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PubMed code 12657269

Compile data set for download or QSAR
Found 52 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126059
PNG
(1-(3-Chloro-phenyl)-2-[1-methyl-2-(6-methyl-1H-ind...)
Show SMILES CC(Cc1c[nH]c2cc(C)ccc12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H23ClN2O/c1-13-6-7-18-16(11-23-19(18)8-13)9-14(2)22-12-20(24)15-4-3-5-17(21)10-15/h3-8,10-11,14,20,22-24H,9,12H2,1-2H3
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n/an/an/an/a 12n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126082
PNG
((3-{2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamin...)
Show SMILES COC(=O)COc1cccc2c(CC(C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C22H25ClN2O4/c1-14(24-12-19(26)15-5-3-6-17(23)10-15)9-16-11-25-22-18(16)7-4-8-20(22)29-13-21(27)28-2/h3-8,10-11,14,19,24-26H,9,12-13H2,1-2H3/t14?,19-/m0/s1
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n/an/an/an/a 0.920n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126063
PNG
(1-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1-methyl-...)
Show SMILES CC(Cc1c[nH]c2ccccc12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3
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n/an/an/an/a 12n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126077
PNG
((R)-1-(3-Chloro-phenyl)-2-[2-(7-ethoxy-1H-indol-3-...)
Show SMILES CCOc1cccc2c(CC(C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C21H25ClN2O2/c1-3-26-20-9-5-8-18-16(12-24-21(18)20)10-14(2)23-13-19(25)15-6-4-7-17(22)11-15/h4-9,11-12,14,19,23-25H,3,10,13H2,1-2H3/t14?,19-/m0/s1
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n/an/an/an/a 0.960n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126065
PNG
((R)-1-((S)-3-Chloro-phenyl)-2-[2-(7-methoxy-1H-ind...)
Show SMILES COc1cccc2c(C[C@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3/t13-,18-/m0/s1
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n/an/an/an/a 120n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126080
PNG
((R)-2-[2-(7-Benzyloxy-1H-indol-3-yl)-1-methyl-ethy...)
Show SMILES CC(Cc1c[nH]c2c(OCc3ccccc3)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C26H27ClN2O2/c1-18(28-16-24(30)20-9-5-10-22(27)14-20)13-21-15-29-26-23(21)11-6-12-25(26)31-17-19-7-3-2-4-8-19/h2-12,14-15,18,24,28-30H,13,16-17H2,1H3/t18?,24-/m0/s1
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n/an/an/an/a 11n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126061
PNG
((R)-1-((S)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19-/m0/s1
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n/an/an/an/a 240n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126069
PNG
((3-{2-[(R)-2-((R)-3-Chloro-phenyl)-2-hydroxy-ethyl...)
Show SMILES C[C@H](Cc1c[nH]c2c(OCC(O)=O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN2O4/c1-13(23-11-18(25)14-4-2-5-16(22)9-14)8-15-10-24-21-17(15)6-3-7-19(21)28-12-20(26)27/h2-7,9-10,13,18,23-25H,8,11-12H2,1H3,(H,26,27)/t13-,18+/m1/s1
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n/an/an/an/a 0.0620n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Homo sapiens (Human))		BDBM50126063
PNG
(1-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1-methyl-...)
Show SMILES CC(Cc1c[nH]c2ccccc12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3
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n/an/an/an/a 23n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126060
PNG
(1-(3-Chloro-phenyl)-2-[2-(7-methoxy-1H-indol-3-yl)...)
Show SMILES COc1cccc2c(CC(C)NCC(O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3
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n/an/an/an/a 1.70n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50126067
PNG
((R)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19+/m1/s1
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n/an/an/an/a 1.90n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126070
PNG
(1-(3-Chloro-phenyl)-2-[1-methyl-2-(4-methyl-1H-ind...)
Show SMILES CC(Cc1c[nH]c2cccc(C)c12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H23ClN2O/c1-13-5-3-8-18-20(13)16(11-23-18)9-14(2)22-12-19(24)15-6-4-7-17(21)10-15/h3-8,10-11,14,19,22-24H,9,12H2,1-2H3
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n/an/an/an/a 96n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50002133
PNG
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Show SMILES C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1
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n/an/an/an/a 21n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126073
PNG
(1-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1,1-dimet...)
Show SMILES CC(C)(Cc1c[nH]c2ccccc12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C20H23ClN2O/c1-20(2,11-15-12-22-18-9-4-3-8-17(15)18)23-13-19(24)14-6-5-7-16(21)10-14/h3-10,12,19,22-24H,11,13H2,1-2H3
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n/an/an/an/a 70n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing Beta-3 adrenergic receptor

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126062
PNG
((3-{2-[(R)-2-((S)-3-Chloro-phenyl)-2-hydroxy-ethyl...)
Show SMILES C[C@@H](Cc1c[nH]c2c(OCC(O)=O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN2O4/c1-13(23-11-18(25)14-4-2-5-16(22)9-14)8-15-10-24-21-17(15)6-3-7-19(21)28-12-20(26)27/h2-7,9-10,13,18,23-25H,8,11-12H2,1H3,(H,26,27)/t13-,18-/m0/s1
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n/an/an/an/a 1.20n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126079
PNG
((R)-1-(3-Chloro-phenyl)-2-[2-(7-isopropoxy-1H-indo...)
Show SMILES CC(C)Oc1cccc2c(CC(C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C22H27ClN2O2/c1-14(2)27-21-9-5-8-19-17(12-25-22(19)21)10-15(3)24-13-20(26)16-6-4-7-18(23)11-16/h4-9,11-12,14-15,20,24-26H,10,13H2,1-3H3/t15?,20-/m0/s1
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n/an/an/an/a 2.80n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Homo sapiens (Human))		BDBM50126069
PNG
((3-{2-[(R)-2-((R)-3-Chloro-phenyl)-2-hydroxy-ethyl...)
Show SMILES C[C@H](Cc1c[nH]c2c(OCC(O)=O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN2O4/c1-13(23-11-18(25)14-4-2-5-16(22)9-14)8-15-10-24-21-17(15)6-3-7-19(21)28-12-20(26)27/h2-7,9-10,13,18,23-25H,8,11-12H2,1H3,(H,26,27)/t13-,18+/m1/s1
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n/an/an/an/a 13n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126065
PNG
((R)-1-((S)-3-Chloro-phenyl)-2-[2-(7-methoxy-1H-ind...)
Show SMILES COc1cccc2c(C[C@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3/t13-,18-/m0/s1
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n/an/an/an/a 6.5n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126064
PNG
((S)-1-((S)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19+/m0/s1
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n/an/an/an/a 33n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50002133
PNG
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Show SMILES C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1
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n/an/an/an/a 0.0950n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Homo sapiens (Human))		BDBM50002133
PNG
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Show SMILES C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1
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n/an/an/an/a 290n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126067
PNG
((R)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19+/m1/s1
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n/an/an/an/a 5.40n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126069
PNG
((3-{2-[(R)-2-((R)-3-Chloro-phenyl)-2-hydroxy-ethyl...)
Show SMILES C[C@H](Cc1c[nH]c2c(OCC(O)=O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN2O4/c1-13(23-11-18(25)14-4-2-5-16(22)9-14)8-15-10-24-21-17(15)6-3-7-19(21)28-12-20(26)27/h2-7,9-10,13,18,23-25H,8,11-12H2,1H3,(H,26,27)/t13-,18+/m1/s1
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n/an/an/an/a 0.0160n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126074
PNG
((S)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19-/m1/s1
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n/an/an/an/a 220n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50002133
PNG
((+/-)-2-(4-((R)-2-((R)-2-(3-chlorophenyl)-2-hydrox...)
Show SMILES C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H22ClNO4/c1-13(21-11-18(22)15-3-2-4-16(20)10-15)9-14-5-7-17(8-6-14)25-12-19(23)24/h2-8,10,13,18,21-22H,9,11-12H2,1H3,(H,23,24)/t13-,18+/m1/s1
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n/an/an/an/a 1.70E+3n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126067
PNG
((R)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19+/m1/s1
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n/an/an/an/a 0.360n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50126071
PNG
((R)-1-((R)-3-Chloro-phenyl)-2-[2-(7-methoxy-1H-ind...)
Show SMILES COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3/t13-,18+/m1/s1
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n/an/an/an/a 0.130n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126081
PNG
((R)-1-(3-Chloro-phenyl)-2-[1-methyl-2-(7-propoxy-1...)
Show SMILES CCCOc1cccc2c(CC(C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C22H27ClN2O2/c1-3-10-27-21-9-5-8-19-17(13-25-22(19)21)11-15(2)24-14-20(26)16-6-4-7-18(23)12-16/h4-9,12-13,15,20,24-26H,3,10-11,14H2,1-2H3/t15?,20-/m0/s1
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n/an/an/an/a 14n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126063
PNG
(1-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1-methyl-...)
Show SMILES CC(Cc1c[nH]c2ccccc12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3
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n/an/an/an/a 12n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing Beta-3 adrenergic receptor

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126071
PNG
((R)-1-((R)-3-Chloro-phenyl)-2-[2-(7-methoxy-1H-ind...)
Show SMILES COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3/t13-,18+/m1/s1
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n/an/an/an/a 0.150n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126076
PNG
((R)-1-(3-Chloro-phenyl)-2-[2-(7-methoxy-1H-indol-3...)
Show SMILES COc1cccc2c(CC(C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3/t13?,18-/m0/s1
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n/an/an/an/a 0.670n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126063
PNG
(1-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1-methyl-...)
Show SMILES CC(Cc1c[nH]c2ccccc12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3
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n/an/an/an/a 0.970n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Homo sapiens (Human))		BDBM50126067
PNG
((R)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19+/m1/s1
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n/an/an/an/a 25n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Homo sapiens (Human))		BDBM50126074
PNG
((S)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19-/m1/s1
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n/an/an/an/a 330n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126058
PNG
(2-[2-(6-Bromo-1H-indol-3-yl)-1-methyl-ethylamino]-...)
Show SMILES CC(Cc1c[nH]c2cc(Br)ccc12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H20BrClN2O/c1-12(22-11-19(24)13-3-2-4-16(21)8-13)7-14-10-23-18-9-15(20)5-6-17(14)18/h2-6,8-10,12,19,22-24H,7,11H2,1H3
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n/an/an/an/a 38n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126066
PNG
(3-{2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamino...)
Show SMILES CC(Cc1c[nH]c2c(O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O2/c1-12(21-11-18(24)13-4-2-5-15(20)9-13)8-14-10-22-19-16(14)6-3-7-17(19)23/h2-7,9-10,12,18,21-24H,8,11H2,1H3/t12?,18-/m0/s1
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n/an/an/an/a 1.70n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126068
PNG
(2-[2-(6-Chloro-1H-indol-3-yl)-1-methyl-ethylamino]...)
Show SMILES CC(Cc1c[nH]c2cc(Cl)ccc12)NCC(O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H20Cl2N2O/c1-12(22-11-19(24)13-3-2-4-15(20)8-13)7-14-10-23-18-9-16(21)5-6-17(14)18/h2-6,8-10,12,19,22-24H,7,11H2,1H3
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n/an/an/an/a 28n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126072
PNG
(1-(3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-ethylamin...)
Show SMILES OC(CNCCc1c[nH]c2ccccc12)c1cccc(Cl)c1
Show InChI InChI=1S/C18H19ClN2O/c19-15-5-3-4-13(10-15)18(22)12-20-9-8-14-11-21-17-7-2-1-6-16(14)17/h1-7,10-11,18,20-22H,8-9,12H2
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n/an/an/an/a 69n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing Beta-3 adrenergic receptor

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126074
PNG
((S)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19-/m1/s1
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n/an/an/an/a 11n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50126061
PNG
((R)-1-((S)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19-/m0/s1
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n/an/an/an/a 9.40n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50126065
PNG
((R)-1-((S)-3-Chloro-phenyl)-2-[2-(7-methoxy-1H-ind...)
Show SMILES COc1cccc2c(C[C@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3/t13-,18-/m0/s1
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n/an/an/an/a 130n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126078
PNG
((3-{2-[(R)-2-(3-Chloro-phenyl)-2-hydroxy-ethylamin...)
Show SMILES CC(Cc1c[nH]c2c(OCC(O)=O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN2O4/c1-13(23-11-18(25)14-4-2-5-16(22)9-14)8-15-10-24-21-17(15)6-3-7-19(21)28-12-20(26)27/h2-7,9-10,13,18,23-25H,8,11-12H2,1H3,(H,26,27)/t13?,18-/m0/s1
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n/an/an/an/a 0.110n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126075
PNG
(1-(3-Chloro-phenyl)-2-[2-(6-methoxy-1H-indol-3-yl)...)
Show SMILES COc1ccc2c(CC(C)NCC(O)c3cccc(Cl)c3)c[nH]c2c1
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-20(24)14-4-3-5-16(21)9-14)8-15-11-23-19-10-17(25-2)6-7-18(15)19/h3-7,9-11,13,20,22-24H,8,12H2,1-2H3
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n/an/an/an/a 22n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126064
PNG
((S)-1-((S)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19+/m0/s1
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n/an/an/an/a 3.30E+3n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-2 adrenergic receptor


(Homo sapiens (Human))		BDBM50126071
PNG
((R)-1-((R)-3-Chloro-phenyl)-2-[2-(7-methoxy-1H-ind...)
Show SMILES COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3/t13-,18+/m1/s1
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n/an/an/an/a 5.20n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-2 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126071
PNG
((R)-1-((R)-3-Chloro-phenyl)-2-[2-(7-methoxy-1H-ind...)
Show SMILES COc1cccc2c(C[C@@H](C)NC[C@H](O)c3cccc(Cl)c3)c[nH]c12
Show InChI InChI=1S/C20H23ClN2O2/c1-13(22-12-18(24)14-5-3-6-16(21)10-14)9-15-11-23-20-17(15)7-4-8-19(20)25-2/h3-8,10-11,13,18,22-24H,9,12H2,1-2H3/t13-,18+/m1/s1
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n/an/an/an/a 0.360n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126061
PNG
((R)-1-((S)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@@H](Cc1c[nH]c2ccccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19-/m0/s1
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n/an/an/an/a 13n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-3 adrenergic receptor as cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50126064
PNG
((S)-1-((S)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19+/m0/s1
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n/an/an/an/a 140n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-3 adrenergic receptor


(Homo sapiens (Human))		BDBM50126062
PNG
((3-{2-[(R)-2-((S)-3-Chloro-phenyl)-2-hydroxy-ethyl...)
Show SMILES C[C@@H](Cc1c[nH]c2c(OCC(O)=O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN2O4/c1-13(23-11-18(25)14-4-2-5-16(22)9-14)8-15-10-24-21-17(15)6-3-7-19(21)28-12-20(26)27/h2-7,9-10,13,18,23-25H,8,11-12H2,1H3,(H,26,27)/t13-,18-/m0/s1
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n/an/an/an/a 10n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonism of recombinant human beta-3 adrenergic receptor assayed by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50126069
PNG
((3-{2-[(R)-2-((R)-3-Chloro-phenyl)-2-hydroxy-ethyl...)
Show SMILES C[C@H](Cc1c[nH]c2c(OCC(O)=O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN2O4/c1-13(23-11-18(25)14-4-2-5-16(22)9-14)8-15-10-24-21-17(15)6-3-7-19(21)28-12-20(26)27/h2-7,9-10,13,18,23-25H,8,11-12H2,1H3,(H,26,27)/t13-,18+/m1/s1
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n/an/an/an/a 6.40n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50126074
PNG
((S)-1-((R)-3-Chloro-phenyl)-2-[2-(1H-indol-3-yl)-1...)
Show SMILES C[C@H](Cc1c[nH]c2ccccc12)NC[C@@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H21ClN2O/c1-13(9-15-11-22-18-8-3-2-7-17(15)18)21-12-19(23)14-5-4-6-16(20)10-14/h2-8,10-11,13,19,21-23H,9,12H2,1H3/t13-,19-/m1/s1
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n/an/an/an/a 47n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
Beta-1 adrenergic receptor


(Homo sapiens (Human))		BDBM50126062
PNG
((3-{2-[(R)-2-((S)-3-Chloro-phenyl)-2-hydroxy-ethyl...)
Show SMILES C[C@@H](Cc1c[nH]c2c(OCC(O)=O)cccc12)NC[C@H](O)c1cccc(Cl)c1
Show InChI InChI=1S/C21H23ClN2O4/c1-13(23-11-18(25)14-4-2-5-16(22)9-14)8-15-10-24-21-17(15)6-3-7-19(21)28-12-20(26)27/h2-7,9-10,13,18,23-25H,8,11-12H2,1H3,(H,26,27)/t13-,18-/m0/s1
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n/an/an/an/a 14n/an/an/an/a



Dainippon Pharmaceutical Co., Ltd.

Curated by ChEMBL


Assay Description
Agonistic activity against human Beta-1 adrenergic receptor by measuring cAMP accumulation in CHO cells expressing beta3-AR

Bioorg Med Chem Lett 13: 1301-5 (2003)


BindingDB Entry DOI: 10.7270/Q25B01TS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%