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PubMed code 12372523

Compile data set for download or QSAR
Found 134 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120157
PNG
(C-[(R)-C-((R)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@@H]([C@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m1/s1
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14n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120162
PNG
(C-((R)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3-fluoro-p...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1cccc(F)c1
Show InChI InChI=1S/C21H26ClFN2/c1-2-3-10-19(15-6-5-9-18(23)14-15)25-12-11-20(25)21(24)16-7-4-8-17(22)13-16/h4-9,13-14,19-21H,2-3,10-12,24H2,1H3/t19?,20-,21+/m0/s1
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26n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120151
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-pent...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H27ClN2/c1-2-3-12-19(16-8-5-4-6-9-16)24-14-13-20(24)21(23)17-10-7-11-18(22)15-17/h4-11,15,19-21H,2-3,12-14,23H2,1H3/t19?,20-,21+/m0/s1
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30n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120147
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m0/s1
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31n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120140
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hexy...)
Show SMILES CCCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2/c1-2-3-5-13-20(17-9-6-4-7-10-17)25-15-14-21(25)22(24)18-11-8-12-19(23)16-18/h4,6-12,16,20-22H,2-3,5,13-15,24H2,1H3/t20?,21-,22+/m0/s1
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34n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120156
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-chl...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23ClN2/c24-20-13-7-12-19(16-20)22(25)21-14-15-26(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,25H2/t21-,22-/m0/s1
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37n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120137
PNG
(C-((R)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluo...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H25ClF2N2/c1-2-3-7-19(15-11-17(23)13-18(24)12-15)26-9-8-20(26)21(25)14-5-4-6-16(22)10-14/h4-6,10-13,19-21H,2-3,7-9,25H2,1H3/t19?,20-,21+/m0/s1
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49n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120167
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-flu...)
Show SMILES Cc1ccc(cc1F)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25FN2/c1-17-12-13-20(16-21(17)25)23(26)22-14-15-27(22)24(18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-13,16,22-24H,14-15,26H2,1H3/t22-,23-/m0/s1
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58n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120166
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-fluoro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(F)c1)c1cccc(F)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClF2N2/c24-18-7-1-4-15(12-18)22(27)21-10-11-28(21)23(16-5-2-8-19(25)13-16)17-6-3-9-20(26)14-17/h1-9,12-14,21-23H,10-11,27H2/t21-,22+/m0/s1
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64n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120145
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-buty...)
Show SMILES CCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H25ClN2/c1-2-7-18(15-8-4-3-5-9-15)23-13-12-19(23)20(22)16-10-6-11-17(21)14-16/h3-6,8-11,14,18-20H,2,7,12-13,22H2,1H3/t18?,19-,20+/m0/s1
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79n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120139
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-prop...)
Show SMILES CCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C19H23ClN2/c1-2-17(14-7-4-3-5-8-14)22-12-11-18(22)19(21)15-9-6-10-16(20)13-15/h3-10,13,17-19H,2,11-12,21H2,1H3/t17?,18-,19+/m0/s1
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94n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120149
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-p-toly...)
Show SMILES Cc1ccc(cc1)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2/c1-18-12-14-19(15-13-18)23(25)22-16-17-26(22)24(20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2-15,22-24H,16-17,25H2,1H3/t22-,23-/m0/s1
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94n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120155
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3,5-d...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C23H22F2N2/c24-19-13-18(14-20(25)15-19)22(26)21-11-12-27(21)23(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,13-15,21-23H,11-12,26H2/t21-,22-/m0/s1
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105n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120167
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-flu...)
Show SMILES Cc1ccc(cc1F)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25FN2/c1-17-12-13-20(16-21(17)25)23(26)22-14-15-27(22)24(18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-13,16,22-24H,14-15,26H2,1H3/t22-,23-/m0/s1
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150n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120161
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-chl...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN2/c24-20-13-11-17(12-14-20)22(25)21-15-16-26(21)23(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-23H,15-16,25H2/t21-,22-/m0/s1
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152n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120167
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-flu...)
Show SMILES Cc1ccc(cc1F)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25FN2/c1-17-12-13-20(16-21(17)25)23(26)22-14-15-27(22)24(18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-13,16,22-24H,14-15,26H2,1H3/t22-,23-/m0/s1
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152n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120138
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hept...)
Show SMILES CCCCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C23H31ClN2/c1-2-3-4-8-14-21(18-10-6-5-7-11-18)26-16-15-22(26)23(25)19-12-9-13-20(24)17-19/h5-7,9-13,17,21-23H,2-4,8,14-16,25H2,1H3/t21?,22-,23+/m0/s1
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185n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120150
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-flu...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(F)c1
Show InChI InChI=1S/C23H23FN2/c24-20-13-7-12-19(16-20)22(25)21-14-15-26(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,25H2/t21-,22-/m0/s1
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191n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120165
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-met...)
Show SMILES COc1ccc(cc1)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2O/c1-27-21-14-12-18(13-15-21)23(25)22-16-17-26(22)24(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22-24H,16-17,25H2,1H3/t22-,23-/m0/s1
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198n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120147
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m0/s1
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236n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120148
PNG
(C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluo...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H25ClF2N2/c1-2-3-7-19(15-11-17(23)13-18(24)12-15)26-9-8-20(26)21(25)14-5-4-6-16(22)10-14/h4-6,10-13,19-21H,2-3,7-9,25H2,1H3/t19?,20-,21-/m0/s1
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347n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120146
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-buty...)
Show SMILES CCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H25ClN2/c1-2-7-18(15-8-4-3-5-9-15)23-13-12-19(23)20(22)16-10-6-11-17(21)14-16/h3-6,8-11,14,18-20H,2,7,12-13,22H2,1H3/t18?,19-,20-/m0/s1
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367n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120154
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-chloro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(Cl)c1)c1cccc(Cl)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Cl3N2/c24-18-7-1-4-15(12-18)22(27)21-10-11-28(21)23(16-5-2-8-19(25)13-16)17-6-3-9-20(26)14-17/h1-9,12-14,21-23H,10-11,27H2/t21-,22+/m0/s1
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420n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120149
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-p-toly...)
Show SMILES Cc1ccc(cc1)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2/c1-18-12-14-19(15-13-18)23(25)22-16-17-26(22)24(20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2-15,22-24H,16-17,25H2,1H3/t22-,23-/m0/s1
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488n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120157
PNG
(C-[(R)-C-((R)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@@H]([C@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m1/s1
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516n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120164
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-prop...)
Show SMILES CCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C19H23ClN2/c1-2-17(14-7-4-3-5-8-14)22-12-11-18(22)19(21)15-9-6-10-16(20)13-15/h3-10,13,17-19H,2,11-12,21H2,1H3/t17?,18-,19-/m0/s1
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570n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120161
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-chl...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN2/c24-20-13-11-17(12-14-20)22(25)21-15-16-26(21)23(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-23H,15-16,25H2/t21-,22-/m0/s1
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586n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120161
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-chl...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN2/c24-20-13-11-17(12-14-20)22(25)21-15-16-26(21)23(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-23H,15-16,25H2/t21-,22-/m0/s1
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607n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120167
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-flu...)
Show SMILES Cc1ccc(cc1F)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H25FN2/c1-17-12-13-20(16-21(17)25)23(26)22-14-15-27(22)24(18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-13,16,22-24H,14-15,26H2,1H3/t22-,23-/m0/s1
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634n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120157
PNG
(C-[(R)-C-((R)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@@H]([C@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m1/s1
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641n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120149
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-p-toly...)
Show SMILES Cc1ccc(cc1)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2/c1-18-12-14-19(15-13-18)23(25)22-16-17-26(22)24(20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2-15,22-24H,16-17,25H2,1H3/t22-,23-/m0/s1
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660n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120153
PNG
(C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3-fluoro-p...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cccc(F)c1
Show InChI InChI=1S/C21H26ClFN2/c1-2-3-10-19(15-6-5-9-18(23)14-15)25-12-11-20(25)21(24)16-7-4-8-17(22)13-16/h4-9,13-14,19-21H,2-3,10-12,24H2,1H3/t19?,20-,21-/m0/s1
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680n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120143
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-fluoro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(F)cc1)c1ccc(F)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClF2N2/c24-18-3-1-2-17(14-18)22(27)21-12-13-28(21)23(15-4-8-19(25)9-5-15)16-6-10-20(26)11-7-16/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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684n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120168
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-pent...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H27ClN2/c1-2-3-12-19(16-8-5-4-6-9-16)24-14-13-20(24)21(23)17-10-7-11-18(22)15-17/h4-11,15,19-21H,2-3,12-14,23H2,1H3/t19?,20-,21-/m0/s1
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745n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120144
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hexy...)
Show SMILES CCCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2/c1-2-3-5-13-20(17-9-6-4-7-10-17)25-15-14-21(25)22(24)18-11-8-12-19(23)16-18/h4,6-12,16,20-22H,2-3,5,13-15,24H2,1H3/t20?,21-,22-/m0/s1
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772n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120158
PNG
(C-[(R)-C-(3-Chloro-phenyl)-C-((S)-1-di-p-tolylmeth...)
Show SMILES Cc1ccc(cc1)C(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccc(C)cc1
Show InChI InChI=1S/C25H27ClN2/c1-17-6-10-19(11-7-17)25(20-12-8-18(2)9-13-20)28-15-14-23(28)24(27)21-4-3-5-22(26)16-21/h3-13,16,23-25H,14-15,27H2,1-2H3/t23-,24+/m0/s1
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801n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120165
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-met...)
Show SMILES COc1ccc(cc1)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2O/c1-27-21-14-12-18(13-15-21)23(25)22-16-17-26(22)24(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22-24H,16-17,25H2,1H3/t22-,23-/m0/s1
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865n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120150
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-flu...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(F)c1
Show InChI InChI=1S/C23H23FN2/c24-20-13-7-12-19(16-20)22(25)21-14-15-26(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,25H2/t21-,22-/m0/s1
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997n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120163
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hept...)
Show SMILES CCCCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C23H31ClN2/c1-2-3-4-8-14-21(18-10-6-5-7-11-18)26-16-15-22(26)23(25)19-12-9-13-20(24)17-19/h5-7,9-13,17,21-23H,2-4,8,14-16,25H2,1H3/t21?,22-,23-/m0/s1
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1.02E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120160
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-ethy...)
Show SMILES CC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C18H21ClN2/c1-13(14-6-3-2-4-7-14)21-11-10-17(21)18(20)15-8-5-9-16(19)12-15/h2-9,12-13,17-18H,10-11,20H2,1H3/t13?,17-,18-/m0/s1
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1.06E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120158
PNG
(C-[(R)-C-(3-Chloro-phenyl)-C-((S)-1-di-p-tolylmeth...)
Show SMILES Cc1ccc(cc1)C(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccc(C)cc1
Show InChI InChI=1S/C25H27ClN2/c1-17-6-10-19(11-7-17)25(20-12-8-18(2)9-13-20)28-15-14-23(28)24(27)21-4-3-5-22(26)16-21/h3-13,16,23-25H,14-15,27H2,1-2H3/t23-,24+/m0/s1
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1.14E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120156
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-chl...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23ClN2/c24-20-13-7-12-19(16-20)22(25)21-14-15-26(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,25H2/t21-,22-/m0/s1
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1.23E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120165
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-met...)
Show SMILES COc1ccc(cc1)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2O/c1-27-21-14-12-18(13-15-21)23(25)22-16-17-26(22)24(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22-24H,16-17,25H2,1H3/t22-,23-/m0/s1
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1.34E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120141
PNG
(C-[(S)-C-[(S)-1-(1-Butyl-pentyl)-azetidin-2-yl]-C-...)
Show SMILES CCCCC(CCCC)N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1
Show InChI InChI=1S/C19H31ClN2/c1-3-5-10-17(11-6-4-2)22-13-12-18(22)19(21)15-8-7-9-16(20)14-15/h7-9,14,17-19H,3-6,10-13,21H2,1-2H3/t18-,19-/m0/s1
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1.35E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120161
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-chl...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1ccc(Cl)cc1
Show InChI InChI=1S/C23H23ClN2/c24-20-13-11-17(12-14-20)22(25)21-15-16-26(21)23(18-7-3-1-4-8-18)19-9-5-2-6-10-19/h1-14,21-23H,15-16,25H2/t21-,22-/m0/s1
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1.44E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120152
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-bromo-phenyl)-methyl]-azet...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(Br)cc1)c1ccc(Br)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Br2ClN2/c24-18-8-4-15(5-9-18)23(16-6-10-19(25)11-7-16)28-13-12-21(28)22(27)17-2-1-3-20(26)14-17/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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1.48E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120138
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hept...)
Show SMILES CCCCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C23H31ClN2/c1-2-3-4-8-14-21(18-10-6-5-7-11-18)26-16-15-22(26)23(25)19-12-9-13-20(24)17-19/h5-7,9-13,17,21-23H,2-4,8,14-16,25H2,1H3/t21?,22-,23+/m0/s1
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1.49E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120163
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hept...)
Show SMILES CCCCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C23H31ClN2/c1-2-3-4-8-14-21(18-10-6-5-7-11-18)26-16-15-22(26)23(25)19-12-9-13-20(24)17-19/h5-7,9-13,17,21-23H,2-4,8,14-16,25H2,1H3/t21?,22-,23-/m0/s1
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1.59E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120162
PNG
(C-((R)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3-fluoro-p...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1cccc(F)c1
Show InChI InChI=1S/C21H26ClFN2/c1-2-3-10-19(15-6-5-9-18(23)14-15)25-12-11-20(25)21(24)16-7-4-8-17(22)13-16/h4-9,13-14,19-21H,2-3,10-12,24H2,1H3/t19?,20-,21+/m0/s1
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1.60E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120147
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m0/s1
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1.63E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120156
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-chl...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23ClN2/c24-20-13-7-12-19(16-20)22(25)21-14-15-26(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,25H2/t21-,22-/m0/s1
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1.65E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120150
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-flu...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(F)c1
Show InChI InChI=1S/C23H23FN2/c24-20-13-7-12-19(16-20)22(25)21-14-15-26(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,25H2/t21-,22-/m0/s1
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1.77E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120151
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-pent...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H27ClN2/c1-2-3-12-19(16-8-5-4-6-9-16)24-14-13-20(24)21(23)17-10-7-11-18(22)15-17/h4-11,15,19-21H,2-3,12-14,23H2,1H3/t19?,20-,21+/m0/s1
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1.82E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120158
PNG
(C-[(R)-C-(3-Chloro-phenyl)-C-((S)-1-di-p-tolylmeth...)
Show SMILES Cc1ccc(cc1)C(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccc(C)cc1
Show InChI InChI=1S/C25H27ClN2/c1-17-6-10-19(11-7-17)25(20-12-8-18(2)9-13-20)28-15-14-23(28)24(27)21-4-3-5-22(26)16-21/h3-13,16,23-25H,14-15,27H2,1-2H3/t23-,24+/m0/s1
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1.84E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120149
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-p-toly...)
Show SMILES Cc1ccc(cc1)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2/c1-18-12-14-19(15-13-18)23(25)22-16-17-26(22)24(20-8-4-2-5-9-20)21-10-6-3-7-11-21/h2-15,22-24H,16-17,25H2,1H3/t22-,23-/m0/s1
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1.86E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120140
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hexy...)
Show SMILES CCCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2/c1-2-3-5-13-20(17-9-6-4-7-10-17)25-15-14-21(25)22(24)18-11-8-12-19(23)16-18/h4,6-12,16,20-22H,2-3,5,13-15,24H2,1H3/t20?,21-,22+/m0/s1
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1.94E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120163
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hept...)
Show SMILES CCCCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C23H31ClN2/c1-2-3-4-8-14-21(18-10-6-5-7-11-18)26-16-15-22(26)23(25)19-12-9-13-20(24)17-19/h5-7,9-13,17,21-23H,2-4,8,14-16,25H2,1H3/t21?,22-,23-/m0/s1
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1.95E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120147
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m0/s1
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1.97E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL




Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120162
PNG
(C-((R)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3-fluoro-p...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1cccc(F)c1
Show InChI InChI=1S/C21H26ClFN2/c1-2-3-10-19(15-6-5-9-18(23)14-15)25-12-11-20(25)21(24)16-7-4-8-17(22)13-16/h4-9,13-14,19-21H,2-3,10-12,24H2,1H3/t19?,20-,21+/m0/s1
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2.13E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120144
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hexy...)
Show SMILES CCCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2/c1-2-3-5-13-20(17-9-6-4-7-10-17)25-15-14-21(25)22(24)18-11-8-12-19(23)16-18/h4,6-12,16,20-22H,2-3,5,13-15,24H2,1H3/t20?,21-,22-/m0/s1
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2.15E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120143
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-fluoro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(F)cc1)c1ccc(F)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClF2N2/c24-18-3-1-2-17(14-18)22(27)21-12-13-28(21)23(15-4-8-19(25)9-5-15)16-6-10-20(26)11-7-16/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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2.18E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120143
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-fluoro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(F)cc1)c1ccc(F)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClF2N2/c24-18-3-1-2-17(14-18)22(27)21-12-13-28(21)23(15-4-8-19(25)9-5-15)16-6-10-20(26)11-7-16/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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2.24E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120168
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-pent...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H27ClN2/c1-2-3-12-19(16-8-5-4-6-9-16)24-14-13-20(24)21(23)17-10-7-11-18(22)15-17/h4-11,15,19-21H,2-3,12-14,23H2,1H3/t19?,20-,21-/m0/s1
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2.25E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120152
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-bromo-phenyl)-methyl]-azet...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(Br)cc1)c1ccc(Br)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Br2ClN2/c24-18-8-4-15(5-9-18)23(16-6-10-19(25)11-7-16)28-13-12-21(28)22(27)17-2-1-3-20(26)14-17/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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2.50E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120152
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-bromo-phenyl)-methyl]-azet...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(Br)cc1)c1ccc(Br)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Br2ClN2/c24-18-8-4-15(5-9-18)23(16-6-10-19(25)11-7-16)28-13-12-21(28)22(27)17-2-1-3-20(26)14-17/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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2.53E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120169
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-trifluoromethyl-phenyl)-me...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(c1)C(F)(F)F)c1cccc(c1)C(F)(F)F)c1cccc(Cl)c1
Show InChI InChI=1S/C25H21ClF6N2/c26-20-9-3-4-15(14-20)22(33)21-10-11-34(21)23(16-5-1-7-18(12-16)24(27,28)29)17-6-2-8-19(13-17)25(30,31)32/h1-9,12-14,21-23H,10-11,33H2/t21-,22+/m0/s1
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2.59E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120154
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-chloro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(Cl)c1)c1cccc(Cl)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Cl3N2/c24-18-7-1-4-15(12-18)22(27)21-10-11-28(21)23(16-5-2-8-19(25)13-16)17-6-3-9-20(26)14-17/h1-9,12-14,21-23H,10-11,27H2/t21-,22+/m0/s1
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2.71E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120142
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-phe...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N2O/c30-28(22-16-18-26(19-17-22)32-25-14-8-3-9-15-25)27-20-21-31(27)29(23-10-4-1-5-11-23)24-12-6-2-7-13-24/h1-19,27-29H,20-21,30H2/t27-,28-/m0/s1
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2.77E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120138
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hept...)
Show SMILES CCCCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C23H31ClN2/c1-2-3-4-8-14-21(18-10-6-5-7-11-18)26-16-15-22(26)23(25)19-12-9-13-20(24)17-19/h5-7,9-13,17,21-23H,2-4,8,14-16,25H2,1H3/t21?,22-,23+/m0/s1
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2.86E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120165
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-met...)
Show SMILES COc1ccc(cc1)[C@H](N)[C@@H]1CCN1C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C24H26N2O/c1-27-21-14-12-18(13-15-21)23(25)22-16-17-26(22)24(19-8-4-2-5-9-19)20-10-6-3-7-11-20/h2-15,22-24H,16-17,25H2,1H3/t22-,23-/m0/s1
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2.92E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120150
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-flu...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(F)c1
Show InChI InChI=1S/C23H23FN2/c24-20-13-7-12-19(16-20)22(25)21-14-15-26(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,25H2/t21-,22-/m0/s1
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2.92E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120146
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-buty...)
Show SMILES CCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H25ClN2/c1-2-7-18(15-8-4-3-5-9-15)23-13-12-19(23)20(22)16-10-6-11-17(21)14-16/h3-6,8-11,14,18-20H,2,7,12-13,22H2,1H3/t18?,19-,20-/m0/s1
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2.94E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120140
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hexy...)
Show SMILES CCCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2/c1-2-3-5-13-20(17-9-6-4-7-10-17)25-15-14-21(25)22(24)18-11-8-12-19(23)16-18/h4,6-12,16,20-22H,2-3,5,13-15,24H2,1H3/t20?,21-,22+/m0/s1
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2.99E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120159
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-chloro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Cl3N2/c24-18-8-4-15(5-9-18)23(16-6-10-19(25)11-7-16)28-13-12-21(28)22(27)17-2-1-3-20(26)14-17/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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3.22E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120159
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-chloro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Cl3N2/c24-18-8-4-15(5-9-18)23(16-6-10-19(25)11-7-16)28-13-12-21(28)22(27)17-2-1-3-20(26)14-17/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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3.25E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120157
PNG
(C-[(R)-C-((R)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@@H]([C@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m1/s1
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3.31E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120151
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-pent...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H27ClN2/c1-2-3-12-19(16-8-5-4-6-9-16)24-14-13-20(24)21(23)17-10-7-11-18(22)15-17/h4-11,15,19-21H,2-3,12-14,23H2,1H3/t19?,20-,21+/m0/s1
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3.43E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120159
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-chloro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Cl3N2/c24-18-8-4-15(5-9-18)23(16-6-10-19(25)11-7-16)28-13-12-21(28)22(27)17-2-1-3-20(26)14-17/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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3.45E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120166
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-fluoro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(F)c1)c1cccc(F)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClF2N2/c24-18-7-1-4-15(12-18)22(27)21-10-11-28(21)23(16-5-2-8-19(25)13-16)17-6-3-9-20(26)14-17/h1-9,12-14,21-23H,10-11,27H2/t21-,22+/m0/s1
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3.53E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120147
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m0/s1
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3.57E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL




Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120168
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-pent...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H27ClN2/c1-2-3-12-19(16-8-5-4-6-9-16)24-14-13-20(24)21(23)17-10-7-11-18(22)15-17/h4-11,15,19-21H,2-3,12-14,23H2,1H3/t19?,20-,21-/m0/s1
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3.68E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120144
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hexy...)
Show SMILES CCCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2/c1-2-3-5-13-20(17-9-6-4-7-10-17)25-15-14-21(25)22(24)18-11-8-12-19(23)16-18/h4,6-12,16,20-22H,2-3,5,13-15,24H2,1H3/t20?,21-,22-/m0/s1
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3.91E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120138
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hept...)
Show SMILES CCCCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C23H31ClN2/c1-2-3-4-8-14-21(18-10-6-5-7-11-18)26-16-15-22(26)23(25)19-12-9-13-20(24)17-19/h5-7,9-13,17,21-23H,2-4,8,14-16,25H2,1H3/t21?,22-,23+/m0/s1
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3.91E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human Opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120137
PNG
(C-((R)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluo...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H25ClF2N2/c1-2-3-7-19(15-11-17(23)13-18(24)12-15)26-9-8-20(26)21(25)14-5-4-6-16(22)10-14/h4-6,10-13,19-21H,2-3,7-9,25H2,1H3/t19?,20-,21+/m0/s1
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3.98E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120155
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3,5-d...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C23H22F2N2/c24-19-13-18(14-20(25)15-19)22(26)21-11-12-27(21)23(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,13-15,21-23H,11-12,26H2/t21-,22-/m0/s1
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4.02E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120160
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-ethy...)
Show SMILES CC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C18H21ClN2/c1-13(14-6-3-2-4-7-14)21-11-10-17(21)18(20)15-8-5-9-16(19)12-15/h2-9,12-13,17-18H,10-11,20H2,1H3/t13?,17-,18-/m0/s1
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4.10E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120153
PNG
(C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3-fluoro-p...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cccc(F)c1
Show InChI InChI=1S/C21H26ClFN2/c1-2-3-10-19(15-6-5-9-18(23)14-15)25-12-11-20(25)21(24)16-7-4-8-17(22)13-16/h4-9,13-14,19-21H,2-3,10-12,24H2,1H3/t19?,20-,21-/m0/s1
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4.13E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120146
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-buty...)
Show SMILES CCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H25ClN2/c1-2-7-18(15-8-4-3-5-9-15)23-13-12-19(23)20(22)16-10-6-11-17(21)14-16/h3-6,8-11,14,18-20H,2,7,12-13,22H2,1H3/t18?,19-,20-/m0/s1
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4.13E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120137
PNG
(C-((R)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluo...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H25ClF2N2/c1-2-3-7-19(15-11-17(23)13-18(24)12-15)26-9-8-20(26)21(25)14-5-4-6-16(22)10-14/h4-6,10-13,19-21H,2-3,7-9,25H2,1H3/t19?,20-,21+/m0/s1
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4.22E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120155
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3,5-d...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C23H22F2N2/c24-19-13-18(14-20(25)15-19)22(26)21-11-12-27(21)23(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,13-15,21-23H,11-12,26H2/t21-,22-/m0/s1
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4.25E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120141
PNG
(C-[(S)-C-[(S)-1-(1-Butyl-pentyl)-azetidin-2-yl]-C-...)
Show SMILES CCCCC(CCCC)N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1
Show InChI InChI=1S/C19H31ClN2/c1-3-5-10-17(11-6-4-2)22-13-12-18(22)19(21)15-8-7-9-16(20)14-15/h7-9,14,17-19H,3-6,10-13,21H2,1-2H3/t18-,19-/m0/s1
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4.26E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120166
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-fluoro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(F)c1)c1cccc(F)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClF2N2/c24-18-7-1-4-15(12-18)22(27)21-10-11-28(21)23(16-5-2-8-19(25)13-16)17-6-3-9-20(26)14-17/h1-9,12-14,21-23H,10-11,27H2/t21-,22+/m0/s1
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4.32E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120153
PNG
(C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3-fluoro-p...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cccc(F)c1
Show InChI InChI=1S/C21H26ClFN2/c1-2-3-10-19(15-6-5-9-18(23)14-15)25-12-11-20(25)21(24)16-7-4-8-17(22)13-16/h4-9,13-14,19-21H,2-3,10-12,24H2,1H3/t19?,20-,21-/m0/s1
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4.71E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120166
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-fluoro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(F)c1)c1cccc(F)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClF2N2/c24-18-7-1-4-15(12-18)22(27)21-10-11-28(21)23(16-5-2-8-19(25)13-16)17-6-3-9-20(26)14-17/h1-9,12-14,21-23H,10-11,27H2/t21-,22+/m0/s1
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4.79E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120163
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hept...)
Show SMILES CCCCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C23H31ClN2/c1-2-3-4-8-14-21(18-10-6-5-7-11-18)26-16-15-22(26)23(25)19-12-9-13-20(24)17-19/h5-7,9-13,17,21-23H,2-4,8,14-16,25H2,1H3/t21?,22-,23-/m0/s1
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4.98E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120152
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-bromo-phenyl)-methyl]-azet...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(Br)cc1)c1ccc(Br)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Br2ClN2/c24-18-8-4-15(5-9-18)23(16-6-10-19(25)11-7-16)28-13-12-21(28)22(27)17-2-1-3-20(26)14-17/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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4.99E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120158
PNG
(C-[(R)-C-(3-Chloro-phenyl)-C-((S)-1-di-p-tolylmeth...)
Show SMILES Cc1ccc(cc1)C(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccc(C)cc1
Show InChI InChI=1S/C25H27ClN2/c1-17-6-10-19(11-7-17)25(20-12-8-18(2)9-13-20)28-15-14-23(28)24(27)21-4-3-5-22(26)16-21/h3-13,16,23-25H,14-15,27H2,1-2H3/t23-,24+/m0/s1
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5.01E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120159
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-chloro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(Cl)cc1)c1ccc(Cl)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Cl3N2/c24-18-8-4-15(5-9-18)23(16-6-10-19(25)11-7-16)28-13-12-21(28)22(27)17-2-1-3-20(26)14-17/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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5.01E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120142
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-phe...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N2O/c30-28(22-16-18-26(19-17-22)32-25-14-8-3-9-15-25)27-20-21-31(27)29(23-10-4-1-5-11-23)24-12-6-2-7-13-24/h1-19,27-29H,20-21,30H2/t27-,28-/m0/s1
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5.40E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120148
PNG
(C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluo...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H25ClF2N2/c1-2-3-7-19(15-11-17(23)13-18(24)12-15)26-9-8-20(26)21(25)14-5-4-6-16(22)10-14/h4-6,10-13,19-21H,2-3,7-9,25H2,1H3/t19?,20-,21-/m0/s1
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5.55E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120140
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hexy...)
Show SMILES CCCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2/c1-2-3-5-13-20(17-9-6-4-7-10-17)25-15-14-21(25)22(24)18-11-8-12-19(23)16-18/h4,6-12,16,20-22H,2-3,5,13-15,24H2,1H3/t20?,21-,22+/m0/s1
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5.96E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120145
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-buty...)
Show SMILES CCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H25ClN2/c1-2-7-18(15-8-4-3-5-9-15)23-13-12-19(23)20(22)16-10-6-11-17(21)14-16/h3-6,8-11,14,18-20H,2,7,12-13,22H2,1H3/t18?,19-,20+/m0/s1
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6.02E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120154
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-chloro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(Cl)c1)c1cccc(Cl)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Cl3N2/c24-18-7-1-4-15(12-18)22(27)21-10-11-28(21)23(16-5-2-8-19(25)13-16)17-6-3-9-20(26)14-17/h1-9,12-14,21-23H,10-11,27H2/t21-,22+/m0/s1
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6.04E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120147
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m0/s1
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6.09E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL




Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120147
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m0/s1
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6.09E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120148
PNG
(C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluo...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H25ClF2N2/c1-2-3-7-19(15-11-17(23)13-18(24)12-15)26-9-8-20(26)21(25)14-5-4-6-16(22)10-14/h4-6,10-13,19-21H,2-3,7-9,25H2,1H3/t19?,20-,21-/m0/s1
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6.49E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120154
PNG
(C-[(R)-C-{(S)-1-[Bis-(3-chloro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1cccc(Cl)c1)c1cccc(Cl)c1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21Cl3N2/c24-18-7-1-4-15(12-18)22(27)21-10-11-28(21)23(16-5-2-8-19(25)13-16)17-6-3-9-20(26)14-17/h1-9,12-14,21-23H,10-11,27H2/t21-,22+/m0/s1
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7.16E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120145
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-buty...)
Show SMILES CCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H25ClN2/c1-2-7-18(15-8-4-3-5-9-15)23-13-12-19(23)20(22)16-10-6-11-17(21)14-16/h3-6,8-11,14,18-20H,2,7,12-13,22H2,1H3/t18?,19-,20+/m0/s1
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7.17E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120139
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-prop...)
Show SMILES CCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C19H23ClN2/c1-2-17(14-7-4-3-5-8-14)22-12-11-18(22)19(21)15-9-6-10-16(20)13-15/h3-10,13,17-19H,2,11-12,21H2,1H3/t17?,18-,19+/m0/s1
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7.22E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM50120142
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-phe...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N2O/c30-28(22-16-18-26(19-17-22)32-25-14-8-3-9-15-25)27-20-21-31(27)29(23-10-4-1-5-11-23)24-12-6-2-7-13-24/h1-19,27-29H,20-21,30H2/t27-,28-/m0/s1
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7.22E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human ORL1 receptor was determined by using [125I]nociceptin radioligand in Chinese hamster ovary (CHO) cell membranes at a conce...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120143
PNG
(C-[(R)-C-{(S)-1-[Bis-(4-fluoro-phenyl)-methyl]-aze...)
Show SMILES N[C@@H]([C@@H]1CCN1C(c1ccc(F)cc1)c1ccc(F)cc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H21ClF2N2/c24-18-3-1-2-17(14-18)22(27)21-12-13-28(21)23(15-4-8-19(25)9-5-15)16-6-10-20(26)11-7-16/h1-11,14,21-23H,12-13,27H2/t21-,22+/m0/s1
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7.43E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120144
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-hexy...)
Show SMILES CCCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C22H29ClN2/c1-2-3-5-13-20(17-9-6-4-7-10-17)25-15-14-21(25)22(24)18-11-8-12-19(23)16-18/h4,6-12,16,20-22H,2-3,5,13-15,24H2,1H3/t20?,21-,22-/m0/s1
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7.58E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120139
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-prop...)
Show SMILES CCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C19H23ClN2/c1-2-17(14-7-4-3-5-8-14)22-12-11-18(22)19(21)15-9-6-10-16(20)13-15/h3-10,13,17-19H,2,11-12,21H2,1H3/t17?,18-,19+/m0/s1
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7.72E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120142
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(4-phe...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H28N2O/c30-28(22-16-18-26(19-17-22)32-25-14-8-3-9-15-25)27-20-21-31(27)29(23-10-4-1-5-11-23)24-12-6-2-7-13-24/h1-19,27-29H,20-21,30H2/t27-,28-/m0/s1
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7.72E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120151
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-pent...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H27ClN2/c1-2-3-12-19(16-8-5-4-6-9-16)24-14-13-20(24)21(23)17-10-7-11-18(22)15-17/h4-11,15,19-21H,2-3,12-14,23H2,1H3/t19?,20-,21+/m0/s1
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8.05E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120164
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-prop...)
Show SMILES CCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C19H23ClN2/c1-2-17(14-7-4-3-5-8-14)22-12-11-18(22)19(21)15-9-6-10-16(20)13-15/h3-10,13,17-19H,2,11-12,21H2,1H3/t17?,18-,19-/m0/s1
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8.07E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120156
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-chl...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(Cl)c1
Show InChI InChI=1S/C23H23ClN2/c24-20-13-7-12-19(16-20)22(25)21-14-15-26(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,25H2/t21-,22-/m0/s1
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PubMed
8.34E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120162
PNG
(C-((R)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3-fluoro-p...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1cccc(F)c1
Show InChI InChI=1S/C21H26ClFN2/c1-2-3-10-19(15-6-5-9-18(23)14-15)25-12-11-20(25)21(24)16-7-4-8-17(22)13-16/h4-9,13-14,19-21H,2-3,10-12,24H2,1H3/t19?,20-,21+/m0/s1
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8.71E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120168
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-pent...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C21H27ClN2/c1-2-3-12-19(16-8-5-4-6-9-16)24-14-13-20(24)21(23)17-10-7-11-18(22)15-17/h4-11,15,19-21H,2-3,12-14,23H2,1H3/t19?,20-,21-/m0/s1
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8.82E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120148
PNG
(C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluo...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H25ClF2N2/c1-2-3-7-19(15-11-17(23)13-18(24)12-15)26-9-8-20(26)21(25)14-5-4-6-16(22)10-14/h4-6,10-13,19-21H,2-3,7-9,25H2,1H3/t19?,20-,21-/m0/s1
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9.37E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120155
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3,5-d...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C23H22F2N2/c24-19-13-18(14-20(25)15-19)22(26)21-11-12-27(21)23(16-7-3-1-4-8-16)17-9-5-2-6-10-17/h1-10,13-15,21-23H,11-12,26H2/t21-,22-/m0/s1
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9.53E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120141
PNG
(C-[(S)-C-[(S)-1-(1-Butyl-pentyl)-azetidin-2-yl]-C-...)
Show SMILES CCCCC(CCCC)N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1
Show InChI InChI=1S/C19H31ClN2/c1-3-5-10-17(11-6-4-2)22-13-12-18(22)19(21)15-8-7-9-16(20)14-15/h7-9,14,17-19H,3-6,10-13,21H2,1-2H3/t18-,19-/m0/s1
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9.67E+3n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120146
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-buty...)
Show SMILES CCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H25ClN2/c1-2-7-18(15-8-4-3-5-9-15)23-13-12-19(23)20(22)16-10-6-11-17(21)14-16/h3-6,8-11,14,18-20H,2,7,12-13,22H2,1H3/t18?,19-,20-/m0/s1
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1.01E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Mu-type opioid receptor


(Homo sapiens (Human))
BDBM50120160
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-ethy...)
Show SMILES CC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C18H21ClN2/c1-13(14-6-3-2-4-7-14)21-11-10-17(21)18(20)15-8-5-9-16(19)12-15/h2-9,12-13,17-18H,10-11,20H2,1H3/t13?,17-,18-/m0/s1
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1.06E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor mu 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0.12...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120147
PNG
(C-[(S)-C-((S)-1-Benzhydryl-azetidin-2-yl)-C-(3-tri...)
Show SMILES N[C@H]([C@@H]1CCN1C(c1ccccc1)c1ccccc1)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H23F3N2/c25-24(26,27)20-13-7-12-19(16-20)22(28)21-14-15-29(21)23(17-8-3-1-4-9-17)18-10-5-2-6-11-18/h1-13,16,21-23H,14-15,28H2/t21-,22-/m0/s1
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1.10E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120137
PNG
(C-((R)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3,5-difluo...)
Show SMILES CCCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1cc(F)cc(F)c1
Show InChI InChI=1S/C21H25ClF2N2/c1-2-3-7-19(15-11-17(23)13-18(24)12-15)26-9-8-20(26)21(25)14-5-4-6-16(22)10-14/h4-6,10-13,19-21H,2-3,7-9,25H2,1H3/t19?,20-,21+/m0/s1
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1.12E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120153
PNG
(C-((S)-C-(3-Chloro-phenyl)-C-{(S)-1-[1-(3-fluoro-p...)
Show SMILES CCCCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1cccc(F)c1
Show InChI InChI=1S/C21H26ClFN2/c1-2-3-10-19(15-6-5-9-18(23)14-15)25-12-11-20(25)21(24)16-7-4-8-17(22)13-16/h4-9,13-14,19-21H,2-3,10-12,24H2,1H3/t19?,20-,21-/m0/s1
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1.23E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Kappa-type opioid receptor


(Homo sapiens (Human))
BDBM50120164
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-prop...)
Show SMILES CCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C19H23ClN2/c1-2-17(14-7-4-3-5-8-14)22-12-11-18(22)19(21)15-9-6-10-16(20)13-15/h3-10,13,17-19H,2,11-12,21H2,1H3/t17?,18-,19-/m0/s1
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1.31E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor kappa 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120145
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-buty...)
Show SMILES CCCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C20H25ClN2/c1-2-7-18(15-8-4-3-5-9-15)23-13-12-19(23)20(22)16-10-6-11-17(21)14-16/h3-6,8-11,14,18-20H,2,7,12-13,22H2,1H3/t18?,19-,20+/m0/s1
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1.65E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120139
PNG
(C-{(R)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-prop...)
Show SMILES CCC(N1CC[C@H]1[C@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C19H23ClN2/c1-2-17(14-7-4-3-5-8-14)22-12-11-18(22)19(21)15-9-6-10-16(20)13-15/h3-10,13,17-19H,2,11-12,21H2,1H3/t17?,18-,19+/m0/s1
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2.24E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120164
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-prop...)
Show SMILES CCC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C19H23ClN2/c1-2-17(14-7-4-3-5-8-14)22-12-11-18(22)19(21)15-9-6-10-16(20)13-15/h3-10,13,17-19H,2,11-12,21H2,1H3/t17?,18-,19-/m0/s1
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2.24E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120141
PNG
(C-[(S)-C-[(S)-1-(1-Butyl-pentyl)-azetidin-2-yl]-C-...)
Show SMILES CCCCC(CCCC)N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1
Show InChI InChI=1S/C19H31ClN2/c1-3-5-10-17(11-6-4-2)22-13-12-18(22)19(21)15-8-7-9-16(20)14-15/h7-9,14,17-19H,3-6,10-13,21H2,1-2H3/t18-,19-/m0/s1
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3.18E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Delta-type opioid receptor


(Homo sapiens (Human))
BDBM50120160
PNG
(C-{(S)-C-(3-Chloro-phenyl)-C-[(S)-1-(1-phenyl-ethy...)
Show SMILES CC(N1CC[C@H]1[C@@H](N)c1cccc(Cl)c1)c1ccccc1
Show InChI InChI=1S/C18H21ClN2/c1-13(14-6-3-2-4-7-14)21-11-10-17(21)18(20)15-8-5-9-16(19)12-15/h2-9,12-13,17-18H,10-11,20H2,1H3/t13?,17-,18-/m0/s1
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3.91E+4n/an/an/an/an/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Binding affinity at human opioid receptor delta 1 was determined by using [3H]diprenorphine radioligand in CHO cell membranes at a concentration of 0...


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
Nociceptin receptor


(Homo sapiens (Human))
BDBM21842
PNG
((2S)-2-[(2S)-2-[(2S)-2-[(2S)-2-[(2S)-6-amino-2-[(2...)
Show SMILES [#6]-[#6](-[#6])-[#6]-[#6@H](-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6@H](-[#6]-[#8])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]-[#6]-[#7])-[#7]-[#6](=O)-[#6@H](-[#6]-[#6]-[#6]\[#7]=[#6](\[#7])-[#7])-[#7]-[#6](=O)-[#6@H](-[#6])-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7]-[#6](=O)-[#6@H](-[#6]-c1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#7])-[#6]-c1ccccc1)-[#6@@H](-[#6])-[#8])-[#6](=O)-[#7]-[#6@@H](-[#6])-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6](-[#7])=O)-[#6](=O)-[#7]-[#6@@H](-[#6]-[#6]-[#6](-[#7])=O)-[#6](-[#8])=O
Show InChI InChI=1S/C79H129N27O22/c1-41(2)33-54(72(122)95-44(5)66(116)103-56(36-59(84)110)73(123)102-53(77(127)128)27-28-58(83)109)104-70(120)49(23-13-15-29-80)100-69(119)52(26-18-32-90-79(87)88)99-65(115)43(4)96-75(125)57(40-107)105-71(121)50(24-14-16-30-81)101-68(118)51(25-17-31-89-78(85)86)98-64(114)42(3)94-61(112)39-93-76(126)63(45(6)108)106-74(124)55(35-47-21-11-8-12-22-47)97-62(113)38-91-60(111)37-92-67(117)48(82)34-46-19-9-7-10-20-46/h7-12,19-22,41-45,48-57,63,107-108H,13-18,23-40,80-82H2,1-6H3,(H2,83,109)(H2,84,110)(H,91,111)(H,92,117)(H,93,126)(H,94,112)(H,95,122)(H,96,125)(H,97,113)(H,98,114)(H,99,115)(H,100,119)(H,101,118)(H,102,123)(H,103,116)(H,104,120)(H,105,121)(H,106,124)(H,127,128)(H4,85,86,89)(H4,87,88,90)/t42-,43-,44-,45+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,63-/m0/s1
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n/an/an/an/a 0.0800n/an/an/an/a



Schering Plough Research Institute

Curated by ChEMBL


Assay Description
Compound was evaluated for increase in [35S]GTP-gamma-S, binding for human ORL1 receptor carried out in CHO cell membranes ; Nd: no data


Bioorg Med Chem Lett 12: 3157-60 (2002)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%