Found 42 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222081
(CHEMBL327654)Show InChI InChI=1S/C15H16N4/c1-11-13(12-4-3-7-16-10-12)5-2-6-14(11)19-15-17-8-9-18-15/h2-7,10H,8-9H2,1H3,(H2,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 5.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222052
(CHEMBL329548)Show InChI InChI=1S/C14H15N3S/c1-10-11(13-6-3-9-18-13)4-2-5-12(10)17-14-15-7-8-16-14/h2-6,9H,7-8H2,1H3,(H2,15,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 6.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222056
(CHEMBL94017)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-5-3-6-14(11-13)21-2)7-4-8-16(12)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222051
(CHEMBL90118)Show InChI InChI=1S/C14H15N3S/c1-10-12(11-5-8-18-9-11)3-2-4-13(10)17-14-15-6-7-16-14/h2-5,8-9H,6-7H2,1H3,(H2,15,16,17) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 11 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50130287
((4,5-Dihydro-1H-imidazol-2-yl)-(2-methyl-biphenyl-...)Show SMILES [#6]-c1c(cccc1-c1ccccc1)\[#7]=[#6]-1/[#7]-[#6]-[#6]-[#7]-1 Show InChI InChI=1S/C16H17N3/c1-12-14(13-6-3-2-4-7-13)8-5-9-15(12)19-16-17-10-11-18-16/h2-9H,10-11H2,1H3,(H2,17,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222052
(CHEMBL329548)Show InChI InChI=1S/C14H15N3S/c1-10-11(13-6-3-9-18-13)4-2-5-12(10)17-14-15-7-8-16-14/h2-6,9H,7-8H2,1H3,(H2,15,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 17 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222053
(CHEMBL90752)Show InChI InChI=1S/C17H19N3/c1-12-5-3-6-14(11-12)15-7-4-8-16(13(15)2)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 18 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50130287
((4,5-Dihydro-1H-imidazol-2-yl)-(2-methyl-biphenyl-...)Show SMILES [#6]-c1c(cccc1-c1ccccc1)\[#7]=[#6]-1/[#7]-[#6]-[#6]-[#7]-1 Show InChI InChI=1S/C16H17N3/c1-12-14(13-6-3-2-4-7-13)8-5-9-15(12)19-16-17-10-11-18-16/h2-9H,10-11H2,1H3,(H2,17,18,19) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222053
(CHEMBL90752)Show InChI InChI=1S/C17H19N3/c1-12-5-3-6-14(11-12)15-7-4-8-16(13(15)2)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 21 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222082
(CHEMBL544315)Show SMILES Cl.Cc1c(NC2=NCCN2)cccc1-c1cccc(c1)C#N |t:4| Show InChI InChI=1S/C17H16N4/c1-12-15(14-5-2-4-13(10-14)11-18)6-3-7-16(12)21-17-19-8-9-20-17/h2-7,10H,8-9H2,1H3,(H2,19,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 22 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222055
(CHEMBL327906)Show InChI InChI=1S/C16H16ClN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222083
(CHEMBL90538)Show InChI InChI=1S/C16H16FN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222055
(CHEMBL327906)Show InChI InChI=1S/C16H16ClN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222047
(CHEMBL316283)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-6-8-14(21-2)9-7-13)4-3-5-16(12)20-17-18-10-11-19-17/h3-9H,10-11H2,1-2H3,(H2,18,19,20) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 26 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222047
(CHEMBL316283)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-6-8-14(21-2)9-7-13)4-3-5-16(12)20-17-18-10-11-19-17/h3-9H,10-11H2,1-2H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222083
(CHEMBL90538)Show InChI InChI=1S/C16H16FN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 28 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222048
(CHEMBL540821)Show SMILES Cl.CC(=O)c1cccc(c1)-c1cccc(NC2=NCCN2)c1C |t:16| Show InChI InChI=1S/C18H19N3O/c1-12-16(15-6-3-5-14(11-15)13(2)22)7-4-8-17(12)21-18-19-9-10-20-18/h3-8,11H,9-10H2,1-2H3,(H2,19,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222051
(CHEMBL90118)Show InChI InChI=1S/C14H15N3S/c1-10-12(11-5-8-18-9-11)3-2-4-13(10)17-14-15-6-7-16-14/h2-5,8-9H,6-7H2,1H3,(H2,15,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 32 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222056
(CHEMBL94017)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-5-3-6-14(11-13)21-2)7-4-8-16(12)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 35 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222050
(CHEMBL92856)Show SMILES COc1ccc(c(OC)c1)-c1cccc(NC2=NCCN2)c1C |t:17| Show InChI InChI=1S/C18H21N3O2/c1-12-14(15-8-7-13(22-2)11-17(15)23-3)5-4-6-16(12)21-18-19-9-10-20-18/h4-8,11H,9-10H2,1-3H3,(H2,19,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 41 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222056
(CHEMBL94017)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-5-3-6-14(11-13)21-2)7-4-8-16(12)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 44 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222049
(CHEMBL90150)Show SMILES Cc1c(NC2=NCCN2)cccc1-c1cccc(c1)C(F)(F)F |t:4| Show InChI InChI=1S/C17H16F3N3/c1-11-14(12-4-2-5-13(10-12)17(18,19)20)6-3-7-15(11)23-16-21-8-9-22-16/h2-7,10H,8-9H2,1H3,(H2,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222051
(CHEMBL90118)Show InChI InChI=1S/C14H15N3S/c1-10-12(11-5-8-18-9-11)3-2-4-13(10)17-14-15-6-7-16-14/h2-5,8-9H,6-7H2,1H3,(H2,15,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 69 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222050
(CHEMBL92856)Show SMILES COc1ccc(c(OC)c1)-c1cccc(NC2=NCCN2)c1C |t:17| Show InChI InChI=1S/C18H21N3O2/c1-12-14(15-8-7-13(22-2)11-17(15)23-3)5-4-6-16(12)21-18-19-9-10-20-18/h4-8,11H,9-10H2,1-3H3,(H2,19,20,21) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 74 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222049
(CHEMBL90150)Show SMILES Cc1c(NC2=NCCN2)cccc1-c1cccc(c1)C(F)(F)F |t:4| Show InChI InChI=1S/C17H16F3N3/c1-11-14(12-4-2-5-13(10-12)17(18,19)20)6-3-7-15(11)23-16-21-8-9-22-16/h2-7,10H,8-9H2,1H3,(H2,21,22,23) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222048
(CHEMBL540821)Show SMILES Cl.CC(=O)c1cccc(c1)-c1cccc(NC2=NCCN2)c1C |t:16| Show InChI InChI=1S/C18H19N3O/c1-12-16(15-6-3-5-14(11-15)13(2)22)7-4-8-17(12)21-18-19-9-10-20-18/h3-8,11H,9-10H2,1-2H3,(H2,19,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 89 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222082
(CHEMBL544315)Show SMILES Cl.Cc1c(NC2=NCCN2)cccc1-c1cccc(c1)C#N |t:4| Show InChI InChI=1S/C17H16N4/c1-12-15(14-5-2-4-13(10-14)11-18)6-3-7-16(12)21-17-19-8-9-20-17/h2-7,10H,8-9H2,1H3,(H2,19,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 91 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222052
(CHEMBL329548)Show InChI InChI=1S/C14H15N3S/c1-10-11(13-6-3-9-18-13)4-2-5-12(10)17-14-15-7-8-16-14/h2-6,9H,7-8H2,1H3,(H2,15,16,17) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 102 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor
(RAT-NEONATAL RAT-Rattus norvegicus (rat)) | BDBM50222054
(CHEMBL94056)Show SMILES CC(C)c1cccc(c1)-c1cccc(NC2=NCCN2)c1C |t:16| Show InChI InChI=1S/C19H23N3/c1-13(2)15-6-4-7-16(12-15)17-8-5-9-18(14(17)3)22-19-20-10-11-21-19/h4-9,12-13H,10-11H2,1-3H3,(H2,20,21,22) | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-2 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222055
(CHEMBL327906)Show InChI InChI=1S/C16H16ClN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 132 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222048
(CHEMBL540821)Show SMILES Cl.CC(=O)c1cccc(c1)-c1cccc(NC2=NCCN2)c1C |t:16| Show InChI InChI=1S/C18H19N3O/c1-12-16(15-6-3-5-14(11-15)13(2)22)7-4-8-17(12)21-18-19-9-10-20-18/h3-8,11H,9-10H2,1-2H3,(H2,19,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 155 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222053
(CHEMBL90752)Show InChI InChI=1S/C17H19N3/c1-12-5-3-6-14(11-12)15-7-4-8-16(13(15)2)20-17-18-9-10-19-17/h3-8,11H,9-10H2,1-2H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 166 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222082
(CHEMBL544315)Show SMILES Cl.Cc1c(NC2=NCCN2)cccc1-c1cccc(c1)C#N |t:4| Show InChI InChI=1S/C17H16N4/c1-12-15(14-5-2-4-13(10-14)11-18)6-3-7-16(12)21-17-19-8-9-20-17/h2-7,10H,8-9H2,1H3,(H2,19,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 170 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222054
(CHEMBL94056)Show SMILES CC(C)c1cccc(c1)-c1cccc(NC2=NCCN2)c1C |t:16| Show InChI InChI=1S/C19H23N3/c1-13(2)15-6-4-7-16(12-15)17-8-5-9-18(14(17)3)22-19-20-10-11-21-19/h4-9,12-13H,10-11H2,1-3H3,(H2,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| 182 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222050
(CHEMBL92856)Show SMILES COc1ccc(c(OC)c1)-c1cccc(NC2=NCCN2)c1C |t:17| Show InChI InChI=1S/C18H21N3O2/c1-12-14(15-8-7-13(22-2)11-17(15)23-3)5-4-6-16(12)21-18-19-9-10-20-18/h4-8,11H,9-10H2,1-3H3,(H2,19,20,21) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 209 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50130287
((4,5-Dihydro-1H-imidazol-2-yl)-(2-methyl-biphenyl-...)Show SMILES [#6]-c1c(cccc1-c1ccccc1)\[#7]=[#6]-1/[#7]-[#6]-[#6]-[#7]-1 Show InChI InChI=1S/C16H17N3/c1-12-14(13-6-3-2-4-7-13)8-5-9-15(12)19-16-17-10-11-18-16/h2-9H,10-11H2,1H3,(H2,17,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 209 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222049
(CHEMBL90150)Show SMILES Cc1c(NC2=NCCN2)cccc1-c1cccc(c1)C(F)(F)F |t:4| Show InChI InChI=1S/C17H16F3N3/c1-11-14(12-4-2-5-13(10-12)17(18,19)20)6-3-7-15(11)23-16-21-8-9-22-16/h2-7,10H,8-9H2,1H3,(H2,21,22,23) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| PubMed
| 257 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
5-hydroxytryptamine receptor 7
(Rattus norvegicus (rat)) | BDBM50222081
(CHEMBL327654)Show InChI InChI=1S/C15H16N4/c1-11-13(12-4-3-7-16-10-12)5-2-6-14(11)19-15-17-8-9-18-15/h2-7,10H,8-9H2,1H3,(H2,17,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 257 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Inhibition of [3H]-5-CT binding to 5-hydroxytryptamine 7 receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222081
(CHEMBL327654)Show InChI InChI=1S/C15H16N4/c1-11-13(12-4-3-7-16-10-12)5-2-6-14(11)19-15-17-8-9-18-15/h2-7,10H,8-9H2,1H3,(H2,17,18,19) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 257 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222047
(CHEMBL316283)Show InChI InChI=1S/C17H19N3O/c1-12-15(13-6-8-14(21-2)9-7-13)4-3-5-16(12)20-17-18-10-11-19-17/h3-9H,10-11H2,1-2H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| PubMed
| 263 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222083
(CHEMBL90538)Show InChI InChI=1S/C16H16FN3/c1-11-14(12-4-2-5-13(17)10-12)6-3-7-15(11)20-16-18-8-9-19-16/h2-7,10H,8-9H2,1H3,(H2,18,19,20) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| 275 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor
(Rattus norvegicus (rat)-Rattus norvegicus (Rat)) | BDBM50222054
(CHEMBL94056)Show SMILES CC(C)c1cccc(c1)-c1cccc(NC2=NCCN2)c1C |t:16| Show InChI InChI=1S/C19H23N3/c1-13(2)15-6-4-7-16(12-15)17-8-5-9-18(14(17)3)22-19-20-10-11-21-19/h4-9,12-13H,10-11H2,1-3H3,(H2,20,21,22) | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
DrugBank
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
| PubMed
| 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Pfizer Inc.
Curated by ChEMBL
| Assay Description
Affinity for Alpha-1 adrenergic receptor of rat cortical membranes |
Bioorg Med Chem Lett 13: 269-71 (2003)
BindingDB Entry DOI: 10.7270/Q2GQ7108 |
More data for this
Ligand-Target Pair | |
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