Affinity Data by PubMed id=11514172

PubMed code 11514172

Found 20 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6961 (13-(4-hydroxyphenyl)-11-azatetracyclo[8.7.0.0^{2,7...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6960 (13-(3-aminophenyl)-11-azatetracyclo[8.7.0.0^{2,7}....) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.30E+3	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6943 (13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.60E+3	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6947 (13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80E+3	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6962 (13-(4-chlorophenyl)-11-azatetracyclo[8.7.0.0^{2,7}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	9.90E+3	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6953 (11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}]heptadeca...) Show SMILES Oc1ccc2ccc3[nH]c4ccccc4c3c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.74E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6945 (13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.95E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6950 (14-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.20E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6948 (13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.73E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6946 (13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.90E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6956 (5,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...) Show SMILES c1ccc2c(c1)[nH]c1ccc3cnccc3c21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6951 (15-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	3.75E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6959 (5-oxido-5,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,1...) Show SMILES [O-][n+]1ccc2c3c(ccc2c1)[nH]c1ccccc31 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.90E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6952 (16-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	8.30E+4	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6955 (4,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...) Show SMILES c1ccc2c(c1)[nH]c1ccc3ccncc3c21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.59E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6957 (6,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...) Show SMILES c1ccc2c(c1)[nH]c1ccc3ncccc3c21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.97E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6944 (4-methoxy-13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.09E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6949 (13-phenyl-11-azatetracyclo[8.7.0.0^{2,7}.0^{12,17}...) Show SMILES c1ccc(cc1)-c1cccc2c1[nH]c1ccc3ccccc3c21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>3.41E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6954 (3,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,17}]hepta...) Show SMILES c1ccc2c(c1)[nH]c1ccc3cccnc3c21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	4.42E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Homo sapiens (Human))	BDBM6958 (4-oxido-4,11-diazatetracyclo[8.7.0.0^{2,7}.0^{12,1...) Show SMILES [O-][n+]1ccc2ccc3[nH]c4ccccc4c3c2c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	6.05E+5	n/a	n/a	n/a	n/a	7.6	22
DuPont Pharmaceuticals Company					Assay Description The enzyme was assayed with substrate GST-Rb in the presence of 50 mM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...				Bioorg Med Chem Lett 11: 2209-11 (2001) Article DOI: 10.1016/s0960-894x(01)00416-4 BindingDB Entry DOI: 10.7270/Q2P55KPF
DuPont Pharmaceuticals Company					More data for this Ligand-Target Pair

* indicates data uncertainty>20%