Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dihydrofolate reductase (Lactobacillus casei) | BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Lactobacillus casei DHFR | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human)) | BDBM50003058 (2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 1.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst... | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Lactobacillus casei DHFR | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrate | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Homo sapiens (Human)) | BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of recombinant human thymidylate synthase | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human)) | BDBM50003059 (2-[4-(7-Amino-9-oxo-1,3,3a,4,5,8,9,9b-octahydro-2,...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Similars | PubMed | n/a | n/a | >4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst... | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50003058 (2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >8.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of recombinant human Dihydrofolate reductase (DHFR) | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dihydrofolate reductase (Homo sapiens (Human)) | BDBM50003057 (7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of recombinant human Dihydrofolate reductase (DHFR); no inhibition | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50003058 (2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrate | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Bifunctional purine biosynthesis protein ATIC (Homo sapiens (Human)) | BDBM50003057 (7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst... | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Trifunctional purine biosynthetic protein adenosine-3 (Mus musculus) | BDBM50003057 (7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrate | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Lactobacillus casei) | BDBM50003057 (7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Lactobacillus casei thymidylate synthase | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Thymidylate synthase (Lactobacillus casei) | BDBM50003058 (2-[4-(7-Amino-9-oxo-8,9-dihydro-2,5,6,8-tetraaza-c...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem | PubMed | n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Duquesne University Curated by ChEMBL | Assay Description Compound was evaluated for the inhibition of Lactobacillus casei thymidylate synthase | J Med Chem 35: 3678-85 (1992) BindingDB Entry DOI: 10.7270/Q2RJ4HFH | |||||||||||
More data for this Ligand-Target Pair |