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PubMed code 12144928

Compile data set for download or QSAR
Found 11 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Phosphotransferase


(Trypanosoma brucei)		BDBM43835
PNG
(Glucosamine derivative, 8 | MLS000582359 | N-cyclo...)
Show SMILES [O-][N+](=O)c1ccc(N2CCCCC2)c(c1)C(=O)NC1CCCCC1
Show InChI InChI=1S/C18H25N3O3/c22-18(19-14-7-3-1-4-8-14)16-13-15(21(23)24)9-10-17(16)20-11-5-2-6-12-20/h9-10,13-14H,1-8,11-12H2,(H,19,22)
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 2.80E+3 -31.7 5.00E+5n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43833
PNG
(2-hydroxy-N''''-(3-keto-5,5-dimethyl-cyclohexen-1-...)
Show SMILES CC1(C)CC(=O)C=C(C1)NNC(=O)c1ccccc1O |c:6|
Show InChI InChI=1S/C15H18N2O3/c1-15(2)8-10(7-11(18)9-15)16-17-14(20)12-5-3-4-6-13(12)19/h3-7,16,19H,8-9H2,1-2H3,(H,17,20)
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 8.00E+3 -29.1 2.00E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43832
PNG
(2-phenylcyclopropane-1,1-dicarboxylic acid diethyl...)
Show SMILES CCOC(=O)C1(CC1c1ccccc1)C(=O)OCC
Show InChI InChI=1S/C15H18O4/c1-3-18-13(16)15(14(17)19-4-2)10-12(15)11-8-6-5-7-9-11/h5-9,12H,3-4,10H2,1-2H3
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 1.90E+4 -26.9 4.00E+5n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43834
PNG
(2-methoxy-4-[[4-(4-methylphenyl)-1-piperazinyl]met...)
Show SMILES COc1cc(CN2CCN(CC2)c2ccc(C)cc2)cc(c1O)[N+]([O-])=O
Show InChI InChI=1S/C19H23N3O4/c1-14-3-5-16(6-4-14)21-9-7-20(8-10-21)13-15-11-17(22(24)25)19(23)18(12-15)26-2/h3-6,11-12,23H,7-10,13H2,1-2H3
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 2.50E+4 -26.3 3.00E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43838
PNG
(4-O-[5-bromo-2-cyclopropyl-3-(4-methoxyphenyl)-7-m...)
Show SMILES COC(=O)CCC(=O)OC1(C)C(=O)C(Br)=C2C=C(N(C=C2C1=O)C1CC1)c1ccc(OC)cc1 |c:16,19,t:14|
Show InChI InChI=1S/C25H24BrNO7/c1-25(34-21(29)11-10-20(28)33-3)23(30)18-13-27(15-6-7-15)19(12-17(18)22(26)24(25)31)14-4-8-16(32-2)9-5-14/h4-5,8-9,12-13,15H,6-7,10-11H2,1-3H3
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 3.00E+4 -25.8 3.00E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43837
PNG
((4S,5R,6R)-1-(2-ethoxy-2-keto-ethyl)-2-keto-6-meth...)
Show SMILES CCOC(=O)CN1[C@H](C)[C@@H]([C@H](CCc2ccccc2)NC1=O)C(=O)OC
Show InChI InChI=1S/C19H26N2O5/c1-4-26-16(22)12-21-13(2)17(18(23)25-3)15(20-19(21)24)11-10-14-8-6-5-7-9-14/h5-9,13,15,17H,4,10-12H2,1-3H3,(H,20,24)/t13-,15+,17+/m1/s1
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 7.00E+4 -23.7 3.00E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43836
PNG
(Glucosamine derivative, 9 | MLS000580208 | N-(2,5-...)
Show SMILES COc1ccc(OC)c(NC(=O)c2ccccc2NS(=O)(=O)c2cccc3cccnc23)c1
Show InChI InChI=1S/C24H21N3O5S/c1-31-17-12-13-21(32-2)20(15-17)26-24(28)18-9-3-4-10-19(18)27-33(29,30)22-11-5-7-16-8-6-14-25-23(16)22/h3-15,27H,1-2H3,(H,26,28)
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 1.00E+5 -22.8 4.00E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43829
PNG
(Glucosamine derivative, 2 | MLS000568543 | SMR0001...)
Show SMILES Oc1ccccc1N1CCN(CC1)C(=O)c1ccc2ccccc2n1
Show InChI InChI=1S/C20H19N3O2/c24-19-8-4-3-7-18(19)22-11-13-23(14-12-22)20(25)17-10-9-15-5-1-2-6-16(15)21-17/h1-10,24H,11-14H2
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 1.00E+5 -22.8 6.00E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43830
PNG
(5-(amoxymethyl)-3-[2-[(4-phenylthiazol-2-yl)hydraz...)
Show SMILES CCCCCOCC1CC(CC(C)N=Nc2nc(cs2)-c2ccccc2)C(=O)O1 |w:13.12|
Show InChI InChI=1S/C22H29N3O3S/c1-3-4-8-11-27-14-19-13-18(21(26)28-19)12-16(2)24-25-22-23-20(15-29-22)17-9-6-5-7-10-17/h5-7,9-10,15-16,18-19H,3-4,8,11-14H2,1-2H3
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 1.05E+5 -22.7 4.50E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43831
PNG
(5-(4-fluorobenzyl)-4-keto-6,7-dihydropyrazolo[1,5-...)
Show SMILES COC(=O)c1cc2C(=O)N(Cc3ccc(F)cc3)CCn2n1
Show InChI InChI=1S/C15H14FN3O3/c1-22-15(21)12-8-13-14(20)18(6-7-19(13)17-12)9-10-2-4-11(16)5-3-10/h2-5,8H,6-7,9H2,1H3
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 1.14E+5 -22.5 1.80E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
Phosphotransferase


(Trypanosoma brucei)		BDBM43828
PNG
(2-[(4-fluorobenzyl)thio]-N-(4,5,6,7-tetrahydro-1,3...)
Show SMILES Fc1ccc(CSCC(=O)Nc2nc3CCCCc3s2)cc1
Show InChI InChI=1S/C16H17FN2OS2/c17-12-7-5-11(6-8-12)9-21-10-15(20)19-16-18-13-3-1-2-4-14(13)22-16/h5-8H,1-4,9-10H2,(H,18,19,20)
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n/an/a 8.00E+6n/an/an/an/an/a25



Groupe de Chimie Organique Biologique, Laboratoire Synthése Physico-Chimie des Molécules d'Inérêt Biologique



Assay Description
Competitive inhibition assay for glucosamine derivatives on hexokinase from trypanosoma brucei. The inhibition of hexokinase by compounds was measur...

Chem Biol 9: 839-47 (2002)


Article DOI: 10.1016/S1074-5521(02)00169-2
BindingDB Entry DOI: 10.7270/Q2MC8XF1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%