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PubMed code 12570371

Compile data set for download or QSAR
Found 33 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123521
PNG
(CHEMBL317791 | [2'-(2-Pyridin-2-yl-ethylcarbamoyl)...)
Show SMILES C[C@H](OC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1
Show InChI InChI=1S/C30H29N3O3/c1-22(23-11-3-2-4-12-23)36-30(35)33-21-24-13-5-6-15-26(24)27-16-7-8-17-28(27)29(34)32-20-18-25-14-9-10-19-31-25/h2-17,19,22H,18,20-21H2,1H3,(H,32,34)(H,33,35)/t22-/m0/s1
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n/an/a 160n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123525
PNG
(CHEMBL146482 | [2'-(1-Carbamoyl-3-methyl-butylcarb...)
Show SMILES CC(C)C[C@H](NC(=O)c1ccccc1-c1ccccc1CNC(=O)OCc1ccccc1)C(N)=O
Show InChI InChI=1S/C28H31N3O4/c1-19(2)16-25(26(29)32)31-27(33)24-15-9-8-14-23(24)22-13-7-6-12-21(22)17-30-28(34)35-18-20-10-4-3-5-11-20/h3-15,19,25H,16-18H2,1-2H3,(H2,29,32)(H,30,34)(H,31,33)/t25-/m0/s1
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n/an/a 300n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123507
PNG
(2'-[(3-Phenyl-butyrylamino)-methyl]-biphenyl-2-car...)
Show SMILES C[C@H](CC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1
Show InChI InChI=1S/C31H31N3O2/c1-23(24-11-3-2-4-12-24)21-30(35)34-22-25-13-5-6-15-27(25)28-16-7-8-17-29(28)31(36)33-20-18-26-14-9-10-19-32-26/h2-17,19,23H,18,20-22H2,1H3,(H,33,36)(H,34,35)/t23-/m1/s1
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n/an/a 300n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123528
PNG
(CHEMBL148356 | {2-[2-(Cyclopropylmethyl-carbamoyl)...)
Show SMILES C[C@H](OC(=O)NCc1ccccc1-c1cccnc1C(=O)NCC1CC1)c1ccccc1
Show InChI InChI=1S/C26H27N3O3/c1-18(20-8-3-2-4-9-20)32-26(31)29-17-21-10-5-6-11-22(21)23-12-7-15-27-24(23)25(30)28-16-19-13-14-19/h2-12,15,18-19H,13-14,16-17H2,1H3,(H,28,30)(H,29,31)/t18-/m0/s1
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n/an/a 400n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50123521
PNG
(CHEMBL317791 | [2'-(2-Pyridin-2-yl-ethylcarbamoyl)...)
Show SMILES C[C@H](OC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1
Show InChI InChI=1S/C30H29N3O3/c1-22(23-11-3-2-4-12-23)36-30(35)33-21-24-13-5-6-15-26(24)27-16-7-8-17-28(27)29(34)32-20-18-25-14-9-10-19-31-25/h2-17,19,22H,18,20-21H2,1H3,(H,32,34)(H,33,35)/t22-/m0/s1
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n/an/a 500n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.3 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123508
PNG
(CHEMBL148159 | [2'-(2-Pyridin-2-yl-ethylcarbamoyl)...)
Show SMILES O=C(NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)OCc1ccccc1
Show InChI InChI=1S/C29H27N3O3/c33-28(31-19-17-24-13-8-9-18-30-24)27-16-7-6-15-26(27)25-14-5-4-12-23(25)20-32-29(34)35-21-22-10-2-1-3-11-22/h1-16,18H,17,19-21H2,(H,31,33)(H,32,34)
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Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123511
PNG
(CHEMBL148210 | [6,6'-Dimethyl-2'-(2-pyridin-2-yl-e...)
Show SMILES Cc1cccc(CNC(=O)OCc2ccccc2)c1-c1c(C)cccc1C(=O)NCCc1ccccn1 |(14.4,-7.66,;12.86,-7.66,;12.86,-9.2,;11.53,-9.99,;10.2,-9.22,;10.2,-7.68,;8.85,-6.91,;7.52,-7.68,;6.19,-6.91,;6.18,-5.37,;4.85,-7.68,;3.51,-6.91,;2.18,-7.68,;.85,-6.91,;-.48,-7.68,;-.48,-9.22,;.86,-9.99,;2.18,-9.22,;11.51,-6.89,;11.51,-5.35,;10.16,-4.6,;8.84,-5.39,;10.15,-3.06,;11.49,-2.26,;12.83,-3.03,;12.84,-4.57,;14.17,-5.33,;14.19,-6.7,;15.5,-4.56,;16.85,-5.32,;18.16,-4.53,;19.49,-5.3,;19.49,-6.84,;20.82,-7.59,;22.15,-6.84,;22.15,-5.28,;20.82,-4.53,)|
Show InChI InChI=1S/C31H31N3O3/c1-22-10-8-14-25(20-34-31(36)37-21-24-12-4-3-5-13-24)28(22)29-23(2)11-9-16-27(29)30(35)33-19-17-26-15-6-7-18-32-26/h3-16,18H,17,19-21H2,1-2H3,(H,33,35)(H,34,36)
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Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123511
PNG
(CHEMBL148210 | [6,6'-Dimethyl-2'-(2-pyridin-2-yl-e...)
Show SMILES Cc1cccc(CNC(=O)OCc2ccccc2)c1-c1c(C)cccc1C(=O)NCCc1ccccn1 |(14.4,-7.66,;12.86,-7.66,;12.86,-9.2,;11.53,-9.99,;10.2,-9.22,;10.2,-7.68,;8.85,-6.91,;7.52,-7.68,;6.19,-6.91,;6.18,-5.37,;4.85,-7.68,;3.51,-6.91,;2.18,-7.68,;.85,-6.91,;-.48,-7.68,;-.48,-9.22,;.86,-9.99,;2.18,-9.22,;11.51,-6.89,;11.51,-5.35,;10.16,-4.6,;8.84,-5.39,;10.15,-3.06,;11.49,-2.26,;12.83,-3.03,;12.84,-4.57,;14.17,-5.33,;14.19,-6.7,;15.5,-4.56,;16.85,-5.32,;18.16,-4.53,;19.49,-5.3,;19.49,-6.84,;20.82,-7.59,;22.15,-6.84,;22.15,-5.28,;20.82,-4.53,)|
Show InChI InChI=1S/C31H31N3O3/c1-22-10-8-14-25(20-34-31(36)37-21-24-12-4-3-5-13-24)28(22)29-23(2)11-9-16-27(29)30(35)33-19-17-26-15-6-7-18-32-26/h3-16,18H,17,19-21H2,1-2H3,(H,33,35)(H,34,36)
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Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123518
PNG
(CHEMBL147381 | [2'-(3-Methyl-butylcarbamoyl)-biphe...)
Show SMILES CC(C)CCNC(=O)c1ccccc1-c1ccccc1CNC(=O)OCc1ccccc1
Show InChI InChI=1S/C27H30N2O3/c1-20(2)16-17-28-26(30)25-15-9-8-14-24(25)23-13-7-6-12-22(23)18-29-27(31)32-19-21-10-4-3-5-11-21/h3-15,20H,16-19H2,1-2H3,(H,28,30)(H,29,31)
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Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123529
PNG
(CHEMBL147039 | [6,6'-Dimethyl-2'-(3-methyl-butylca...)
Show SMILES CC(C)CCNC(=O)c1cccc(C)c1-c1c(C)cccc1CNC(=O)OCc1ccccc1 |(20.82,-4.53,;19.49,-5.3,;19.49,-6.84,;18.16,-4.53,;16.85,-5.32,;15.5,-4.56,;14.17,-5.33,;14.19,-6.7,;12.84,-4.57,;12.83,-3.03,;11.49,-2.26,;10.15,-3.06,;10.16,-4.6,;8.84,-5.39,;11.51,-5.35,;11.51,-6.89,;12.86,-7.66,;14.4,-7.66,;12.86,-9.2,;11.53,-9.99,;10.2,-9.22,;10.2,-7.68,;8.85,-6.91,;7.52,-7.68,;6.19,-6.91,;6.18,-5.37,;4.85,-7.68,;3.51,-6.91,;2.18,-7.68,;2.18,-9.22,;.86,-9.99,;-.48,-9.22,;-.48,-7.68,;.85,-6.91,)|
Show InChI InChI=1S/C29H34N2O3/c1-20(2)16-17-30-28(32)25-15-9-11-22(4)27(25)26-21(3)10-8-14-24(26)18-31-29(33)34-19-23-12-6-5-7-13-23/h5-15,20H,16-19H2,1-4H3,(H,30,32)(H,31,33)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123510
PNG
(2'-[(3-Phenyl-butyrylamino)-methyl]-biphenyl-2-car...)
Show SMILES C[C@@H](CC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1
Show InChI InChI=1S/C31H31N3O2/c1-23(24-11-3-2-4-12-24)21-30(35)34-22-25-13-5-6-15-27(25)28-16-7-8-17-29(28)31(36)33-20-18-26-14-9-10-19-32-26/h2-17,19,23H,18,20-22H2,1H3,(H,33,36)(H,34,35)/t23-/m0/s1
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Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123529
PNG
(CHEMBL147039 | [6,6'-Dimethyl-2'-(3-methyl-butylca...)
Show SMILES CC(C)CCNC(=O)c1cccc(C)c1-c1c(C)cccc1CNC(=O)OCc1ccccc1 |(20.82,-4.53,;19.49,-5.3,;19.49,-6.84,;18.16,-4.53,;16.85,-5.32,;15.5,-4.56,;14.17,-5.33,;14.19,-6.7,;12.84,-4.57,;12.83,-3.03,;11.49,-2.26,;10.15,-3.06,;10.16,-4.6,;8.84,-5.39,;11.51,-5.35,;11.51,-6.89,;12.86,-7.66,;14.4,-7.66,;12.86,-9.2,;11.53,-9.99,;10.2,-9.22,;10.2,-7.68,;8.85,-6.91,;7.52,-7.68,;6.19,-6.91,;6.18,-5.37,;4.85,-7.68,;3.51,-6.91,;2.18,-7.68,;2.18,-9.22,;.86,-9.99,;-.48,-9.22,;-.48,-7.68,;.85,-6.91,)|
Show InChI InChI=1S/C29H34N2O3/c1-20(2)16-17-30-28(32)25-15-9-11-22(4)27(25)26-21(3)10-8-14-24(26)18-31-29(33)34-19-23-12-6-5-7-13-23/h5-15,20H,16-19H2,1-4H3,(H,30,32)(H,31,33)
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n/an/a 1.00E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123519
PNG
(2'-{[2-(4-Methoxy-phenyl)-acetylamino]-methyl}-bip...)
Show SMILES COc1ccc(CC(=O)NCc2ccccc2-c2ccccc2C(=O)NCc2ccc(F)cc2F)cc1
Show InChI InChI=1S/C30H26F2N2O3/c1-37-24-14-10-20(11-15-24)16-29(35)33-18-21-6-2-3-7-25(21)26-8-4-5-9-27(26)30(36)34-19-22-12-13-23(31)17-28(22)32/h2-15,17H,16,18-19H2,1H3,(H,33,35)(H,34,36)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123530
PNG
(CHEMBL147315 | [2'-(2,4-Difluoro-benzylcarbamoyl)-...)
Show SMILES Fc1ccc(CNC(=O)c2ccccc2-c2ccccc2CNC(=O)OCc2ccccc2)c(F)c1
Show InChI InChI=1S/C29H24F2N2O3/c30-23-15-14-22(27(31)16-23)18-32-28(34)26-13-7-6-12-25(26)24-11-5-4-10-21(24)17-33-29(35)36-19-20-8-2-1-3-9-20/h1-16H,17-19H2,(H,32,34)(H,33,35)
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Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123531
PNG
(CHEMBL147962 | [2'-(3-Dimethylamino-2,2-dimethyl-p...)
Show SMILES CN(C)CC(C)(C)CNC(=O)c1ccccc1-c1ccccc1CNC(=O)OCc1ccccc1
Show InChI InChI=1S/C29H35N3O3/c1-29(2,21-32(3)4)20-31-27(33)26-17-11-10-16-25(26)24-15-9-8-14-23(24)18-30-28(34)35-19-22-12-6-5-7-13-22/h5-17H,18-21H2,1-4H3,(H,30,34)(H,31,33)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 3


(Homo sapiens (Human))		BDBM50123508
PNG
(CHEMBL148159 | [2'-(2-Pyridin-2-yl-ethylcarbamoyl)...)
Show SMILES O=C(NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)OCc1ccccc1
Show InChI InChI=1S/C29H27N3O3/c33-28(31-19-17-24-13-8-9-18-30-24)27-16-7-6-15-26(27)25-14-5-4-12-23(25)20-32-29(34)35-21-22-10-2-1-3-11-22/h1-16,18H,17,19-21H2,(H,31,33)(H,32,34)
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n/an/a 2.30E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.3 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123524
PNG
(CHEMBL146771 | [2'-(2-Pyridin-2-yl-ethylcarbamoyl)...)
Show SMILES C[C@@H](OC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCc1ccccn1)c1ccccc1
Show InChI InChI=1S/C30H29N3O3/c1-22(23-11-3-2-4-12-23)36-30(35)33-21-24-13-5-6-15-26(24)27-16-7-8-17-28(27)29(34)32-20-18-25-14-9-10-19-31-25/h2-17,19,22H,18,20-21H2,1H3,(H,32,34)(H,33,35)/t22-/m1/s1
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n/an/a 2.40E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123533
PNG
(2'-(Benzenesulfonylamino-methyl)-biphenyl-2-carbox...)
Show SMILES CC(C)CCNC(=O)c1ccccc1-c1ccccc1CNS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C25H28N2O3S/c1-19(2)16-17-26-25(28)24-15-9-8-14-23(24)22-13-7-6-10-20(22)18-27-31(29,30)21-11-4-3-5-12-21/h3-15,19,27H,16-18H2,1-2H3,(H,26,28)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123516
PNG
(CHEMBL144170 | {2-[2-(3-Methyl-butylcarbamoyl)-pyr...)
Show SMILES CC(C)CCNC(=O)c1ncccc1-c1ccccc1CNC(=O)OCc1ccccc1
Show InChI InChI=1S/C26H29N3O3/c1-19(2)14-16-28-25(30)24-23(13-8-15-27-24)22-12-7-6-11-21(22)17-29-26(31)32-18-20-9-4-3-5-10-20/h3-13,15,19H,14,16-18H2,1-2H3,(H,28,30)(H,29,31)
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n/an/a 2.60E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123515
PNG
(CHEMBL144106 | [2'-(3-Methyl-butylcarbamoyl)-biphe...)
Show SMILES CC(C)CCNC(=O)c1ccccc1-c1ccccc1CNC(=O)Oc1ccccc1
Show InChI InChI=1S/C26H28N2O3/c1-19(2)16-17-27-25(29)24-15-9-8-14-23(24)22-13-7-6-10-20(22)18-28-26(30)31-21-11-4-3-5-12-21/h3-15,19H,16-18H2,1-2H3,(H,27,29)(H,28,30)
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n/an/a 3.30E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123512
PNG
(CHEMBL148258 | [2'-(3-Methyl-butylcarbamoyl)-biphe...)
Show SMILES CC(C)CCNC(=O)c1ccccc1-c1ccccc1CNC(=O)OC(C)(C)C
Show InChI InChI=1S/C24H32N2O3/c1-17(2)14-15-25-22(27)21-13-9-8-12-20(21)19-11-7-6-10-18(19)16-26-23(28)29-24(3,4)5/h6-13,17H,14-16H2,1-5H3,(H,25,27)(H,26,28)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123513
PNG
(2'-(Phenethylamino-methyl)-biphenyl-2-carboxylic a...)
Show SMILES CC(C)CCNC(=O)c1ccccc1-c1ccccc1CNCCc1ccccc1
Show InChI InChI=1S/C27H32N2O/c1-21(2)16-19-29-27(30)26-15-9-8-14-25(26)24-13-7-6-12-23(24)20-28-18-17-22-10-4-3-5-11-22/h3-15,21,28H,16-20H2,1-2H3,(H,29,30)
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n/an/a 4.00E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123534
PNG
(2'-(Benzoylamino-methyl)-biphenyl-2-carboxylic aci...)
Show SMILES CC(C)CCNC(=O)c1ccccc1-c1ccccc1CNC(=O)c1ccccc1
Show InChI InChI=1S/C26H28N2O2/c1-19(2)16-17-27-26(30)24-15-9-8-14-23(24)22-13-7-6-12-21(22)18-28-25(29)20-10-4-3-5-11-20/h3-15,19H,16-18H2,1-2H3,(H,27,30)(H,28,29)
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n/an/a 4.10E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123522
PNG
(2'-[(3-Phenyl-ureido)-methyl]-biphenyl-2-carboxyli...)
Show SMILES CC(C)CCNC(=O)c1ccccc1-c1ccccc1CNC(=O)Nc1ccccc1
Show InChI InChI=1S/C26H29N3O2/c1-19(2)16-17-27-25(30)24-15-9-8-14-23(24)22-13-7-6-10-20(22)18-28-26(31)29-21-11-4-3-5-12-21/h3-15,19H,16-18H2,1-2H3,(H,27,30)(H2,28,29,31)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123527
PNG
(2'-[(3-Trifluoromethyl-benzenesulfonylamino)-methy...)
Show SMILES NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1-c1ccccc1CNS(=O)(=O)c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C30H26F3N3O4S/c31-30(32,33)22-12-8-13-23(18-22)41(39,40)35-19-21-11-4-5-14-24(21)25-15-6-7-16-26(25)29(38)36-27(28(34)37)17-20-9-2-1-3-10-20/h1-16,18,27,35H,17,19H2,(H2,34,37)(H,36,38)/t27-/m0/s1
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n/an/a 4.80E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123517
PNG
(CHEMBL358048 | {4-[2-(3-Methyl-butylcarbamoyl)-phe...)
Show SMILES CC(C)CCNC(=O)c1ccccc1-c1ccncc1CNC(=O)OCc1ccccc1
Show InChI InChI=1S/C26H29N3O3/c1-19(2)12-15-28-25(30)24-11-7-6-10-23(24)22-13-14-27-16-21(22)17-29-26(31)32-18-20-8-4-3-5-9-20/h3-11,13-14,16,19H,12,15,17-18H2,1-2H3,(H,28,30)(H,29,31)
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n/an/a 7.00E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123523
PNG
(CHEMBL146772 | [2'-(3-Methyl-butylcarbamoyl)-biphe...)
Show SMILES COC(=O)NCc1ccccc1-c1ccccc1C(=O)NCCC(C)C
Show InChI InChI=1S/C21H26N2O3/c1-15(2)12-13-22-20(24)19-11-7-6-10-18(19)17-9-5-4-8-16(17)14-23-21(25)26-3/h4-11,15H,12-14H2,1-3H3,(H,22,24)(H,23,25)
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n/an/a 7.10E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123509
PNG
(2'-[(4-Acetyl-benzenesulfonylamino)-methyl]-biphen...)
Show SMILES CC(=O)c1ccc(cc1)S(=O)(=O)NCc1ccccc1-c1ccccc1C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C31H29N3O5S/c1-21(35)23-15-17-25(18-16-23)40(38,39)33-20-24-11-5-6-12-26(24)27-13-7-8-14-28(27)31(37)34-29(30(32)36)19-22-9-3-2-4-10-22/h2-18,29,33H,19-20H2,1H3,(H2,32,36)(H,34,37)/t29-/m0/s1
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n/an/a 7.70E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123526
PNG
(CHEMBL143727 | {2-[3-(3-Methyl-butylcarbamoyl)-pyr...)
Show SMILES CC(C)CCNC(=O)c1cccnc1-c1ccccc1CNC(=O)OCc1ccccc1
Show InChI InChI=1S/C26H29N3O3/c1-19(2)14-16-28-25(30)23-13-8-15-27-24(23)22-12-7-6-11-21(22)17-29-26(31)32-18-20-9-4-3-5-10-20/h3-13,15,19H,14,16-18H2,1-2H3,(H,28,30)(H,29,31)
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n/an/a 7.80E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123514
PNG
(2'-[(Naphthalene-1-sulfonylamino)-methyl]-biphenyl...)
Show SMILES NC(=O)[C@H](Cc1ccccc1)NC(=O)c1ccccc1-c1ccccc1CNS(=O)(=O)c1cccc2ccccc12
Show InChI InChI=1S/C33H29N3O4S/c34-32(37)30(21-23-11-2-1-3-12-23)36-33(38)29-19-9-8-18-28(29)26-16-6-5-14-25(26)22-35-41(39,40)31-20-10-15-24-13-4-7-17-27(24)31/h1-20,30,35H,21-22H2,(H2,34,37)(H,36,38)/t30-/m0/s1
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n/an/a 9.10E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123520
PNG
(8-(4-Chloro-benzenesulfonylamino)-naphthalene-1-ca...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)Nc1cccc2cccc(C(=O)NC3CCCCC3)c12
Show InChI InChI=1S/C23H23ClN2O3S/c24-17-12-14-19(15-13-17)30(28,29)26-21-11-5-7-16-6-4-10-20(22(16)21)23(27)25-18-8-2-1-3-9-18/h4-7,10-15,18,26H,1-3,8-9H2,(H,25,27)
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n/an/a 9.50E+3n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123532
PNG
(2'-[(Naphthalene-1-sulfonylamino)-methyl]-biphenyl...)
Show SMILES CC(C)[C@H](NC(=O)c1ccccc1-c1ccccc1CNS(=O)(=O)c1cccc2ccccc12)C(N)=O
Show InChI InChI=1S/C29H29N3O4S/c1-19(2)27(28(30)33)32-29(34)25-16-8-7-15-24(25)22-13-5-4-11-21(22)18-31-37(35,36)26-17-9-12-20-10-3-6-14-23(20)26/h3-17,19,27,31H,18H2,1-2H3,(H2,30,33)(H,32,34)/t27-/m0/s1
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n/an/a 1.12E+4n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily A member 5


(Homo sapiens (Human))		BDBM50123535
PNG
(CHEMBL146726 | {2-[4-(3-Methyl-butylcarbamoyl)-pyr...)
Show SMILES CC(C)CCNC(=O)c1ccncc1-c1ccccc1CNC(=O)OCc1ccccc1
Show InChI InChI=1S/C26H29N3O3/c1-19(2)12-15-28-25(30)23-13-14-27-17-24(23)22-11-7-6-10-21(22)16-29-26(31)32-18-20-8-4-3-5-9-20/h3-11,13-14,17,19H,12,15-16,18H2,1-2H3,(H,28,30)(H,29,31)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Aventis Pharma Deutschland GmbH

Curated by ChEMBL


Assay Description
Inhibition of human voltage-gated potassium channel subunit Kv1.5 expressed in Xenopus oocytes

J Med Chem 46: 486-98 (2003)


Article DOI: 10.1021/jm0210461
BindingDB Entry DOI: 10.7270/Q2RJ4HTF
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%