Affinity Data by PubMed id=11689063

PubMed code 11689063

Found 28 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106179 (CHEMBL125327 \| Enantiomer-4-(3-Butyl-[1,2,4]oxadia...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106169 (CHEMBL338973 \| Enantiomer-4-(3-Butyl-[1,2,4]oxadia...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106167 (CHEMBL125000 \| Enantiomer-4-(3-Cyclopropylmethyl-[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptor				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106167 (CHEMBL125000 \| Enantiomer-4-(3-Cyclopropylmethyl-[...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	18	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106178 (4-(3-Butyl-[1,2,4]oxadiazol-5-yl)-N-(3,3-dimethyl-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106168 (CHEMBL124448 \| Enantiomer-N-(2,2-Dimethyl-cyclopen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptor				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106168 (CHEMBL124448 \| Enantiomer-N-(2,2-Dimethyl-cyclopen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	27	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50061218 ((E)-3-(2,4-Dichloro-phenyl)-N-((R)-1-methyl-2-oxo-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL KEGG PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	31	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106176 (CHEMBL340681 \| Enantiomer-N-(2,2-Dimethyl-cyclopen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106176 (CHEMBL340681 \| Enantiomer-N-(2,2-Dimethyl-cyclopen...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Bindind affinity values obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brain				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106182 (CHEMBL123085 \| N-(3,3-Dimethyl-butyl)-4-(3-phenyl-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	130	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106166 (CHEMBL122341 \| N-(3,3-Dimethyl-butyl)-4-hexyloxy-b...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCCC(C)(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106177 (CHEMBL431682 \| N-(3,3-Dimethyl-butyl)-4-indol-1-yl...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	260	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106184 (CHEMBL121751 \| N-(3,3-Dimethyl-cyclopentyl)-4-hexy...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NC1CCC(C)(C)C1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	360	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106180 (CHEMBL124595 \| N-(3,3-Dimethyl-cyclohexylmethyl)-4...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCC(C)(C)C1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	370	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106181 (Biphenyl-4-carboxylic acid (3,3-dimethyl-butyl)-am...) Show SMILES CC(C)(C)CCNC(=O)c1ccc(cc1)-c1ccccc1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	540	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106164 (CHEMBL123569 \| Enantiomer-N-(2,2-Dimethyl-cyclopen...) Show SMILES Cc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brain				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106164 (CHEMBL123569 \| Enantiomer-N-(2,2-Dimethyl-cyclopen...) Show SMILES Cc1noc(n1)-c1ccc(cc1)C(=O)NCC1CCCC1(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	580	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106175 (CHEMBL121750 \| Enantiomer-N-(2,2-Dimethyl-cyclopen...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCC1(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from whole rat brain Nicotinic acetylcholine receptor				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106175 (CHEMBL121750 \| Enantiomer-N-(2,2-Dimethyl-cyclopen...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCC1(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	710	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106174 (CHEMBL332297 \| N-(2,2-Dimethyl-cyclohexylmethyl)-4...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCCC1(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106174 (CHEMBL332297 \| N-(2,2-Dimethyl-cyclohexylmethyl)-4...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCC1CCCCC1(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Bindind affinity value obtained by measuring the displacement of radioligand [3H]-(-)-cytisine from a preparation of whole rat brain				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106165 ((3-tert-Butyl-pyrrolidin-1-yl)-(4-hexyloxy-phenyl)...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)N1CCC(C1)C(C)(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106170 (CHEMBL122865 \| N-(2-Diethylamino-ethyl)-4-hexyloxy...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NCCN(CC)CC Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106183 (1-(4-(Hexyloxy)phenyl)-3-(piperidin-1-yl)propan-1-...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)CCN1CCCCC1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	4.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106171 (CHEMBL122637 \| Diethyl-{2-[4-(1,1,3,3-tetramethyl-...) Show SMILES CCN(CC)CCOc1ccc(cc1)C(C)(C)CC(C)(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106173 (CHEMBL341368 \| N,N-Diethyl-2-[4-(1,1,3,3-tetrameth...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily KQT member 1 (Cavia porcellus)	BDBM50106172 (CHEMBL340222 \| N-(2,2-Dimethyl-cyclopentyl)-4-hexy...) Show SMILES CCCCCCOc1ccc(cc1)C(=O)NC1CCCC1(C)C Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 44: 3764-7 (2001) BindingDB Entry DOI: 10.7270/Q2G1604C
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%