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PubMed code 11855980

Compile data set for download or QSAR
Found 46 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6595
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-(dimethy...)
Show SMILES CN(C)CC(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C21H19N3O3/c1-24(2)12-20(25)27-15-7-8-17-14(9-15)11-19(23-17)21(26)18-10-13-5-3-4-6-16(13)22-18/h3-11,22-23H,12H2,1-2H3
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n/an/a 100n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6609
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-methoxya...)
Show SMILES COCC(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C20H16N2O4/c1-25-11-19(23)26-14-6-7-16-13(8-14)10-18(22-16)20(24)17-9-12-4-2-3-5-15(12)21-17/h2-10,21-22H,11H2,1H3
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n/an/a 200n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6581
PNG
((5-Hydroxy-1H-2-indolyl)(1H-2-indolyl)-methanone |...)
Show SMILES Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C17H12N2O2/c20-12-5-6-14-11(7-12)9-16(19-14)17(21)15-8-10-3-1-2-4-13(10)18-15/h1-9,18-20H
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PubMed
n/an/a 200n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6592
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl acetate | ...)
Show SMILES CC(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H14N2O3/c1-11(22)24-14-6-7-16-13(8-14)10-18(21-16)19(23)17-9-12-4-2-3-5-15(12)20-17/h2-10,20-21H,1H3
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n/an/a 300n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6574
PNG
((6-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1ccc2cc([nH]c2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-13-7-6-12-9-17(20-15(12)10-13)18(21)16-8-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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n/an/a 300n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6573
PNG
((5-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-13-6-7-15-12(8-13)10-17(20-15)18(21)16-9-11-4-2-3-5-14(11)19-16/h2-10,19-20H,1H3
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n/an/a 300n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6610
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl quinoline-...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1ccc2ccccc2n1
Show InChI InChI=1S/C27H17N3O3/c31-26(24-14-17-6-2-4-8-21(17)29-24)25-15-18-13-19(10-12-22(18)30-25)33-27(32)23-11-9-16-5-1-3-7-20(16)28-23/h1-15,29-30H
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n/an/a 400n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6608
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl furan-2-ca...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1ccco1
Show InChI InChI=1S/C22H14N2O4/c25-21(18-11-13-4-1-2-5-16(13)23-18)19-12-14-10-15(7-8-17(14)24-19)28-22(26)20-6-3-9-27-20/h1-12,23-24H
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n/an/a 600n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6587
PNG
((2-{[2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl]oxy}e...)
Show SMILES CN(C)CCOc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C21H21N3O2/c1-24(2)9-10-26-16-7-8-18-15(11-16)13-20(23-18)21(25)19-12-14-5-3-4-6-17(14)22-19/h3-8,11-13,22-23H,9-10H2,1-2H3
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n/an/a 800n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6597
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-(thiophe...)
Show SMILES O=C(Cc1cccs1)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C23H16N2O3S/c26-22(13-17-5-3-9-29-17)28-16-7-8-19-15(10-16)12-21(25-19)23(27)20-11-14-4-1-2-6-18(14)24-20/h1-12,24-25H,13H2
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n/an/a 800n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6602
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl benzoate |...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C24H16N2O3/c27-23(21-13-16-8-4-5-9-19(16)25-21)22-14-17-12-18(10-11-20(17)26-22)29-24(28)15-6-2-1-3-7-15/h1-14,25-26H
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n/an/a 800n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6591
PNG
(1H-2-Indolyl-[5-(2-piperidin-1-ylethoxy)-1H-2-indo...)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2cc(OCCN3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C24H25N3O2/c28-24(22-15-17-6-2-3-7-20(17)25-22)23-16-18-14-19(8-9-21(18)26-23)29-13-12-27-10-4-1-5-11-27/h2-3,6-9,14-16,25-26H,1,4-5,10-13H2
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n/an/a 800n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6605
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 4-nitroben...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H15N3O5/c28-23(21-12-15-3-1-2-4-19(15)25-21)22-13-16-11-18(9-10-20(16)26-22)32-24(29)14-5-7-17(8-6-14)27(30)31/h1-13,25-26H
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n/an/a 900n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6601
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-(acetylo...)
Show SMILES [H]C(OC(C)=O)(C(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1ccccc1 |w:1.0|
Show InChI InChI=1S/C27H20N2O5/c1-16(30)33-26(17-7-3-2-4-8-17)27(32)34-20-11-12-22-19(13-20)15-24(29-22)25(31)23-14-18-9-5-6-10-21(18)28-23/h2-15,26,28-29H,1H3
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n/an/a 900n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6596
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl propanoate...)
Show SMILES CCC(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C20H16N2O3/c1-2-19(23)25-14-7-8-16-13(9-14)11-18(22-16)20(24)17-10-12-5-3-4-6-15(12)21-17/h3-11,21-22H,2H2,1H3
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n/an/a 900n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6614
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl pyridine-3...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1cccnc1
Show InChI InChI=1S/C23H15N3O3/c27-22(20-11-14-4-1-2-6-18(14)25-20)21-12-16-10-17(7-8-19(16)26-21)29-23(28)15-5-3-9-24-13-15/h1-13,25-26H
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n/an/a 1.00E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6603
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-(3-metho...)
Show SMILES COc1cccc(CC(=O)Oc2ccc3[nH]c(cc3c2)C(=O)c2cc3ccccc3[nH]2)c1
Show InChI InChI=1S/C26H20N2O4/c1-31-19-7-4-5-16(11-19)12-25(29)32-20-9-10-22-18(13-20)15-24(28-22)26(30)23-14-17-6-2-3-8-21(17)27-23/h2-11,13-15,27-28H,12H2,1H3
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n/an/a 1.00E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6578
PNG
((Benzo[b]thiophen-2-yl)(5-methoxy-1H-2-indolyl)-1-...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2s1
Show InChI InChI=1S/C18H13NO2S/c1-21-13-6-7-14-12(8-13)9-15(19-14)18(20)17-10-11-4-2-3-5-16(11)22-17/h2-10,19H,1H3
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n/an/a 1.00E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6594
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl butanoate ...)
Show SMILES CCCC(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C21H18N2O3/c1-2-5-20(24)26-15-8-9-17-14(10-15)12-19(23-17)21(25)18-11-13-6-3-4-7-16(13)22-18/h3-4,6-12,22-23H,2,5H2,1H3
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n/an/a 1.10E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6600
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 3-phenylpr...)
Show SMILES O=C(CCc1ccccc1)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C26H20N2O3/c29-25(13-10-17-6-2-1-3-7-17)31-20-11-12-22-19(14-20)16-24(28-22)26(30)23-15-18-8-4-5-9-21(18)27-23/h1-9,11-12,14-16,27-28H,10,13H2
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n/an/a 1.20E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6611
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 4-ethoxybe...)
Show SMILES CCOc1ccc(cc1)C(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C26H20N2O4/c1-2-31-19-9-7-16(8-10-19)26(30)32-20-11-12-22-18(13-20)15-24(28-22)25(29)23-14-17-5-3-4-6-21(17)27-23/h3-15,27-28H,2H2,1H3
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n/an/a 1.30E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6599
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 4-phenylbe...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C30H20N2O3/c33-29(27-17-22-8-4-5-9-25(22)31-27)28-18-23-16-24(14-15-26(23)32-28)35-30(34)21-12-10-20(11-13-21)19-6-2-1-3-7-19/h1-18,31-32H
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n/an/a 1.70E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6598
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-(acetylo...)
Show SMILES CC(=O)Oc1ccccc1C(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C26H18N2O5/c1-15(29)32-24-9-5-3-7-19(24)26(31)33-18-10-11-21-17(12-18)14-23(28-21)25(30)22-13-16-6-2-4-8-20(16)27-22/h2-14,27-28H,1H3
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n/an/a 2.20E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6583
PNG
((5-Ethoxy-1H-2-indolyl)(1H-2-indolyl)methanone | 5...)
Show SMILES CCOc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C19H16N2O2/c1-2-23-14-7-8-16-13(9-14)11-18(21-16)19(22)17-10-12-5-3-4-6-15(12)20-17/h3-11,20-21H,2H2,1H3
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n/an/a 2.30E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6584
PNG
(1H-2-Indolyl-[5-(2-(morpholin-1-yl)ethoxy)-1H-2-in...)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2cc(OCCN3CCOCC3)ccc2[nH]1
Show InChI InChI=1S/C23H23N3O3/c27-23(21-14-16-3-1-2-4-19(16)24-21)22-15-17-13-18(5-6-20(17)25-22)29-12-9-26-7-10-28-11-8-26/h1-6,13-15,24-25H,7-12H2
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n/an/a 2.50E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6585
PNG
((3-{[2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl]oxy}p...)
Show SMILES CN(C)CCCOc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C22H23N3O2/c1-25(2)10-5-11-27-17-8-9-19-16(12-17)14-21(24-19)22(26)20-13-15-6-3-4-7-18(15)23-20/h3-4,6-9,12-14,23-24H,5,10-11H2,1-2H3
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n/an/a 3.20E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6593
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 4-methoxyb...)
Show SMILES COc1ccc(cc1)C(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C25H18N2O4/c1-30-18-8-6-15(7-9-18)25(29)31-19-10-11-21-17(12-19)14-23(27-21)24(28)22-13-16-4-2-3-5-20(16)26-22/h2-14,26-27H,1H3
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n/an/a 3.20E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6607
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl (2E)-3-phe...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)\C=C\c1ccccc1
Show InChI InChI=1S/C26H18N2O3/c29-25(13-10-17-6-2-1-3-7-17)31-20-11-12-22-19(14-20)16-24(28-22)26(30)23-15-18-8-4-5-9-21(18)27-23/h1-16,27-28H/b13-10+
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n/an/a 3.40E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6579
PNG
((Benzo[b]furan-2-yl)(5-methoxy-1H-2-indolyl)methan...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2o1
Show InChI InChI=1S/C18H13NO3/c1-21-13-6-7-14-12(8-13)9-15(19-14)18(20)17-10-11-4-2-3-5-16(11)22-17/h2-10,19H,1H3
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n/an/a 4.00E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6606
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 3,4,5-trim...)
Show SMILES COc1cc(cc(OC)c1OC)C(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C27H22N2O6/c1-32-23-13-17(14-24(33-2)26(23)34-3)27(31)35-18-8-9-20-16(10-18)12-22(29-20)25(30)21-11-15-6-4-5-7-19(15)28-21/h4-14,28-29H,1-3H3
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n/an/a 4.10E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6604
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-chlorobe...)
Show SMILES Clc1ccccc1C(=O)Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C24H15ClN2O3/c25-18-7-3-2-6-17(18)24(29)30-16-9-10-20-15(11-16)13-22(27-20)23(28)21-12-14-5-1-4-8-19(14)26-21/h1-13,26-27H
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n/an/a 4.60E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6613
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl cyclobutan...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)C1CCC1
Show InChI InChI=1S/C22H18N2O3/c25-21(19-11-14-4-1-2-7-17(14)23-19)20-12-15-10-16(8-9-18(15)24-20)27-22(26)13-5-3-6-13/h1-2,4,7-13,23-24H,3,5-6H2
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n/an/a 5.70E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6577
PNG
((1H-2-Indolyl)(5-methyl-1H-2-indolyl)methanone | 2...)
Show SMILES Cc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O/c1-11-6-7-15-13(8-11)10-17(20-15)18(21)16-9-12-4-2-3-5-14(12)19-16/h2-10,19-20H,1H3
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n/an/a 7.50E+3n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6612
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl cyclopropa...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)C1CC1
Show InChI InChI=1S/C21H16N2O3/c24-20(18-10-13-3-1-2-4-16(13)22-18)19-11-14-9-15(7-8-17(14)23-19)26-21(25)12-5-6-12/h1-4,7-12,22-23H,5-6H2
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n/an/a 9.10E+3n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6586
PNG
(2-(1H-indol-2-ylcarbonyl)-5-(4-iodobutoxy)-1H-indo...)
Show SMILES ICCCCOc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C21H19IN2O2/c22-9-3-4-10-26-16-7-8-18-15(11-16)13-20(24-18)21(25)19-12-14-5-1-2-6-17(14)23-19/h1-2,5-8,11-13,23-24H,3-4,9-10H2
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n/an/a 1.25E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6576
PNG
(5-methoxy-2-[(5-methoxy-1H-indol-2-yl)carbonyl]-1H...)
Show SMILES COc1ccc2[nH]c(cc2c1)C(=O)c1cc2cc(OC)ccc2[nH]1
Show InChI InChI=1S/C19H16N2O3/c1-23-13-3-5-15-11(7-13)9-17(20-15)19(22)18-10-12-8-14(24-2)4-6-16(12)21-18/h3-10,20-21H,1-2H3
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n/an/a 2.00E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6589
PNG
(2-(1H-indol-2-ylcarbonyl)-5-[(5-iodopentyl)oxy]-1H...)
Show SMILES ICCCCCOc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C22H21IN2O2/c23-10-4-1-5-11-27-17-8-9-19-16(12-17)14-21(25-19)22(26)20-13-15-6-2-3-7-18(15)24-20/h2-3,6-9,12-14,24-25H,1,4-5,10-11H2
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n/an/a>2.00E+4n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6582
PNG
(5-(benzyloxy)-2-(1H-indol-2-ylcarbonyl)-1H-indole ...)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2cc(OCc3ccccc3)ccc2[nH]1
Show InChI InChI=1S/C24H18N2O2/c27-24(22-13-17-8-4-5-9-20(17)25-22)23-14-18-12-19(10-11-21(18)26-23)28-15-16-6-2-1-3-7-16/h1-14,25-26H,15H2
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n/an/a 2.00E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6617
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 3-phenoxyb...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C30H20N2O4/c33-29(27-17-19-7-4-5-12-25(19)31-27)28-18-21-16-24(13-14-26(21)32-28)36-30(34)20-8-6-11-23(15-20)35-22-9-2-1-3-10-22/h1-18,31-32H
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n/an/a>3.00E+4n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6618
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-benzoylb...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1ccccc1C(=O)c1ccccc1
Show InChI InChI=1S/C31H20N2O4/c34-29(19-8-2-1-3-9-19)23-11-5-6-12-24(23)31(36)37-22-14-15-26-21(16-22)18-28(33-26)30(35)27-17-20-10-4-7-13-25(20)32-27/h1-18,32-33H
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n/an/a>3.00E+4n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6580
PNG
(Bis(1H-2-indolyl)methanone 18 | bis(1-benzothiophe...)
Show SMILES O=C(c1cc2ccccc2s1)c1cc2ccccc2s1
Show InChI InChI=1S/C17H10OS2/c18-17(15-9-11-5-1-3-7-13(11)19-15)16-10-12-6-2-4-8-14(12)20-16/h1-10H
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n/an/a>3.00E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6615
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2,2-diphen...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C31H22N2O3/c34-30(27-18-22-13-7-8-14-25(22)32-27)28-19-23-17-24(15-16-26(23)33-28)36-31(35)29(20-9-3-1-4-10-20)21-11-5-2-6-12-21/h1-19,29,32-33H
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n/an/a>3.00E+4n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6590
PNG
(1H-2-Indolyl-[5-(1-phenylethoxy)-1H-2-indolyl]meth...)
Show SMILES CC(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1ccccc1
Show InChI InChI=1S/C25H20N2O2/c1-16(17-7-3-2-4-8-17)29-20-11-12-22-19(13-20)15-24(27-22)25(28)23-14-18-9-5-6-10-21(18)26-23/h2-16,26-27H,1H3
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n/an/a>3.00E+4n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6616
PNG
(2-(1H-indol-2-ylcarbonyl)-1H-indol-5-yl 2-phenoxyb...)
Show SMILES O=C(Oc1ccc2[nH]c(cc2c1)C(=O)c1cc2ccccc2[nH]1)c1ccccc1Oc1ccccc1
Show InChI InChI=1S/C30H20N2O4/c33-29(26-17-19-8-4-6-12-24(19)31-26)27-18-20-16-22(14-15-25(20)32-27)36-30(34)23-11-5-7-13-28(23)35-21-9-2-1-3-10-21/h1-18,31-32H
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n/an/a>3.00E+4n/an/an/an/an/a25



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6575
PNG
((7-Methoxy-1H-2-indolyl)(1H-2-indolyl)methanone | ...)
Show SMILES COc1cccc2cc([nH]c12)C(=O)c1cc2ccccc2[nH]1
Show InChI InChI=1S/C18H14N2O2/c1-22-16-8-4-6-12-10-15(20-17(12)16)18(21)14-9-11-5-2-3-7-13(11)19-14/h2-10,19-20H,1H3
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n/an/a>3.00E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM6588
PNG
((5-Cyclohexylmethoxy-1H-2-indolyl)(1H-2-indolyl)me...)
Show SMILES O=C(c1cc2ccccc2[nH]1)c1cc2cc(OCC3CCCCC3)ccc2[nH]1
Show InChI InChI=1S/C24H24N2O2/c27-24(22-13-17-8-4-5-9-20(17)25-22)23-14-18-12-19(10-11-21(18)26-23)28-15-16-6-2-1-3-7-16/h4-5,8-14,16,25-26H,1-3,6-7,15H2
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n/an/a>3.00E+4n/an/an/an/a7.422



University of Regensburg



Assay Description
The cells were stimulated with PDGF (100 ng/mL) for 10 min at room temperature. Then the cell lysates were analyzed by SDS-PAGE and immunoblotting wi...


J Med Chem 45: 1002-18 (2002)


Article DOI: 10.1021/jm050408c
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%