Affinity Data by PubMed id=12039574

PubMed code 12039574

Found 16 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50218255 (CHEMBL290100) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50218255 (CHEMBL290100) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of rolipram binding in rat brain				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50219815 (CHEMBL43570) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of rolipram binding in rat brain				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM14361 ((R,S)-Rolipram \| 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	20	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of rolipram binding in rat brain				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50219817 (CHEMBL43607) Show SMILES COc1ccc(C(=O)Nc2ccncc2Cl)c2cccnc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50219815 (CHEMBL43570) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	120	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50219816 (CHEMBL39058) Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cccnc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	170	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50219818 (CHEMBL295994) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of rolipram binding in rat brain				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50219813 (CHEMBL296358) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	290	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50219813 (CHEMBL296358) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of rolipram binding in rat brain				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50219817 (CHEMBL43607) Show SMILES COc1ccc(C(=O)Nc2ccncc2Cl)c2cccnc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of rolipram binding in rat brain				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50219818 (CHEMBL295994) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	480	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50219816 (CHEMBL39058) Show SMILES COc1ccc(C(=O)Nc2c(Cl)cncc2Cl)c2cccnc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of rolipram binding in rat brain				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM50219814 (CHEMBL288808) Show SMILES COc1ccc(C(=O)Nc2ccncc2)c2cccnc12 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D (Homo sapiens (Human))	BDBM14361 ((R,S)-Rolipram \| 4-(3-cyclopentyloxy-4-methoxy-phe...) Show SMILES COc1ccc(cc1OC1CCCC1)C1CNC(=O)C1 Show InChI	PDB UniProtKB/SwissProt antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of Phosphodiesterase 4 (PDE-4) from human U937 cells				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
cAMP-specific 3',5'-cyclic phosphodiesterase 4C (Rattus norvegicus)	BDBM50219814 (CHEMBL288808) Show SMILES COc1ccc(C(=O)Nc2ccncc2)c2cccnc12 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Celltech R&D Curated by ChEMBL					Assay Description Inhibition of rolipram binding in rat brain				Bioorg Med Chem Lett 12: 1613-5 (2002) BindingDB Entry DOI: 10.7270/Q2D220S3
Celltech R&D Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%