Affinity Data by PubMed id=12061886

PubMed code 12061886

Found 11 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114773 (5-(Azetidin-2-ylmethoxy)-2-chloro-3-(2-pyridin-4-y...) Show SMILES Clc1ncc(OCC2CCN2)cc1\C=C\c1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.00900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Binding affinity for nAChR with [3H]-imidacloprid in Drosophila				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50049757 (()-2-(6-Chloro-pyridin-3-yl)-7-aza-bicyclo[2.2.1]h...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid PDB UniChem Patents Similars	PubMed	0.0100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Binding affinity for nAChR with [3H]-imidacloprid in Myzus persicae				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114771 (2-Chloro-3-(2-pyridin-4-yl-ethyl)-5-(pyrrolidin-2-...) Show SMILES Clc1ncc(OCC2CCCN2)cc1CCc1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0110	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114774 (2-Chloro-3-(2-pyridin-4-yl-vinyl)-5-(pyrrolidin-2-...) Show SMILES Clc1ncc(OCC2CCCN2)cc1\C=C\c1ccncc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Binding affinity for nAChR with [3H]-imidacloprid in Drosophila				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114768 (2-Chloro-5-(1-methyl-pyrrolidin-2-ylmethoxy)-3-(2-...) Show SMILES CN1CCCC1COc1cnc(Cl)c(CCc2ccncc2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0230	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114769 (2-Chloro-5-(1-methyl-pyrrolidin-2-ylmethoxy)-3-(2-...) Show SMILES CN1CCCC1COc1cnc(Cl)c(\C=C\c2ccncc2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Binding affinity for nAChR with [3H]-imidacloprid in Myzus persicae				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114767 (2-Chloro-3-(2-pyridin-3-yl-vinyl)-5-(pyrrolidin-2-...) Show SMILES Clc1ncc(OCC2CCCN2)cc1\C=C\c1cccnc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Binding affinity for nAChR with [3H]-imidacloprid in Drosophila				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114775 (2-Chloro-5-(1-methyl-azetidin-2-ylmethoxy)-3-(2-py...) Show SMILES CN1CCC1COc1cnc(Cl)c(\C=C\c2ccncc2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0720	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Molar concentration required to inhibit 50% of the activating delayed-rectifier K+ current in isolated guinea pig ventricularmyocytes				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114778 (2-Chloro-5-(1-methyl-pyrrolidin-2-ylmethoxy)-3-(2-...) Show SMILES CN1CCCC1COc1cnc(Cl)c(\C=C\c2cccnc2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0880	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Binding affinity for nAChR with [3H]-imidacloprid in Myzus persicae				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114776 (2-Chloro-5-(1-methyl-pyrrolidin-2-ylmethoxy)-3-(2-...) Show SMILES CN1CCCC1COc1cnc(Cl)c(\C=C\c2ccccn2)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.265	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Binding affinity for nAChR with [3H]-imidacloprid in Myzus persicae				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50114777 (2-Chloro-3-(2-pyridin-2-yl-vinyl)-5-(pyrrolidin-2-...) Show SMILES Clc1ncc(OCC2CCCN2)cc1\C=C\c1ccccn1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.331	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
National Institute on Drug Abuse Curated by ChEMBL					Assay Description Binding affinity for nAChR with [3H]-imidacloprid in Drosophila				J Med Chem 45: 2841-9 (2002) BindingDB Entry DOI: 10.7270/Q2FN15JT
National Institute on Drug Abuse Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%