Found 7 hits of Enzyme Inhibition Constant Data Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM50004108
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| DrugBank PDB Article PubMed
| 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 407-20 (2003)
Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM50004108
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 407-20 (2003)
Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-4
(Homo sapiens (Human)) | BDBM50170601
((1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.0^{1,10...)Show InChI InChI=1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| 36 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 407-20 (2003)
Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM50170601
((1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.0^{1,10...)Show InChI InChI=1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| 116 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 407-20 (2003)
Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM50004108
((+-)-nicotine | (R,S)-nicotine | (RS)-nicotine | 3...)Show InChI InChI=1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 187 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 407-20 (2003)
Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX |
More data for this Ligand-Target Pair | |
Neuronal acetylcholine receptor subunit alpha-3
(Homo sapiens (Human)) | BDBM50170601
((1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.0^{1,10...)Show InChI InChI=1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| 1.79E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 407-20 (2003)
Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX |
More data for this Ligand-Target Pair | |
Acetylcholine receptor subunit alpha
(Homo sapiens (Human)) | BDBM50170601
((1R,10S)-9-oxa-4,13-diazatetracyclo[11.2.1.0^{1,10...)Show InChI InChI=1S/C13H16N2O/c1-2-11-10(14-5-1)8-13-4-7-15(9-13)6-3-12(13)16-11/h1-2,5,12H,3-4,6-9H2/t12-,13+/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
| Article PubMed
| 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Synthelabo Research
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 306: 407-20 (2003)
Article DOI: 10.1124/jpet.103.049262 BindingDB Entry DOI: 10.7270/Q2GM85WX |
More data for this Ligand-Target Pair | |