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PubMed code 14643326

Compile data set for download or QSAR
Found 10 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50126335
PNG
(6-[(R)-Amino-(4-chloro-phenyl)-(3-methyl-3H-imidaz...)
Show SMILES Cn1ccnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C27H22Cl2N4O/c1-32-13-12-31-26(32)27(30,18-6-9-20(28)10-7-18)19-8-11-24-23(15-19)22(16-25(34)33(24)2)17-4-3-5-21(29)14-17/h3-16H,30H2,1-2H3
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n/an/a 0.900n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136377
PNG
(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(4-methyl...)
Show SMILES Cn1cnnc1C(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C26H20Cl2N4O/c1-31-15-29-30-26(31)25(16-6-9-19(27)10-7-16)18-8-11-23-22(13-18)21(14-24(33)32(23)2)17-4-3-5-20(28)12-17/h3-15,25H,1-2H3
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n/an/a 1n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136375
PNG
(6-[Amino-(4-chloro-phenyl)-(4-methyl-4H-[1,2,4]tri...)
Show SMILES Cn1cnnc1C(N)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C26H21Cl2N5O/c1-32-15-30-31-25(32)26(29,17-6-9-19(27)10-7-17)18-8-11-23-22(13-18)21(14-24(34)33(23)2)16-4-3-5-20(28)12-16/h3-15H,29H2,1-2H3
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n/an/a 1.30n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136379
PNG
(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C27H21Cl2N3O2/c1-31-16-30-15-25(31)27(34,18-6-9-20(28)10-7-18)19-8-11-24-23(13-19)22(14-26(33)32(24)2)17-4-3-5-21(29)12-17/h3-16,34H,1-2H3
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n/an/a 1.70n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136376
PNG
(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-(3-methyl...)
Show SMILES Cn1cncc1C(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C27H21Cl2N3O/c1-31-16-30-15-25(31)27(17-6-9-20(28)10-7-17)19-8-11-24-23(13-19)22(14-26(33)32(24)2)18-4-3-5-21(29)12-18/h3-16,27H,1-2H3
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n/an/a 3n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136378
PNG
(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Show SMILES Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C26H19Cl2N3O2/c1-31-15-29-14-24(31)26(33,17-5-8-19(27)9-6-17)18-7-10-23-22(12-18)21(13-25(32)30-23)16-3-2-4-20(28)11-16/h2-15,33H,1H3,(H,30,32)
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n/an/a 4n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136380
PNG
(4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(3-me...)
Show SMILES Cn1cncc1C(C)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C28H23Cl2N3O/c1-28(26-16-31-17-32(26)2,19-7-10-21(29)11-8-19)20-9-12-25-24(14-20)23(15-27(34)33(25)3)18-5-4-6-22(30)13-18/h4-17H,1-3H3
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n/an/a 4n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair		3D
3D Structure (docked)
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136382
PNG
(4-(3-Chloro-phenyl)-6-[1-(4-chloro-phenyl)-1-(4-me...)
Show SMILES Cn1cnnc1C(C)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C27H22Cl2N4O/c1-27(26-31-30-16-32(26)2,18-7-10-20(28)11-8-18)19-9-12-24-23(14-19)22(15-25(34)33(24)3)17-5-4-6-21(29)13-17/h4-16H,1-3H3
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n/an/a 5n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136381
PNG
(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Show SMILES Cn1cnnc1C(O)(c1ccc(Cl)cc1)c1ccc2n(C)c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C26H20Cl2N4O2/c1-31-15-29-30-25(31)26(34,17-6-9-19(27)10-7-17)18-8-11-23-22(13-18)21(14-24(33)32(23)2)16-4-3-5-20(28)12-16/h3-15,34H,1-2H3
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n/an/a 6n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))		BDBM50136374
PNG
(4-(3-Chloro-phenyl)-6-[(4-chloro-phenyl)-hydroxy-(...)
Show SMILES Cn1cnnc1C(O)(c1ccc(Cl)cc1)c1ccc2[nH]c(=O)cc(-c3cccc(Cl)c3)c2c1
Show InChI InChI=1S/C25H18Cl2N4O2/c1-31-14-28-30-24(31)25(33,16-5-8-18(26)9-6-16)17-7-10-22-21(12-17)20(13-23(32)29-22)15-3-2-4-19(27)11-15/h2-14,33H,1H3,(H,29,32)
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n/an/a 26n/an/an/an/an/an/a



Medicinal Chemistry Department Johnson & Johnson Pharmaceutical Research & Development (J&JPRD)

Curated by ChEMBL


Assay Description
Inhibition of [3H]-FPP incorporation into biotinylated lamin B peptide by farnesyl transferase

Bioorg Med Chem Lett 13: 4361-4 (2003)


BindingDB Entry DOI: 10.7270/Q25H7FPB
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%