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PubMed code 12238930

Compile data set for download or QSAR
Found 94 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50115347
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C25H31N5O3/c1-25(2,3)17-6-8-18(9-7-17)28-24(31)30-12-10-29(11-13-30)23-19-14-21(32-4)22(33-5)15-20(19)26-16-27-23/h6-9,14-16H,10-13H2,1-5H3,(H,28,31)
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n/an/a 30n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118881
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(Br)cc3)c2cc1OC
Show InChI InChI=1S/C22H24BrN5O2S/c1-29-19-11-17-18(12-20(19)30-2)25-14-26-21(17)27-7-9-28(10-8-27)22(31)24-13-15-3-5-16(23)6-4-15/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,31)
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n/an/a 30n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118880
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C23H27N5O2S/c1-16-4-6-17(7-5-16)14-24-23(31)28-10-8-27(9-11-28)22-18-12-20(29-2)21(30-3)13-19(18)25-15-26-22/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,24,31)
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n/an/a 30n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118859
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C22H24ClN5O2S/c1-29-19-11-17-18(12-20(19)30-2)25-14-26-21(17)27-7-9-28(10-8-27)22(31)24-13-15-3-5-16(23)6-4-15/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,31)
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n/an/a 70n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50115301
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33)
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n/an/a 80n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50115302
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C(C)C)c2cc1OC
Show InChI InChI=1S/C24H29N5O3/c1-16(2)17-5-7-18(8-6-17)27-24(30)29-11-9-28(10-12-29)23-19-13-21(31-3)22(32-4)14-20(19)25-15-26-23/h5-8,13-16H,9-12H2,1-4H3,(H,27,30)
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n/an/a 80n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118858
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-2-methyl-piperaz...)
Show SMILES COc1cc2ncnc(N3CCN(C(C)C3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-19-17-32(27-23-15-25(35-2)26(36-3)16-24(23)29-18-30-27)13-14-33(19)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,15-16,18-19H,13-14,17H2,1-3H3,(H,31,34)
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n/an/a 80n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a 90n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a 90n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118857
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1ccc(CNC(=S)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C23H27N5O3S/c1-29-17-6-4-16(5-7-17)14-24-23(32)28-10-8-27(9-11-28)22-18-12-20(30-2)21(31-3)13-19(18)25-15-26-22/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,24,32)
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n/an/a 100n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118869
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C26H33N5O3/c1-26(2,3)19-8-6-18(7-9-19)16-27-25(32)31-12-10-30(11-13-31)24-20-14-22(33-4)23(34-5)15-21(20)28-17-29-24/h6-9,14-15,17H,10-13,16H2,1-5H3,(H,27,32)
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n/an/a 110n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118848
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCC(=O)c3ccc(Br)cc3)c2cc1OC
Show InChI InChI=1S/C23H24BrN5O4/c1-32-20-11-17-18(12-21(20)33-2)26-14-27-22(17)28-7-9-29(10-8-28)23(31)25-13-19(30)15-3-5-16(24)6-4-15/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,25,31)
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n/an/a 140n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118874
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(cc3)C(C)(C)C)c2cc1OC
Show InChI InChI=1S/C26H33N5O2S/c1-26(2,3)19-8-6-18(7-9-19)16-27-25(34)31-12-10-30(11-13-31)24-20-14-22(32-4)23(33-5)15-21(20)28-17-29-24/h6-9,14-15,17H,10-13,16H2,1-5H3,(H,27,34)
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n/an/a 160n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118833
PNG
(CHEMBL140702 | [Benzo(1,3)dioxol]-methylene-cyanam...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(NCc3ccc4OCOc4c3)=NC#N)c2cc1OC |w:27.30|
Show InChI InChI=1S/C24H25N7O4/c1-32-20-10-17-18(11-21(20)33-2)28-14-29-23(17)30-5-7-31(8-6-30)24(27-13-25)26-12-16-3-4-19-22(9-16)35-15-34-19/h3-4,9-11,14H,5-8,12,15H2,1-2H3,(H,26,27)
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n/an/a 190n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118879
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(cc3)C(C)C)c2cc1OC
Show InChI InChI=1S/C25H31N5O2S/c1-17(2)19-7-5-18(6-8-19)15-26-25(33)30-11-9-29(10-12-30)24-20-13-22(31-3)23(32-4)14-21(20)27-16-28-24/h5-8,13-14,16-17H,9-12,15H2,1-4H3,(H,26,33)
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n/an/a 200n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a 210n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PDGF receptor alpha autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a 220n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118840
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3cccc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H24ClN5O2S/c1-29-19-11-17-18(12-20(19)30-2)25-14-26-21(17)27-6-8-28(9-7-27)22(31)24-13-15-4-3-5-16(23)10-15/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,24,31)
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n/an/a 230n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a 240n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of PDGF receptor alpha autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118849
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3cccnc3)c2cc1OC
Show InChI InChI=1S/C21H24N6O2S/c1-28-18-10-16-17(11-19(18)29-2)24-14-25-20(16)26-6-8-27(9-7-26)21(30)23-13-15-4-3-5-22-12-15/h3-5,10-12,14H,6-9,13H2,1-2H3,(H,23,30)
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n/an/a 280n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118846
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccco3)c2cc1OC
Show InChI InChI=1S/C20H23N5O3S/c1-26-17-10-15-16(11-18(17)27-2)22-13-23-19(15)24-5-7-25(8-6-24)20(29)21-12-14-4-3-9-28-14/h3-4,9-11,13H,5-8,12H2,1-2H3,(H,21,29)
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n/an/a 330n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118853
PNG
((4-methyl-benzyl)-methylene-cyanamide-[4-(6,7-dime...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(NCc3ccc(C)cc3)=NC#N)c2cc1OC |w:25.27|
Show InChI InChI=1S/C24H27N7O2/c1-17-4-6-18(7-5-17)14-26-24(27-15-25)31-10-8-30(9-11-31)23-19-12-21(32-2)22(33-3)13-20(19)28-16-29-23/h4-7,12-13,16H,8-11,14H2,1-3H3,(H,26,27)
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n/an/a 340n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a 360n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118856
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-35-25-16-23-24(17-26(25)36-2)30-19-31-27(23)32-12-14-33(15-13-32)28(34)29-18-20-8-10-22(11-9-20)37-21-6-4-3-5-7-21/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,29,34)
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n/an/a 380n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118834
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3cccnc3)c2cc1OC
Show InChI InChI=1S/C20H22N6O2S/c1-27-17-10-15-16(11-18(17)28-2)22-13-23-19(15)25-6-8-26(9-7-25)20(29)24-14-4-3-5-21-12-14/h3-5,10-13H,6-9H2,1-2H3,(H,24,29)
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n/an/a 410n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118829
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3cccs3)c2cc1OC
Show InChI InChI=1S/C19H21N5O3S/c1-26-15-10-13-14(11-16(15)27-2)20-12-21-18(13)23-5-7-24(8-6-23)19(25)22-17-4-3-9-28-17/h3-4,9-12H,5-8H2,1-2H3,(H,22,25)
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n/an/a 410n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50115298
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Br)cc3)c2cc1OC
Show InChI InChI=1S/C21H22BrN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28)
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n/an/a 530n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50370160
PNG
(CHEMBL1788249)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)N[C@@H](C)c3ccccc3)c2cc1OC |r|
Show InChI InChI=1S/C23H27N5O2S/c1-16(17-7-5-4-6-8-17)26-23(31)28-11-9-27(10-12-28)22-18-13-20(29-2)21(30-3)14-19(18)24-15-25-22/h4-8,13-16H,9-12H2,1-3H3,(H,26,31)/t16-/m0/s1
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n/an/a 540n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118837
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3cncc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C20H21ClN6O2S/c1-28-17-8-15-16(9-18(17)29-2)23-12-24-19(15)26-3-5-27(6-4-26)20(30)25-14-7-13(21)10-22-11-14/h7-12H,3-6H2,1-2H3,(H,25,30)
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n/an/a 550n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118828
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES CCCc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C25H31N5O3/c1-4-5-18-6-8-19(9-7-18)16-26-25(31)30-12-10-29(11-13-30)24-20-14-22(32-2)23(33-3)15-21(20)27-17-28-24/h6-9,14-15,17H,4-5,10-13,16H2,1-3H3,(H,26,31)
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n/an/a 550n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a 550n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118824
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccsc3)c2cc1OC
Show InChI InChI=1S/C19H21N5O3S/c1-26-16-9-14-15(10-17(16)27-2)20-12-21-18(14)23-4-6-24(7-5-23)19(25)22-13-3-8-28-11-13/h3,8-12H,4-7H2,1-2H3,(H,22,25)
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n/an/a 560n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118824
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccsc3)c2cc1OC
Show InChI InChI=1S/C19H21N5O3S/c1-26-16-9-14-15(10-17(16)27-2)20-12-21-18(14)23-4-6-24(7-5-23)19(25)22-13-3-8-28-11-13/h3,8-12H,4-7H2,1-2H3,(H,22,25)
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n/an/a 560n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118875
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-2,6-dimethyl-pip...)
Show SMILES COc1cc2ncnc(N3CC(C)N(C(C)C3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C24H29N5O2S/c1-16-13-28(14-17(2)29(16)24(32)25-12-18-8-6-5-7-9-18)23-19-10-21(30-3)22(31-4)11-20(19)26-15-27-23/h5-11,15-17H,12-14H2,1-4H3,(H,25,32)
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n/an/a 640n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118845
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-[1,4]diazepane-1...)
Show SMILES COc1cc2ncnc(N3CCCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-35-25-17-23-24(18-26(25)36-2)29-19-30-27(23)32-13-6-14-33(16-15-32)28(34)31-20-9-11-22(12-10-20)37-21-7-4-3-5-8-21/h3-5,7-12,17-19H,6,13-16H2,1-2H3,(H,31,34)
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n/an/a 650n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50115295
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC
Show InChI InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28)
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n/an/a 700n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118867
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(Br)cc3)c2cc1OC
Show InChI InChI=1S/C22H24BrN5O3/c1-30-19-11-17-18(12-20(19)31-2)25-14-26-21(17)27-7-9-28(10-8-27)22(29)24-13-15-3-5-16(23)6-4-15/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,29)
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n/an/a 740n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50115332
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C21H22ClN5O2S/c1-28-18-11-16-17(12-19(18)29-2)23-13-24-20(16)26-7-9-27(10-8-26)21(30)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,30)
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n/an/a 790n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM50118824
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccsc3)c2cc1OC
Show InChI InChI=1S/C19H21N5O3S/c1-26-16-9-14-15(10-17(16)27-2)20-12-21-18(14)23-4-6-24(7-5-23)19(25)22-13-3-8-28-11-13/h3,8-12H,4-7H2,1-2H3,(H,22,25)
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n/an/a 800n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Mast/stem cell growth factor receptor (c-kit) autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118847
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(NCc3ccc(Cl)cc3)=NC#N)c2cc1OC |w:25.27|
Show InChI InChI=1S/C23H24ClN7O2/c1-32-20-11-18-19(12-21(20)33-2)28-15-29-22(18)30-7-9-31(10-8-30)23(27-14-25)26-13-16-3-5-17(24)6-4-16/h3-6,11-12,15H,7-10,13H2,1-2H3,(H,26,27)
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n/an/a 960n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118876
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O3S/c1-34-25-16-23-24(17-26(25)35-2)30-19-31-27(23)32-12-14-33(15-13-32)28(37)29-18-20-8-10-22(11-9-20)36-21-6-4-3-5-7-21/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,29,37)
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n/an/a 960n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118872
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3Cl)c2cc1OC
Show InChI InChI=1S/C22H24ClN5O2S/c1-29-19-11-16-18(12-20(19)30-2)25-14-26-21(16)27-7-9-28(10-8-27)22(31)24-13-15-5-3-4-6-17(15)23/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,31)
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n/an/a 980n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118878
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccncc3)c2cc1OC
Show InChI InChI=1S/C20H22N6O2S/c1-27-17-11-15-16(12-18(17)28-2)22-13-23-19(15)25-7-9-26(10-8-25)20(29)24-14-3-5-21-6-4-14/h3-6,11-13H,7-10H2,1-2H3,(H,21,24,29)
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n/an/a 980n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118852
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCCc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C23H26ClN5O2S/c1-30-20-13-18-19(14-21(20)31-2)26-15-27-22(18)28-9-11-29(12-10-28)23(32)25-8-7-16-3-5-17(24)6-4-16/h3-6,13-15H,7-12H2,1-2H3,(H,25,32)
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n/an/a 1.09E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50115340
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C21H22ClN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118843
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C22H24ClN5O3/c1-30-19-11-17-18(12-20(19)31-2)25-14-26-21(17)27-7-9-28(10-8-27)22(29)24-13-15-3-5-16(23)6-4-15/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,29)
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n/an/a 1.27E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118841
PNG
((4-isopropyl-benzyl)-methylene-cyanamide-[4-(6,7-d...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(NCc3ccc(cc3)C(C)C)=NC#N)c2cc1OC |w:27.29|
Show InChI InChI=1S/C26H31N7O2/c1-18(2)20-7-5-19(6-8-20)15-28-26(29-16-27)33-11-9-32(10-12-33)25-21-13-23(34-3)24(35-4)14-22(21)30-17-31-25/h5-8,13-14,17-18H,9-12,15H2,1-4H3,(H,28,29)
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n/an/a 1.38E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118877
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O5/c1-30-19-10-16-17(11-20(19)31-2)25-13-26-22(16)27-5-7-28(8-6-27)23(29)24-12-15-3-4-18-21(9-15)33-14-32-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,29)
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n/an/a 1.87E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118835
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1ccc(CNC(=S)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1OC
Show InChI InChI=1S/C24H29N5O4S/c1-30-19-6-5-16(11-20(19)31-2)14-25-24(34)29-9-7-28(8-10-29)23-17-12-21(32-3)22(33-4)13-18(17)26-15-27-23/h5-6,11-13,15H,7-10,14H2,1-4H3,(H,25,34)
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n/an/a 2.41E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118863
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(C)cc3)c2cc1OC
Show InChI InChI=1S/C23H27N5O3/c1-16-4-6-17(7-5-16)14-24-23(29)28-10-8-27(9-11-28)22-18-12-20(30-2)21(31-3)13-19(18)25-15-26-22/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,24,29)
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n/an/a 2.94E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118855
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1ccc(CNC(=O)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)cc1
Show InChI InChI=1S/C23H27N5O4/c1-30-17-6-4-16(5-7-17)14-24-23(29)28-10-8-27(9-11-28)22-18-12-20(31-2)21(32-3)13-19(18)25-15-26-22/h4-7,12-13,15H,8-11,14H2,1-3H3,(H,24,29)
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n/an/a 3.06E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118825
PNG
(2-{(4-Chloro-benzylamino)-[4-(6,7-dimethoxy-quinaz...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=NCc3ccc(Cl)cc3)C(C#N)C#N)c2cc1OC |w:16.17|
Show InChI InChI=1S/C25H24ClN7O2/c1-34-22-11-20-21(12-23(22)35-2)30-16-31-25(20)33-9-7-32(8-10-33)24(18(13-27)14-28)29-15-17-3-5-19(26)6-4-17/h3-6,11-12,16,18H,7-10,15H2,1-2H3
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n/an/a 5.24E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118860
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCCc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C23H26ClN5O3/c1-31-20-13-18-19(14-21(20)32-2)26-15-27-22(18)28-9-11-29(12-10-28)23(30)25-8-7-16-3-5-17(24)6-4-16/h3-6,13-15H,7-12H2,1-2H3,(H,25,30)
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n/an/a 5.84E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50118824
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccsc3)c2cc1OC
Show InChI InChI=1S/C19H21N5O3S/c1-26-16-9-14-15(10-17(16)27-2)20-12-21-18(14)23-4-6-24(7-5-23)19(25)22-13-3-8-28-11-13/h3,8-12H,4-7H2,1-2H3,(H,22,25)
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n/an/a 7.02E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Flt3 autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118836
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3cncc(Cl)c3)c2cc1OC
Show InChI InChI=1S/C20H21ClN6O3/c1-29-17-8-15-16(9-18(17)30-2)23-12-24-19(15)26-3-5-27(6-4-26)20(28)25-14-7-13(21)10-22-11-14/h7-12H,3-6H2,1-2H3,(H,25,28)
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n/an/a 8.23E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118871
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccc(F)cc3)c2cc1OC
Show InChI InChI=1S/C22H24FN5O3/c1-30-19-11-17-18(12-20(19)31-2)25-14-26-21(17)27-7-9-28(10-8-27)22(29)24-13-15-3-5-16(23)6-4-15/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,24,29)
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n/an/a 9.59E+3n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118873
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCC3CCCCC3)c2cc1OC
Show InChI InChI=1S/C22H31N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h12-13,15-16H,3-11,14H2,1-2H3,(H,23,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118850
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccccn3)c2cc1OC
Show InChI InChI=1S/C20H22N6O3/c1-28-16-11-14-15(12-17(16)29-2)22-13-23-19(14)25-7-9-26(10-8-25)20(27)24-18-5-3-4-6-21-18/h3-6,11-13H,7-10H2,1-2H3,(H,21,24,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118827
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccncc3)c2cc1OC
Show InChI InChI=1S/C20H22N6O3/c1-28-17-11-15-16(12-18(17)29-2)22-13-23-19(15)25-7-9-26(10-8-25)20(27)24-14-3-5-21-6-4-14/h3-6,11-13H,7-10H2,1-2H3,(H,21,24,27)
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n/an/a 1.41E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a 1.49E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Flt3 autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a 1.73E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118870
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCCc3cccnc3)c2cc1OC
Show InChI InChI=1S/C22H26N6O2S/c1-29-19-12-17-18(13-20(19)30-2)25-15-26-21(17)27-8-10-28(11-9-27)22(31)24-7-5-16-4-3-6-23-14-16/h3-4,6,12-15H,5,7-11H2,1-2H3,(H,24,31)
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n/an/a 2.01E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118868
PNG
((3-Chloro-benzyl)-methylene-cyanamide-[4-(6,7-dime...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(NCc3cccc(Cl)c3)=NC#N)c2cc1OC |w:25.27|
Show InChI InChI=1S/C23H24ClN7O2/c1-32-20-11-18-19(12-21(20)33-2)28-15-29-22(18)30-6-8-31(9-7-30)23(27-14-25)26-13-16-4-3-5-17(24)10-16/h3-5,10-12,15H,6-9,13H2,1-2H3,(H,26,27)
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n/an/a 2.35E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Src protein tryrosine kinase

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50370161
PNG
(CHEMBL1744060)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)N[C@H](C)c3ccccc3)c2cc1OC |r|
Show InChI InChI=1S/C23H27N5O2S/c1-16(17-7-5-4-6-8-17)26-23(31)28-11-9-27(10-12-28)22-18-13-20(29-2)21(30-3)14-19(18)24-15-25-22/h4-8,13-16H,9-12H2,1-3H3,(H,26,31)/t16-/m1/s1
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118883
PNG
(4-Chloro-N-[4-(6,7-dimethoxy-quinazolin-4-yl)-pipe...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NS(=O)(=O)c3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C21H22ClN5O5S/c1-31-18-11-16-17(12-19(18)32-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-33(29,30)15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 3


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Mitogen activated protein kinase kinase 3

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118842
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCC3CCCO3)c2cc1OC
Show InChI InChI=1S/C20H27N5O3S/c1-26-17-10-15-16(11-18(17)27-2)22-13-23-19(15)24-5-7-25(8-6-24)20(29)21-12-14-4-3-9-28-14/h10-11,13-14H,3-9,12H2,1-2H3,(H,21,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Tyrosine-protein kinase ABL1/ABL2


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Abl tyrosine kinase

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Jun N-terminal kinase (Jnk)

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118839
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)N(C)Cc3ccccc3)c2cc1OC
Show InChI InChI=1S/C23H27N5O2S/c1-26(15-17-7-5-4-6-8-17)23(31)28-11-9-27(10-12-28)22-18-13-20(29-2)21(30-3)14-19(18)24-16-25-22/h4-8,13-14,16H,9-12,15H2,1-3H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Mitogen activated protein kinase kinase 1

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118862
PNG
(Benzo[1,3]dioxol-5-ylmethyl-{1-[4-(6,7-dimethoxy-q...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(C[N+]([O-])=O)=NCc3ccc4OCOc4c3)c2cc1OC |w:20.21|
Show InChI InChI=1S/C24H26N6O6/c1-33-20-10-17-18(11-21(20)34-2)26-14-27-24(17)29-7-5-28(6-8-29)23(13-30(31)32)25-12-16-3-4-19-22(9-16)36-15-35-19/h3-4,9-11,14H,5-8,12-13,15H2,1-2H3
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n/an/a>3.00E+4n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 6


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Mitogen activated protein kinase kinase 6

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118851
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Oc3ccc(cc3)[N+]([O-])=O)c2cc1OC
Show InChI InChI=1S/C21H21N5O6/c1-30-18-11-16-17(12-19(18)31-2)22-13-23-20(16)24-7-9-25(10-8-24)21(27)32-15-5-3-14(4-6-15)26(28)29/h3-6,11-13H,7-10H2,1-2H3
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118865
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3cccnc3)c2cc1OC
Show InChI InChI=1S/C20H22N6O3/c1-28-17-10-15-16(11-18(17)29-2)22-13-23-19(15)25-6-8-26(9-7-25)20(27)24-14-4-3-5-21-12-14/h3-5,10-13H,6-9H2,1-2H3,(H,24,27)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118830
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)Nc3ccccn3)c2cc1OC
Show InChI InChI=1S/C20H22N6O2S/c1-27-16-11-14-15(12-17(16)28-2)22-13-23-19(14)25-7-9-26(10-8-25)20(29)24-18-5-3-4-6-21-18/h3-6,11-13H,7-10H2,1-2H3,(H,21,24,29)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Mitogen-activated protein kinase 8


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of c-Jun N-terminal kinase (Jnk)

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118882
PNG
(4-Chloro-N-[4-(6,7-dimethoxy-quinazolin-4-yl)-pipe...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NC(=O)c3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C22H22ClN5O3S/c1-30-18-11-16-17(12-19(18)31-2)24-13-25-20(16)27-7-9-28(10-8-27)22(32)26-21(29)14-3-5-15(23)6-4-14/h3-6,11-13H,7-10H2,1-2H3,(H,26,29,32)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118864
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)N(C)c3ccc(Br)cc3)c2cc1OC
Show InChI InChI=1S/C22H24BrN5O3/c1-26(16-6-4-15(23)5-7-16)22(29)28-10-8-27(9-11-28)21-17-12-19(30-2)20(31-3)13-18(17)24-14-25-21/h4-7,12-14H,8-11H2,1-3H3
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118866
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-2,5-dimethyl-pip...)
Show SMILES COc1cc2ncnc(N3CC(C)N(CC3C)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C29H31N5O4/c1-19-17-34(29(35)32-21-10-12-23(13-11-21)38-22-8-6-5-7-9-22)20(2)16-33(19)28-24-14-26(36-3)27(37-4)15-25(24)30-18-31-28/h5-15,18-20H,16-17H2,1-4H3,(H,32,35)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118844
PNG
((2-Chloro-benzyl)-methylene-cyanamide-[4-(6,7-dime...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(NCc3ccccc3Cl)=NC#N)c2cc1OC |w:25.27|
Show InChI InChI=1S/C23H24ClN7O2/c1-32-20-11-17-19(12-21(20)33-2)28-15-29-22(17)30-7-9-31(10-8-30)23(27-14-25)26-13-16-5-3-4-6-18(16)24/h3-6,11-12,15H,7-10,13H2,1-2H3,(H,26,27)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Colony stimulating factor 1 receptor (CSF-1R) autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 6


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Mitogen activated protein kinase kinase 6

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118832
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCC3(CC3)c3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C25H28ClN5O2S/c1-32-21-13-19-20(14-22(21)33-2)28-16-29-23(19)30-9-11-31(12-10-30)24(34)27-15-25(7-8-25)17-3-5-18(26)6-4-17/h3-6,13-14,16H,7-12,15H2,1-2H3,(H,27,34)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Src protein tryrosine kinase

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor alpha/beta


(Homo sapiens (Human))		BDBM50118838
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)NCc3ccsc3)c2cc1OC
Show InChI InChI=1S/C20H23N5O3S/c1-27-17-9-15-16(10-18(17)28-2)22-13-23-19(15)24-4-6-25(7-5-24)20(26)21-11-14-3-8-29-12-14/h3,8-10,12-13H,4-7,11H2,1-2H3,(H,21,26)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Concentration required for 50% inhibition against autophosphorylation of Platelet-derived growth factor receptor beta in intact cells using a two sit...

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Mitogen activated protein kinase kinase 1

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Colony stimulating factor 1 receptor (CSF-1R) autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Flt3 autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50118824
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccsc3)c2cc1OC
Show InChI InChI=1S/C19H21N5O3S/c1-26-16-9-14-15(10-17(16)27-2)20-12-21-18(14)23-4-6-24(7-5-23)19(25)22-13-3-8-28-11-13/h3,8-12H,4-7H2,1-2H3,(H,22,25)
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Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Epidermal growth factor receptor autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a>1.00E+5n/an/an/an/an/an/a



Kyowa Hakko Kogyo Co., Ltd.

Curated by ChEMBL


Assay Description
Inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) autophosphorylation

J Med Chem 45: 4513-23 (2002)


BindingDB Entry DOI: 10.7270/Q2JH3MXF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%