Affinity Data by PubMed id=1433179

PubMed code 1433179

Found 13 hits of Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Dihydrofolate reductase (Lactobacillus casei)	BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	5.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Lactobacillus casei DHFR				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM50003058 (2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Lactobacillus casei DHFR				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus)	BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrate				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Homo sapiens (Human))	BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of recombinant human thymidylate synthase				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	>4.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50003058 (2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>8.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of recombinant human Dihydrofolate reductase (DHFR)				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Dihydrofolate reductase (Homo sapiens (Human))	BDBM50003057 (7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...) Show SMILES Cc1n(C)c(C)c2c1cnc1nc(N)[nH]c(=O)c21 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of recombinant human Dihydrofolate reductase (DHFR); no inhibition				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus)	BDBM50003058 (2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrate				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human))	BDBM50003057 (7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...) Show SMILES Cc1n(C)c(C)c2c1cnc1nc(N)[nH]c(=O)c21 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus)	BDBM50003057 (7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...) Show SMILES Cc1n(C)c(C)c2c1cnc1nc(N)[nH]c(=O)c21 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrate				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Lactobacillus casei)	BDBM50003057 (7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...) Show SMILES Cc1n(C)c(C)c2c1cnc1nc(N)[nH]c(=O)c21 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	9.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Lactobacillus casei thymidylate synthase				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair
Thymidylate synthase (Lactobacillus casei)	BDBM50003058 (2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Duquesne University Curated by ChEMBL					Assay Description Compound was evaluated for the inhibition of Lactobacillus casei thymidylate synthase				J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH
Duquesne University Curated by ChEMBL					More data for this Ligand-Target Pair

* indicates data uncertainty>20%