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PubMed code 14592495

Compile data set for download or QSAR
Found 60 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Proto-oncogene tyrosine-protein kinase Src


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 10n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Src kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50135404
PNG
(2-(Cyclopropanecarbonyl-amino)-thiazole-5-carboxyl...)
Show SMILES Cc1cc(C)c(NC(=O)c2cnc(NC(=O)C3CC3)s2)c(C)c1
Show InChI InChI=1S/C17H19N3O2S/c1-9-6-10(2)14(11(3)7-9)19-16(22)13-8-18-17(23-13)20-15(21)12-4-5-12/h6-8,12H,4-5H2,1-3H3,(H,19,22)(H,18,20,21)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13242
PNG
(2-[(butylcarbamoyl)amino]-4-methyl-N-(2,4,6-trimet...)
Show SMILES CCCCNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C19H26N4O2S/c1-6-7-8-20-18(25)23-19-21-14(5)16(26-19)17(24)22-15-12(3)9-11(2)10-13(15)4/h9-10H,6-8H2,1-5H3,(H,22,24)(H2,20,21,23,25)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL




Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Lck kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK3


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 44n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Jak3 kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13242
PNG
(2-[(butylcarbamoyl)amino]-4-methyl-N-(2,4,6-trimet...)
Show SMILES CCCCNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C19H26N4O2S/c1-6-7-8-20-18(25)23-19-21-14(5)16(26-19)17(24)22-15-12(3)9-11(2)10-13(15)4/h9-10H,6-8H2,1-5H3,(H,22,24)(H2,20,21,23,25)
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n/an/a 70n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Fyn


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 71n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Fyn kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13240
PNG
(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Show SMILES CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H20N4O2S/c1-8-6-9(2)12(10(3)7-8)19-14(21)13-11(4)18-16(23-13)20-15(22)17-5/h6-7H,1-5H3,(H,19,21)(H2,17,18,20,22)
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n/an/a 170n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13240
PNG
(2-[[(Methylamino)-carbonyl]amino]-4-methyl-N-(2,4,...)
Show SMILES CNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H20N4O2S/c1-8-6-9(2)12(10(3)7-8)19-14(21)13-11(4)18-16(23-13)20-15(22)17-5/h6-7H,1-5H3,(H,19,21)(H2,17,18,20,22)
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n/an/a 240n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase HCK


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 310n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of Hck kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13224
PNG
(2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...)
Show SMILES Cc1nc(NC(=O)c2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H21N3O2S/c1-12-10-13(2)17(14(3)11-12)23-20(26)18-15(4)22-21(27-18)24-19(25)16-8-6-5-7-9-16/h5-11H,1-4H3,(H,23,26)(H,22,24,25)
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n/an/a 320n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13232
PNG
(2-(2-furoylamino)-N-mesityl-4-methyl-1,3-thiazole-...)
Show SMILES Cc1nc(NC(=O)c2ccco2)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C19H19N3O3S/c1-10-8-11(2)15(12(3)9-10)21-18(24)16-13(4)20-19(26-16)22-17(23)14-6-5-7-25-14/h5-9H,1-4H3,(H,21,24)(H,20,22,23)
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n/an/a 360n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13245
PNG
(2-[(butylcarbamoyl)amino]-N-(2-chloro-6-methylphen...)
Show SMILES CCCCNC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C17H21ClN4O2S/c1-4-5-9-19-16(24)22-17-20-11(3)14(25-17)15(23)21-13-10(2)7-6-8-12(13)18/h6-8H,4-5,9H2,1-3H3,(H,21,23)(H2,19,20,22,24)
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n/an/a 620n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13222
PNG
(2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...)
Show SMILES COC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19N3O3S/c1-8-6-9(2)12(10(3)7-8)18-14(20)13-11(4)17-15(23-13)19-16(21)22-5/h6-7H,1-5H3,(H,18,20)(H,17,19,21)
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n/an/a 700n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13237
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-(furan-2-)-4-met...)
Show SMILES Cc1nc(NC(=O)c2ccco2)sc1C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C17H14ClN3O3S/c1-9-5-3-6-11(18)13(9)20-16(23)14-10(2)19-17(25-14)21-15(22)12-7-4-8-24-12/h3-8H,1-2H3,(H,20,23)(H,19,21,22)
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n/an/a 710n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13222
PNG
(2-[[(Methoxy)carbonyl]-amino]-4-methyl-N-(2,4,6-tr...)
Show SMILES COC(=O)Nc1nc(C)c(s1)C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C16H19N3O3S/c1-8-6-9(2)12(10(3)7-8)18-14(20)13-11(4)17-15(23-13)19-16(21)22-5/h6-7H,1-5H3,(H,18,20)(H,17,19,21)
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n/an/a 720n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13224
PNG
(2-N-benzene-4-methyl-5-N-(2,4,6-trimethylphenyl)-1...)
Show SMILES Cc1nc(NC(=O)c2ccccc2)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C21H21N3O2S/c1-12-10-13(2)17(14(3)11-12)23-20(26)18-15(4)22-21(27-18)24-19(25)16-8-6-5-7-9-16/h5-11H,1-4H3,(H,23,26)(H,22,24,25)
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n/an/a 800n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 880n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CD3/CD28 T-cell proliferation assay in PBL (peripheral blood lymphocytes)


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13250
PNG
(2-N-benzene-5-N-(2-chloro-6-methylphenyl)-1,3-thia...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)c2ccccc2)s1
Show InChI InChI=1S/C18H14ClN3O2S/c1-11-6-5-9-13(19)15(11)21-17(24)14-10-20-18(25-14)22-16(23)12-7-3-2-4-8-12/h2-10H,1H3,(H,21,24)(H,20,22,23)
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n/an/a 890n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13239
PNG
(2-[[(Cyclopropyl)carbonyl]-amino]-4-methyl-N-(2-ch...)
Show SMILES Cc1nc(NC(=O)C2CC2)sc1C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C16H16ClN3O2S/c1-8-4-3-5-11(17)12(8)19-15(22)13-9(2)18-16(23-13)20-14(21)10-6-7-10/h3-5,10H,6-7H2,1-2H3,(H,19,22)(H,18,20,21)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13220
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C
Show InChI InChI=1S/C18H22BrN3O3S/c1-9-7-12(19)8-10(2)13(9)21-15(23)14-11(3)20-16(26-14)22-17(24)25-18(4,5)6/h7-8H,1-6H3,(H,21,23)(H,20,22,24)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13217
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C19H25N3O3S/c1-10-8-11(2)14(12(3)9-10)21-16(23)15-13(4)20-17(26-15)22-18(24)25-19(5,6)7/h8-9H,1-7H3,(H,21,23)(H,20,22,24)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13220
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(4-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(Br)cc1C
Show InChI InChI=1S/C18H22BrN3O3S/c1-9-7-12(19)8-10(2)13(9)21-15(23)14-11(3)20-16(26-14)22-17(24)25-18(4,5)6/h7-8H,1-6H3,(H,21,23)(H,20,22,24)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13217
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C19H25N3O3S/c1-10-8-11(2)14(12(3)9-10)21-16(23)15-13(4)20-17(26-15)22-18(24)25-19(5,6)7/h8-9H,1-7H3,(H,21,23)(H,20,22,24)
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n/an/a 3.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13253
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-(furan-2-)-1,3-t...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)c2ccco2)s1
Show InChI InChI=1S/C16H12ClN3O3S/c1-9-4-2-5-10(17)13(9)19-15(22)12-8-18-16(24-12)20-14(21)11-6-3-7-23-11/h2-8H,1H3,(H,19,22)(H,18,20,21)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13219
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H23N3O3S/c1-10-8-7-9-11(2)13(10)20-15(22)14-12(3)19-16(25-14)21-17(23)24-18(4,5)6/h7-9H,1-6H3,(H,20,22)(H,19,21,23)
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n/an/a 4.40E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13238
PNG
(2-N-benzene-5-N-(2-chloro-6-methylphenyl)-4-methyl...)
Show SMILES Cc1nc(NC(=O)c2ccccc2)sc1C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C19H16ClN3O2S/c1-11-7-6-10-14(20)15(11)22-18(25)16-12(2)21-19(26-16)23-17(24)13-8-4-3-5-9-13/h3-10H,1-2H3,(H,22,25)(H,21,23,24)
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n/an/a 4.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13215
PNG
(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Show SMILES Cc1nc(N)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C14H17N3OS/c1-7-5-8(2)11(9(3)6-7)17-13(18)12-10(4)16-14(15)19-12/h5-6H,1-4H3,(H2,15,16)(H,17,18)
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n/an/a 5.00E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13215
PNG
(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Show SMILES Cc1nc(N)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C14H17N3OS/c1-7-5-8(2)11(9(3)6-7)17-13(18)12-10(4)16-14(15)19-12/h5-6H,1-4H3,(H2,15,16)(H,17,18)
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n/an/a 6.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13219
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H23N3O3S/c1-10-8-7-9-11(2)13(10)20-15(22)14-12(3)19-16(25-14)21-17(23)24-18(4,5)6/h7-9H,1-6H3,(H,20,22)(H,19,21,23)
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n/an/a 7.50E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13218
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C17H20ClN3O3S/c1-9-7-6-8-11(18)12(9)20-14(22)13-10(2)19-15(25-13)21-16(23)24-17(3,4)5/h6-8H,1-5H3,(H,20,22)(H,19,21,23)
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n/an/a 9.60E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of mouse p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Epidermal growth factor receptor


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound against HER1 kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13221
PNG
(BMS-354825 tert-Butoxycarbamate Analog 5e | CHEMBL...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(Cl)cccc1Cl
Show InChI InChI=1S/C16H17Cl2N3O3S/c1-8-12(13(22)20-11-9(17)6-5-7-10(11)18)25-14(19-8)21-15(23)24-16(2,3)4/h5-7H,1-4H3,(H,20,22)(H,19,21,23)
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n/an/a 1.25E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13228
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES COc1cccc(C)c1NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C18H23N3O4S/c1-10-8-7-9-12(24-6)13(10)20-15(22)14-11(2)19-16(26-14)21-17(23)25-18(3,4)5/h7-9H,1-6H3,(H,20,22)(H,19,21,23)
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n/an/a 2.43E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of KDR kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Fibroblast growth factor receptor


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL




Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of HER2 kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
MAP kinase p38


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a 2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Cyclin-dependent kinase 2


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of CDK2 kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Focal adhesion kinase 1


(Homo sapiens (Human))
BDBM13246
PNG
(5-N-(2-chloro-6-methylphenyl)-2-N-cyclopropane-1,3...)
Show SMILES Cc1cccc(Cl)c1NC(=O)c1cnc(NC(=O)C2CC2)s1
Show InChI InChI=1S/C15H14ClN3O2S/c1-8-3-2-4-10(16)12(8)18-14(21)11-7-17-15(22-11)19-13(20)9-5-6-9/h2-4,7,9H,5-6H2,1H3,(H,18,21)(H,17,19,20)
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n/an/a>2.50E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of FAK kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM13218
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1Cl
Show InChI InChI=1S/C17H20ClN3O3S/c1-9-7-6-8-11(18)12(9)20-14(22)13-10(2)19-15(25-13)21-16(23)24-17(3,4)5/h6-8H,1-5H3,(H,20,22)(H,19,21,23)
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n/an/a 2.80E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of human p56 Lck tyrosine kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50135402
PNG
(CHEMBL130971 | [4-Ethyl-5-(2,4,6-trimethyl-phenylc...)
Show SMILES CCc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cc(C)cc1C
Show InChI InChI=1S/C20H27N3O3S/c1-8-14-16(27-18(21-14)23-19(25)26-20(5,6)7)17(24)22-15-12(3)9-11(2)10-13(15)4/h9-10H,8H2,1-7H3,(H,22,24)(H,21,23,25)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50135407
PNG
(CHEMBL128581 | [4-Trifluoromethyl-5-(2,4,6-trimeth...)
Show SMILES Cc1cc(C)c(NC(=O)c2sc(NC(=O)OC(C)(C)C)nc2C(F)(F)F)c(C)c1
Show InChI InChI=1S/C19H22F3N3O3S/c1-9-7-10(2)12(11(3)8-9)23-15(26)13-14(19(20,21)22)24-16(29-13)25-17(27)28-18(4,5)6/h7-8H,1-6H3,(H,23,26)(H,24,25,27)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50135403
PNG
(CHEMBL130320 | [5-(2,4,6-Trimethyl-phenylcarbamoyl...)
Show SMILES Cc1cc(C)c(NC(=O)c2cnc(NC(=O)OC(C)(C)C)s2)c(C)c1
Show InChI InChI=1S/C18H23N3O3S/c1-10-7-11(2)14(12(3)8-10)20-15(22)13-9-19-16(25-13)21-17(23)24-18(4,5)6/h7-9H,1-6H3,(H,20,22)(H,19,21,23)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50135397
PNG
(CHEMBL340773 | [4-Phenyl-5-(2,4,6-trimethyl-phenyl...)
Show SMILES Cc1cc(C)c(NC(=O)c2sc(NC(=O)OC(C)(C)C)nc2-c2ccccc2)c(C)c1
Show InChI InChI=1S/C24H27N3O3S/c1-14-12-15(2)18(16(3)13-14)25-21(28)20-19(17-10-8-7-9-11-17)26-22(31-20)27-23(29)30-24(4,5)6/h7-13H,1-6H3,(H,25,28)(H,26,27,29)
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n/an/a>3.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13227
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES CC(C)c1cccc(C)c1NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C20H27N3O3S/c1-11(2)14-10-8-9-12(3)15(14)22-17(24)16-13(4)21-18(27-16)23-19(25)26-20(5,6)7/h8-11H,1-7H3,(H,22,24)(H,21,23,25)
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n/an/a 4.03E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13226
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2-...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1ccccc1C
Show InChI InChI=1S/C17H21N3O3S/c1-10-8-6-7-9-12(10)19-14(21)13-11(2)18-15(24-13)20-16(22)23-17(3,4)5/h6-9H,1-5H3,(H,19,21)(H,18,20,22)
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n/an/a 4.57E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135399
PNG
(CHEMBL130075 | [5-(4-Formyl-piperazine-1-carbonyl)...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)N1CCN(CC1)C=O
Show InChI InChI=1S/C15H22N4O4S/c1-10-11(12(21)19-7-5-18(9-20)6-8-19)24-13(16-10)17-14(22)23-15(2,3)4/h9H,5-8H2,1-4H3,(H,16,17,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135405
PNG
(CHEMBL334341 | [5-(2,6-Diisopropyl-phenylcarbamoyl...)
Show SMILES CC(C)c1cccc(C(C)C)c1NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C22H31N3O3S/c1-12(2)15-10-9-11-16(13(3)4)17(15)24-19(26)18-14(5)23-20(29-18)25-21(27)28-22(6,7)8/h9-13H,1-8H3,(H,24,26)(H,23,25,27)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135400
PNG
(CHEMBL338488 | [5-(2-tert-Butyl-6-methyl-phenylcar...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1C(C)(C)C
Show InChI InChI=1S/C21H29N3O3S/c1-12-10-9-11-14(20(3,4)5)15(12)23-17(25)16-13(2)22-18(28-16)24-19(26)27-21(6,7)8/h9-11H,1-8H3,(H,23,25)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM13225
PNG
(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-phe...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1ccccc1
Show InChI InChI=1S/C16H19N3O3S/c1-10-12(13(20)18-11-8-6-5-7-9-11)23-14(17-10)19-15(21)22-16(2,3)4/h5-9H,1-4H3,(H,18,20)(H,17,19,21)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135396
PNG
(CHEMBL336544 | [5-(2,4-Dichloro-phenylcarbamoyl)-4...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C16H17Cl2N3O3S/c1-8-12(13(22)20-11-6-5-9(17)7-10(11)18)25-14(19-8)21-15(23)24-16(2,3)4/h5-7H,1-4H3,(H,20,22)(H,19,21,23)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135409
PNG
(CHEMBL128795 | [5-(2,2-Dimethyl-propylcarbamoyl)-4...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)NCC(C)(C)C
Show InChI InChI=1S/C15H25N3O3S/c1-9-10(11(19)16-8-14(2,3)4)22-12(17-9)18-13(20)21-15(5,6)7/h8H2,1-7H3,(H,16,19)(H,17,18,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135395
PNG
(CHEMBL341026 | [5-(Cyclohexylmethyl-carbamoyl)-4-m...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)NCC1CCCCC1
Show InChI InChI=1S/C17H27N3O3S/c1-11-13(14(21)18-10-12-8-6-5-7-9-12)24-15(19-11)20-16(22)23-17(2,3)4/h12H,5-10H2,1-4H3,(H,18,21)(H,19,20,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135398
PNG
(CHEMBL423516 | [4-Methyl-5-(2-nitro-phenylcarbamoy...)
Show SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C16H18N4O5S/c1-9-12(26-14(17-9)19-15(22)25-16(2,3)4)13(21)18-10-7-5-6-8-11(10)20(23)24/h5-8H,1-4H3,(H,18,21)(H,17,19,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135408
PNG
(CHEMBL128455 | [5-(2,5-Dimethyl-1H-pyrrol-3-ylcarb...)
Show SMILES Cc1cc(NC(=O)c2sc(NC(=O)OC(C)(C)C)nc2C)c(C)[nH]1
Show InChI InChI=1S/C16H22N4O3S/c1-8-7-11(9(2)17-8)19-13(21)12-10(3)18-14(24-12)20-15(22)23-16(4,5)6/h7,17H,1-6H3,(H,19,21)(H,18,20,22)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135406
PNG
(CHEMBL131167 | [5-(1,2-Dimethyl-propylcarbamoyl)-4...)
Show SMILES CC(C)C(C)NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C15H25N3O3S/c1-8(2)9(3)16-12(19)11-10(4)17-13(22-11)18-14(20)21-15(5,6)7/h8-9H,1-7H3,(H,16,19)(H,17,18,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Lck


(Homo sapiens (Human))
BDBM50135406
PNG
(CHEMBL131167 | [5-(1,2-Dimethyl-propylcarbamoyl)-4...)
Show SMILES CC(C)C(C)NC(=O)c1sc(NC(=O)OC(C)(C)C)nc1C
Show InChI InChI=1S/C15H25N3O3S/c1-8(2)9(3)16-12(19)11-10(4)17-13(22-11)18-14(20)21-15(5,6)7/h8-9H,1-7H3,(H,16,19)(H,17,18,20)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity of the compound human Lck(hLck) kinase


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
Tyrosine-protein kinase LCK


(Mus musculus)
BDBM50135401
PNG
(CHEMBL130943 | [5-(3-Methoxy-5-trifluoromethyl-phe...)
Show SMILES COc1cc(NC(=O)c2sc(NC(=O)OC(C)(C)C)nc2C)cc(c1)C(F)(F)F
Show InChI InChI=1S/C18H20F3N3O4S/c1-9-13(29-15(22-9)24-16(26)28-17(2,3)4)14(25)23-11-6-10(18(19,20)21)7-12(8-11)27-5/h6-8H,1-5H3,(H,23,25)(H,22,24,26)
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n/an/a>5.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
In vitro inhibition of murine Lck kinase.


Bioorg Med Chem Lett 13: 4007-10 (2003)


BindingDB Entry DOI: 10.7270/Q2CC103J
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%