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PubMed code 12877582

Compile data set for download or QSAR
Found 3 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50131562
PNG
(CHEMBL117603 | Deca-2,4,6,8-tetraenedioic acid mon...)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@H](-[#6]-[#6][C@]2([#6]-[#8]2)[#6@H]-1[C@@]1([#6])[#8]-[#6@H]1-[#6]\[#6]=[#6](/[#6])-[#6])-[#8]-[#6](=O)\[#6]=[#6]\[#6]=[#6]\[#6]=[#6]\[#6]=[#6]\[#6](-[#8])=O
Show InChI InChI=1S/C26H34O7/c1-18(2)13-14-20-25(3,33-20)24-23(30-4)19(15-16-26(24)17-31-26)32-22(29)12-10-8-6-5-7-9-11-21(27)28/h5-13,19-20,23-24H,14-17H2,1-4H3,(H,27,28)/b7-5+,8-6+,11-9+,12-10+/t19-,20-,23+,24+,25-,26-/m0/s1
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Article
PubMed
n/an/a 1n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against purified recombinant human Methionine Aminopeptidase 2 (MetAP2)

J Med Chem 46: 3452-4 (2003)


Article DOI: 10.1021/jm0341103
BindingDB Entry DOI: 10.7270/Q2NG4Q0J
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50131561
PNG
(1-Hydroxy-3-methoxy-2-[2-methyl-3-(3-methyl-but-2-...)
Show SMILES [#6]-[#8]-[#6@H]-1-[#6@H]([C@@]2([#6])[#8]-[#6@H]2-[#6]\[#6]=[#6](/[#6])-[#6])[C@]([#8])([#6]-[#6]-[#6]-1=O)[#6]=O
Show InChI InChI=1S/C16H24O5/c1-10(2)5-6-12-15(3,21-12)14-13(20-4)11(18)7-8-16(14,19)9-17/h5,9,12-14,19H,6-8H2,1-4H3/t12-,13+,14+,15-,16-/m0/s1
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n/an/a 8.00E+3n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against purified recombinant human Methionine Aminopeptidase-2 (MetAP2)

J Med Chem 46: 3452-4 (2003)


Article DOI: 10.1021/jm0341103
BindingDB Entry DOI: 10.7270/Q2NG4Q0J
More data for this
Ligand-Target Pair
Methionine aminopeptidase 2


(Homo sapiens (Human))		BDBM50131563
PNG
(1,4-Dihydroxy-3-methoxy-2-[2-methyl-3-(3-methyl-bu...)
Show SMILES [#6]-[#8]-[#6@@H]-1-[#6@H](-[#8])-[#6]-[#6][C@]([#8])([#6]=O)[#6@H]-1[C@@]1([#6])[#8]-[#6@@H]1-[#6]\[#6]=[#6](\[#6])-[#6]
Show InChI InChI=1S/C16H26O5/c1-10(2)5-6-12-15(3,21-12)14-13(20-4)11(18)7-8-16(14,19)9-17/h5,9,11-14,18-19H,6-8H2,1-4H3/t11-,12-,13-,14-,15+,16+/m1/s1
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n/an/a 5.36E+4n/an/an/an/an/an/a



Johns Hopkins University School of Medicine

Curated by ChEMBL


Assay Description
In vitro inhibitory activity against purified recombinant human Methionine Aminopeptidase 2 (MetAP2)

J Med Chem 46: 3452-4 (2003)


Article DOI: 10.1021/jm0341103
BindingDB Entry DOI: 10.7270/Q2NG4Q0J
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
* indicates data uncertainty>20%