Found 16 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50125936
(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show SMILES C[C@H](c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1 |c:22| Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Inhibition of currents when compound wascoapplied with acetylcholine to recombinant Torpedo nAcChoR (from 6 oocytes) |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(MOUSE-Mus musculus) | BDBM50125934
(3-(1-Phenyl-ethyl)-3H-imidazole-4-carboxylic acid ...)Show SMILES CC(c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1 |c:22| Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes) |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(Torpedo californica) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 4.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-[125I]-A-85,380 binding to alpha2 beta4 nicotinic acetylcholine receptor (nAChR) in rat brain |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Acetylcholine receptor subunit alpha/beta/delta/gamma
(MOUSE-Mus musculus) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB MMDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Inhibition of recombinant embryonic mouse muscle Nicotinic Acetylcholine Receptor (3 oocytes) |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125939
(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show SMILES C[C@@H](c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1 |c:22| Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6.63E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125936
(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show SMILES C[C@H](c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1 |c:22| Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.04E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125937
(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 2.95E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | 5.77E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Inhibition of currents elicited by GABA at EC5 (6-12 uM) |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125937
(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 4.70E+4 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM) |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 6.40E+4 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM) |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Ability to enhance currents from alpha-1-beta-2-gamma-2L-subunit of GABA receptor elicited by low concentrations of GABA |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125936
(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show SMILES C[C@H](c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1 |c:22| Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 3.70E+4 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABA |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125936
(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show SMILES C[C@H](c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1 |c:22| Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125936
(3-((R)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show SMILES C[C@H](c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1 |c:22| Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3/t12-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Direct activation of Gamma-aminobutyric acid A receptor in the absence of GABA |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125939
(3-((S)-1-Phenyl-ethyl)-3H-imidazole-4-carboxylic a...)Show SMILES C[C@@H](c1ccccc1)n1cncc1C(=O)OCCC1(C)N=N1 |c:22| Show InChI InChI=1S/C16H18N4O2/c1-12(13-6-4-3-5-7-13)20-11-17-10-14(20)15(21)22-9-8-16(2)18-19-16/h3-7,10-12H,8-9H2,1-2H3/t12-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description Enhancement of currents elicited by GABA at EC5 (6-12 uM) |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | |
Gamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2
(Homo sapiens (Human)) | BDBM50125935
((R)-1-(1-phenylethyl)-1H-imidazole-5-carboxylic ac...)Show InChI InChI=1S/C14H16N2O2/c1-3-18-14(17)13-9-15-10-16(13)11(2)12-7-5-4-6-8-12/h4-11H,3H2,1-2H3/t11-/m1/s1 | PDB
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| PDB Article PubMed
| n/a | n/a | n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a |
Massachusetts General Hospital
Curated by ChEMBL
| Assay Description In vitro inhibition of 5-(125I)A-85380 binding to nicotinic acetylcholine receptor (nAChR) of rat brain |
J Med Chem 46: 1257-65 (2003)
Article DOI: 10.1021/jm020465v BindingDB Entry DOI: 10.7270/Q24J0FVZ |
More data for this Ligand-Target Pair | 3D Structure (crystal) |