Affinity Data by PubMed id=12852756

PubMed code 12852756

Found 5 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50069571 (3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	33	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Potency of the compound at Endothelin A receptor was determined				J Med Chem 46: 3257-74 (2003) Article DOI: 10.1021/jm0300429 BindingDB Entry DOI: 10.7270/Q2W37VQ4
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50069573 (3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]thiadiazol-5...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	97	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Potency of the compound at Endothelin A receptor was determined				J Med Chem 46: 3257-74 (2003) Article DOI: 10.1021/jm0300429 BindingDB Entry DOI: 10.7270/Q2W37VQ4
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50069565 (3-Benzo[1,3]dioxol-5-yl-1-benzo[1,3]dioxol-5-ylmet...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Potency of the compound at Endothelin A receptor was determined				J Med Chem 46: 3257-74 (2003) Article DOI: 10.1021/jm0300429 BindingDB Entry DOI: 10.7270/Q2W37VQ4
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50069567 (3-Benzo[1,3]dioxol-5-yl-1-benzo[1,3]dioxol-5-ylmet...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	250	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Potency of the compound at Endothelin A receptor was determined				J Med Chem 46: 3257-74 (2003) Article DOI: 10.1021/jm0300429 BindingDB Entry DOI: 10.7270/Q2W37VQ4
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair
Endothelin-1 receptor (Homo sapiens (Human))	BDBM50069574 (3-Benzo[1,3]dioxol-5-yl-1-benzo[1,2,5]oxadiazol-5-...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Research and Development Curated by ChEMBL					Assay Description Potency of the compound at Endothelin A receptor was determined				J Med Chem 46: 3257-74 (2003) Article DOI: 10.1021/jm0300429 BindingDB Entry DOI: 10.7270/Q2W37VQ4
GlaxoSmithKline Research and Development Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%