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PubMed code 1317924

Compile data set for download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000714
PNG
(3-[4-(2-Chloro-phenyl)-9-methyl-6H-1-thia-5,7,8,9a...)
Show SMILES Cc1nnc2CN=C(c3cc(CCC(=O)N4CCOCC4)sc3-n12)c1ccccc1Cl |c:6|
Show InChI InChI=1S/C22H22ClN5O2S/c1-14-25-26-19-13-24-21(16-4-2-3-5-18(16)23)17-12-15(31-22(17)28(14)19)6-7-20(29)27-8-10-30-11-9-27/h2-5,12H,6-11,13H2,1H3
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 98n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000717
PNG
(2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methox...)
Show SMILES CNC(=O)CN1CCC2=C(C1)c1c(OC)cc(cc1OC2(C)C)C(C)CCCc1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C29H37FN2O3/c1-19(7-6-8-20-9-11-22(30)12-10-20)21-15-25(34-5)28-23-17-32(18-27(33)31-4)14-13-24(23)29(2,3)35-26(28)16-21/h9-12,15-16,19H,6-8,13-14,17-18H2,1-5H3,(H,31,33)
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 142n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000701
PNG
(2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-di...)
Show SMILES CNC(=O)CN1CCC2=C(C1)c1c(OCC(=O)N(C)C)cc(cc1OC2(C)C)C(C)CCCc1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C32H42FN3O4/c1-21(8-7-9-22-10-12-24(33)13-11-22)23-16-27(39-20-30(38)35(5)6)31-25-18-36(19-29(37)34-4)15-14-26(25)32(2,3)40-28(31)17-23/h10-13,16-17,21H,7-9,14-15,18-20H2,1-6H3,(H,34,37)
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 157n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000707
PNG
(2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-di...)
Show SMILES CNC(=O)COc1cc(cc2OC(C)(C)C3=C(CN(CC(=O)NC)CC3)c12)C(C)CCCc1ccc(F)cc1 |t:15|
Show InChI InChI=1S/C31H40FN3O4/c1-20(7-6-8-21-9-11-23(32)12-10-21)22-15-26(38-19-29(37)34-5)30-24-17-35(18-28(36)33-4)14-13-25(24)31(2,3)39-27(30)16-22/h9-12,15-16,20H,6-8,13-14,17-19H2,1-5H3,(H,33,36)(H,34,37)
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 167n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000722
PNG
(2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydrox...)
Show SMILES CNC(=O)CN1CCC2=C(C1)c1c(O)cc(cc1OC2(C)C)C(C)CCCc1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C28H35FN2O3/c1-18(6-5-7-19-8-10-21(29)11-9-19)20-14-24(32)27-22-16-31(17-26(33)30-4)13-12-23(22)28(2,3)34-25(27)15-20/h8-11,14-15,18,32H,5-7,12-13,16-17H2,1-4H3,(H,30,33)
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 331n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000720
PNG
(2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-di...)
Show SMILES CNC(=O)CN1CCC2=C(C1)c1ccc(cc1OC2(C)C)C(C)CCCc1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C28H35FN2O2/c1-19(6-5-7-20-8-11-22(29)12-9-20)21-10-13-23-24-17-31(18-27(32)30-4)15-14-25(24)28(2,3)33-26(23)16-21/h8-13,16,19H,5-7,14-15,17-18H2,1-4H3,(H,30,32)
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 345n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000719
PNG
(CHEMBL62812 | {7-[4-(4-Fluoro-phenyl)-1-methyl-but...)
Show SMILES CCOC(=O)COc1cc(cc2OC(C)(C)C3=C(CN(CC(=O)NC)CC3)c12)C(C)CCCc1ccc(F)cc1 |t:16|
Show InChI InChI=1S/C32H41FN2O5/c1-6-38-30(37)20-39-27-16-23(21(2)8-7-9-22-10-12-24(33)13-11-22)17-28-31(27)25-18-35(19-29(36)34-5)15-14-26(25)32(3,4)40-28/h10-13,16-17,21H,6-9,14-15,18-20H2,1-5H3,(H,34,36)
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 390n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000708
PNG
(4-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydrox...)
Show SMILES CC(CCCc1ccc(F)cc1)c1cc(O)c2C3=C(CCN(CCCC(O)=O)C3)C(C)(C)Oc2c1 |t:18|
Show InChI InChI=1S/C29H36FNO4/c1-19(6-4-7-20-9-11-22(30)12-10-20)21-16-25(32)28-23-18-31(14-5-8-27(33)34)15-13-24(23)29(2,3)35-26(28)17-21/h9-12,16-17,19,32H,4-8,13-15,18H2,1-3H3,(H,33,34)
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 656n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000700
PNG
(4-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methox...)
Show SMILES COc1cc(cc2OC(C)(C)C3=C(CN(CCCC(O)=O)CC3)c12)C(C)CCCc1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C30H38FNO4/c1-20(7-5-8-21-10-12-23(31)13-11-21)22-17-26(35-4)29-24-19-32(15-6-9-28(33)34)16-14-25(24)30(2,3)36-27(29)18-22/h10-13,17-18,20H,5-9,14-16,19H2,1-4H3,(H,33,34)
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 690n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000716
PNG
(CHEMBL61680 | {7-[4-(4-Fluoro-phenyl)-1-methyl-but...)
Show SMILES CNC(=O)CN1CCC2=C(C1)c1c(OCC(O)=O)cc(cc1OC2(C)C)C(C)CCCc1ccc(F)cc1 |c:8|
Show InChI InChI=1S/C30H37FN2O5/c1-19(6-5-7-20-8-10-22(31)11-9-20)21-14-25(37-18-28(35)36)29-23-16-33(17-27(34)32-4)13-12-24(23)30(2,3)38-26(29)15-21/h8-11,14-15,19H,5-7,12-13,16-18H2,1-4H3,(H,32,34)(H,35,36)
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 925n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000718
PNG
(2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methox...)
Show SMILES COc1cc(cc2OC(C)(C)C3=C(CN(CC(N)=O)CC3)c12)C(C)CCCc1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C28H35FN2O3/c1-18(6-5-7-19-8-10-21(29)11-9-19)20-14-24(33-4)27-22-16-31(17-26(30)32)13-12-23(22)28(2,3)34-25(27)15-20/h8-11,14-15,18H,5-7,12-13,16-17H2,1-4H3,(H2,30,32)
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 945n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000705
PNG
(2-({7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydro...)
Show SMILES CNC(=O)CN(C)CC1=CC(C)(C)Oc2cc(cc(O)c12)C(C)CCCc1ccc(F)cc1 |t:8|
Show InChI InChI=1S/C27H35FN2O3/c1-18(7-6-8-19-9-11-22(28)12-10-19)20-13-23(31)26-21(16-30(5)17-25(32)29-4)15-27(2,3)33-24(26)14-20/h9-15,18,31H,6-8,16-17H2,1-5H3,(H,29,32)
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 1.58E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000712
PNG
(7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-dimet...)
Show SMILES CC(CCCc1ccc(F)cc1)c1cc(O)c2C3=C(CCN(CC#C)C3)C(C)(C)Oc2c1 |t:18|
Show InChI InChI=1S/C28H32FNO2/c1-5-14-30-15-13-24-23(18-30)27-25(31)16-21(17-26(27)32-28(24,3)4)19(2)7-6-8-20-9-11-22(29)12-10-20/h1,9-12,16-17,19,31H,6-8,13-15,18H2,2-4H3
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 3.25E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000711
PNG
(2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydrox...)
Show SMILES CNC(=O)CN1CCC2C(C1)c1c(O)cc(cc1OC2(C)C)C(C)CCCc1ccc(F)cc1
Show InChI InChI=1S/C28H37FN2O3/c1-18(6-5-7-19-8-10-21(29)11-9-19)20-14-24(32)27-22-16-31(17-26(33)30-4)13-12-23(22)28(2,3)34-25(27)15-20/h8-11,14-15,18,22-23,32H,5-7,12-13,16-17H2,1-4H3,(H,30,33)
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 3.30E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000715
PNG
(2-[7-(1,2-Dimethyl-heptyl)-5-hydroxy-10,10-dimethy...)
Show SMILES CCCCCC(C)C(C)c1cc(O)c2C3=C(CCN(CC(=O)NC)C3)C(C)(C)Oc2c1 |t:14|
Show InChI InChI=1S/C26H40N2O3/c1-7-8-9-10-17(2)18(3)19-13-22(29)25-20-15-28(16-24(30)27-6)12-11-21(20)26(4,5)31-23(25)14-19/h13-14,17-18,29H,7-12,15-16H2,1-6H3,(H,27,30)
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 3.68E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000702
PNG
(7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methoxy-1...)
Show SMILES COc1cc(cc2OC(C)(C)C3=C(CN(Cc4ccccn4)CC3)c12)C(C)CCCc1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C32H37FN2O2/c1-22(8-7-9-23-11-13-25(33)14-12-23)24-18-29(36-4)31-27-21-35(20-26-10-5-6-16-34-26)17-15-28(27)32(2,3)37-30(31)19-24/h5-6,10-14,16,18-19,22H,7-9,15,17,20-21H2,1-4H3
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 4.21E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000710
PNG
(3-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methox...)
Show SMILES COc1cc(cc2OC(C)(C)C3=C(CN(CCC(O)=O)CC3)c12)C(C)CCCc1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C29H36FNO4/c1-19(6-5-7-20-8-10-22(30)11-9-20)21-16-25(34-4)28-23-18-31(15-13-27(32)33)14-12-24(23)29(2,3)35-26(28)17-21/h8-11,16-17,19H,5-7,12-15,18H2,1-4H3,(H,32,33)
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 4.40E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000709
PNG
(5-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methox...)
Show SMILES COc1cc(cc2OC(C)(C)C3=C(CN(CCCCC(O)=O)CC3)c12)C(C)CCCc1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C31H40FNO4/c1-21(8-7-9-22-11-13-24(32)14-12-22)23-18-27(36-4)30-25-20-33(16-6-5-10-29(34)35)17-15-26(25)31(2,3)37-28(30)19-23/h11-14,18-19,21H,5-10,15-17,20H2,1-4H3,(H,34,35)
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 5.50E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000699
PNG
(3-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methox...)
Show SMILES CNC(=O)CCN1CCC2=C(C1)c1c(OC)cc(cc1OC2(C)C)C(C)CCCc1ccc(F)cc1 |c:9|
Show InChI InChI=1S/C30H39FN2O3/c1-20(7-6-8-21-9-11-23(31)12-10-21)22-17-26(35-5)29-24-19-33(16-14-28(34)32-4)15-13-25(24)30(2,3)36-27(29)18-22/h9-12,17-18,20H,6-8,13-16,19H2,1-5H3,(H,32,34)
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 5.50E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000724
PNG
(2-(5-Hydroxy-7-isopropyl-10,10-dimethyl-1,2,4,10-t...)
Show SMILES CNC(=O)CN1CCC2=C(C1)c1c(O)cc(cc1OC2(C)C)C(C)C |c:8|
Show InChI InChI=1S/C20H28N2O3/c1-12(2)13-8-16(23)19-14-10-22(11-18(24)21-5)7-6-15(14)20(3,4)25-17(19)9-13/h8-9,12,23H,6-7,10-11H2,1-5H3,(H,21,24)
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 9.00E+3n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000725
PNG
(7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-10,10-dimet...)
Show SMILES CC(CCCc1ccc(F)cc1)c1cc(O)c2C3=C(CCNC3)C(C)(C)Oc2c1 |t:18|
Show InChI InChI=1S/C25H30FNO2/c1-16(5-4-6-17-7-9-19(26)10-8-17)18-13-22(28)24-20-15-27-12-11-21(20)25(2,3)29-23(24)14-18/h7-10,13-14,16,27-28H,4-6,11-12,15H2,1-3H3
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 1.18E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000721
PNG
(2-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydrox...)
Show SMILES CC(CCCc1ccc(F)cc1)c1cc(O)c2C3=C(CCN(CC(=O)N(C)C)C3)C(C)(C)Oc2c1 |t:18|
Show InChI InChI=1S/C29H37FN2O3/c1-19(7-6-8-20-9-11-22(30)12-10-20)21-15-25(33)28-23-17-32(18-27(34)31(4)5)14-13-24(23)29(2,3)35-26(28)16-21/h9-12,15-16,19,33H,6-8,13-14,17-18H2,1-5H3
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 1.58E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000703
PNG
(7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methoxy-1...)
Show SMILES COc1cc(cc2OC(C)(C)C3=C(CNCC3)c12)C(C)CCCc1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C26H32FNO2/c1-17(6-5-7-18-8-10-20(27)11-9-18)19-14-23(29-4)25-21-16-28-13-12-22(21)26(2,3)30-24(25)15-19/h8-11,14-15,17,28H,5-7,12-13,16H2,1-4H3
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 1.69E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000723
PNG
(1-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydrox...)
Show SMILES CC(CCCc1ccc(F)cc1)c1cc(O)c2C3=C(CCN(C3)C(=O)CO)C(C)(C)Oc2c1 |t:18|
Show InChI InChI=1S/C27H32FNO4/c1-17(5-4-6-18-7-9-20(28)10-8-18)19-13-23(31)26-21-15-29(25(32)16-30)12-11-22(21)27(2,3)33-24(26)14-19/h7-10,13-14,17,30-31H,4-6,11-12,15-16H2,1-3H3
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 2.05E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000726
PNG
(4-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-hydrox...)
Show SMILES CNC(=O)CCCN1CCC2=C(C1)c1c(O)cc(cc1OC2(C)C)C(C)CCCc1ccc(F)cc1 |c:10|
Show InChI InChI=1S/C30H39FN2O3/c1-20(7-5-8-21-10-12-23(31)13-11-21)22-17-26(34)29-24-19-33(15-6-9-28(35)32-4)16-14-25(24)30(2,3)36-27(29)18-22/h10-13,17-18,20,34H,5-9,14-16,19H2,1-4H3,(H,32,35)
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 2.07E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000713
PNG
(2-[5-{4-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-2,6-d...)
Show SMILES CNC(=O)CN1CCC(=C(C1)c1c(O)cc(cc1O)C(C)CCCc1ccc(F)cc1)C(C)(C)O |c:8,(7.36,1.79,;6.01,1.02,;6.03,-.52,;7.36,-1.29,;4.7,-1.32,;4.7,-2.86,;3.38,-3.63,;3.38,-5.17,;4.7,-5.91,;6.03,-5.17,;6.03,-3.63,;7.36,-5.91,;7.36,-7.45,;6.03,-8.22,;8.67,-8.21,;10.01,-7.45,;9.99,-5.91,;8.67,-5.17,;8.67,-3.63,;11.34,-8.22,;11.34,-9.76,;12.67,-7.44,;14,-8.21,;15.34,-7.44,;16.66,-8.21,;16.66,-9.75,;18.01,-10.5,;19.35,-9.73,;20.67,-10.5,;19.33,-8.19,;18,-7.42,;3.35,-6.68,;3.34,-8.21,;2.03,-5.88,;2.02,-7.44,)|
Show InChI InChI=1S/C28H37FN2O4/c1-18(6-5-7-19-8-10-21(29)11-9-19)20-14-24(32)27(25(33)15-20)22-16-31(17-26(34)30-4)13-12-23(22)28(2,3)35/h8-11,14-15,18,32-33,35H,5-7,12-13,16-17H2,1-4H3,(H,30,34)
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 2.35E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000706
PNG
(6-{7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-5-methox...)
Show SMILES COc1cc(cc2OC(C)(C)C3=C(CN(CCCCCC(O)=O)CC3)c12)C(C)CCCc1ccc(F)cc1 |t:11|
Show InChI InChI=1S/C32H42FNO4/c1-22(9-8-10-23-12-14-25(33)15-13-23)24-19-28(37-4)31-26-21-34(17-7-5-6-11-30(35)36)18-16-27(26)32(2,3)38-29(31)20-24/h12-15,19-20,22H,5-11,16-18,21H2,1-4H3,(H,35,36)
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 2.50E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
Platelet-activating factor receptor


(Cavia porcellus)		BDBM50000704
PNG
(7-[4-(4-Fluoro-phenyl)-1-methyl-butyl]-1,4,4-trime...)
Show SMILES CC(CCCc1ccc(F)cc1)c1cc(O)c2C3=C(SCC3C)C(C)(C)Oc2c1 |t:18|
Show InChI InChI=1S/C25H29FO2S/c1-15(6-5-7-17-8-10-19(26)11-9-17)18-12-20(27)23-21(13-18)28-25(3,4)24-22(23)16(2)14-29-24/h8-13,15-16,27H,5-7,14H2,1-4H3
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 4.38E+4n/an/an/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro intrinsic binding affinity at platelet activating factor receptor using rabbit platelet membranes

J Med Chem 35: 2055-61 (1992)


BindingDB Entry DOI: 10.7270/Q2NZ86K9
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%