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PubMed code 11844695

Compile data set for download or QSAR
Found 35 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Glucagon receptor


(Rattus norvegicus)		BDBM50110054
PNG
(3-Cyano-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(c2)C#N)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C27H27N3O5/c1-17(2)20-7-5-18(6-8-20)16-35-26-24(33-3)11-19(12-25(26)34-4)15-29-30-27(32)21-9-10-23(31)22(13-21)14-28/h5-13,15,17,31H,16H2,1-4H3,(H,30,32)/b29-15+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Compound was evaluated in vitro for its inhibitory activity against rat glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110054
PNG
(3-Cyano-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(c2)C#N)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C27H27N3O5/c1-17(2)20-7-5-18(6-8-20)16-35-26-24(33-3)11-19(12-25(26)34-4)15-29-30-27(32)21-9-10-23(31)22(13-21)14-28/h5-13,15,17,31H,16H2,1-4H3,(H,30,32)/b29-15+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110068
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H27ClN2O5/c1-16(2)19-7-5-17(6-8-19)15-34-25-23(32-3)11-18(12-24(25)33-4)14-28-29-26(31)20-9-10-22(30)21(27)13-20/h5-14,16,30H,15H2,1-4H3,(H,29,31)/b28-14+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110056
PNG
(2,3-Dichloro-4-hydroxy-benzoic acid [1-[4-(4-isopr...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(Cl)c2Cl)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H26Cl2N2O5/c1-15(2)18-7-5-16(6-8-18)14-35-25-21(33-3)11-17(12-22(25)34-4)13-29-30-26(32)19-9-10-20(31)24(28)23(19)27/h5-13,15,31H,14H2,1-4H3,(H,30,32)/b29-13+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110067
PNG
(2,3-Difluoro-4-hydroxy-benzoic acid [1-[4-(4-isopr...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(F)c2F)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H26F2N2O5/c1-15(2)18-7-5-16(6-8-18)14-35-25-21(33-3)11-17(12-22(25)34-4)13-29-30-26(32)19-9-10-20(31)24(28)23(19)27/h5-13,15,31H,14H2,1-4H3,(H,30,32)/b29-13+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110073
PNG
(4-Hydroxy-3-nitro-benzoic acid [1-[4-(4-isopropyl-...)
Show SMILES COc1cc([CH+][N-]NC(=O)c2ccc(O)c(c2)[N+]([O-])=O)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H27N3O7/c1-16(2)19-7-5-17(6-8-19)15-36-25-23(34-3)11-18(12-24(25)35-4)14-27-28-26(31)20-9-10-22(30)21(13-20)29(32)33/h5-14,16H,15H2,1-4H3,(H2,28,30,31)
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110074
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES CC(C)c1ccc(COc2ccc(\C=N\NC(=O)c3ccc(O)c(Cl)c3)c3ccccc23)cc1
Show InChI InChI=1S/C28H25ClN2O3/c1-18(2)20-9-7-19(8-10-20)17-34-27-14-12-22(23-5-3-4-6-24(23)27)16-30-31-28(33)21-11-13-26(32)25(29)15-21/h3-16,18,32H,17H2,1-2H3,(H,31,33)/b30-16+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110066
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-trifluoro...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(OCc2ccc(OC(F)(F)F)cc2)c2ccccc12
Show InChI InChI=1S/C26H18ClF3N2O4/c27-22-13-17(7-11-23(22)33)25(34)32-31-14-18-8-12-24(21-4-2-1-3-20(18)21)35-15-16-5-9-19(10-6-16)36-26(28,29)30/h1-14,33H,15H2,(H,32,34)/b31-14+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110055
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-(4-isopropyl-be...)
Show SMILES CC(C)c1ccc(Cn2ccc3c(\C=N\NC(=O)c4ccc(O)c(Cl)c4)cccc23)cc1
Show InChI InChI=1S/C26H24ClN3O2/c1-17(2)19-8-6-18(7-9-19)16-30-13-12-22-21(4-3-5-24(22)30)15-28-29-26(32)20-10-11-25(31)23(27)14-20/h3-15,17,31H,16H2,1-2H3,(H,29,32)/b28-15+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110057
PNG
(3-Fluoro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(F)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H27FN2O5/c1-16(2)19-7-5-17(6-8-19)15-34-25-23(32-3)11-18(12-24(25)33-4)14-28-29-26(31)20-9-10-22(30)21(27)13-20/h5-14,16,30H,15H2,1-4H3,(H,29,31)/b28-14+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110084
PNG
(2-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl...)
Show SMILES CCN(CC)C(=O)COc1ccc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C24H24ClN3O4/c1-3-28(4-2)23(30)15-32-22-12-10-17(18-7-5-6-8-19(18)22)14-26-27-24(31)16-9-11-21(29)20(25)13-16/h5-14,29H,3-4,15H2,1-2H3,(H,27,31)/b26-14+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110070
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(tetrahydro-...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(OCC2CCCCO2)c2ccccc12
Show InChI InChI=1S/C24H23ClN2O4/c25-21-13-16(8-10-22(21)28)24(29)27-26-14-17-9-11-23(20-7-2-1-6-19(17)20)31-15-18-5-3-4-12-30-18/h1-2,6-11,13-14,18,28H,3-5,12,15H2,(H,27,29)/b26-14+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110063
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(3,4-difluor...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(F)c(F)c1
Show InChI InChI=1S/C23H19ClF2N2O5/c1-31-20-8-14(11-27-28-23(30)15-4-6-19(29)16(24)10-15)9-21(32-2)22(20)33-12-13-3-5-17(25)18(26)7-13/h3-11,29H,12H2,1-2H3,(H,28,30)/b27-11+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110053
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(5-tert-buty...)
Show SMILES CC(C)(C)c1nc(COc2ccc(\C=N\NC(=O)c3ccc(O)c(Cl)c3)c3ccccc23)no1
Show InChI InChI=1S/C25H23ClN4O4/c1-25(2,3)24-28-22(30-34-24)14-33-21-11-9-16(17-6-4-5-7-18(17)21)13-27-29-23(32)15-8-10-20(31)19(26)12-15/h4-13,31H,14H2,1-3H3,(H,29,32)/b27-13+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110080
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[3,5-dimethoxy-...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C24H20ClF3N2O6/c1-33-20-9-15(12-29-30-23(32)16-5-8-19(31)18(25)11-16)10-21(34-2)22(20)35-13-14-3-6-17(7-4-14)36-24(26,27)28/h3-12,31H,13H2,1-2H3,(H,30,32)/b29-12+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50104096
PNG
(3-Chloro-4-hydroxy-benzoic acid (4-hydroxy-naphtha...)
Show SMILES Oc1ccc(cc1Cl)C(=O)N\N=C\c1ccc(O)c2ccccc12
Show InChI InChI=1S/C18H13ClN2O3/c19-15-9-11(5-8-17(15)23)18(24)21-20-10-12-6-7-16(22)14-4-2-1-3-13(12)14/h1-10,22-23H,(H,21,24)/b20-10+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110077
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES CC(C)c1ccc(COc2c(C)cc(\C=N\NC(=O)c3ccc(O)c(Cl)c3)cc2C)cc1
Show InChI InChI=1S/C26H27ClN2O3/c1-16(2)21-7-5-19(6-8-21)15-32-25-17(3)11-20(12-18(25)4)14-28-29-26(31)22-9-10-24(30)23(27)13-22/h5-14,16,30H,15H2,1-4H3,(H,29,31)/b28-14+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110083
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[1-(4-isopropyl...)
Show SMILES CC(C)c1ccc(Cn2cc(\C=N\NC(=O)c3ccc(O)c(Cl)c3)c3ccccc23)cc1
Show InChI InChI=1S/C26H24ClN3O2/c1-17(2)19-9-7-18(8-10-19)15-30-16-21(22-5-3-4-6-24(22)30)14-28-29-26(32)20-11-12-25(31)23(27)13-20/h3-14,16-17,31H,15H2,1-2H3,(H,29,32)/b28-14+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110071
PNG
(4-Hydroxy-benzoic acid [1-[4-(4-isopropyl-benzylox...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)cc2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H28N2O5/c1-17(2)20-7-5-18(6-8-20)16-33-25-23(31-3)13-19(14-24(25)32-4)15-27-28-26(30)21-9-11-22(29)12-10-21/h5-15,17,29H,16H2,1-4H3,(H,28,30)/b27-15+
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Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110081
PNG
(CHEMBL161401 | {4-[(3-Chloro-4-hydroxy-benzoyl)-hy...)
Show SMILES COC(=O)C(Oc1c(OC)cc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)cc1OC)c1ccccc1
Show InChI InChI=1S/C25H23ClN2O7/c1-32-20-11-15(14-27-28-24(30)17-9-10-19(29)18(26)13-17)12-21(33-2)23(20)35-22(25(31)34-3)16-7-5-4-6-8-16/h4-14,22,29H,1-3H3,(H,28,30)/b27-14+
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n/an/a 690n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110085
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES CC(C)c1ccc(COc2ccc(\C=N\NC(=O)c3ccc(O)c(Cl)c3)c(C)c2C)cc1
Show InChI InChI=1S/C26H27ClN2O3/c1-16(2)20-7-5-19(6-8-20)15-32-25-12-10-22(17(3)18(25)4)14-28-29-26(31)21-9-11-24(30)23(27)13-21/h5-14,16,30H,15H2,1-4H3,(H,29,31)/b28-14+
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n/an/a 740n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110062
PNG
(3-Chloro-4-hydroxy-benzoic acid (4-methoxy-naphtha...)
Show SMILES COc1ccc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C19H15ClN2O3/c1-25-18-9-7-13(14-4-2-3-5-15(14)18)11-21-22-19(24)12-6-8-17(23)16(20)10-12/h2-11,23H,1H3,(H,22,24)/b21-11+
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n/an/a 870n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110060
PNG
(3-Chloro-4-hydroxy-benzoic acid N'-[4-(4-isopropyl...)
Show SMILES COc1cc(CNNC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H29ClN2O5/c1-16(2)19-7-5-17(6-8-19)15-34-25-23(32-3)11-18(12-24(25)33-4)14-28-29-26(31)20-9-10-22(30)21(27)13-20/h5-13,16,28,30H,14-15H2,1-4H3,(H,29,31)
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n/an/a 880n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110076
PNG
(3-Amino-4-hydroxy-benzoic acid [1-[4-(4-isopropyl-...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(N)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H29N3O5/c1-16(2)19-7-5-17(6-8-19)15-34-25-23(32-3)11-18(12-24(25)33-4)14-28-29-26(31)20-9-10-22(30)21(27)13-20/h5-14,16,30H,15,27H2,1-4H3,(H,29,31)/b28-14+
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n/an/a 940n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110065
PNG
(2-{4-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl...)
Show SMILES NC(=O)COc1ccc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)c2ccccc12
Show InChI InChI=1S/C20H16ClN3O4/c21-16-9-12(5-7-17(16)25)20(27)24-23-10-13-6-8-18(28-11-19(22)26)15-4-2-1-3-14(13)15/h1-10,25H,11H2,(H2,22,26)(H,24,27)/b23-10+
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n/an/a 1.20E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110082
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)ccc1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C25H25ClN2O4/c1-16(2)19-7-4-17(5-8-19)15-32-23-11-6-18(12-24(23)31-3)14-27-28-25(30)20-9-10-22(29)21(26)13-20/h4-14,16,29H,15H2,1-3H3,(H,28,30)/b27-14+
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n/an/a 1.30E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110078
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES CC(C)c1ccc(COc2ccc(\C=N\NC(=O)c3ccc(O)c(Cl)c3)cc2)cc1
Show InChI InChI=1S/C24H23ClN2O3/c1-16(2)19-7-3-18(4-8-19)15-30-21-10-5-17(6-11-21)14-26-27-24(29)20-9-12-23(28)22(25)13-20/h3-14,16,28H,15H2,1-2H3,(H,27,29)/b26-14+
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110069
PNG
(3-Chloro-4-hydroxy-N-{2-[4-(4-isopropyl-benzyloxy)...)
Show SMILES COc1cc(CCNC(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C27H30ClNO5/c1-17(2)20-7-5-18(6-8-20)16-34-26-24(32-3)13-19(14-25(26)33-4)11-12-29-27(31)21-9-10-23(30)22(28)15-21/h5-10,13-15,17,30H,11-12,16H2,1-4H3,(H,29,31)
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n/an/a 1.90E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110058
PNG
(3,4-Dihydroxy-benzoic acid [1-[4-(4-isopropyl-benz...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(O)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H28N2O6/c1-16(2)19-7-5-17(6-8-19)15-34-25-23(32-3)11-18(12-24(25)33-4)14-27-28-26(31)20-9-10-21(29)22(30)13-20/h5-14,16,29-30H,15H2,1-4H3,(H,28,31)/b27-14+
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n/an/a 2.70E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110059
PNG
(3-Chloro-4-hydroxy-N-{2-[4-(4-isopropyl-benzyloxy)...)
Show SMILES COc1cc(CCNC(=N)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C27H31ClN2O4/c1-17(2)20-7-5-18(6-8-20)16-34-26-24(32-3)13-19(14-25(26)33-4)11-12-30-27(29)21-9-10-23(31)22(28)15-21/h5-10,13-15,17,31H,11-12,16H2,1-4H3,(H2,29,30)
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n/an/a 5.20E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110072
PNG
((E)-N-(3-Chloro-4-hydroxy-phenyl)-3-[4-(4-isopropy...)
Show SMILES COc1cc(\C=C\C(=O)Nc2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C27H28ClNO5/c1-17(2)20-8-5-18(6-9-20)16-34-27-24(32-3)13-19(14-25(27)33-4)7-12-26(31)29-21-10-11-23(30)22(28)15-21/h5-15,17,30H,16H2,1-4H3,(H,29,31)/b12-7+
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n/an/a 6.40E+3n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110079
PNG
(3-Cyano-4-hydroxy-benzoic acid (4-isopropyl-3,5-di...)
Show SMILES COc1cc(CO\C=N\NC(=O)c2ccc(O)c(c2)C#N)cc(OC)c1C(C)C
Show InChI InChI=1S/C21H23N3O5/c1-13(2)20-18(27-3)7-14(8-19(20)28-4)11-29-12-23-24-21(26)15-5-6-17(25)16(9-15)10-22/h5-9,12-13,25H,11H2,1-4H3,(H,24,26)/b23-12+
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n/an/a 2.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110064
PNG
(5-[(3-Chloro-4-hydroxy-benzoyl)-hydrazonomethyl]-2...)
Show SMILES COc1cc(\C=N\NC(=O)c2ccc(O)c(Cl)c2)cc(C(O)=O)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C26H25ClN2O6/c1-15(2)18-6-4-16(5-7-18)14-35-24-20(26(32)33)10-17(11-23(24)34-3)13-28-29-25(31)19-8-9-22(30)21(27)12-19/h4-13,15,30H,14H2,1-3H3,(H,29,31)(H,32,33)/b28-13+
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n/an/a 3.00E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110061
PNG
(2-chloro-4-[1-[4-(4-isopropylbenzyloxy)-3,5-dimeth...)
Show SMILES COc1cc(\C=N\NS(=O)(=O)c2ccc(O)c(Cl)c2)cc(OC)c1OCc1ccc(cc1)C(C)C
Show InChI InChI=1S/C25H27ClN2O6S/c1-16(2)19-7-5-17(6-8-19)15-34-25-23(32-3)11-18(12-24(25)33-4)14-27-28-35(30,31)20-9-10-22(29)21(26)13-20/h5-14,16,28-29H,15H2,1-4H3/b27-14+
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n/an/a 7.83E+4n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
Glucagon receptor


(Homo sapiens (Human))		BDBM50110075
PNG
(3-Chloro-4-hydroxy-benzoic acid [1-[4-(4-isopropyl...)
Show SMILES COc1cc(cc(OC)c1OCc1ccc(cc1)C(C)C)C(C)=NNC(=O)c1ccc(O)c(Cl)c1 |w:23.25|
Show InChI InChI=1S/C27H29ClN2O5/c1-16(2)19-8-6-18(7-9-19)15-35-26-24(33-4)13-21(14-25(26)34-5)17(3)29-30-27(32)20-10-11-23(31)22(28)12-20/h6-14,16,31H,15H2,1-5H3,(H,30,32)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against human glucagon receptor using [127I]-labeled glucagon

Bioorg Med Chem Lett 12: 663-6 (2002)


BindingDB Entry DOI: 10.7270/Q2J67G77
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%