Found 19 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86174
(CAS_486-12-4 | NSC_5282443 | Triprolidine)Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3 | UniProtKB/SwissProt
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| 1.15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM86174
(CAS_486-12-4 | NSC_5282443 | Triprolidine)Show InChI InChI=1S/C19H22N2/c1-16-7-9-17(10-8-16)18(19-6-2-3-12-20-19)11-15-21-13-4-5-14-21/h2-3,6-12H,4-5,13-15H2,1H3 | PDB
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| 3.01 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86171
(Arpromidine | CAS_65895 | NSC_65895)Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27) | UniProtKB/SwissProt
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| 33.3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86169
(BU-E 47)Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1cccc(Cl)c1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25ClN6/c22-17-6-3-5-16(13-17)19(20-8-1-2-10-25-20)9-12-27-21(23)26-11-4-7-18-14-24-15-28-18/h1-3,5-6,8,10,13-15,19H,4,7,9,11-12H2,(H,24,28)(H3,23,26,27) | UniProtKB/SwissProt
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| 53.9 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM86169
(BU-E 47)Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1cccc(Cl)c1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25ClN6/c22-17-6-3-5-16(13-17)19(20-8-1-2-10-25-20)9-12-27-21(23)26-11-4-7-18-14-24-15-28-18/h1-3,5-6,8,10,13-15,19H,4,7,9,11-12H2,(H,24,28)(H3,23,26,27) | PDB
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| 255 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86175
(Methylhistaprodifen | N-Methyl-2-(3,3-diphenylprop...)Show InChI InChI=1S/C21H25N3/c1-22-15-14-19-16-23-21(24-19)13-12-20(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,16,20,22H,12-15H2,1H3,(H,23,24) | UniProtKB/SwissProt
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| 290 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86170
(Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...)Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24) | UniProtKB/SwissProt
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| 310 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM86171
(Arpromidine | CAS_65895 | NSC_65895)Show SMILES NC(NCCCc1cnc[nH]1)=NCCC(c1ccc(F)cc1)c1ccccn1 |w:11.12| Show InChI InChI=1S/C21H25FN6/c22-17-8-6-16(7-9-17)19(20-5-1-2-11-25-20)10-13-27-21(23)26-12-3-4-18-14-24-15-28-18/h1-2,5-9,11,14-15,19H,3-4,10,12-13H2,(H,24,28)(H3,23,26,27) | PDB
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| PC cid
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| 353 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM86175
(Methylhistaprodifen | N-Methyl-2-(3,3-diphenylprop...)Show InChI InChI=1S/C21H25N3/c1-22-15-14-19-16-23-21(24-19)13-12-20(17-8-4-2-5-9-17)18-10-6-3-7-11-18/h2-11,16,20,22H,12-15H2,1H3,(H,23,24) | PDB
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| 370 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM86170
(Dimethylhistaprodifen | N,N-Dimethyl-2-(3,3-diphen...)Show InChI InChI=1S/C22H27N3/c1-25(2)16-15-20-17-23-22(24-20)14-13-21(18-9-5-3-6-10-18)19-11-7-4-8-12-19/h3-12,17,21H,13-16H2,1-2H3,(H,23,24) | PDB
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| 400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86172
(2-(3-Chlorophenyl)histamine)Show InChI InChI=1S/C11H12ClN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15) | UniProtKB/SwissProt
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| 600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM86173
(2-(3-Iodophenyl)histamine)Show InChI InChI=1S/C11H12IN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15) | UniProtKB/SwissProt
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| 610 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22863
(2-(3-Bromophenyl)histamine | 2-[2-(3-bromophenyl)-...)Show InChI InChI=1S/C11H12BrN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15) | UniProtKB/SwissProt
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| 700 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM86173
(2-(3-Iodophenyl)histamine)Show InChI InChI=1S/C11H12IN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15) | PDB
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| 1.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM86172
(2-(3-Chlorophenyl)histamine)Show InChI InChI=1S/C11H12ClN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15) | PDB
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| 1.78E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | PDB
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PubMed
| 2.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Homo sapiens (Human)) | BDBM22863
(2-(3-Bromophenyl)histamine | 2-[2-(3-bromophenyl)-...)Show InChI InChI=1S/C11H12BrN3/c12-9-3-1-2-8(6-9)11-14-7-10(15-11)4-5-13/h1-3,6-7H,4-5,13H2,(H,14,15) | PDB
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| 2.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM7966
(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)Show InChI InChI=1S/C5H9N3/c6-2-1-5-3-7-4-8-5/h3-4H,1-2,6H2,(H,7,8) | UniProtKB/SwissProt
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| 4.65E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
Histamine H1 receptor
(Cavia porcellus (domestic guinea pig)) | BDBM22866
(2-(1,3-thiazol-2-yl)ethan-1-amine | 2-(2-Thiazolyl...)Show InChI InChI=1S/C5H8N2S/c6-2-1-5-7-3-4-8-5/h3-4H,1-2,6H2 | UniProtKB/SwissProt
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| 8.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Kansas
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 305: 1104-15 (2003)
Article DOI: 10.1124/jpet.103.049619
BindingDB Entry DOI: 10.7270/Q2HM5708 |
More data for this
Ligand-Target Pair | |
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