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PubMed code 14584942

Compile data set for download or QSAR
Found 91 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132222
PNG
(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-3-36-26-18-24-23(17-25(26)35-2)27(30-19-29-24)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,31,34)
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n/an/a 10n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50117352
PNG
(4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C29H31N5O5/c1-36-16-17-38-27-19-25-24(18-26(27)37-2)28(31-20-30-25)33-12-14-34(15-13-33)29(35)32-21-8-10-23(11-9-21)39-22-6-4-3-5-7-22/h3-11,18-20H,12-17H2,1-2H3,(H,32,35)
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n/an/a 10n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134899
PNG
(4-[7-Methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Show SMILES COCCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H31N5O5/c1-36-16-17-38-27-18-24-25(19-26(27)37-2)30-20-31-28(24)33-12-14-34(15-13-33)29(35)32-21-8-10-23(11-9-21)39-22-6-4-3-5-7-22/h3-11,18-20H,12-17H2,1-2H3,(H,32,35)
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n/an/a 20n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134907
PNG
(4-[7-(2-Ethoxy-ethoxy)-6-methoxy-quinazolin-4-yl]-...)
Show SMILES CCOCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C30H33N5O5/c1-3-38-17-18-39-28-20-26-25(19-27(28)37-2)29(32-21-31-26)34-13-15-35(16-14-34)30(36)33-22-9-11-24(12-10-22)40-23-7-5-4-6-8-23/h4-12,19-21H,3,13-18H2,1-2H3,(H,33,36)
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n/an/a 20n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132206
PNG
(4-(6-Ethoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H29N5O4/c1-3-36-26-17-23-24(18-25(26)35-2)29-19-30-27(23)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,31,34)
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n/an/a 40n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134903
PNG
(4-(7-Allyloxy-6-methoxy-quinazolin-4-yl)-piperazin...)
Show SMILES COc1cc2c(ncnc2cc1OCC=C)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H29N5O4/c1-3-17-37-27-19-25-24(18-26(27)36-2)28(31-20-30-25)33-13-15-34(16-14-33)29(35)32-21-9-11-23(12-10-21)38-22-7-5-4-6-8-22/h3-12,18-20H,1,13-17H2,2H3,(H,32,35)
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n/an/a 50n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134858
PNG
(4-(7-Methoxy-6-prop-2-ynyloxy-quinazolin-4-yl)-pip...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OCC#C
Show InChI InChI=1S/C29H27N5O4/c1-3-17-37-27-18-24-25(19-26(27)36-2)30-20-31-28(24)33-13-15-34(16-14-33)29(35)32-21-9-11-23(12-10-21)38-22-7-5-4-6-8-22/h1,4-12,18-20H,13-17H2,2H3,(H,32,35)
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n/an/a 60n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134866
PNG
(CHEMBL344091 | Methanesulfonic acid 7-methoxy-4-[4...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OS(C)(=O)=O
Show InChI InChI=1S/C27H27N5O6S/c1-36-24-17-23-22(16-25(24)38-39(2,34)35)26(29-18-28-23)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)37-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33)
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n/an/a 70n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134871
PNG
(4-(7,8-Dihydro-[1,4]dioxino[2,3-g]quinazolin-4-yl)...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2cc3OCCOc3cc12
Show InChI InChI=1S/C27H25N5O4/c33-27(30-19-6-8-21(9-7-19)36-20-4-2-1-3-5-20)32-12-10-31(11-13-32)26-22-16-24-25(35-15-14-34-24)17-23(22)28-18-29-26/h1-9,16-18H,10-15H2,(H,30,33)
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n/an/a 70n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134889
PNG
(4-(6-Methoxy-7-prop-2-ynyloxy-quinazolin-4-yl)-pip...)
Show SMILES COc1cc2c(ncnc2cc1OCC#C)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H27N5O4/c1-3-17-37-27-19-25-24(18-26(27)36-2)28(31-20-30-25)33-13-15-34(16-14-33)29(35)32-21-9-11-23(12-10-21)38-22-7-5-4-6-8-22/h1,4-12,18-20H,13-17H2,2H3,(H,32,35)
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n/an/a 70n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134898
PNG
(4-[6-Methoxy-7-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C25H29N5O5S/c1-31-9-10-33-23-13-19-18(12-21(23)32-2)24(28-15-27-19)29-5-7-30(8-6-29)25(36)26-14-17-3-4-20-22(11-17)35-16-34-20/h3-4,11-13,15H,5-10,14,16H2,1-2H3,(H,26,36)
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Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134882
PNG
(4-[7-Methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Show SMILES COCCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=S)NCc1ccc2OCOc2c1
Show InChI InChI=1S/C25H29N5O5S/c1-31-9-10-33-23-12-18-19(13-21(23)32-2)27-15-28-24(18)29-5-7-30(8-6-29)25(36)26-14-17-3-4-20-22(11-17)35-16-34-20/h3-4,11-13,15H,5-10,14,16H2,1-2H3,(H,26,36)
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Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50115301
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H27N5O4/c1-34-24-16-22-23(17-25(24)35-2)28-18-29-26(22)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33)
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n/an/a 80n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134874
PNG
(4-(6,7-Diethoxy-quinazolin-4-yl)-piperazine-1-carb...)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OCC
Show InChI InChI=1S/C29H31N5O4/c1-3-36-26-18-24-25(19-27(26)37-4-2)30-20-31-28(24)33-14-16-34(17-15-33)29(35)32-21-10-12-23(13-11-21)38-22-8-6-5-7-9-22/h5-13,18-20H,3-4,14-17H2,1-2H3,(H,32,35)
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n/an/a 80n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134852
PNG
(4-(6-Cyanomethoxy-7-methoxy-quinazolin-4-yl)-piper...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OCC#N
Show InChI InChI=1S/C28H26N6O4/c1-36-25-18-24-23(17-26(25)37-16-11-29)27(31-19-30-24)33-12-14-34(15-13-33)28(35)32-20-7-9-22(10-8-20)38-21-5-3-2-4-6-21/h2-10,17-19H,12-16H2,1H3,(H,32,35)
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Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50118831
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C22H25N5O2S/c1-28-19-12-17-18(13-20(19)29-2)24-15-25-21(17)26-8-10-27(11-9-26)22(30)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,30)
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n/an/a 90n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134868
PNG
(6,7-Dimethoxy-4-[4-(4-phenoxy-phenylcarbamoyl)-pip...)
Show SMILES CCOC(=O)c1cnc2cc(OC)c(OC)cc2c1N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C31H32N4O6/c1-4-40-30(36)25-20-32-26-19-28(39-3)27(38-2)18-24(26)29(25)34-14-16-35(17-15-34)31(37)33-21-10-12-23(13-11-21)41-22-8-6-5-7-9-22/h5-13,18-20H,4,14-17H2,1-3H3,(H,33,37)
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n/an/a 90n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134911
PNG
(4-[1,3]Dioxolo[4,5-g]quinazolin-8-yl-piperazine-1-...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2cc3OCOc3cc12
Show InChI InChI=1S/C26H23N5O4/c32-26(29-18-6-8-20(9-7-18)35-19-4-2-1-3-5-19)31-12-10-30(11-13-31)25-21-14-23-24(34-17-33-23)15-22(21)27-16-28-25/h1-9,14-16H,10-13,17H2,(H,29,32)
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Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50118826
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccc4OCOc4c3)c2cc1OC
Show InChI InChI=1S/C23H25N5O4S/c1-29-19-10-16-17(11-20(19)30-2)25-13-26-22(16)27-5-7-28(8-6-27)23(33)24-12-15-3-4-18-21(9-15)32-14-31-18/h3-4,9-11,13H,5-8,12,14H2,1-2H3,(H,24,33)
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n/an/a 90n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134895
PNG
(4-(7-Chloro-quinolin-4-yl)-piperazine-1-carboxylic...)
Show SMILES Clc1ccc2c(ccnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H23ClN4O2/c27-19-6-11-23-24(18-19)28-13-12-25(23)30-14-16-31(17-15-30)26(32)29-20-7-9-22(10-8-20)33-21-4-2-1-3-5-21/h1-13,18H,14-17H2,(H,29,32)
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n/an/a 100n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134875
PNG
(4-(1,3-Dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-g...)
Show SMILES Cn1c2cc3ncnc(N4CCN(CC4)C(=O)Nc4ccc(Oc5ccccc5)cc4)c3cc2n(C)c1=O
Show InChI InChI=1S/C28H27N7O3/c1-32-24-16-22-23(17-25(24)33(2)28(32)37)29-18-30-26(22)34-12-14-35(15-13-34)27(36)31-19-8-10-21(11-9-19)38-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,31,36)
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n/an/a 100n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134864
PNG
(4-(6-Allyloxy-7-methoxy-quinazolin-4-yl)-piperazin...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OCC=C
Show InChI InChI=1S/C29H29N5O4/c1-3-17-37-27-18-24-25(19-26(27)36-2)30-20-31-28(24)33-13-15-34(16-14-33)29(35)32-21-9-11-23(12-10-21)38-22-7-5-4-6-8-22/h3-12,18-20H,1,13-17H2,2H3,(H,32,35)
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n/an/a 100n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134844
PNG
(4-(6-Chloro-quinolin-4-yl)-piperazine-1-carboxylic...)
Show SMILES Clc1ccc2nccc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C26H23ClN4O2/c27-19-6-11-24-23(18-19)25(12-13-28-24)30-14-16-31(17-15-30)26(32)29-20-7-9-22(10-8-20)33-21-4-2-1-3-5-21/h1-13,18H,14-17H2,(H,29,32)
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n/an/a 130n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134847
PNG
(4-(3-Ethyl-1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4...)
Show SMILES CCn1c2cc3ncnc(N4CCN(CC4)C(=S)NCc4ccccc4)c3cc2n(C)c1=O
Show InChI InChI=1S/C24H27N7OS/c1-3-31-21-14-19-18(13-20(21)28(2)24(31)32)22(27-16-26-19)29-9-11-30(12-10-29)23(33)25-15-17-7-5-4-6-8-17/h4-8,13-14,16H,3,9-12,15H2,1-2H3,(H,25,33)
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n/an/a 140n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132227
PNG
(4-(7-Ethoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OC
Show InChI InChI=1S/C23H27N5O2S/c1-3-30-21-14-19-18(13-20(21)29-2)22(26-16-25-19)27-9-11-28(12-10-27)23(31)24-15-17-7-5-4-6-8-17/h4-8,13-14,16H,3,9-12,15H2,1-2H3,(H,24,31)
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n/an/a 150n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134897
PNG
(4-(1H-Pyrazolo[3,4-d]pyrimidin-4-yl)-piperazine-1-...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2n[nH]cc12
Show InChI InChI=1S/C22H21N7O2/c30-22(26-16-6-8-18(9-7-16)31-17-4-2-1-3-5-17)29-12-10-28(11-13-29)21-19-14-25-27-20(19)23-15-24-21/h1-9,14-15H,10-13H2,(H,26,30)(H,23,24,25,27)
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n/an/a 170n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134853
PNG
(4-(6-Methoxy-7-methyl-quinazolin-4-yl)-piperazine-...)
Show SMILES COc1cc2c(ncnc2cc1C)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H27N5O3/c1-19-16-24-23(17-25(19)34-2)26(29-18-28-24)31-12-14-32(15-13-31)27(33)30-20-8-10-22(11-9-20)35-21-6-4-3-5-7-21/h3-11,16-18H,12-15H2,1-2H3,(H,30,33)
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n/an/a 180n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134869
PNG
(4-(6,7-Dimethoxy-quinolin-4-yl)-piperazine-1-carbo...)
Show SMILES COc1cc2nccc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H28N4O4/c1-34-26-18-23-24(19-27(26)35-2)29-13-12-25(23)31-14-16-32(17-15-31)28(33)30-20-8-10-22(11-9-20)36-21-6-4-3-5-7-21/h3-13,18-19H,14-17H2,1-2H3,(H,30,33)
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n/an/a 180n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134905
PNG
(4-(7-Methoxy-6-propoxy-quinazolin-4-yl)-piperazine...)
Show SMILES CCCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H31N5O4/c1-3-17-37-27-18-24-25(19-26(27)36-2)30-20-31-28(24)33-13-15-34(16-14-33)29(35)32-21-9-11-23(12-10-21)38-22-7-5-4-6-8-22/h4-12,18-20H,3,13-17H2,1-2H3,(H,32,35)
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n/an/a 190n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132211
PNG
(4-(7-Ethylamino-6-nitro-quinazolin-4-yl)-piperazin...)
Show SMILES CCNc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1[N+]([O-])=O
Show InChI InChI=1S/C27H27N7O4/c1-2-28-24-17-23-22(16-25(24)34(36)37)26(30-18-29-23)32-12-14-33(15-13-32)27(35)31-19-8-10-21(11-9-19)38-20-6-4-3-5-7-20/h3-11,16-18,28H,2,12-15H2,1H3,(H,31,35)
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n/an/a 200n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134848
PNG
(4-Quinolin-4-yl-piperazine-1-carboxylic acid (4-ph...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ccnc2ccccc12
Show InChI InChI=1S/C26H24N4O2/c31-26(28-20-10-12-22(13-11-20)32-21-6-2-1-3-7-21)30-18-16-29(17-19-30)25-14-15-27-24-9-5-4-8-23(24)25/h1-15H,16-19H2,(H,28,31)
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n/an/a 270n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134870
PNG
(4-(3-Ethyl-3H-1,2,3,5,7-pentaaza-cyclopenta[b]naph...)
Show SMILES CCn1nnc2cc3c(ncnc3cc12)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H26N8O2/c1-2-35-25-17-23-22(16-24(25)31-32-35)26(29-18-28-23)33-12-14-34(15-13-33)27(36)30-19-8-10-21(11-9-19)37-20-6-4-3-5-7-20/h3-11,16-18H,2,12-15H2,1H3,(H,30,36)
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n/an/a 290n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134862
PNG
(4-(6-Methoxy-7-propoxy-quinazolin-4-yl)-piperazine...)
Show SMILES CCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C29H31N5O4/c1-3-17-37-27-19-25-24(18-26(27)36-2)28(31-20-30-25)33-13-15-34(16-14-33)29(35)32-21-9-11-23(12-10-21)38-22-7-5-4-6-8-22/h4-12,18-20H,3,13-17H2,1-2H3,(H,32,35)
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n/an/a 290n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134902
PNG
(4-[7-Methoxy-6-(2-oxo-propoxy)-quinazolin-4-yl]-pi...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OCC(C)=O
Show InChI InChI=1S/C29H29N5O5/c1-20(35)18-38-27-16-24-25(17-26(27)37-2)30-19-31-28(24)33-12-14-34(15-13-33)29(36)32-21-8-10-23(11-9-21)39-22-6-4-3-5-7-22/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,32,36)
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n/an/a 300n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134855
PNG
(4-(6,7-Diethoxy-quinazolin-4-yl)-piperazine-1-carb...)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OCC
Show InChI InChI=1S/C24H29N5O2S/c1-3-30-21-14-19-20(15-22(21)31-4-2)26-17-27-23(19)28-10-12-29(13-11-28)24(32)25-16-18-8-6-5-7-9-18/h5-9,14-15,17H,3-4,10-13,16H2,1-2H3,(H,25,32)
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n/an/a 310n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134846
PNG
(4-(3-Ethyl-1-methyl-2-oxo-2,3-dihydro-1H-imidazo[4...)
Show SMILES CCn1c2cc3ncnc(N4CCN(CC4)C(=O)Nc4ccc(Oc5ccccc5)cc4)c3cc2n(C)c1=O
Show InChI InChI=1S/C29H29N7O3/c1-3-36-26-18-24-23(17-25(26)33(2)29(36)38)27(31-19-30-24)34-13-15-35(16-14-34)28(37)32-20-9-11-22(12-10-20)39-21-7-5-4-6-8-21/h4-12,17-19H,3,13-16H2,1-2H3,(H,32,37)
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n/an/a 330n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132232
PNG
(4-Quinazolin-4-yl-piperazine-1-carboxylic acid (4-...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2ccccc12
Show InChI InChI=1S/C25H23N5O2/c31-25(28-19-10-12-21(13-11-19)32-20-6-2-1-3-7-20)30-16-14-29(15-17-30)24-22-8-4-5-9-23(22)26-18-27-24/h1-13,18H,14-17H2,(H,28,31)
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n/an/a 380n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134863
PNG
(4-Benzo[g]quinazolin-4-yl-piperazine-1-carboxylic ...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2cc3ccccc3cc12
Show InChI InChI=1S/C29H25N5O2/c35-29(32-23-10-12-25(13-11-23)36-24-8-2-1-3-9-24)34-16-14-33(15-17-34)28-26-18-21-6-4-5-7-22(21)19-27(26)30-20-31-28/h1-13,18-20H,14-17H2,(H,32,35)
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n/an/a 390n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134856
PNG
(4-(9H-Purin-6-yl)-piperazine-1-carboxylic acid (4-...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2nc[nH]c12
Show InChI InChI=1S/C22H21N7O2/c30-22(27-16-6-8-18(9-7-16)31-17-4-2-1-3-5-17)29-12-10-28(11-13-29)21-19-20(24-14-23-19)25-15-26-21/h1-9,14-15H,10-13H2,(H,27,30)(H,23,24,25,26)
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n/an/a 490n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134876
PNG
(4-[7-Methoxy-6-(2-methoxy-ethoxy)-quinazolin-4-yl]...)
Show SMILES COCCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C24H26N6O4/c1-32-11-12-34-22-13-19-20(14-21(22)33-2)26-16-27-23(19)29-7-9-30(10-8-29)24(31)28-18-5-3-17(15-25)4-6-18/h3-6,13-14,16H,7-12H2,1-2H3,(H,28,31)
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n/an/a 510n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134873
PNG
(4-(7-Trifluoromethyl-quinolin-4-yl)-piperazine-1-c...)
Show SMILES FC(F)(F)c1ccc2c(ccnc2c1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H23F3N4O2/c28-27(29,30)19-6-11-23-24(18-19)31-13-12-25(23)33-14-16-34(17-15-33)26(35)32-20-7-9-22(10-8-20)36-21-4-2-1-3-5-21/h1-13,18H,14-17H2,(H,32,35)
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n/an/a 550n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132220
PNG
(4-(6-Ethoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=S)NCc1ccccc1
Show InChI InChI=1S/C23H27N5O2S/c1-3-30-21-13-18-19(14-20(21)29-2)25-16-26-22(18)27-9-11-28(12-10-27)23(31)24-15-17-7-5-4-6-8-17/h4-8,13-14,16H,3,9-12,15H2,1-2H3,(H,24,31)
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n/an/a 620n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134845
PNG
(4-(7-Isopropoxy-6-methoxy-quinazolin-4-yl)-piperaz...)
Show SMILES COc1cc2c(ncnc2cc1OC(C)C)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C29H31N5O4/c1-20(2)37-27-18-25-24(17-26(27)36-3)28(31-19-30-25)33-13-15-34(16-14-33)29(35)32-21-9-11-23(12-10-21)38-22-7-5-4-6-8-22/h4-12,17-20H,13-16H2,1-3H3,(H,32,35)
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n/an/a 640n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134891
PNG
(4-(7-Butoxy-6-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCCCOc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C30H33N5O4/c1-3-4-18-38-28-20-26-25(19-27(28)37-2)29(32-21-31-26)34-14-16-35(17-15-34)30(36)33-22-10-12-24(13-11-22)39-23-8-6-5-7-9-23/h5-13,19-21H,3-4,14-18H2,1-2H3,(H,33,36)
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n/an/a 650n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50115295
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)[N+]([O-])=O)c2cc1OC
Show InChI InChI=1S/C21H22N6O5/c1-31-18-11-16-17(12-19(18)32-2)22-13-23-20(16)25-7-9-26(10-8-25)21(28)24-14-3-5-15(6-4-14)27(29)30/h3-6,11-13H,7-10H2,1-2H3,(H,24,28)
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n/an/a 700n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134851
PNG
(4-(1,3-Diethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-g]...)
Show SMILES CCn1c2cc3ncnc(N4CCN(CC4)C(=O)Nc4ccc(Oc5ccccc5)cc4)c3cc2n(CC)c1=O
Show InChI InChI=1S/C30H31N7O3/c1-3-36-26-18-24-25(19-27(26)37(4-2)30(36)39)31-20-32-28(24)34-14-16-35(17-15-34)29(38)33-21-10-12-23(13-11-21)40-22-8-6-5-7-9-22/h5-13,18-20H,3-4,14-17H2,1-2H3,(H,33,38)
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n/an/a 780n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134888
PNG
(4-(6,7-Dimethoxy-cinnolin-4-yl)-piperazine-1-carbo...)
Show SMILES COc1cc2nncc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H27N5O4/c1-34-25-16-22-23(17-26(25)35-2)30-28-18-24(22)31-12-14-32(15-13-31)27(33)29-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,29,33)
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n/an/a 810n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50115297
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OC
Show InChI InChI=1S/C22H22N6O3/c1-30-19-11-17-18(12-20(19)31-2)24-14-25-21(17)27-7-9-28(10-8-27)22(29)26-16-5-3-15(13-23)4-6-16/h3-6,11-12,14H,7-10H2,1-2H3,(H,26,29)
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n/an/a 850n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50115340
PNG
(4-(6,7-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Cl)cc3)c2cc1OC
Show InChI InChI=1S/C21H22ClN5O3/c1-29-18-11-16-17(12-19(18)30-2)23-13-24-20(16)26-7-9-27(10-8-26)21(28)25-15-5-3-14(22)4-6-15/h3-6,11-13H,7-10H2,1-2H3,(H,25,28)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134883
PNG
(4-Benzo[g]quinazolin-4-yl-piperazine-1-carbothioic...)
Show SMILES S=C(NCc1ccccc1)N1CCN(CC1)c1ncnc2cc3ccccc3cc12
Show InChI InChI=1S/C24H23N5S/c30-24(25-16-18-6-2-1-3-7-18)29-12-10-28(11-13-29)23-21-14-19-8-4-5-9-20(19)15-22(21)26-17-27-23/h1-9,14-15,17H,10-13,16H2,(H,25,30)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134904
PNG
(4-(6-Butoxy-7-methoxy-quinazolin-4-yl)-piperazine-...)
Show SMILES CCCCOc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C30H33N5O4/c1-3-4-18-38-28-19-25-26(20-27(28)37-2)31-21-32-29(25)34-14-16-35(17-15-34)30(36)33-22-10-12-24(13-11-22)39-23-8-6-5-7-9-23/h5-13,19-21H,3-4,14-18H2,1-2H3,(H,33,36)
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n/an/a 1.39E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132208
PNG
(4-(6-Amino-7-ethylamino-quinazolin-4-yl)-piperazin...)
Show SMILES CCNc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1N
Show InChI InChI=1S/C22H27N7S/c1-2-24-20-13-19-17(12-18(20)23)21(27-15-26-19)28-8-10-29(11-9-28)22(30)25-14-16-6-4-3-5-7-16/h3-7,12-13,15,24H,2,8-11,14,23H2,1H3,(H,25,30)
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n/an/a 1.44E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134886
PNG
(4-(2-Amino-9H-purin-6-yl)-piperazine-1-carboxylic ...)
Show SMILES Nc1nc(N2CCN(CC2)C(=O)Nc2ccc(Oc3ccccc3)cc2)c2[nH]cnc2n1
Show InChI InChI=1S/C22H22N8O2/c23-21-27-19-18(24-14-25-19)20(28-21)29-10-12-30(13-11-29)22(31)26-15-6-8-17(9-7-15)32-16-4-2-1-3-5-16/h1-9,14H,10-13H2,(H,26,31)(H3,23,24,25,27,28)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134850
PNG
(4-(6-Methoxy-7-methyl-quinazolin-4-yl)-piperazine-...)
Show SMILES COc1cc2c(ncnc2cc1C)N1CCN(CC1)C(=S)NCc1ccccc1
Show InChI InChI=1S/C22H25N5OS/c1-16-12-19-18(13-20(16)28-2)21(25-15-24-19)26-8-10-27(11-9-26)22(29)23-14-17-6-4-3-5-7-17/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,29)
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n/an/a 1.54E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134854
PNG
(4-(3-Ethyl-3H-imidazo[4,5-g]quinazolin-8-yl)-piper...)
Show SMILES CCn1cnc2cc3c(ncnc3cc12)N1CCN(CC1)C(=S)NCc1ccccc1
Show InChI InChI=1S/C23H25N7S/c1-2-28-16-27-20-12-18-19(13-21(20)28)25-15-26-22(18)29-8-10-30(11-9-29)23(31)24-14-17-6-4-3-5-7-17/h3-7,12-13,15-16H,2,8-11,14H2,1H3,(H,24,31)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134881
PNG
(4-(4-Benzylthiocarbamoyl-piperazin-1-yl)-6,7-dimet...)
Show SMILES CCOC(=O)c1cnc2cc(OC)c(OC)cc2c1N1CCN(CC1)C(=S)NCc1ccccc1
Show InChI InChI=1S/C26H30N4O4S/c1-4-34-25(31)20-17-27-21-15-23(33-3)22(32-2)14-19(21)24(20)29-10-12-30(13-11-29)26(35)28-16-18-8-6-5-7-9-18/h5-9,14-15,17H,4,10-13,16H2,1-3H3,(H,28,35)
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n/an/a 3.26E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134884
PNG
(4-(6-Hydroxy-7-methoxy-quinazolin-4-yl)-piperazine...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1O
Show InChI InChI=1S/C21H20N6O3/c1-30-19-11-17-16(10-18(19)28)20(24-13-23-17)26-6-8-27(9-7-26)21(29)25-15-4-2-14(12-22)3-5-15/h2-5,10-11,13,28H,6-9H2,1H3,(H,25,29)
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n/an/a 4.59E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134909
PNG
(CHEMBL144279 | {4-[4-(4-Cyano-phenylcarbamoyl)-pip...)
Show SMILES COC(=O)COc1cc2c(ncnc2cc1OC)N1CCN(CC1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C24H24N6O5/c1-33-20-12-19-18(11-21(20)35-14-22(31)34-2)23(27-15-26-19)29-7-9-30(10-8-29)24(32)28-17-5-3-16(13-25)4-6-17/h3-6,11-12,15H,7-10,14H2,1-2H3,(H,28,32)
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n/an/a 6.08E+3n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134894
PNG
(4-(8-Oxo-8,9-dihydro-7H-purin-6-yl)-piperazine-1-c...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2[nH]c(=O)[nH]c12
Show InChI InChI=1S/C22H21N7O3/c30-21-26-18-19(27-21)23-14-24-20(18)28-10-12-29(13-11-28)22(31)25-15-6-8-17(9-7-15)32-16-4-2-1-3-5-16/h1-9,14H,10-13H2,(H,25,31)(H2,23,24,26,27,30)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134867
PNG
(4-(8-Chloro-quinolin-4-yl)-piperazine-1-carboxylic...)
Show SMILES Clc1cccc2c(ccnc12)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H23ClN4O2/c27-23-8-4-7-22-24(13-14-28-25(22)23)30-15-17-31(18-16-30)26(32)29-19-9-11-21(12-10-19)33-20-5-2-1-3-6-20/h1-14H,15-18H2,(H,29,32)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134872
PNG
(CHEMBL144109 | Methanesulfonic acid 4-(4-benzylthi...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=S)NCc3ccccc3)c2cc1OS(C)(=O)=O
Show InChI InChI=1S/C22H25N5O4S2/c1-30-19-13-18-17(12-20(19)31-33(2,28)29)21(25-15-24-18)26-8-10-27(11-9-26)22(32)23-14-16-6-4-3-5-7-16/h3-7,12-13,15H,8-11,14H2,1-2H3,(H,23,32)
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n/an/a 1.02E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134900
PNG
(4-Phthalazin-1-yl-piperazine-1-carboxylic acid (4-...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1nncc2ccccc12
Show InChI InChI=1S/C25H23N5O2/c31-25(27-20-10-12-22(13-11-20)32-21-7-2-1-3-8-21)30-16-14-29(15-17-30)24-23-9-5-4-6-19(23)18-26-28-24/h1-13,18H,14-17H2,(H,27,31)
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n/an/a 1.03E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132214
PNG
(4-(6,8-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1cc(OC)c2ncnc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2c1
Show InChI InChI=1S/C27H27N5O4/c1-34-22-16-23-25(24(17-22)35-2)28-18-29-26(23)31-12-14-32(15-13-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-11,16-18H,12-15H2,1-2H3,(H,30,33)
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n/an/a 1.09E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134861
PNG
(4-(6-Fluoro-pyrido[3,4-d]pyrimidin-4-yl)-piperazin...)
Show SMILES Fc1cc2c(ncnc2cn1)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H21FN6O2/c25-22-14-20-21(15-26-22)27-16-28-23(20)30-10-12-31(13-11-30)24(32)29-17-6-8-19(9-7-17)33-18-4-2-1-3-5-18/h1-9,14-16H,10-13H2,(H,29,32)
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n/an/a 1.33E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134892
PNG
(4-(2-Oxo-1,3-dipropyl-2,3-dihydro-1H-imidazo[4,5-g...)
Show SMILES CCCn1c2cc3ncnc(N4CCN(CC4)C(=O)Nc4ccc(Oc5ccccc5)cc4)c3cc2n(CCC)c1=O
Show InChI InChI=1S/C32H35N7O3/c1-3-14-38-28-20-26-27(21-29(28)39(15-4-2)32(38)41)33-22-34-30(26)36-16-18-37(19-17-36)31(40)35-23-10-12-25(13-11-23)42-24-8-6-5-7-9-24/h5-13,20-22H,3-4,14-19H2,1-2H3,(H,35,40)
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n/an/a 2.10E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132204
PNG
(4-(7,8-Dimethoxy-quinazolin-4-yl)-piperazine-1-car...)
Show SMILES COc1ccc2c(ncnc2c1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H27N5O4/c1-34-23-13-12-22-24(25(23)35-2)28-18-29-26(22)31-14-16-32(17-15-31)27(33)30-19-8-10-21(11-9-19)36-20-6-4-3-5-7-20/h3-13,18H,14-17H2,1-2H3,(H,30,33)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134893
PNG
(4-(4-Chloro-phthalazin-1-yl)-piperazine-1-carboxyl...)
Show SMILES Clc1nnc(N2CCN(CC2)C(=O)Nc2ccc(Oc3ccccc3)cc2)c2ccccc12
Show InChI InChI=1S/C25H22ClN5O2/c26-23-21-8-4-5-9-22(21)24(29-28-23)30-14-16-31(17-15-30)25(32)27-18-10-12-20(13-11-18)33-19-6-2-1-3-7-19/h1-13H,14-17H2,(H,27,32)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134908
PNG
(4-(3-Ethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-g]quin...)
Show SMILES CCn1c2cc3ncnc(N4CCN(CC4)C(=O)Nc4ccc(Oc5ccccc5)cc4)c3cc2[nH]c1=O
Show InChI InChI=1S/C28H27N7O3/c1-2-35-25-17-23-22(16-24(25)32-28(35)37)26(30-18-29-23)33-12-14-34(15-13-33)27(36)31-19-8-10-21(11-9-19)38-20-6-4-3-5-7-20/h3-11,16-18H,2,12-15H2,1H3,(H,31,36)(H,32,37)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132230
PNG
(4-(6,7,8-Trimethoxy-quinazolin-4-yl)-piperazine-1-...)
Show SMILES COc1cc2c(ncnc2c(OC)c1OC)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H29N5O5/c1-35-23-17-22-24(26(37-3)25(23)36-2)29-18-30-27(22)32-13-15-33(16-14-32)28(34)31-19-9-11-21(12-10-19)38-20-7-5-4-6-8-20/h4-12,17-18H,13-16H2,1-3H3,(H,31,34)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134906
PNG
(4-(4-Benzyl-phthalazin-1-yl)-piperazine-1-carboxyl...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1nnc(Cc2ccccc2)c2ccccc12
Show InChI InChI=1S/C32H29N5O2/c38-32(33-25-15-17-27(18-16-25)39-26-11-5-2-6-12-26)37-21-19-36(20-22-37)31-29-14-8-7-13-28(29)30(34-35-31)23-24-9-3-1-4-10-24/h1-18H,19-23H2,(H,33,38)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134860
PNG
(4-Pyrido[2,3-d]pyrimidin-4-yl-piperazine-1-carboxy...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2ncccc12
Show InChI InChI=1S/C24H22N6O2/c31-24(28-18-8-10-20(11-9-18)32-19-5-2-1-3-6-19)30-15-13-29(14-16-30)23-21-7-4-12-25-22(21)26-17-27-23/h1-12,17H,13-16H2,(H,28,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132223
PNG
(4-(6,7-Dimethoxy-2-morpholin-4-yl-quinazolin-4-yl)...)
Show SMILES COc1cc2nc(nc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC)N1CCOCC1
Show InChI InChI=1S/C31H34N6O5/c1-39-27-20-25-26(21-28(27)40-2)33-30(36-16-18-41-19-17-36)34-29(25)35-12-14-37(15-13-35)31(38)32-22-8-10-24(11-9-22)42-23-6-4-3-5-7-23/h3-11,20-21H,12-19H2,1-2H3,(H,32,38)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134878
PNG
(4-(6,7-Dimethoxy-isoquinolin-4-yl)-piperazine-1-ca...)
Show SMILES COc1cc2cncc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H28N4O4/c1-34-26-16-20-18-29-19-25(24(20)17-27(26)35-2)31-12-14-32(15-13-31)28(33)30-21-8-10-23(11-9-21)36-22-6-4-3-5-7-22/h3-11,16-19H,12-15H2,1-2H3,(H,30,33)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134885
PNG
(4-(6,7-Bis-benzyloxy-quinazolin-4-yl)-piperazine-1...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1ncnc2cc(OCc3ccccc3)c(OCc3ccccc3)cc12
Show InChI InChI=1S/C39H35N5O4/c45-39(42-31-16-18-33(19-17-31)48-32-14-8-3-9-15-32)44-22-20-43(21-23-44)38-34-24-36(46-26-29-10-4-1-5-11-29)37(25-35(34)40-28-41-38)47-27-30-12-6-2-7-13-30/h1-19,24-25,28H,20-23,26-27H2,(H,42,45)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134910
PNG
(4-(6-Chloro-quinolin-4-yl)-piperazine-1-carbothioi...)
Show SMILES Clc1ccc2nccc(N3CCN(CC3)C(=S)NCc3ccccc3)c2c1
Show InChI InChI=1S/C21H21ClN4S/c22-17-6-7-19-18(14-17)20(8-9-23-19)25-10-12-26(13-11-25)21(27)24-15-16-4-2-1-3-5-16/h1-9,14H,10-13,15H2,(H,24,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132235
PNG
(4-Quinazolin-4-yl-piperazine-1-carbothioic acid be...)
Show SMILES S=C(NCc1ccccc1)N1CCN(CC1)c1ncnc2ccccc12
Show InChI InChI=1S/C20H21N5S/c26-20(21-14-16-6-2-1-3-7-16)25-12-10-24(11-13-25)19-17-8-4-5-9-18(17)22-15-23-19/h1-9,15H,10-14H2,(H,21,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134877
PNG
(4-(7,8-Dihydro-[1,4]dioxino[2,3-g]quinazolin-4-yl)...)
Show SMILES S=C(NCc1ccccc1)N1CCN(CC1)c1ncnc2cc3OCCOc3cc12
Show InChI InChI=1S/C22H23N5O2S/c30-22(23-14-16-4-2-1-3-5-16)27-8-6-26(7-9-27)21-17-12-19-20(29-11-10-28-19)13-18(17)24-15-25-21/h1-5,12-13,15H,6-11,14H2,(H,23,30)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132203
PNG
(4-(2-Chloro-6,7-dimethoxy-quinazolin-4-yl)-piperaz...)
Show SMILES COc1cc2nc(Cl)nc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C27H26ClN5O4/c1-35-23-16-21-22(17-24(23)36-2)30-26(28)31-25(21)32-12-14-33(15-13-32)27(34)29-18-8-10-20(11-9-18)37-19-6-4-3-5-7-19/h3-11,16-17H,12-15H2,1-2H3,(H,29,34)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134879
PNG
(4-(1,3-Dibutyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-g]...)
Show SMILES CCCCn1c2cc3ncnc(N4CCN(CC4)C(=O)Nc4ccc(Oc5ccccc5)cc4)c3cc2n(CCCC)c1=O
Show InChI InChI=1S/C34H39N7O3/c1-3-5-16-40-30-22-28-29(23-31(30)41(34(40)43)17-6-4-2)35-24-36-32(28)38-18-20-39(21-19-38)33(42)37-25-12-14-27(15-13-25)44-26-10-8-7-9-11-26/h7-15,22-24H,3-6,16-21H2,1-2H3,(H,37,42)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132217
PNG
(4-(7-Ethylamino-6-nitro-quinazolin-4-yl)-piperazin...)
Show SMILES CCNc1cc2ncnc(N3CCN(CC3)C(=[SH+])[N-]Cc3ccccc3)c2cc1[N+]([O-])=O
Show InChI InChI=1S/C22H25N7O2S/c1-2-23-19-13-18-17(12-20(19)29(30)31)21(26-15-25-18)27-8-10-28(11-9-27)22(32)24-14-16-6-4-3-5-7-16/h3-7,12-13,15H,2,8-11,14H2,1H3,(H2,23,24,25,26,32)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134887
PNG
(CHEMBL148221 | {4-[4-(4-Cyano-phenylcarbamoyl)-pip...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OCC(O)=O
Show InChI InChI=1S/C23H22N6O5/c1-33-19-11-18-17(10-20(19)34-13-21(30)31)22(26-14-25-18)28-6-8-29(9-7-28)23(32)27-16-4-2-15(12-24)3-5-16/h2-5,10-11,14H,6-9,13H2,1H3,(H,27,32)(H,30,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134843
PNG
(4-(1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)-pipe...)
Show SMILES Cn1ncc2c(ncnc12)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H23N7O2/c1-28-21-20(15-26-28)22(25-16-24-21)29-11-13-30(14-12-29)23(31)27-17-7-9-19(10-8-17)32-18-5-3-2-4-6-18/h2-10,15-16H,11-14H2,1H3,(H,27,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134849
PNG
(4-(2-Trifluoromethyl-quinolin-4-yl)-piperazine-1-c...)
Show SMILES FC(F)(F)c1cc(N2CCN(CC2)C(=O)Nc2ccc(Oc3ccccc3)cc2)c2ccccc2n1
Show InChI InChI=1S/C27H23F3N4O2/c28-27(29,30)25-18-24(22-8-4-5-9-23(22)32-25)33-14-16-34(17-15-33)26(35)31-19-10-12-21(13-11-19)36-20-6-2-1-3-7-20/h1-13,18H,14-17H2,(H,31,35)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134880
PNG
(4-(7-Chloro-quinolin-4-yl)-piperazine-1-carbothioi...)
Show SMILES Clc1ccc2c(ccnc2c1)N1CCN(CC1)C(=S)NCc1ccccc1
Show InChI InChI=1S/C21H21ClN4S/c22-17-6-7-18-19(14-17)23-9-8-20(18)25-10-12-26(13-11-25)21(27)24-15-16-4-2-1-3-5-16/h1-9,14H,10-13,15H2,(H,24,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134896
PNG
(4-Isoquinolin-4-yl-piperazine-1-carboxylic acid (4...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)N1CCN(CC1)c1cncc2ccccc12
Show InChI InChI=1S/C26H24N4O2/c31-26(28-21-10-12-23(13-11-21)32-22-7-2-1-3-8-22)30-16-14-29(15-17-30)25-19-27-18-20-6-4-5-9-24(20)25/h1-13,18-19H,14-17H2,(H,28,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50132218
PNG
(4-(6,7-Dimethoxy-2-methyl-quinazolin-4-yl)-piperaz...)
Show SMILES COc1cc2nc(C)nc(N3CCN(CC3)C(=O)Nc3ccc(Oc4ccccc4)cc3)c2cc1OC
Show InChI InChI=1S/C28H29N5O4/c1-19-29-24-18-26(36-3)25(35-2)17-23(24)27(30-19)32-13-15-33(16-14-32)28(34)31-20-9-11-22(12-10-20)37-21-7-5-4-6-8-21/h4-12,17-18H,13-16H2,1-3H3,(H,31,34)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134890
PNG
(4-(9-Methyl-9H-purin-6-yl)-piperazine-1-carboxylic...)
Show SMILES Cn1cnc2c(ncnc12)N1CCN(CC1)C(=O)Nc1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C23H23N7O2/c1-28-16-26-20-21(28)24-15-25-22(20)29-11-13-30(14-12-29)23(31)27-17-7-9-19(10-8-17)32-18-5-3-2-4-6-18/h2-10,15-16H,11-14H2,1H3,(H,27,31)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134901
PNG
(4-[1,3]Dioxolo[4,5-g]quinazolin-8-yl-piperazine-1-...)
Show SMILES S=C(NCc1ccccc1)N1CCN(CC1)c1ncnc2cc3OCOc3cc12
Show InChI InChI=1S/C21H21N5O2S/c29-21(22-12-15-4-2-1-3-5-15)26-8-6-25(7-9-26)20-16-10-18-19(28-14-27-18)11-17(16)23-13-24-20/h1-5,10-11,13H,6-9,12,14H2,(H,22,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134857
PNG
(4-(9H-Purin-6-yl)-piperazine-1-carbothioic acid be...)
Show SMILES S=C(NCc1ccccc1)N1CCN(CC1)c1ncnc2nc[nH]c12
Show InChI InChI=1S/C17H19N7S/c25-17(18-10-13-4-2-1-3-5-13)24-8-6-23(7-9-24)16-14-15(20-11-19-14)21-12-22-16/h1-5,11-12H,6-10H2,(H,18,25)(H,19,20,21,22)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134865
PNG
(4-Quinolin-4-yl-piperazine-1-carbothioic acid benz...)
Show SMILES S=C(NCc1ccccc1)N1CCN(CC1)c1ccnc2ccccc12
Show InChI InChI=1S/C21H22N4S/c26-21(23-16-17-6-2-1-3-7-17)25-14-12-24(13-15-25)20-10-11-22-19-9-5-4-8-18(19)20/h1-11H,12-16H2,(H,23,26)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
Platelet-derived growth factor receptor beta


(Homo sapiens (Human))
BDBM50134859
PNG
(4-(6-Benzyloxy-7-methoxy-quinazolin-4-yl)-piperazi...)
Show SMILES COc1cc2ncnc(N3CCN(CC3)C(=O)Nc3ccc(cc3)C#N)c2cc1OCc1ccccc1
Show InChI InChI=1S/C28H26N6O3/c1-36-25-16-24-23(15-26(25)37-18-21-5-3-2-4-6-21)27(31-19-30-24)33-11-13-34(14-12-33)28(35)32-22-9-7-20(17-29)8-10-22/h2-10,15-16,19H,11-14,18H2,1H3,(H,32,35)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of platelet-derived growth factor receptor beta phosphorylation was measured in intact cells using a two-site enzyme linked immunosorbent ...


J Med Chem 46: 4910-25 (2003)


Article DOI: 10.1021/jm020505v
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%