BindingDB logo
myBDB logout

PubMed code 14643340

Compile data set for download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136531
PNG
((R)-1,2,3,4-Tetrahydro-quinoline-2-carboxylic acid...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2CCc3ccccc3N2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C33H41ClN6O2/c34-27-13-10-24(11-14-27)20-30(38-31(41)29-15-12-25-6-4-5-9-28(25)37-29)32(42)39-18-16-33(17-19-39,21-40-23-35-22-36-40)26-7-2-1-3-8-26/h4-6,9-11,13-14,22-23,26,29-30,37H,1-3,7-8,12,15-21H2,(H,38,41)/t29-,30-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 1.20n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136534
PNG
(3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCC(=O)NC2CCCCNC2=O)c1=O
Show InChI InChI=1S/C26H27ClN4O4S/c1-35-20-10-8-19(9-11-20)31-26(34)17(16-24(30-31)36-21-12-6-18(27)7-13-21)5-14-23(32)29-22-4-2-3-15-28-25(22)33/h6-13,16,22H,2-5,14-15H2,1H3,(H,28,33)(H,29,32)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.30n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136535
PNG
(3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCC(=O)NCCOc2ccccc2)c1=O
Show InChI InChI=1S/C28H26ClN3O4S/c1-35-23-12-10-22(11-13-23)32-28(34)20(19-27(31-32)37-25-14-8-21(29)9-15-25)7-16-26(33)30-17-18-36-24-5-3-2-4-6-24/h2-6,8-15,19H,7,16-18H2,1H3,(H,30,33)
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 5.60n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136514
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29-,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 33n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136529
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCC(C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22?,29-,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 41n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136530
PNG
((3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CCNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)29-18-19-35-21-30(29)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29+,30-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 130n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136528
PNG
(3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCC(=O)N[C@@H]2CCc3ccccc3NC2=O)c1=O
Show InChI InChI=1S/C30H27ClN4O4S/c1-39-23-12-10-22(11-13-23)35-30(38)20(18-28(34-35)40-24-14-8-21(31)9-15-24)7-17-27(36)32-26-16-6-19-4-2-3-5-25(19)33-29(26)37/h2-5,8-15,18,26H,6-7,16-17H2,1H3,(H,32,36)(H,33,37)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 144n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136518
PNG
((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(R...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-21(35-31(38)29-20-34-19-28(29)22-6-4-3-5-7-22)8-9-23-18-30(41-27-16-10-24(33)11-17-27)36-37(32(23)39)25-12-14-26(40-2)15-13-25/h3-7,10-18,21,28-29,34H,8-9,19-20H2,1-2H3,(H,35,38)/t21-,28-,29+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 190n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136524
PNG
((3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCC(C)NC(=O)[C@H]2CCNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)29-18-19-35-21-30(29)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22?,29-,30+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 339n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136518
PNG
((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(R...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-21(35-31(38)29-20-34-19-28(29)22-6-4-3-5-7-22)8-9-23-18-30(41-27-16-10-24(33)11-17-27)36-37(32(23)39)25-12-14-26(40-2)15-13-25/h3-7,10-18,21,28-29,34H,8-9,19-20H2,1-2H3,(H,35,38)/t21-,28-,29+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 380n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136515
PNG
((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(S...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@H](C)NC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-21(35-31(38)29-20-34-19-28(29)22-6-4-3-5-7-22)8-9-23-18-30(41-27-16-10-24(33)11-17-27)36-37(32(23)39)25-12-14-26(40-2)15-13-25/h3-7,10-18,21,28-29,34H,8-9,19-20H2,1-2H3,(H,35,38)/t21-,28+,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 975n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136522
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(S)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@H](C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29+,30-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.20E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136521
PNG
((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {3-...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCCNC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C31H31ClN4O3S/c1-39-25-13-11-24(12-14-25)36-31(38)22(18-29(35-36)40-26-15-9-23(32)10-16-26)8-5-17-34-30(37)28-20-33-19-27(28)21-6-3-2-4-7-21/h2-4,6-7,9-16,18,27-28,33H,5,8,17,19-20H2,1H3,(H,34,37)/t27-,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.25E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 5


(Homo sapiens (Human))		BDBM50136514
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29-,30+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.41E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-5-recep...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136516
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCCNC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-40-26-13-11-25(12-14-26)37-32(39)23(20-30(36-37)41-27-15-9-24(33)10-16-27)8-5-18-35-31(38)29-21-34-19-17-28(29)22-6-3-2-4-7-22/h2-4,6-7,9-16,20,28-29,34H,5,8,17-19,21H2,1H3,(H,35,38)/t28-,29+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 1.97E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136526
PNG
((3S,4R)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@@H]2CNCC[C@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29+,30-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.06E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136520
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC(C)CNC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(20-36-32(39)30-21-35-17-16-29(30)23-6-4-3-5-7-23)18-24-19-31(42-28-14-8-25(34)9-15-28)37-38(33(24)40)26-10-12-27(41-2)13-11-26/h3-15,19,22,29-30,35H,16-18,20-21H2,1-2H3,(H,36,39)/t22?,29-,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.17E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 3


(Homo sapiens (Human))		BDBM50136514
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29-,30+/m1/s1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.17E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-3-recep...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136525
PNG
((3R,4R)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNCC[C@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29+,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.24E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136517
PNG
((3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCCNC(=O)[C@H]2CCNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-40-26-13-11-25(12-14-26)37-32(39)23(20-30(36-37)41-27-15-9-24(33)10-16-27)8-5-18-35-31(38)28-17-19-34-21-29(28)22-6-3-2-4-7-22/h2-4,6-7,9-16,20,28-29,34H,5,8,17-19,21H2,1H3,(H,35,38)/t28-,29+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.76E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136527
PNG
((3S,4R)-4-Phenyl-piperidine-3-carboxylic acid {(S)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@H](C)NC(=O)[C@@H]2CNCC[C@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29-,30+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 2.99E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136523
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(C(C)CCNC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(16-19-36-32(39)30-21-35-18-17-28(30)23-6-4-3-5-7-23)29-20-31(42-27-14-8-24(34)9-15-27)37-38(33(29)40)25-10-12-26(41-2)13-11-25/h3-15,20,22,28,30,35H,16-19,21H2,1-2H3,(H,36,39)/t22?,28-,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 3.93E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136519
PNG
((3R,4R)-4-Phenyl-piperidine-3-carboxylic acid {(S)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@H](C)NC(=O)[C@H]2CNCC[C@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29-,30-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 9.02E+3n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136521
PNG
((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {3-...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCCNC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C31H31ClN4O3S/c1-39-25-13-11-24(12-14-25)36-31(38)22(18-29(35-36)40-26-15-9-23(32)10-16-26)8-5-17-34-30(37)28-20-33-19-27(28)21-6-3-2-4-7-21/h2-4,6-7,9-16,18,27-28,33H,5,8,17,19-20H2,1H3,(H,34,37)/t27-,28+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 820n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136525
PNG
((3R,4R)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNCC[C@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29+,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 4.05E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136518
PNG
((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(R...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-21(35-31(38)29-20-34-19-28(29)22-6-4-3-5-7-22)8-9-23-18-30(41-27-16-10-24(33)11-17-27)36-37(32(23)39)25-12-14-26(40-2)15-13-25/h3-7,10-18,21,28-29,34H,8-9,19-20H2,1-2H3,(H,35,38)/t21-,28-,29+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 405n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136515
PNG
((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(S...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@H](C)NC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-21(35-31(38)29-20-34-19-28(29)22-6-4-3-5-7-22)8-9-23-18-30(41-27-16-10-24(33)11-17-27)36-37(32(23)39)25-12-14-26(40-2)15-13-25/h3-7,10-18,21,28-29,34H,8-9,19-20H2,1-2H3,(H,35,38)/t21-,28+,29-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 5.80E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136514
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29-,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 177n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136526
PNG
((3S,4R)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@@H]2CNCC[C@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29+,30-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>5.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136529
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCC(C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22?,29-,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 227n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136516
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCCNC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-40-26-13-11-25(12-14-26)37-32(39)23(20-30(36-37)41-27-15-9-24(33)10-16-27)8-5-18-35-31(38)29-21-34-19-17-28(29)22-6-3-2-4-7-22/h2-4,6-7,9-16,20,28-29,34H,5,8,17-19,21H2,1H3,(H,35,38)/t28-,29+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 500n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136517
PNG
((3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCCNC(=O)[C@H]2CCNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-40-26-13-11-25(12-14-26)37-32(39)23(20-30(36-37)41-27-15-9-24(33)10-16-27)8-5-18-35-31(38)28-17-19-34-21-29(28)22-6-3-2-4-7-22/h2-4,6-7,9-16,20,28-29,34H,5,8,17-19,21H2,1H3,(H,35,38)/t28-,29+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>5.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136520
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC(C)CNC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(20-36-32(39)30-21-35-17-16-29(30)23-6-4-3-5-7-23)18-24-19-31(42-28-14-8-25(34)9-15-28)37-38(33(24)40)26-10-12-27(41-2)13-11-26/h3-15,19,22,29-30,35H,16-18,20-21H2,1-2H3,(H,36,39)/t22?,29-,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>5.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136531
PNG
((R)-1,2,3,4-Tetrahydro-quinoline-2-carboxylic acid...)
Show SMILES Clc1ccc(C[C@@H](NC(=O)[C@H]2CCc3ccccc3N2)C(=O)N2CCC(Cn3cncn3)(CC2)C2CCCCC2)cc1
Show InChI InChI=1S/C33H41ClN6O2/c34-27-13-10-24(11-14-27)20-30(38-31(41)29-15-12-25-6-4-5-9-28(25)37-29)32(42)39-18-16-33(17-19-39,21-40-23-35-22-36-40)26-7-2-1-3-8-26/h4-6,9-11,13-14,22-23,26,29-30,37H,1-3,7-8,12,15-21H2,(H,38,41)/t29-,30-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/an/an/a 2.10n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136528
PNG
(3-[6-(4-Chloro-phenylsulfanyl)-2-(4-methoxy-phenyl...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCC(=O)N[C@@H]2CCc3ccccc3NC2=O)c1=O
Show InChI InChI=1S/C30H27ClN4O4S/c1-39-23-12-10-22(11-13-23)35-30(38)20(18-28(34-35)40-24-14-8-21(31)9-15-24)7-17-27(36)32-26-16-6-19-4-2-3-5-25(19)33-29(26)37/h2-5,8-15,18,26H,6-7,16-17H2,1H3,(H,32,36)(H,33,37)/t26-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 3.06E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136523
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(C(C)CCNC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(16-19-36-32(39)30-21-35-18-17-28(30)23-6-4-3-5-7-23)29-20-31(42-27-14-8-24(34)9-15-27)37-38(33(29)40)25-10-12-26(41-2)13-11-25/h3-15,20,22,28,30,35H,16-19,21H2,1-2H3,(H,36,39)/t22?,28-,30+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>5.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136533
PNG
((3S,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29-,30-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a>5.00E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136530
PNG
((3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {(R)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CCNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)29-18-19-35-21-30(29)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29+,30-/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 237n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136522
PNG
((3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(S)...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@H](C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)30-21-35-19-18-29(30)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22-,29+,30-/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 1.73E+3n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136518
PNG
((3R,4S)-4-Phenyl-pyrrolidine-3-carboxylic acid {(R...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C32H33ClN4O3S/c1-21(35-31(38)29-20-34-19-28(29)22-6-4-3-5-7-22)8-9-23-18-30(41-27-16-10-24(33)11-17-27)36-37(32(23)39)25-12-14-26(40-2)15-13-25/h3-7,10-18,21,28-29,34H,8-9,19-20H2,1-2H3,(H,35,38)/t21-,28-,29+/m1/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 250n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
Melanocortin receptor 4


(Homo sapiens (Human))		BDBM50136524
PNG
((3S,4S)-3-Phenyl-piperidine-4-carboxylic acid {3-[...)
Show SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CCC(C)NC(=O)[C@H]2CCNC[C@@H]2c2ccccc2)c1=O
Show InChI InChI=1S/C33H35ClN4O3S/c1-22(36-32(39)29-18-19-35-21-30(29)23-6-4-3-5-7-23)8-9-24-20-31(42-28-16-10-25(34)11-17-28)37-38(33(24)40)26-12-14-27(41-2)15-13-26/h3-7,10-17,20,22,29-30,35H,8-9,18-19,21H2,1-2H3,(H,36,39)/t22?,29-,30+/m0/s1
PDB

KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/an/an/a 260n/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4R

Bioorg Med Chem Lett 13: 4431-5 (2003)


BindingDB Entry DOI: 10.7270/Q2WH2QJG
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%