BindingDB logo
myBDB logout

PubMed code 14684291

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223369
PNG
(CHEMBL111171)
Show SMILES COc1cccc(Nc2c(cnc3n(C)nc(C)c23)C(N)=O)c1
Show InChI InChI=1S/C16H17N5O2/c1-9-13-14(19-10-5-4-6-11(7-10)23-3)12(15(17)22)8-18-16(13)21(2)20-9/h4-8H,1-3H3,(H2,17,22)(H,18,19)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 5n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223350
PNG
(CHEMBL107968)
Show SMILES COC(=O)N1CC[C@@H](C1)Oc1cccc(Nc2c(cnc3n(C)nc(C)c23)C(N)=O)c1 |r|
Show InChI InChI=1S/C21H24N6O4/c1-12-17-18(16(19(22)28)10-23-20(17)26(2)25-12)24-13-5-4-6-14(9-13)31-15-7-8-27(11-15)21(29)30-3/h4-6,9-10,15H,7-8,11H2,1-3H3,(H2,22,28)(H,23,24)/t15-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 10n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223370
PNG
(CHEMBL110984)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3ccccc3)c12
Show InChI InChI=1S/C15H15N5O/c1-9-12-13(18-10-6-4-3-5-7-10)11(14(16)21)8-17-15(12)20(2)19-9/h3-8H,1-2H3,(H2,16,21)(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 36n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223351
PNG
(CHEMBL321625)
Show SMILES COc1ccccc1Nc1c(cnc2n(C)nc(C)c12)C(N)=O
Show InChI InChI=1S/C16H17N5O2/c1-9-13-14(19-11-6-4-5-7-12(11)23-3)10(15(17)22)8-18-16(13)21(2)20-9/h4-8H,1-3H3,(H2,17,22)(H,18,19)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 76n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223371
PNG
(CHEMBL111381)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(c3)C#N)c12
Show InChI InChI=1S/C16H14N6O/c1-9-13-14(20-11-5-3-4-10(6-11)7-17)12(15(18)23)8-19-16(13)22(2)21-9/h3-6,8H,1-2H3,(H2,18,23)(H,19,20)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 85n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223402
PNG
(CHEMBL108205)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(O)c3)c12
Show InChI InChI=1S/C15H15N5O2/c1-8-12-13(18-9-4-3-5-10(21)6-9)11(14(16)22)7-17-15(12)20(2)19-8/h3-7,21H,1-2H3,(H2,16,22)(H,17,18)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 97n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223353
PNG
(CHEMBL322317)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(OC4CCCC4)c3)c12
Show InChI InChI=1S/C20H23N5O2/c1-12-17-18(16(19(21)26)11-22-20(17)25(2)24-12)23-13-6-5-9-15(10-13)27-14-7-3-4-8-14/h5-6,9-11,14H,3-4,7-8H2,1-2H3,(H2,21,26)(H,22,23)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>100n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223403
PNG
(CHEMBL107982)
Show SMILES COc1ccc(Nc2c(cnc3n(C)nc(C)c23)C(N)=O)cc1
Show InChI InChI=1S/C16H17N5O2/c1-9-13-14(19-10-4-6-11(23-3)7-5-10)12(15(17)22)8-18-16(13)21(2)20-9/h4-8H,1-3H3,(H2,17,22)(H,18,19)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>100n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223373
PNG
(CHEMBL430877)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(OC4CCC4)c3)c12
Show InChI InChI=1S/C19H21N5O2/c1-11-16-17(15(18(20)25)10-21-19(16)24(2)23-11)22-12-5-3-8-14(9-12)26-13-6-4-7-13/h3,5,8-10,13H,4,6-7H2,1-2H3,(H2,20,25)(H,21,22)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>100n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223367
PNG
(CHEMBL107766)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(OC4CCCCC4)c3)c12
Show InChI InChI=1S/C21H25N5O2/c1-13-18-19(17(20(22)27)12-23-21(18)26(2)25-13)24-14-7-6-10-16(11-14)28-15-8-4-3-5-9-15/h6-7,10-12,15H,3-5,8-9H2,1-2H3,(H2,22,27)(H,23,24)
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>100n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223374
PNG
(CHEMBL325137)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(O[C@H]4CCN(C4)S(C)(=O)=O)c3)c12
Show InChI InChI=1S/C20H24N6O4S/c1-12-17-18(16(19(21)27)10-22-20(17)25(2)24-12)23-13-5-4-6-14(9-13)30-15-7-8-26(11-15)31(3,28)29/h4-6,9-10,15H,7-8,11H2,1-3H3,(H2,21,27)(H,22,23)/t15-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a 250n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223372
PNG
(CHEMBL108638)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(O[C@H]4CCN(C4)C(=O)OC(C)(C)C)c3)c12
Show InChI InChI=1S/C24H30N6O4/c1-14-19-20(18(21(25)31)12-26-22(19)29(5)28-14)27-15-7-6-8-16(11-15)33-17-9-10-30(13-17)23(32)34-24(2,3)4/h6-8,11-12,17H,9-10,13H2,1-5H3,(H2,25,31)(H,26,27)/t17-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Similars
PubMed
n/an/a>300n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223352
PNG
(CHEMBL419382)
Show SMILES Cc1nn(C)c2ncc(C(N)=O)c(Nc3cccc(O[C@H]4CCNC4)c3)c12
Show InChI InChI=1S/C19H22N6O2/c1-11-16-17(15(18(20)26)10-22-19(16)25(2)24-11)23-12-4-3-5-13(8-12)27-14-6-7-21-9-14/h3-5,8,10,14,21H,6-7,9H2,1-2H3,(H2,20,26)(H,22,23)/t14-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a>300n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D


(Homo sapiens (Human))		BDBM50223349
PNG
(CHEMBL110819)
Show SMILES CC(=O)N1CC[C@@H](C1)Oc1cccc(Nc2c(cnc3n(C)nc(C)c23)C(N)=O)c1
Show InChI InChI=1S/C21H24N6O3/c1-12-18-19(17(20(22)29)10-23-21(18)26(3)25-12)24-14-5-4-6-15(9-14)30-16-7-8-27(11-16)13(2)28/h4-6,9-10,16H,7-8,11H2,1-3H3,(H2,22,29)(H,23,24)/t16-/m0/s1
PDB

UniProtKB/SwissProt

antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
MMDB
PC cid
PC sid
UniChem

Patents

Similars
PubMed
n/an/a>300n/an/an/an/an/an/a



Minase Research Institute

Curated by ChEMBL


Assay Description
Inhibition of phosphodiesterase 4 (PDE4) from U937 cells

Bioorg Med Chem Lett 14: 29-32 (2004)


BindingDB Entry DOI: 10.7270/Q2WS8WF7
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%