Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Rattus norvegicus (rat)) | BDBM50006412 ((3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydro...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 4.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Research Institute Curated by ChEMBL | Assay Description In vitro HMG-CoA reductase inhibitory activity of the compound to inhibit sterol synthesis in cell free system in rat | Bioorg Med Chem Lett 11: 1285-8 (2001) BindingDB Entry DOI: 10.7270/Q26D5S8M | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
3-hydroxy-3-methylglutaryl-coenzyme A reductase (Homo sapiens (Human)) | BDBM50006412 ((3R,5R)-3,5-dihydroxy-7-((1S,2S,6S,8S,8aR)-6-hydro...) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase CHEMBL KEGG PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Central Research Institute Curated by ChEMBL | Assay Description In vitro HMG-CoA reductase inhibitory activity of the compound to inhibit cellular steroidgenesis in Hep G2 cells (human hepatoma cell line) | Bioorg Med Chem Lett 11: 1285-8 (2001) BindingDB Entry DOI: 10.7270/Q26D5S8M | |||||||||||
More data for this Ligand-Target Pair |