show InChI InChI=1S/C17H11BrClNO2/c1-9-6-12(19)7-15-16(9)13(17(21)22)8-14(20-15)10-2-4-11(18)5-3-10/h2-8H,1H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097092
(2-{[2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline...)Show SMILES COC(=O)C(Cc1ccccc1)NC(=O)c1cc(nc2c(C)cc(Cl)cc12)-c1ccc(Br)cc1 Show InChI InChI=1S/C27H22BrClN2O3/c1-16-12-20(29)14-21-22(15-23(30-25(16)21)18-8-10-19(28)11-9-18)26(32)31-24(27(33)34-2)13-17-6-4-3-5-7-17/h3-12,14-15,24H,13H2,1-2H3,(H,31,32) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097097
(2-Pyridin-4-yl-quinoline-4-carboxylic acid | CHEMB...)Show InChI InChI=1S/C15H10N2O2/c18-15(19)12-9-14(10-5-7-16-8-6-10)17-13-4-2-1-3-11(12)13/h1-9H,(H,18,19) | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097108
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show SMILES Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C30H21BrClNO2/c1-19-15-25(32)16-26-27(17-28(33-29(19)26)23-11-13-24(31)14-12-23)30(34)35-18-20-7-9-22(10-8-20)21-5-3-2-4-6-21/h2-17H,18H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097100
(2-Phenyl-quinoline-4-carboxylic acid | 2-phenylqui...)Show InChI InChI=1S/C16H11NO2/c18-16(19)13-10-15(11-6-2-1-3-7-11)17-14-9-5-4-8-12(13)14/h1-10H,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097086
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show SMILES Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)Oc1nnn[nH]1 Show InChI InChI=1S/C18H11BrClN5O2/c1-9-6-12(20)7-13-14(17(26)27-18-22-24-25-23-18)8-15(21-16(9)13)10-2-4-11(19)5-3-10/h2-8H,1H3,(H,22,23,24,25) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097088
(2-(4-Bromo-phenyl)-6,8-dimethyl-quinoline-4-carbox...)Show InChI InChI=1S/C18H14BrNO2/c1-10-7-11(2)17-14(8-10)15(18(21)22)9-16(20-17)12-3-5-13(19)6-4-12/h3-9H,1-2H3,(H,21,22) | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
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antibodypedia
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CHEMBL
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097110
(2-(4-Trifluoromethyl-phenyl)-quinoline-4-carboxyli...)Show InChI InChI=1S/C17H10F3NO2/c18-17(19,20)11-7-5-10(6-8-11)15-9-13(16(22)23)12-3-1-2-4-14(12)21-15/h1-9H,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097095
(2-(4-Bromo-phenyl)-6-chloro-8-methyl-quinoline-4-c...)Show SMILES Cc1cc(Cl)cc2c(cc(nc12)-c1ccc(Br)cc1)C(=O)OCc1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C24H15BrCl3NO2/c1-13-8-17(26)10-18-19(24(30)31-12-14-2-7-20(27)21(28)9-14)11-22(29-23(13)18)15-3-5-16(25)6-4-15/h2-11H,12H2,1H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097085
(2-(4-Bromo-phenyl)-6-sulfo-quinoline-4-carboxylic ...)Show SMILES OC(=O)c1cc(nc2ccc(cc12)S(O)(=O)=O)-c1ccc(Br)cc1 Show InChI InChI=1S/C16H10BrNO5S/c17-10-3-1-9(2-4-10)15-8-13(16(19)20)12-7-11(24(21,22)23)5-6-14(12)18-15/h1-8H,(H,19,20)(H,21,22,23) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097097
(2-Pyridin-4-yl-quinoline-4-carboxylic acid | CHEMB...)Show InChI InChI=1S/C15H10N2O2/c18-15(19)12-9-14(10-5-7-16-8-6-10)17-13-4-2-1-3-11(12)13/h1-9H,(H,18,19) | PDB
MMDB
Reactome pathway
KEGG
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM35453
(2-(2-furanyl)-4-quinolinecarboxylic acid | 2-(2-fu...)Show InChI InChI=1S/C14H9NO3/c16-14(17)10-8-12(13-6-3-7-18-13)15-11-5-2-1-4-9(10)11/h1-8H,(H,16,17) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
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antibodypedia
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CHEMBL
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097112
(2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid |...)Show InChI InChI=1S/C17H13NO3/c1-21-12-8-6-11(7-9-12)16-10-14(17(19)20)13-4-2-3-5-15(13)18-16/h2-10H,1H3,(H,19,20) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
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| Purchase
CHEMBL
PC cid
PC sid
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| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097113
(2-(4-Bromo-phenyl)-6-trifluoromethoxy-quinoline-4-...)Show SMILES OC(=O)c1cc(nc2ccc(OC(F)(F)F)cc12)-c1ccc(Br)cc1 Show InChI InChI=1S/C17H9BrF3NO3/c18-10-3-1-9(2-4-10)15-8-13(16(23)24)12-7-11(25-17(19,20)21)5-6-14(12)22-15/h1-8H,(H,23,24) | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Bifunctional glutamate/proline--tRNA ligase
(Homo sapiens (Human)) | BDBM50097101
(2-Naphthalen-2-yl-quinoline-4-carboxylic acid | CH...)Show InChI InChI=1S/C20H13NO2/c22-20(23)17-12-19(21-18-8-4-3-7-16(17)18)15-10-9-13-5-1-2-6-14(13)11-15/h1-12H,(H,22,23) | PDB
MMDB
Reactome pathway
KEGG
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B.MOAD
DrugBank
antibodypedia
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CHEMBL
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PC cid
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Similars
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against human prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
Proline--tRNA ligase, cytoplasmic
(Candida albicans) | BDBM50097112
(2-(4-Methoxy-phenyl)-quinoline-4-carboxylic acid |...)Show InChI InChI=1S/C17H13NO3/c1-21-12-8-6-11(7-9-12)16-10-14(17(19)20)13-4-2-3-5-15(13)18-16/h2-10H,1H3,(H,19,20) | UniProtKB/SwissProt
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| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Cubist Pharmaceuticals, Inc.
Curated by ChEMBL
| Assay Description
Aminoacylation activity against Candida albicans prolyl-tRNA synthetase |
Bioorg Med Chem Lett 11: 541-4 (2001)
BindingDB Entry DOI: 10.7270/Q2Q23ZH8 |
More data for this
Ligand-Target Pair | |
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