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PubMed code 12723959

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Nischarin


(Homo sapiens (Human))		BDBM50127591
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,6-dimethyl-3,4-...)
Show SMILES CN1CC(Oc2ccc(C)cc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-9-3-4-11-10(7-9)16(2)8-12(17-11)13-14-5-6-15-13/h3-4,7,12H,5-6,8H2,1-2H3,(H,14,15)
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 2n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127595
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES COC(=O)c1ccc2OC(CN(C)c2c1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C14H17N3O3/c1-17-8-12(13-15-5-6-16-13)20-11-4-3-9(7-10(11)17)14(18)19-2/h3-4,7,12H,5-6,8H2,1-2H3,(H,15,16)
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 7n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127600
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-2,3,5,6-tetrahydr...)
Show SMILES C1CN=C(N1)C1CN2CCCc3cccc(O1)c23 |c:2|
Show InChI InChI=1S/C14H17N3O/c1-3-10-4-2-8-17-9-12(14-15-6-7-16-14)18-11(5-1)13(10)17/h1,3,5,12H,2,4,6-9H2,(H,15,16)
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 10n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127590
PNG
(4-(4,5-Dihydro-1H-imidazol-2-yl)-3,4-dihydro-5-oxa...)
Show SMILES C1CN=C(N1)C1Cn2ccc3cccc(O1)c23 |c:2|
Show InChI InChI=1S/C13H13N3O/c1-2-9-4-7-16-8-11(13-14-5-6-15-13)17-10(3-1)12(9)16/h1-4,7,11H,5-6,8H2,(H,14,15)
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 13n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127590
PNG
(4-(4,5-Dihydro-1H-imidazol-2-yl)-3,4-dihydro-5-oxa...)
Show SMILES C1CN=C(N1)C1Cn2ccc3cccc(O1)c23 |c:2|
Show InChI InChI=1S/C13H13N3O/c1-2-9-4-7-16-8-11(13-14-5-6-15-13)17-10(3-1)12(9)16/h1-4,7,11H,5-6,8H2,(H,14,15)
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 13n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127573
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-ethoxymethyl-4-...)
Show SMILES CCOCc1ccc2OC(CN(C)c2c1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C15H21N3O2/c1-3-19-10-11-4-5-13-12(8-11)18(2)9-14(20-13)15-16-6-7-17-15/h4-5,8,14H,3,6-7,9-10H2,1-2H3,(H,16,17)
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 17n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127572
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-fluoro-4-methyl...)
Show SMILES CN1CC(Oc2ccc(F)cc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C12H14FN3O/c1-16-7-11(12-14-4-5-15-12)17-10-3-2-8(13)6-9(10)16/h2-3,6,11H,4-5,7H2,1H3,(H,14,15)
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 17n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127591
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,6-dimethyl-3,4-...)
Show SMILES CN1CC(Oc2ccc(C)cc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-9-3-4-11-10(7-9)16(2)8-12(17-11)13-14-5-6-15-13/h3-4,7,12H,5-6,8H2,1-2H3,(H,14,15)
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 22n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127599
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,8-dimethyl-3,4-...)
Show SMILES CN1CC(Oc2c(C)cccc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-9-4-3-5-10-12(9)17-11(8-16(10)2)13-14-6-7-15-13/h3-5,11H,6-8H2,1-2H3,(H,14,15)
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 23n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127572
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-fluoro-4-methyl...)
Show SMILES CN1CC(Oc2ccc(F)cc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C12H14FN3O/c1-16-7-11(12-14-4-5-15-12)17-10-3-2-8(13)6-9(10)16/h2-3,6,11H,4-5,7H2,1H3,(H,14,15)
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 31n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127572
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-fluoro-4-methyl...)
Show SMILES CN1CC(Oc2ccc(F)cc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C12H14FN3O/c1-16-7-11(12-14-4-5-15-12)17-10-3-2-8(13)6-9(10)16/h2-3,6,11H,4-5,7H2,1H3,(H,14,15)
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 31n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127578
PNG
(4-(4,5-Dihydro-1H-imidazol-2-yl)-1,2,3,4-tetrahydr...)
Show SMILES C1CN=C(N1)C1CN2CCc3cccc(O1)c23 |c:2|
Show InChI InChI=1S/C13H15N3O/c1-2-9-4-7-16-8-11(13-14-5-6-15-13)17-10(3-1)12(9)16/h1-3,11H,4-8H2,(H,14,15)
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 33n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127586
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,6,7-trimethyl-3...)
Show SMILES CN1CC(Oc2cc(C)c(C)cc12)C1=NCCN1 |t:15|
Show InChI InChI=1S/C14H19N3O/c1-9-6-11-12(7-10(9)2)18-13(8-17(11)3)14-15-4-5-16-14/h6-7,13H,4-5,8H2,1-3H3,(H,15,16)
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 43n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127586
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,6,7-trimethyl-3...)
Show SMILES CN1CC(Oc2cc(C)c(C)cc12)C1=NCCN1 |t:15|
Show InChI InChI=1S/C14H19N3O/c1-9-6-11-12(7-10(9)2)18-13(8-17(11)3)14-15-4-5-16-14/h6-7,13H,4-5,8H2,1-3H3,(H,15,16)
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 44n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127592
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,7-dimethyl-3,4-...)
Show SMILES CN1CC(Oc2cc(C)ccc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-9-3-4-10-11(7-9)17-12(8-16(10)2)13-14-5-6-15-13/h3-4,7,12H,5-6,8H2,1-2H3,(H,14,15)
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 47n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127592
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,7-dimethyl-3,4-...)
Show SMILES CN1CC(Oc2cc(C)ccc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-9-3-4-10-11(7-9)17-12(8-16(10)2)13-14-5-6-15-13/h3-4,7,12H,5-6,8H2,1-2H3,(H,14,15)
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 47n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127578
PNG
(4-(4,5-Dihydro-1H-imidazol-2-yl)-1,2,3,4-tetrahydr...)
Show SMILES C1CN=C(N1)C1CN2CCc3cccc(O1)c23 |c:2|
Show InChI InChI=1S/C13H15N3O/c1-2-9-4-7-16-8-11(13-14-5-6-15-13)17-10(3-1)12(9)16/h1-3,11H,4-8H2,(H,14,15)
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 48n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127585
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-be...)
Show SMILES C1CN=C(N1)C1CNc2ccccc2O1 |c:2|
Show InChI InChI=1S/C11H13N3O/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10,14H,5-7H2,(H,12,13)
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 51n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127599
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,8-dimethyl-3,4-...)
Show SMILES CN1CC(Oc2c(C)cccc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-9-4-3-5-10-12(9)17-11(8-16(10)2)13-14-6-7-15-13/h3-5,11H,6-8H2,1-2H3,(H,14,15)
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 54n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127575
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES CN1CC(Oc2ccccc12)C1=NCCN1 |t:13|
Show InChI InChI=1S/C12H15N3O/c1-15-8-11(12-13-6-7-14-12)16-10-5-3-2-4-9(10)15/h2-5,11H,6-8H2,1H3,(H,13,14)
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 56n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127575
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES CN1CC(Oc2ccccc12)C1=NCCN1 |t:13|
Show InChI InChI=1S/C12H15N3O/c1-15-8-11(12-13-6-7-14-12)16-10-5-3-2-4-9(10)15/h2-5,11H,6-8H2,1H3,(H,13,14)
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 56n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127574
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-methoxy-4-methy...)
Show SMILES COc1ccc2OC(CN(C)c2c1)C1=NCCN1 |t:15|
Show InChI InChI=1S/C13H17N3O2/c1-16-8-12(13-14-5-6-15-13)18-11-4-3-9(17-2)7-10(11)16/h3-4,7,12H,5-6,8H2,1-2H3,(H,14,15)
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 78.6n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127574
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-methoxy-4-methy...)
Show SMILES COc1ccc2OC(CN(C)c2c1)C1=NCCN1 |t:15|
Show InChI InChI=1S/C13H17N3O2/c1-16-8-12(13-14-5-6-15-13)18-11-4-3-9(17-2)7-10(11)16/h3-4,7,12H,5-6,8H2,1-2H3,(H,14,15)
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 79n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127595
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES COC(=O)c1ccc2OC(CN(C)c2c1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C14H17N3O3/c1-17-8-12(13-15-5-6-16-13)20-11-4-3-9(7-10(11)17)14(18)19-2/h3-4,7,12H,5-6,8H2,1-2H3,(H,15,16)
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 88n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127579
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES CN1CC(Oc2cc3ccccc3cc12)C1=NCCN1 |t:18|
Show InChI InChI=1S/C16H17N3O/c1-19-10-15(16-17-6-7-18-16)20-14-9-12-5-3-2-4-11(12)8-13(14)19/h2-5,8-9,15H,6-7,10H2,1H3,(H,17,18)
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 93n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127576
PNG
(CHEMBL58187 | [2-(4,5-Dihydro-1H-imidazol-2-yl)-4-...)
Show SMILES CN1CC(Oc2ccc(CO)cc12)C1=NCCN1 |t:15|
Show InChI InChI=1S/C13H17N3O2/c1-16-7-12(13-14-4-5-15-13)18-11-3-2-9(8-17)6-10(11)16/h2-3,6,12,17H,4-5,7-8H2,1H3,(H,14,15)
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 100n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127584
PNG
(6-Chloro-2-(4,5-dihydro-1H-imidazol-2-yl)-4-methyl...)
Show SMILES CN1CC(Oc2ccc(Cl)cc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C12H14ClN3O/c1-16-7-11(12-14-4-5-15-12)17-10-3-2-8(13)6-9(10)16/h2-3,6,11H,4-5,7H2,1H3,(H,14,15)
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 140n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127600
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-2,3,5,6-tetrahydr...)
Show SMILES C1CN=C(N1)C1CN2CCCc3cccc(O1)c23 |c:2|
Show InChI InChI=1S/C14H17N3O/c1-3-10-4-2-8-17-9-12(14-15-6-7-16-14)18-11(5-1)13(10)17/h1,3,5,12H,2,4,6-9H2,(H,15,16)
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 150n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127596
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-propyl-3,4-dihy...)
Show SMILES CCCN1CC(Oc2ccccc12)C1=NCCN1 |t:15|
Show InChI InChI=1S/C14H19N3O/c1-2-9-17-10-13(14-15-7-8-16-14)18-12-6-4-3-5-11(12)17/h3-6,13H,2,7-10H2,1H3,(H,15,16)
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 160n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127596
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-propyl-3,4-dihy...)
Show SMILES CCCN1CC(Oc2ccccc12)C1=NCCN1 |t:15|
Show InChI InChI=1S/C14H19N3O/c1-2-9-17-10-13(14-15-7-8-16-14)18-12-6-4-3-5-11(12)17/h3-6,13H,2,7-10H2,1H3,(H,15,16)
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 160n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127584
PNG
(6-Chloro-2-(4,5-dihydro-1H-imidazol-2-yl)-4-methyl...)
Show SMILES CN1CC(Oc2ccc(Cl)cc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C12H14ClN3O/c1-16-7-11(12-14-4-5-15-12)17-10-3-2-8(13)6-9(10)16/h2-3,6,11H,4-5,7H2,1H3,(H,14,15)
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 173n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127576
PNG
(CHEMBL58187 | [2-(4,5-Dihydro-1H-imidazol-2-yl)-4-...)
Show SMILES CN1CC(Oc2ccc(CO)cc12)C1=NCCN1 |t:15|
Show InChI InChI=1S/C13H17N3O2/c1-16-7-12(13-14-4-5-15-13)18-11-3-2-9(8-17)6-10(11)16/h2-3,6,12,17H,4-5,7-8H2,1H3,(H,14,15)
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 204n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127579
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES CN1CC(Oc2cc3ccccc3cc12)C1=NCCN1 |t:18|
Show InChI InChI=1S/C16H17N3O/c1-19-10-15(16-17-6-7-18-16)20-14-9-12-5-3-2-4-11(12)8-13(14)19/h2-5,8-9,15H,6-7,10H2,1H3,(H,17,18)
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 278n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127582
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,5-dimethyl-3,4-...)
Show SMILES CN1CC(Oc2cccc(C)c12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-9-4-3-5-10-12(9)16(2)8-11(17-10)13-14-6-7-15-13/h3-5,11H,6-8H2,1-2H3,(H,14,15)
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 470n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127577
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-methoxy-2,3-dih...)
Show SMILES COc1cc(=O)n2CC(Oc3cccc1c23)C1=NCCN1 |t:19|
Show InChI InChI=1S/C15H15N3O3/c1-20-11-7-13(19)18-8-12(15-16-5-6-17-15)21-10-4-2-3-9(11)14(10)18/h2-4,7,12H,5-6,8H2,1H3,(H,16,17)
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 560n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127588
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES CN1CC(Oc2c1ccc1ccccc21)C1=NCCN1 |t:18|
Show InChI InChI=1S/C16H17N3O/c1-19-10-14(16-17-8-9-18-16)20-15-12-5-3-2-4-11(12)6-7-13(15)19/h2-7,14H,8-10H2,1H3,(H,17,18)
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 621n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127581
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-1,2,7,8,9,10-hexa...)
Show SMILES C1CN=C(N1)C1CN2CCCCc3cccc(O1)c23 |c:2|
Show InChI InChI=1S/C15H19N3O/c1-2-9-18-10-13(15-16-7-8-17-15)19-12-6-3-5-11(4-1)14(12)18/h3,5-6,13H,1-2,4,7-10H2,(H,16,17)
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 643n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127597
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4,6,7,...)
Show SMILES CN1CC(Oc2cc3CCCCc3cc12)C1=NCCN1 |t:18|
Show InChI InChI=1S/C16H21N3O/c1-19-10-15(16-17-6-7-18-16)20-14-9-12-5-3-2-4-11(12)8-13(14)19/h8-9,15H,2-7,10H2,1H3,(H,17,18)
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 690n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127577
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-methoxy-2,3-dih...)
Show SMILES COc1cc(=O)n2CC(Oc3cccc1c23)C1=NCCN1 |t:19|
Show InChI InChI=1S/C15H15N3O3/c1-20-11-7-13(19)18-8-12(15-16-5-6-17-15)21-10-4-2-3-9(11)14(10)18/h2-4,7,12H,5-6,8H2,1H3,(H,16,17)
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 750n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127582
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,5-dimethyl-3,4-...)
Show SMILES CN1CC(Oc2cccc(C)c12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-9-4-3-5-10-12(9)16(2)8-11(17-10)13-14-6-7-15-13/h3-5,11H,6-8H2,1-2H3,(H,14,15)
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 760n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127597
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4,6,7,...)
Show SMILES CN1CC(Oc2cc3CCCCc3cc12)C1=NCCN1 |t:18|
Show InChI InChI=1S/C16H21N3O/c1-19-10-15(16-17-6-7-18-16)20-14-9-12-5-3-2-4-11(12)8-13(14)19/h8-9,15H,2-7,10H2,1H3,(H,17,18)
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 800n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127585
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-be...)
Show SMILES C1CN=C(N1)C1CNc2ccccc2O1 |c:2|
Show InChI InChI=1S/C11H13N3O/c1-2-4-9-8(3-1)14-7-10(15-9)11-12-5-6-13-11/h1-4,10,14H,5-7H2,(H,12,13)
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 840n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127589
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-6-triflu...)
Show SMILES CN1CC(Oc2ccc(cc12)C(F)(F)F)C1=NCCN1 |t:17|
Show InChI InChI=1S/C13H14F3N3O/c1-19-7-11(12-17-4-5-18-12)20-10-3-2-8(6-9(10)19)13(14,15)16/h2-3,6,11H,4-5,7H2,1H3,(H,17,18)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127594
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-7-methyl-2,3,5,6-...)
Show SMILES Cc1ccc2OC(CN3CCCc1c23)C1=NCCN1 |t:17|
Show InChI InChI=1S/C15H19N3O/c1-10-4-5-12-14-11(10)3-2-8-18(14)9-13(19-12)15-16-6-7-17-15/h4-5,13H,2-3,6-9H2,1H3,(H,16,17)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127587
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,6,8-trimethyl-3...)
Show SMILES CN1CC(Oc2c(C)cc(C)cc12)C1=NCCN1 |t:15|
Show InChI InChI=1S/C14H19N3O/c1-9-6-10(2)13-11(7-9)17(3)8-12(18-13)14-15-4-5-16-14/h6-7,12H,4-5,8H2,1-3H3,(H,15,16)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127589
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-6-triflu...)
Show SMILES CN1CC(Oc2ccc(cc12)C(F)(F)F)C1=NCCN1 |t:17|
Show InChI InChI=1S/C13H14F3N3O/c1-19-7-11(12-17-4-5-18-12)20-10-3-2-8(6-9(10)19)13(14,15)16/h2-3,6,11H,4-5,7H2,1H3,(H,17,18)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127587
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4,6,8-trimethyl-3...)
Show SMILES CN1CC(Oc2c(C)cc(C)cc12)C1=NCCN1 |t:15|
Show InChI InChI=1S/C14H19N3O/c1-9-6-10(2)13-11(7-9)17(3)8-12(18-13)14-15-4-5-16-14/h6-7,12H,4-5,8H2,1-3H3,(H,15,16)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127594
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-7-methyl-2,3,5,6-...)
Show SMILES Cc1ccc2OC(CN3CCCc1c23)C1=NCCN1 |t:17|
Show InChI InChI=1S/C15H19N3O/c1-10-4-5-12-14-11(10)3-2-8-18(14)9-13(19-12)15-16-6-7-17-15/h4-5,13H,2-3,6-9H2,1H3,(H,16,17)
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>1.00E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Alpha-1A adrenergic receptor


(CALF)		BDBM50127575
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES CN1CC(Oc2ccccc12)C1=NCCN1 |t:13|
Show InChI InChI=1S/C12H15N3O/c1-15-8-11(12-13-6-7-14-12)16-10-5-3-2-4-9(10)15/h2-5,11H,6-8H2,1H3,(H,13,14)
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 1.10E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In Vitro Alpha-1 adrenergic receptor binding affinity on calf frontal cortex membrane preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127588
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-3,4-dihy...)
Show SMILES CN1CC(Oc2c1ccc1ccccc21)C1=NCCN1 |t:18|
Show InChI InChI=1S/C16H17N3O/c1-19-10-14(16-17-8-9-18-16)20-15-12-5-3-2-4-11(12)6-7-13(15)19/h2-7,14H,8-10H2,1H3,(H,17,18)
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 1.43E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127598
PNG
(4-Benzyl-2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihy...)
Show SMILES C(N1CC(Oc2ccccc12)C1=NCCN1)c1ccccc1 |t:13|
Show InChI InChI=1S/C18H19N3O/c1-2-6-14(7-3-1)12-21-13-17(18-19-10-11-20-18)22-16-9-5-4-8-15(16)21/h1-9,17H,10-13H2,(H,19,20)
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 1.60E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127581
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-1,2,7,8,9,10-hexa...)
Show SMILES C1CN=C(N1)C1CN2CCCCc3cccc(O1)c23 |c:2|
Show InChI InChI=1S/C15H19N3O/c1-2-9-18-10-13(15-16-7-8-17-15)19-12-6-3-5-11(4-1)14(12)18/h3,5-6,13H,1-2,4,7-10H2,(H,16,17)
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 2.44E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127598
PNG
(4-Benzyl-2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihy...)
Show SMILES C(N1CC(Oc2ccccc12)C1=NCCN1)c1ccccc1 |t:13|
Show InChI InChI=1S/C18H19N3O/c1-2-6-14(7-3-1)12-21-13-17(18-19-10-11-20-18)22-16-9-5-4-8-15(16)21/h1-9,17H,10-13H2,(H,19,20)
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 3.80E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127580
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-methoxy-7-methy...)
Show SMILES COc1cc(=O)n2CC(Oc3ccc(C)c1c23)C1=NCCN1 |t:20|
Show InChI InChI=1S/C16H17N3O3/c1-9-3-4-10-15-14(9)11(21-2)7-13(20)19(15)8-12(22-10)16-17-5-6-18-16/h3-4,7,12H,5-6,8H2,1-2H3,(H,17,18)
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 5.30E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127583
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-2-propyl...)
Show SMILES CCCC1(CN(C)c2ccccc2O1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H21N3O/c1-3-8-15(14-16-9-10-17-14)11-18(2)12-6-4-5-7-13(12)19-15/h4-7H,3,8-11H2,1-2H3,(H,16,17)
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 5.59E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127583
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-4-methyl-2-propyl...)
Show SMILES CCCC1(CN(C)c2ccccc2O1)C1=NCCN1 |t:16|
Show InChI InChI=1S/C15H21N3O/c1-3-8-15(14-16-9-10-17-14)11-18(2)12-6-4-5-7-13(12)19-15/h4-7H,3,8-11H2,1-2H3,(H,16,17)
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 8.53E+3n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127593
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-2,4-dimethyl-3,4-...)
Show SMILES CN1CC(C)(Oc2ccccc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-13(12-14-7-8-15-12)9-16(2)10-5-3-4-6-11(10)17-13/h3-6H,7-9H2,1-2H3,(H,14,15)
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>1.00E+4n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127573
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-ethoxymethyl-4-...)
Show SMILES CCOCc1ccc2OC(CN(C)c2c1)C1=NCCN1 |t:17|
Show InChI InChI=1S/C15H21N3O2/c1-3-19-10-11-4-5-13-12(8-11)18(2)9-14(20-13)15-16-6-7-17-15/h4-5,8,14H,3,6-7,9-10H2,1-2H3,(H,16,17)
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>1.00E+4n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127593
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-2,4-dimethyl-3,4-...)
Show SMILES CN1CC(C)(Oc2ccccc12)C1=NCCN1 |t:14|
Show InChI InChI=1S/C13H17N3O/c1-13(12-14-7-8-15-12)9-16(2)10-5-3-4-6-11(10)17-13/h3-6H,7-9H2,1-2H3,(H,14,15)
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>1.00E+4n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-1 from rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
Nischarin


(Homo sapiens (Human))		BDBM50127580
PNG
(2-(4,5-Dihydro-1H-imidazol-2-yl)-6-methoxy-7-methy...)
Show SMILES COc1cc(=O)n2CC(Oc3ccc(C)c1c23)C1=NCCN1 |t:20|
Show InChI InChI=1S/C16H17N3O3/c1-9-3-4-10-15-14(9)11(21-2)7-13(20)19(15)8-12(22-10)16-17-5-6-18-16/h3-4,7,12H,5-6,8H2,1-2H3,(H,17,18)
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 1.80E+4n/an/an/an/an/an/an/an/a



Université d'Orléans

Curated by ChEMBL


Assay Description
In vitro binding affinity determined against imidazoline receptor I-2 using rabbit kidney preparation

J Med Chem 46: 1962-79 (2003)


Article DOI: 10.1021/jm021050c
BindingDB Entry DOI: 10.7270/Q22806Z1
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%